ATE396180T1 - Verfahren zur herstellung von 2,6-diamino-4,5,6,7-tetrahydrobenzothiazol - Google Patents
Verfahren zur herstellung von 2,6-diamino-4,5,6,7-tetrahydrobenzothiazolInfo
- Publication number
- ATE396180T1 ATE396180T1 AT03769701T AT03769701T ATE396180T1 AT E396180 T1 ATE396180 T1 AT E396180T1 AT 03769701 T AT03769701 T AT 03769701T AT 03769701 T AT03769701 T AT 03769701T AT E396180 T1 ATE396180 T1 AT E396180T1
- Authority
- AT
- Austria
- Prior art keywords
- tetrahydrobenzothiazole
- diamino
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0225701A GB2394951A (en) | 2002-11-04 | 2002-11-04 | One pot synthesis of 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE396180T1 true ATE396180T1 (de) | 2008-06-15 |
Family
ID=9947186
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03769701T ATE396180T1 (de) | 2002-11-04 | 2003-11-03 | Verfahren zur herstellung von 2,6-diamino-4,5,6,7-tetrahydrobenzothiazol |
Country Status (25)
Country | Link |
---|---|
US (1) | US7285669B2 (de) |
EP (1) | EP1562921B1 (de) |
JP (1) | JP4708792B2 (de) |
KR (1) | KR101086844B1 (de) |
CN (1) | CN100551918C (de) |
AP (1) | AP1882A (de) |
AT (1) | ATE396180T1 (de) |
AU (1) | AU2003278396B2 (de) |
BR (1) | BR0315919A (de) |
CA (1) | CA2505179C (de) |
DE (1) | DE60321208D1 (de) |
EC (1) | ECSP055835A (de) |
GB (1) | GB2394951A (de) |
HR (1) | HRPK20050403B3 (de) |
IS (1) | IS7882A (de) |
MA (1) | MA27534A1 (de) |
MX (1) | MXPA05004815A (de) |
NO (1) | NO20052189L (de) |
NZ (1) | NZ539953A (de) |
PL (1) | PL376543A1 (de) |
PT (1) | PT1562921E (de) |
RU (1) | RU2305097C2 (de) |
TN (1) | TNSN05125A1 (de) |
WO (1) | WO2004041797A1 (de) |
ZA (1) | ZA200503548B (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0221513D0 (en) * | 2002-09-17 | 2002-10-23 | Generics Uk Ltd | Novel compounds and processes |
WO2006012277A2 (en) * | 2004-06-30 | 2006-02-02 | Amr Technology, Inc. | Biocatalytic process for preparing enantiomerically enriched pramipexole |
WO2006003677A1 (en) * | 2004-07-01 | 2006-01-12 | Alembic Limited | Improved process for the preparation of biologically active tetrahydrobenzthiazole derivative |
US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
CA2652251A1 (en) | 2006-05-16 | 2007-11-29 | Knopp Neurosciences, Inc. | Compositions of r(+) and s(-) pramipexole and methods for using the same |
US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
SI22446A (sl) * | 2007-02-07 | 2008-08-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek za sintezo pramipeksola in njegovih farmacevtsko sprejemljivih soli |
WO2008104847A2 (en) * | 2007-02-26 | 2008-09-04 | Wockhardt Research Centre | Processes for the preparation of pramipexole and salts thereof |
US8519148B2 (en) | 2007-03-14 | 2013-08-27 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
CN101429173B (zh) * | 2007-11-09 | 2012-12-05 | 重庆医药工业研究院有限责任公司 | 一种普拉克索中间体2,6-二氨基-4,5,6,7-四氢-苯并噻唑的制备方法 |
KR20110071064A (ko) | 2008-08-19 | 2011-06-28 | 크놉 뉴로사이언시스 인코포레이티드 | (r)-프라미펙솔을 사용하는 조성물 및 방법 |
WO2011021214A2 (en) * | 2009-08-07 | 2011-02-24 | Msn Laboratories Limited | Improved process for the preparation of (s)-2-amino-4,5,6,7-tetrahydro-6 - (propylamino) benzothiazole and its pharmaceutically acceptable salts |
