ATE388705T1 - Fentanyl zusammensetzung zur nasalen anwendung - Google Patents
Fentanyl zusammensetzung zur nasalen anwendungInfo
- Publication number
- ATE388705T1 ATE388705T1 AT01960190T AT01960190T ATE388705T1 AT E388705 T1 ATE388705 T1 AT E388705T1 AT 01960190 T AT01960190 T AT 01960190T AT 01960190 T AT01960190 T AT 01960190T AT E388705 T1 ATE388705 T1 AT E388705T1
- Authority
- AT
- Austria
- Prior art keywords
- fentanyl
- administration
- nasal
- results
- action
- Prior art date
Links
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 title abstract 4
- 229960002428 fentanyl Drugs 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 208000002193 Pain Diseases 0.000 abstract 2
- 238000001990 intravenous administration Methods 0.000 abstract 2
- 208000004756 Respiratory Insufficiency Diseases 0.000 abstract 1
- 206010038678 Respiratory depression Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 208000005298 acute pain Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000036470 plasma concentration Effects 0.000 abstract 1
- 238000004448 titration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001154 | 2000-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE388705T1 true ATE388705T1 (de) | 2008-03-15 |
Family
ID=8159630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01960190T ATE388705T1 (de) | 2000-07-31 | 2001-07-31 | Fentanyl zusammensetzung zur nasalen anwendung |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US8017627B2 (enExample) |
| EP (3) | EP1642578B2 (enExample) |
| JP (2) | JP4898073B2 (enExample) |
| KR (2) | KR100888275B1 (enExample) |
| CN (2) | CN100346788C (enExample) |
| AT (1) | ATE388705T1 (enExample) |
| AU (2) | AU8174601A (enExample) |
| CA (1) | CA2417727C (enExample) |
| CY (2) | CY1107405T1 (enExample) |
| DE (2) | DE20122843U1 (enExample) |
| DK (2) | DK1307194T4 (enExample) |
| EA (1) | EA006384B1 (enExample) |
| EE (1) | EE05420B1 (enExample) |
| ES (2) | ES2427976T5 (enExample) |
| IL (2) | IL154041A0 (enExample) |
| IS (1) | IS2803B (enExample) |
| NO (2) | NO330565B1 (enExample) |
| NZ (1) | NZ524396A (enExample) |
| PL (1) | PL207845B1 (enExample) |
| PT (2) | PT1307194E (enExample) |
| SI (2) | SI1642578T2 (enExample) |
| UA (2) | UA77398C2 (enExample) |
| WO (1) | WO2002009707A1 (enExample) |
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| US20040115133A1 (en) * | 2000-05-10 | 2004-06-17 | Wermeling Daniel P. | Intranasal opioid compositions |
| DE20122843U1 (de) | 2000-07-31 | 2008-06-26 | Nycomed Danmark Aps | Fentanyl Zusammensetzung zur nasalen Anwendung |
| US20020106407A1 (en) * | 2000-12-11 | 2002-08-08 | Dennis Coleman | Method and apparatus for treating breakthrough pain |
| US20090281023A9 (en) * | 2001-06-04 | 2009-11-12 | Nobex Corporation | Mixtures Of Calcitonin Drug-Oligomer Conjugates And Methods Of Use In Pain Treatment |
| DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
| GB0210264D0 (en) * | 2002-05-03 | 2002-06-12 | Arakis Ltd | The treatment of pain and migraine headache |
| GB0300531D0 (en) * | 2003-01-10 | 2003-02-12 | West Pharm Serv Drug Res Ltd | Pharmaceutical compositions |
| GB0305579D0 (en) * | 2003-03-11 | 2003-04-16 | Dallas Burston Ltd | Pharmaceutical compositions |
| GB0315632D0 (en) | 2003-07-04 | 2003-08-13 | West Pharm Serv Drug Res Ltd | Pharmaceutical formulations |
| US20070053965A1 (en) * | 2005-02-25 | 2007-03-08 | Gruenenthal Gmbh | Kit comprising a plaster, optionally containing an active substance, and an agent that at least partially reduces skin irritation |
| US8535714B2 (en) | 2006-01-06 | 2013-09-17 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8252329B2 (en) | 2007-01-05 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US8252328B2 (en) * | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| US9289583B2 (en) | 2006-01-06 | 2016-03-22 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US9066847B2 (en) | 2007-01-05 | 2015-06-30 | Aceirx Pharmaceuticals, Inc. | Storage and dispensing devices for administration of oral transmucosal dosage forms |
| US8865743B2 (en) | 2006-01-06 | 2014-10-21 | Acelrx Pharmaceuticals, Inc. | Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain |
| US8753308B2 (en) | 2006-01-06 | 2014-06-17 | Acelrx Pharmaceuticals, Inc. | Methods for administering small volume oral transmucosal dosage forms using a dispensing device |
| US8357114B2 (en) | 2006-01-06 | 2013-01-22 | Acelrx Pharmaceuticals, Inc. | Drug dispensing device with flexible push rod |
| US8202535B2 (en) * | 2006-01-06 | 2012-06-19 | Acelrx Pharmaceuticals, Inc. | Small-volume oral transmucosal dosage forms |
| CN101472644B (zh) * | 2006-04-13 | 2014-04-23 | 纽帕特公司 | 递送抗偏头痛化合物的透皮方法和系统 |
| US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
| US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
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| WO2009100383A2 (en) | 2008-02-07 | 2009-08-13 | University Of Washington | Circumferential aerosol device |
| GB2464282A (en) * | 2008-10-08 | 2010-04-14 | Archimedes Dev Ltd | A device for administering a dose of opioid analgesic |
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| EP2605816B1 (en) | 2010-08-20 | 2019-01-23 | University Of Washington | Circumferential aerosol device for delivering drugs to olfactory epithelium and brain |
| SI2670674T1 (sl) | 2011-02-04 | 2016-11-30 | Archimedes Development Limited | Izboljšan vsebnik |
| JP6339371B2 (ja) | 2011-03-03 | 2018-06-06 | インペル ニューロファーマ インコーポレイテッド | 経鼻薬物送達デバイス |
| CN103619485B (zh) | 2011-05-09 | 2017-08-08 | 英倍尔药业股份有限公司 | 用于鼻腔药物递送的喷嘴 |
| DK2706982T4 (da) * | 2011-05-13 | 2021-05-10 | Euro Celtique Sa | Intranasale farmaceutiske dosisformer omfattende naloxon |
| HK1222358A1 (zh) | 2013-04-28 | 2017-06-30 | Impel Neuropharma Inc. | 医用单位剂量容器 |
| NZ732808A (en) | 2014-12-23 | 2021-12-24 | Acelrx Pharmaceuticals Inc | Systems, devices and methods for dispensing oral transmucosal dosage forms |
| CN108601916B (zh) | 2015-09-10 | 2021-07-09 | 英倍尔药业股份有限公司 | 直列式鼻部递送装置 |
| WO2019104192A1 (en) | 2017-11-21 | 2019-05-31 | Impel Neuropharma, Inc. | Intranasal device with inlet interface |
| JP7191099B2 (ja) | 2017-11-21 | 2022-12-16 | インペル ファーマシューティカルズ インコーポレイテッド | 浸漬管を備えた鼻腔内装置 |
| AU2019205329B2 (en) | 2018-01-05 | 2023-04-20 | Impel Pharmaceuticals Inc. | Intranasal delivery of olanzapine by precision olfactory device |
| RU2020125871A (ru) | 2018-01-05 | 2022-02-07 | Импел Ньюрофарма, Инк. | Интраназальная доставка дигидроэрготамина с помощью прецизионного устройства для доставки в обонятельную область |
| EP3823607A4 (en) | 2018-07-19 | 2022-04-06 | Impel NeuroPharma Inc. | ADMINISTRATION OF LEVODOPA AND DOPA DECARBOXYLASE INHIBITOR INTO THE RESPIRATORY TRACT FOR THE TREATMENT OF PARKINSON'S DISEASE |
| SG11202107019VA (en) | 2019-01-03 | 2021-07-29 | Impel Neuropharma Inc | Nasal drug delivery device |
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| US20230372327A1 (en) | 2020-10-15 | 2023-11-23 | Pharmbiotest Poland Sp. z o. o. | Pharmaceutical composition based on nalbuphine and/or its salts for nasal administration |
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| PT1976521E (pt) | 2006-01-25 | 2015-06-09 | Insys Therapeutics Inc | Aerossol sublingual de fentanilo |
| WO2009047779A2 (en) | 2007-06-20 | 2009-04-16 | Nikki Nikhilesh Singh | Composition containing fentanyl base aromatic oils and alkyl salicylate for the delivery of fentanyl base in vapour form |
| ES2668366T3 (es) | 2007-08-02 | 2018-05-17 | Insys Development Company, Inc. | Pulverización sublingual de fentanilo |
| WO2009070829A1 (en) | 2007-12-05 | 2009-06-11 | Krius Pty Ltd | Non-aqueous oil-based fentanyl compositions for transmucosal administration |
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2001
- 2001-07-31 DE DE20122843U patent/DE20122843U1/de not_active Expired - Lifetime
- 2001-07-31 KR KR1020037001578A patent/KR100888275B1/ko not_active Expired - Lifetime
- 2001-07-31 EE EEP200300050A patent/EE05420B1/xx unknown
- 2001-07-31 KR KR1020087013535A patent/KR20080053423A/ko not_active Withdrawn
- 2001-07-31 CA CA002417727A patent/CA2417727C/en not_active Expired - Lifetime
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- 2001-07-31 ES ES05078002T patent/ES2427976T5/es not_active Expired - Lifetime
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- 2001-07-31 DK DK01960190.5T patent/DK1307194T4/da active
- 2001-07-31 AU AU8174601A patent/AU8174601A/xx active Pending
- 2001-07-31 UA UA2003021772A patent/UA77398C2/uk unknown
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- 2001-07-31 NZ NZ524396A patent/NZ524396A/en not_active IP Right Cessation
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- 2001-07-31 DK DK05078002.2T patent/DK1642578T3/da active
- 2001-07-31 EP EP01960190A patent/EP1307194B2/en not_active Expired - Lifetime
- 2001-07-31 AT AT01960190T patent/ATE388705T1/de active
- 2001-07-31 JP JP2002515260A patent/JP4898073B2/ja not_active Expired - Lifetime
- 2001-07-31 WO PCT/DK2001/000521 patent/WO2002009707A1/en not_active Ceased
- 2001-07-31 CN CNA2007101539372A patent/CN101181241A/zh active Pending
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- 2001-07-31 EP EP10176843A patent/EP2255806A3/en not_active Withdrawn
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2003
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2006
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2011
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- 2011-07-22 US US13/188,862 patent/US8653107B2/en not_active Expired - Fee Related
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2013
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