DE602005006985D1 - Auf produktsezernierung beruhende verfahren zur aufreinigung von zellen - Google Patents

Auf produktsezernierung beruhende verfahren zur aufreinigung von zellen

Info

Publication number
DE602005006985D1
DE602005006985D1 DE602005006985T DE602005006985T DE602005006985D1 DE 602005006985 D1 DE602005006985 D1 DE 602005006985D1 DE 602005006985 T DE602005006985 T DE 602005006985T DE 602005006985 T DE602005006985 T DE 602005006985T DE 602005006985 D1 DE602005006985 D1 DE 602005006985D1
Authority
DE
Germany
Prior art keywords
cells
light
property
population
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005006985T
Other languages
English (en)
Inventor
Manfred R Koller
Elie G Hanania
Annabeth Fieck
Timothy M Eisfeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncosis Inc
Original Assignee
Oncosis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncosis Inc filed Critical Oncosis Inc
Publication of DE602005006985D1 publication Critical patent/DE602005006985D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves

Landscapes

  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
DE602005006985T 2004-03-15 2005-03-14 Auf produktsezernierung beruhende verfahren zur aufreinigung von zellen Active DE602005006985D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/801,931 US7425426B2 (en) 2004-03-15 2004-03-15 Methods for purification of cells based on product secretion
PCT/US2005/008347 WO2005090555A1 (en) 2004-03-15 2005-03-14 Methods for purification of cells based on product secretion

Publications (1)

Publication Number Publication Date
DE602005006985D1 true DE602005006985D1 (de) 2008-07-03

Family

ID=34920875

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005006985T Active DE602005006985D1 (de) 2004-03-15 2005-03-14 Auf produktsezernierung beruhende verfahren zur aufreinigung von zellen

Country Status (8)

Country Link
US (3) US7425426B2 (de)
EP (1) EP1725653B1 (de)
JP (2) JP4728319B2 (de)
AT (1) ATE396254T1 (de)
AU (1) AU2005224624B2 (de)
CA (1) CA2559736C (de)
DE (1) DE602005006985D1 (de)
WO (1) WO2005090555A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6753161B2 (en) * 1997-03-27 2004-06-22 Oncosis Llc Optoinjection methods
AU785290B2 (en) 1999-11-30 2006-12-21 Intrexon Corporation Method and apparatus for selectively targeting specific cells within a cell population
AU2002232892B2 (en) 2000-10-24 2008-06-26 Intrexon Corporation Method and device for selectively targeting cells within a three -dimensional specimen
US20050095578A1 (en) * 2003-10-31 2005-05-05 Koller Manfred R. Method and apparatus for cell permeabilization
US7425426B2 (en) * 2004-03-15 2008-09-16 Cyntellect, Inc. Methods for purification of cells based on product secretion
WO2010081052A1 (en) 2009-01-09 2010-07-15 Cyntellect, Inc. Genetic analysis of cells
WO2010081171A2 (en) 2009-01-12 2010-07-15 Cyntellect, Inc. Laser mediated sectioning and transfer of cell colonies
JP6829469B2 (ja) 2015-08-10 2021-02-10 国立大学法人富山大学 抗原特異的モノクローナル抗体作製方法
PL413909A1 (pl) * 2015-09-15 2017-03-27 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Sposób detekcji i selekcji komórek hybrydomalnych produkujących pożądane przeciwciała
JP6532063B2 (ja) 2017-02-13 2019-06-19 株式会社片岡製作所 細胞処理装置
JP6541160B2 (ja) 2017-02-13 2019-07-10 株式会社片岡製作所 細胞処理装置および対象物の処理方法
JP6574028B1 (ja) 2018-06-29 2019-09-11 株式会社片岡製作所 細胞処理装置および細胞のレーザ処理方法