US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
RS61539B1 (sr) | 2013-07-12 | 2021-04-29 | Knopp Biosciences Llc | Lečenje povišenih nivoa eozinofila i/ili bazofila |
US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
CA2921381A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
WO2015023786A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
CN104311507A (zh) * | 2013-10-09 | 2015-01-28 | 安徽万邦医药科技有限公司 | (6s)-2,6-二氨基-4,5,6,7-四氢苯并噻唑的制备方法 |
CN103613562B (zh) * | 2013-11-25 | 2015-09-30 | 浙江美诺华药物化学有限公司 | 一种普拉克索的制备方法 |
CN107573301B (zh) * | 2017-11-08 | 2020-08-11 | 江苏长青农化股份有限公司 | 一种三环唑中间体的制备方法 |
CN109232471B (zh) * | 2018-10-31 | 2022-05-10 | 安徽省庆云医药股份有限公司 | 一种盐酸普拉克索的制备方法 |
CN111362884A (zh) * | 2018-12-26 | 2020-07-03 | 江苏神龙药业股份有限公司 | 一种2,6-二氨基-4,5,6,7-四氢-苯并噻唑的工业化制备方法 |
CN110734413A (zh) * | 2019-12-02 | 2020-01-31 | 山东铂源药业有限公司 | 一种普拉克索中间体2,6-二氨基-4,5,6,7-四氢苯并噻唑的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE45735T1 (de) * | 1984-12-22 | 1989-09-15 | Thomae Gmbh Dr K | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel. |
DE3447075A1 (de) * | 1984-12-22 | 1986-07-03 | Dr. Karl Thomae Gmbh, 7950 Biberach | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel |
ES2187249B1 (es) * | 2000-09-18 | 2004-09-16 | Synthon Bv | Procedimiento para la preparacion de 2-amino-6-(alquil)amino-4,5,6,7-tetrahidrobenzotiazoles. |
-
2002
- 2002-11-04 GB GB0225701A patent/GB2394951A/en not_active Withdrawn
-
2003
- 2003-11-03 KR KR1020057007963A patent/KR101086844B1/ko not_active IP Right Cessation
- 2003-11-03 RU RU2005117364/04A patent/RU2305097C2/ru not_active IP Right Cessation
- 2003-11-03 AU AU2003278396A patent/AU2003278396B2/en not_active Ceased
- 2003-11-03 BR BR0315919-1A patent/BR0315919A/pt not_active IP Right Cessation
- 2003-11-03 WO PCT/GB2003/004734 patent/WO2004041797A1/en active IP Right Grant
- 2003-11-03 MX MXPA05004815A patent/MXPA05004815A/es active IP Right Grant
- 2003-11-03 PT PT03769701T patent/PT1562921E/pt unknown
- 2003-11-03 JP JP2004549326A patent/JP4708792B2/ja not_active Expired - Fee Related
- 2003-11-03 AT AT03769701T patent/ATE396180T1/de not_active IP Right Cessation
- 2003-11-03 ZA ZA200503548A patent/ZA200503548B/en unknown
- 2003-11-03 NZ NZ539953A patent/NZ539953A/en not_active IP Right Cessation
- 2003-11-03 AP AP2005003306A patent/AP1882A/xx active
- 2003-11-03 CA CA2505179A patent/CA2505179C/en not_active Expired - Fee Related
- 2003-11-03 DE DE60321208T patent/DE60321208D1/de not_active Expired - Lifetime
- 2003-11-03 PL PL376543A patent/PL376543A1/pl not_active IP Right Cessation
- 2003-11-03 CN CNB2003801082013A patent/CN100551918C/zh not_active Expired - Fee Related
- 2003-11-03 US US10/533,637 patent/US7285669B2/en not_active Expired - Fee Related
- 2003-11-03 EP EP03769701A patent/EP1562921B1/de not_active Expired - Lifetime
-
2005
- 2005-05-04 NO NO20052189A patent/NO20052189L/no unknown
- 2005-05-04 TN TNP2005000125A patent/TNSN05125A1/en unknown
- 2005-05-05 HR HR20050403A patent/HRPK20050403B3/xx not_active IP Right Cessation
- 2005-06-02 IS IS7882A patent/IS7882A/is unknown
- 2005-06-02 MA MA28311A patent/MA27534A1/fr unknown
- 2005-06-03 EC EC2005005835A patent/ECSP055835A/es unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |