ATE382344T1 - Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe - Google Patents

Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe

Info

Publication number
ATE382344T1
ATE382344T1 AT04010770T AT04010770T ATE382344T1 AT E382344 T1 ATE382344 T1 AT E382344T1 AT 04010770 T AT04010770 T AT 04010770T AT 04010770 T AT04010770 T AT 04010770T AT E382344 T1 ATE382344 T1 AT E382344T1
Authority
AT
Austria
Prior art keywords
recovering
fermentation broth
statin compounds
statin
compounds
Prior art date
Application number
AT04010770T
Other languages
German (de)
English (en)
Inventor
Vilmos Keri
Lajos Deak
Ilona Forgacs
Csaba Szabo
Edit Arvai Nagyne
Original Assignee
Teva Gyogyszergyar Zartkoeruee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22609918&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE382344(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teva Gyogyszergyar Zartkoeruee filed Critical Teva Gyogyszergyar Zartkoeruee
Application granted granted Critical
Publication of ATE382344T1 publication Critical patent/ATE382344T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Manufacturing & Machinery (AREA)
  • Cardiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT04010770T 1999-11-30 2000-11-28 Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe ATE382344T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16805699P 1999-11-30 1999-11-30

Publications (1)

Publication Number Publication Date
ATE382344T1 true ATE382344T1 (de) 2008-01-15

Family

ID=22609918

Family Applications (2)

Application Number Title Priority Date Filing Date
AT00980834T ATE342717T1 (de) 1999-11-30 2000-11-28 Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe
AT04010770T ATE382344T1 (de) 1999-11-30 2000-11-28 Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT00980834T ATE342717T1 (de) 1999-11-30 2000-11-28 Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe

Country Status (22)

Country Link
US (3) US6444452B1 (enExample)
EP (1) EP1265604B1 (enExample)
JP (5) JP3881240B2 (enExample)
KR (1) KR20030026920A (enExample)
CN (2) CN1433305A (enExample)
AT (2) ATE342717T1 (enExample)
AU (1) AU1804601A (enExample)
CA (1) CA2393057C (enExample)
CY (1) CY1105925T1 (enExample)
DE (3) DE60031447T2 (enExample)
DK (1) DK1265604T3 (enExample)
ES (2) ES2273737T3 (enExample)
HR (1) HRP20020454A2 (enExample)
HU (1) HUP0204012A3 (enExample)
MX (1) MXPA02005283A (enExample)
PL (1) PL364918A1 (enExample)
PT (1) PT1265604E (enExample)
RU (1) RU2002114072A (enExample)
SK (1) SK7342002A3 (enExample)
WO (1) WO2001039768A1 (enExample)
YU (1) YU39102A (enExample)
ZA (1) ZA200203912B (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141602B2 (en) * 1998-09-18 2006-11-28 Lek Pharmaceuticals D.D. Process for obtaining HMG-CoA reductase inhibitors of high purity
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
YU39102A (sh) * 1999-11-30 2006-01-16 Biogal Gyogyszergyar Rt Postupak dobijanja statina iz fermentacione smeše
JP2003516959A (ja) * 1999-12-14 2003-05-20 ビオガル ジョジセルジャール アール テー． プラバスタチンナトリウムの新規フォーム
US20050215636A1 (en) * 2000-10-05 2005-09-29 Vilmos Keri Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
JP3737801B2 (ja) * 2000-10-05 2006-01-25 テバ ジョジセルジャール レースベニュタールシャシャーグ プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウム、並びにそれを含む組成物
JP2002121172A (ja) * 2000-10-16 2002-04-23 Sankyo Co Ltd プラバスタチン又はその薬理上許容される塩の精製方法
DE10119718A1 (de) * 2001-04-21 2002-10-31 Boehringer Ingelheim Pharma Verfahren zur kontinuierlichen Herstellung inhalierfähiger Arzneistoffe, Vorrichtung zur Durchführung des Verfahrens und nach diesem Verfahren hergestellter Arzneistoff
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
US6716615B2 (en) 2002-02-27 2004-04-06 Yung Shin Pharmaceutical Ind. Co., Ltd. Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
EP1477471A1 (en) * 2003-05-14 2004-11-17 Chunghwa Chemical Synthesis & Biotech Co., Ltd. Process for purifying pravastin sodium from a fermentation broth
ATE412409T1 (de) * 2003-11-24 2008-11-15 Teva Gyogyszergyar Zartkoeruee Verfahren zur reinigung von pravastatin
AU2003286417A1 (en) * 2003-12-05 2005-06-24 Biocon Limited Process for the purification of macrolides
WO2006046130A2 (en) * 2004-10-29 2006-05-04 Ranbaxy Laboratories Limited Process for the preparation of pravastatin
MX2007009229A (es) * 2005-02-09 2007-09-25 Teva Gyogyszergyar Zartkoruen Metodos para realizar pravastatina de sodio.
JP4813841B2 (ja) * 2005-07-25 2011-11-09 キユーピー株式会社 プラバスタチンナトリウムの製造方法
DE102006028817A1 (de) * 2006-06-21 2007-12-27 Evonik Degussa Gmbh Aufarbeitung von Reaktionslösungen aus Ganzzell-Biotransformationen
WO2009078033A2 (en) * 2007-12-18 2009-06-25 Themis Medicare Limited Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth
US20110130450A1 (en) * 2008-04-02 2011-06-02 Aad Johannes Bouman Pravastatin extraction
IN2009MU00380A (enExample) * 2009-02-18 2010-04-02
CN102993145B (zh) * 2011-09-19 2015-06-03 北大方正集团有限公司 一种提取纯化洛伐他汀的方法