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3674926A (en) * 1968-10-15 1972-07-04 Reynolds Metals Co Feature counter with improved masking and grey level detection
US3864571A (en) 1971-02-10 1975-02-04 Wheeler International Inc Method and Apparatus for Automatically, Identifying and Counting Various Cells in Body Fluids
US4000417A (en) * 1975-08-25 1976-12-28 Honeywell Inc. Scanning microscope system with automatic cell find and autofocus
JPS5391754A (en) * 1977-01-21 1978-08-11 Canon Inc Scannint type photo detector
JPS53135660A (en) * 1977-04-30 1978-11-27 Olympus Optical Co Ltd Fluorescent photometric microscope using laser light
US4803992A (en) * 1980-10-28 1989-02-14 Lemelson Jerome H Electro-optical instruments and methods for producing same
US4395397A (en) * 1981-09-17 1983-07-26 Sidney Farber Cancer Institute, Inc. Apparatus and method for killing unwanted cells
US5272081A (en) * 1982-05-10 1993-12-21 Bar-Ilan University System and methods for cell selection
US4624915A (en) * 1982-07-29 1986-11-25 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US4629687A (en) * 1982-07-29 1986-12-16 Board Of Trustees Of Michigan State University Positive selection sorting of cells
US4532402A (en) * 1983-09-02 1985-07-30 Xrl, Inc. Method and apparatus for positioning a focused beam on an integrated circuit
JPS6083584A (ja) * 1983-10-13 1985-05-11 Rikagaku Kenkyusho 生細胞内への物質移入法
US5103660A (en) * 1984-04-23 1992-04-14 Johnson Virgil T Removable steering wheel device, and methods of constructing and utilizing same
US4998284A (en) * 1987-11-17 1991-03-05 Cell Analysis Systems, Inc. Dual color camera microscope and methodology for cell staining and analysis
DE3708511A1 (de) * 1987-03-16 1988-09-29 Kratzer Michael Einrichtung zur selektiven zerstoerung von zellen
US5188633A (en) * 1987-03-16 1993-02-23 Michael Kratzer Device for selective destruction of cells
JPH07122902B2 (ja) 1987-04-17 1995-12-25 株式会社日立製作所 細胞位置検出装置
US4950592A (en) * 1987-05-12 1990-08-21 Eastman Kodak Company Blend of monoclonal antibodies
HU204856B (en) 1987-08-12 1992-02-28 Orszagos Mueszaki Fejlesztesi Process for releasing cell mixtures and tissues from undesired populations and for producing monoclonal antibody - hematoporphyrin conjugates
US5121436A (en) * 1987-08-14 1992-06-09 International Remote Imaging Systems, Inc. Method and apparatus for generating a plurality of parameters of an object in a field of view
US4965725B1 (en) * 1988-04-08 1996-05-07 Neuromedical Systems Inc Neural network based automated cytological specimen classification system and method
US5109276A (en) * 1988-05-27 1992-04-28 The University Of Connecticut Multi-dimensional multi-spectral imaging system
DE3836716A1 (de) * 1988-10-28 1990-05-03 Zeiss Carl Fa Verfahren zur auswertung von zellbildern
US5089384A (en) * 1988-11-04 1992-02-18 Amoco Corporation Method and apparatus for selective cell destruction using amplified immunofluorescence
JPH02168160A (ja) * 1988-12-22 1990-06-28 Omron Tateisi Electron Co 細胞選別装置
US6099522A (en) * 1989-02-06 2000-08-08 Visx Inc. Automated laser workstation for high precision surgical and industrial interventions
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5072382A (en) 1989-10-02 1991-12-10 Kamentsky Louis A Methods and apparatus for measuring multiple optical properties of biological specimens
EP0433824B1 (de) * 1989-12-22 1994-03-02 Asea Brown Boveri Ag Faseroptischer Sensor
US5093866A (en) * 1990-02-09 1992-03-03 Hamilton Equine Associates Limited Fluorescence and motility characterization system for cells, bacteria, and particles in fluids
US5202230A (en) * 1990-09-07 1993-04-13 Kamentsky Louis A Methods of detecting cut cells in a tissue section
US5235522A (en) * 1990-10-10 1993-08-10 Cell Analysis Systems, Inc. Method and apparatus for automated analysis of biological specimens
US5257182B1 (en) * 1991-01-29 1996-05-07 Neuromedical Systems Inc Morphological classification system and method
US5784162A (en) * 1993-08-18 1998-07-21 Applied Spectral Imaging Ltd. Spectral bio-imaging methods for biological research, medical diagnostics and therapy
EP0501688A1 (de) * 1991-02-27 1992-09-02 Hitachi, Ltd. Apparat und Methode zur Einspiegelung eines Laserstrahls in einen Mikroskopstrahlengang
US5790710A (en) * 1991-07-12 1998-08-04 Jeffrey H. Price Autofocus system for scanning microscopy
US5548661A (en) 1991-07-12 1996-08-20 Price; Jeffrey H. Operator independent image cytometer
US5428690A (en) * 1991-09-23 1995-06-27 Becton Dickinson And Company Method and apparatus for automated assay of biological specimens
CA2077781A1 (en) 1991-09-23 1993-03-24 James W. Bacus Method and apparatus for automated assay of biological specimens
US5298963A (en) * 1992-02-26 1994-03-29 Mitsui Mining & Smelting Co., Ltd. Apparatus for inspecting the surface of materials
US6007814A (en) * 1992-06-15 1999-12-28 Sloan-Kettering Institute For Cancer Research Therapeutic uses of the hypervariable region of monoclonal antibody M195 and constructs thereof
JP3099049B2 (ja) 1992-07-29 2000-10-16 農林水産省果樹試験場長 電気的細胞融合及び電気的核酸導入のための大量処理用電極
JP3120387B2 (ja) * 1992-08-04 2000-12-25 ユニデン株式会社 コードレス電話装置
RU2054486C1 (ru) 1992-09-01 1996-02-20 Валерий Георгиевич Петухов Способ идентификации микроорганизмов
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5450463A (en) * 1992-12-25 1995-09-12 Olympus Optical Co., Ltd. X-ray microscope
CA2102884A1 (en) * 1993-03-04 1994-09-05 James J. Wynne Dental procedures and apparatus using ultraviolet radiation
US5422720A (en) * 1993-07-21 1995-06-06 Becton Dickinson And Company Blood culture sensor station utilizing two distinct light sources
US5995645A (en) 1993-08-18 1999-11-30 Applied Spectral Imaging Ltd. Method of cancer cell detection
US5878746A (en) 1993-08-25 1999-03-09 Lemelson; Jerome H. Computerized medical diagnostic system
US5381224A (en) * 1993-08-30 1995-01-10 A. E. Dixon Scanning laser imaging system
US6056738A (en) * 1997-01-31 2000-05-02 Transmedica International, Inc. Interstitial fluid monitoring
EP0662512A3 (de) 1993-12-20 1997-01-15 Becton Dickinson Co Menschliche hämatopoietische Stammzellen.
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US5932872A (en) * 1994-07-01 1999-08-03 Jeffrey H. Price Autofocus system for scanning microscopy having a volume image formation
US5795755A (en) * 1994-07-05 1998-08-18 Lemelson; Jerome H. Method of implanting living cells by laser poration at selected sites
US5523543A (en) * 1994-09-09 1996-06-04 Litel Instruments Laser ablation control system and method
AU3544995A (en) * 1994-09-20 1996-04-09 Neopath, Inc. Apparatus for identification and integration of multiple cell patterns
US5552605A (en) 1994-11-18 1996-09-03 Picker International, Inc. Motion correction based on reprojection data
DE69530072T2 (de) * 1994-12-08 2004-03-04 Molecular Dynamics, Sunnyvale System zur fluoreszenzabbildung unter verwendung eines objektivs mit makroabtastung
JP3077539B2 (ja) * 1994-12-22 2000-08-14 松下電器産業株式会社 レーザ加工方法
US5713364A (en) 1995-08-01 1998-02-03 Medispectra, Inc. Spectral volume microprobe analysis of materials
DE19529371C3 (de) 1995-08-10 2003-05-28 Nmi Univ Tuebingen Mikroelektroden-Anordnung
US6148096A (en) * 1995-09-15 2000-11-14 Accumed International, Inc. Specimen preview and inspection system
US6166385A (en) * 1995-09-19 2000-12-26 Cornell Research Foundation, Inc. Multi-photon laser microscopy
US6040139A (en) 1995-09-19 2000-03-21 Bova; G. Steven Laser cell purification system
US5732150A (en) * 1995-09-19 1998-03-24 Ihc Health Services, Inc. Method and system for multiple wavelength microscopy image analysis
WO1997020198A2 (en) * 1995-11-30 1997-06-05 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
US5646411A (en) * 1996-02-01 1997-07-08 Molecular Dynamics, Inc. Fluorescence imaging system compatible with macro and micro scanning objectives
US5890846A (en) * 1996-04-25 1999-04-06 The Gleason Works Cutting tool for toothed articles
US5750356A (en) * 1996-05-31 1998-05-12 Anergen, Inc. Method for monitoring T cell reactivity
US5952651A (en) * 1996-06-10 1999-09-14 Moritex Corporation Laser manipulation apparatus and cell plate used therefor
US6122396A (en) * 1996-12-16 2000-09-19 Bio-Tech Imaging, Inc. Method of and apparatus for automating detection of microorganisms
US5995143A (en) * 1997-02-07 1999-11-30 Q3Dm, Llc Analog circuit for an autofocus microscope system
US6759206B1 (en) 1997-02-27 2004-07-06 Cellomics, Inc. System for cell-based screening
US6534308B1 (en) 1997-03-27 2003-03-18 Oncosis, Llc Method and apparatus for selectively targeting specific cells within a mixed cell population
US5874266A (en) * 1997-03-27 1999-02-23 Palsson; Bernhard O. Targeted system for removing tumor cells from cell populations
US6753161B2 (en) * 1997-03-27 2004-06-22 Oncosis Llc Optoinjection methods
CA2287947A1 (en) 1997-05-09 1998-11-19 Ryan S. Raz Multi-spectral imaging system and method for cytology
US5981268A (en) 1997-05-30 1999-11-09 Board Of Trustees, Leland Stanford, Jr. University Hybrid biosensors
US6326489B1 (en) 1997-08-05 2001-12-04 Howard Hughes Medical Institute Surface-bound, bimolecular, double-stranded DNA arrays
JP2001518295A (ja) * 1997-09-30 2001-10-16 エール ユニヴァーシティ 真核細胞において膜タンパク質ディスプレイおよびタンパク質分泌を選択的に制御する方法
JP3735190B2 (ja) * 1997-10-28 2006-01-18 オリンパス株式会社 走査型サイトメータ
US6005256A (en) * 1998-02-12 1999-12-21 Raytheon Company Method and apparatus for performing cell analysis based on simultaneous multiple marker emissions from neoplasia (CASMMEN)
US6156576A (en) 1998-03-06 2000-12-05 The Regents Of The University Of California Fast controllable laser lysis of cells for analysis
US6642018B1 (en) * 1998-03-27 2003-11-04 Oncosis Llc Method for inducing a response in one or more targeted cells
US6298264B1 (en) * 1998-08-31 2001-10-02 Duke University Apparatus and method for macromolecule delivery into living cells
WO2000034434A1 (en) 1998-12-07 2000-06-15 Acacia Biosciences, Inc. Multi-channel electrode arrays
AU3771500A (en) * 1999-03-26 2000-10-16 Stephen T Flock Delivery of pharmaceutical compounds and collection of biomolecules using electromagnetic energy and uses thereof
US6381224B1 (en) * 1999-03-31 2002-04-30 Motorola, Inc. Method and apparatus for controlling a full-duplex communication system
AU785290B2 (en) 1999-11-30 2006-12-21 Intrexon Corporation Method and apparatus for selectively targeting specific cells within a cell population
AU2002232892B2 (en) * 2000-10-24 2008-06-26 Intrexon Corporation Method and device for selectively targeting cells within a three -dimensional specimen
US6509166B1 (en) * 2000-11-28 2003-01-21 Robert A. Levine Detection and quantification of one or more target analytes in a sample using spatially localized analyte reproduction
JP2002325572A (ja) * 2000-12-25 2002-11-12 Univ Osaka 外来物質の導入方法
CA2457473A1 (en) * 2001-08-06 2003-09-18 Vanderbilt University Device and methods for measuring the response of at least one cell to a medium
JP2003076569A (ja) 2001-08-31 2003-03-14 Nippon Signal Co Ltd:The バス同期２重系コンピュータ
US6995143B2 (en) * 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
JP2003259076A (ja) 2002-03-04 2003-09-12 Ricoh Co Ltd 通信端末装置
NZ552851A (en) * 2002-05-22 2008-09-26 Biogen Idec Inc Detection of a secreted polypeptide on the surface of a cell used as a marker for cellular productivity of the secreted polypeptide
US20040082017A1 (en) * 2002-08-14 2004-04-29 Boehringer Ingelheim Phamaceuticals, Inc. Methods and compositions for targeting secretory lysosomes
EP1664774A4 (de) * 2003-08-29 2007-06-27 Centocor Inc Schneller weg zum erhalten von säugerzellklonen mit hoher expression unter verwendung einer methylcellulose und immunpräzipitation-screening-verfahren
US20050095578A1 (en) * 2003-10-31 2005-05-05 Koller Manfred R. Method and apparatus for cell permeabilization
US7425426B2 (en) * 2004-03-15 2008-09-16 Cyntellect, Inc. Methods for purification of cells based on product secretion
TWI270362B (en) 2004-12-28 2007-01-11 Ind Tech Res Inst Cell subcloning device
US7999161B2 (en) 2005-01-22 2011-08-16 Alexander Oraevsky Laser-activated nanothermolysis of cells
US8785193B2 (en) 2006-09-14 2014-07-22 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Dissection tool and methods of use
US8338166B2 (en) 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
WO2010081052A1 (en) 2009-01-09 2010-07-15 Cyntellect, Inc. Genetic analysis of cells
WO2010081171A2 (en) 2009-01-12 2010-07-15 Cyntellect, Inc. Laser mediated sectioning and transfer of cell colonies