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4319039A (en) * 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
DK149080C (da) 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
DE3682557D1 (de) * 1985-09-13 1992-01-02 Sankyo Co Hydroxy-ml-236b-derivate, deren herstellung und anwendung.
US4857547A (en) * 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4857522A (en) * 1988-03-21 1989-08-15 E. R. Squibb & Sons, Inc. Derivatives of pravastatin for inhibiting cholesterol biosynthesis
US5180589A (en) * 1988-03-31 1993-01-19 E. R. Squibb & Sons, Inc. Pravastatin pharmaceuatical compositions having good stability
US5099035A (en) * 1989-02-27 1992-03-24 E. R. Squibb & Sons, Inc. Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
US5140012A (en) * 1990-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Method for preventing onset of restenosis after angioplasty employing pravastatin
US5202029A (en) 1991-03-13 1993-04-13 Caron Kabushiki Kaisha Process for purification of hmg-coa reductase inhibitors
US5157025A (en) * 1991-04-01 1992-10-20 E. R. Squibb & Sons, Inc. Method for lowering serum cholesterol employing a phosphorus containing ace inhibitor alone or in combination with a cholesterol lowering drug
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
SI9300303A (en) 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5616595A (en) 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
US5942423A (en) 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
US5883109A (en) * 1996-07-24 1999-03-16 Bristol-Myers Squibb Company Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug
AU6726398A (en) * 1997-02-20 1998-09-09 Gist-Brocades B.V. Nitrogen feed in statin fermentation
AU9264598A (en) 1997-08-22 1999-03-16 Gist-Brocades B.V. Statin production by fermentation
SI9800046A (sl) * 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
BR0009180A (pt) * 1999-02-03 2002-03-26 Inst Drug Res Ltd Processo microbiológico para a preparação de pravastatin
HUP9902352A1 (hu) 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
YU39102A (sh) * 1999-11-30 2006-01-16 Biogal Gyogyszergyar Rt Postupak dobijanja statina iz fermentacione smeše
JP3737801B2 (ja) * 2000-10-05 2006-01-25 テバ ジョジセルジャール レースベニュタールシャシャーグ プラバスタチンラクトン及びエピプラバスタチンを実質的に含まないプラバスタチンナトリウム、並びにそれを含む組成物

Also Published As

Publication number Publication date
PL364918A1 (en) 2004-12-27
JP2003515334A (ja) 2003-05-07
JP4343987B2 (ja) 2009-10-14
EP1265604A4 (en) 2004-06-16
ZA200203912B (en) 2003-08-21
HUP0204012A3 (en) 2003-12-29
JP2008109948A (ja) 2008-05-15
SK7342002A3 (en) 2004-03-02
JP2006055174A (ja) 2006-03-02
DE60037687D1 (de) 2008-02-14
US20040115781A1 (en) 2004-06-17
CA2393057A1 (en) 2001-06-07
KR20030026920A (ko) 2003-04-03
US6444452B1 (en) 2002-09-03
JP2004350687A (ja) 2004-12-16
CY1105925T1 (el) 2011-04-06
CN1433305A (zh) 2003-07-30
DE60031447D1 (de) 2006-11-30
HUP0204012A2 (hu) 2003-03-28
YU39102A (sh) 2006-01-16
DK1265604T3 (da) 2007-02-05
CN1754872A (zh) 2006-04-05
ATE342717T1 (de) 2006-11-15
ES2273737T3 (es) 2007-05-16
DE04010770T1 (de) 2005-10-20
ES2239937T1 (es) 2005-10-16
DE60031447T2 (de) 2007-08-30
WO2001039768A1 (en) 2001-06-07
EP1265604A1 (en) 2002-12-18
US6689590B2 (en) 2004-02-10
HRP20020454A2 (en) 2005-10-31
RU2002114072A (ru) 2004-07-20
AU1804601A (en) 2001-06-12
MXPA02005283A (es) 2003-10-06
PT1265604E (pt) 2006-12-29
EP1265604B1 (en) 2006-10-18
US20020187531A1 (en) 2002-12-12
JP3881240B2 (ja) 2007-02-14
CA2393057C (en) 2008-01-29
JP2006273861A (ja) 2006-10-12

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