Also Published As

Publication number Publication date
JP2007529221A (ja) 2007-10-25
US20050202558A1 (en) 2005-09-15
US7622274B2 (en) 2009-11-24
JP2011097957A (ja) 2011-05-19
JP4728319B2 (ja) 2011-07-20
US20100136683A1 (en) 2010-06-03
CA2559736C (en) 2014-05-13
US20080014606A1 (en) 2008-01-17
CA2559736A1 (en) 2005-09-29
WO2005090555A1 (en) 2005-09-29
AU2005224624A1 (en) 2005-09-29
US7425426B2 (en) 2008-09-16
ATE396254T1 (de) 2008-06-15
US8236521B2 (en) 2012-08-07
EP1725653B1 (de) 2008-05-21
AU2005224624B2 (en) 2009-12-03
EP1725653A1 (de) 2006-11-29
JP5580755B2 (ja) 2014-08-27

Similar Documents

Publication Publication Date Title
DE602005006985D1 (de) Auf produktsezernierung beruhende verfahren zur aufreinigung von zellen
BRPI0513308A (pt) sistemas e métodos de análise de polìmeros de ácido nucléico e componentes relacionados
UY37994A (es) Moléculas de adn correspondientes a evento transgénico mon88017 y métodos para su detección
CR7966A (es) Metodo y sistema mejorado pata detectar y/o predecir anomalias biologicas, tales como desordenes cerebrales
CL2010000485A1 (es) Sistemas y metodos para el analisis y la sintesis de los datos a partir de una pluralidad de fuentes de datos de muestra para el aprendizaje y la regresion del proceso gaussiano.
HN2008000346A (es) Secuencias de nucleotidos que codifican proteinas insecticidas
BRPI0508299A (pt) sistema livre de produto animal e processo para purificação de uma toxina botulina
DK2018441T3 (da) Mærkede mikroorganismer og fremgangsmåde til mærkning
ATE527385T1 (de) Mit tumoren assoziierte genetische variationen
DE69738996D1 (de) Miniaturisierte zellenanordnung und verfahren und vorrichtung zum screening mittels zellen
CY1111612T1 (el) Μεθοδος για προβλεψη της αποκρισης σε μια θεραπευτικη αγωγη με εναν αναστολεαδιmερισmου του her
ATE490306T1 (de) Methoden zur medikamentenaufspürung auf der basis von in vitro differenzierten zellen
TW200636075A (en) Detection of nucleic acid variation by cleavage-amplification method
ATE405841T1 (de) In-vitro-verfahren zum gleichzeitigen nachweisen und identifizieren von antibiotika unterschiedlicher klassen sowie entsprechender diagnostischer kit
WO2006006148A3 (en) Multi mode inspection method and apparatus
BR0206318A (pt) Detecção de analitos
AR067924A1 (es) Procedimiento de purificacion o de deteccion de una proteina diana
ATE495254T1 (de) Biologisch wirksame moleküle, insbesondere auf grundlage von pna und sirna, verfahren zu deren zellspezifischen aktivierung sowie applikationskit zur verabreichung
BRPI0912927A2 (pt) "método de detectar um tumor independente de vegf em um indivíduo e método de tratar um tumor independente de vegf em um indivíduo"
ATE466079T1 (de) Nukleinsäure konstrukten, pharmazeutische kompositionen und methoden für die behandlung von krebs
DE602008006254D1 (de) Doppel-oligonukleotid-nukleinsäurenachweisverfahren
ATE456666T1 (de) Verfahren zur auswertung von ribonukleotidsequenzen
JP2011097957A5 (de)
ATE403151T1 (de) Trägerplatte zur durchführung funktioneller tests an biologischen zellen sowie verfahren zur beschichtung der trägerplatte
Gendarme et al. Image-based drug screen identifies HDAC inhibitors as novel Golgi disruptors synergizing with JQ1

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R082 Change of representative

Ref document number: 1725653

Country of ref document: EP

Representative=s name: MUELLER-BORE & PARTNER, PATENTANWAELTE, EUROPEAN P