ATE353977T1 - Methoden um dns von verschiedenen individuen nachzuweisen - Google Patents

Methoden um dns von verschiedenen individuen nachzuweisen

Info

Publication number
ATE353977T1
ATE353977T1 AT02758554T AT02758554T ATE353977T1 AT E353977 T1 ATE353977 T1 AT E353977T1 AT 02758554 T AT02758554 T AT 02758554T AT 02758554 T AT02758554 T AT 02758554T AT E353977 T1 ATE353977 T1 AT E353977T1
Authority
AT
Austria
Prior art keywords
dna
methods
invention features
present
different individuals
Prior art date
Application number
AT02758554T
Other languages
English (en)
Inventor
Yuk Ming Dennis Lo
Lit Man Poon
Original Assignee
Univ Hong Kong Chinese
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Hong Kong Chinese filed Critical Univ Hong Kong Chinese
Application granted granted Critical
Publication of ATE353977T1 publication Critical patent/ATE353977T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT02758554T 2001-08-31 2002-08-30 Methoden um dns von verschiedenen individuen nachzuweisen ATE353977T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/944,951 US6927028B2 (en) 2001-08-31 2001-08-31 Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA

Publications (1)

Publication Number Publication Date
ATE353977T1 true ATE353977T1 (de) 2007-03-15

Family

ID=25482355

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02758554T ATE353977T1 (de) 2001-08-31 2002-08-30 Methoden um dns von verschiedenen individuen nachzuweisen

Country Status (13)

Country Link
US (7) US6927028B2 (de)
EP (1) EP1421211B1 (de)
JP (1) JP2005501566A (de)
CN (1) CN100352939C (de)
AT (1) ATE353977T1 (de)
AU (1) AU2002324135A1 (de)
CA (4) CA2973165C (de)
DE (1) DE60218182T2 (de)
DK (1) DK1421211T3 (de)
ES (1) ES2280562T3 (de)
HK (1) HK1076840A1 (de)
PT (1) PT1421211E (de)
WO (1) WO2003020974A2 (de)

Families Citing this family (182)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6927028B2 (en) * 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
US20030211522A1 (en) * 2002-01-18 2003-11-13 Landes Gregory M. Methods for fetal DNA detection and allele quantitation
KR20040102024A (ko) * 2002-03-01 2004-12-03 라브겐, 인코퍼레이티드 유전적 장애의 검출 방법
US6977162B2 (en) * 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
EP1342794B1 (de) * 2002-03-05 2005-12-14 Epigenomics AG Verfahren und Vorrichtung zur Bestimmung der Gewebespezifität von freier DNA in Körperflüssigkeiten
US7727720B2 (en) * 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US7442506B2 (en) * 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
AU2004217872B2 (en) * 2003-03-05 2010-03-25 Genetic Technologies Limited Identification of fetal DNA and fetal cell markers in maternal plasma or serum
US20050282213A1 (en) * 2003-09-22 2005-12-22 Trisogen Biotechnology Limited Partnership Methods and kits useful for detecting an alteration in a locus copy number
KR20060101470A (ko) * 2003-09-22 2006-09-25 트라이소겐 바이오테크놀로지 리미티드 파트너쉽 좌위 복제 수에서의 변동을 검출하기 위한 방법 및 이에유용한 키트
CN1930303B (zh) * 2003-10-08 2013-11-20 波士顿大学信托人 染色体异常的产前诊断试剂盒
US8529744B2 (en) 2004-02-02 2013-09-10 Boreal Genomics Corp. Enrichment of nucleic acid targets
JP2007526823A (ja) 2004-02-02 2007-09-20 ザ ユニバーシティ オブ ブリティッシュ コロンビア 粒子を運動および濃縮させるためのスコダ泳動ならびに方法および装置
US9186685B2 (en) 2012-01-13 2015-11-17 The University Of British Columbia Multiple arm apparatus and methods for separation of particles
US10337054B2 (en) 2004-02-02 2019-07-02 Quantum-Si Incorporated Enrichment of nucleic acid targets
US8518228B2 (en) 2011-05-20 2013-08-27 The University Of British Columbia Systems and methods for enhanced SCODA
US7709194B2 (en) * 2004-06-04 2010-05-04 The Chinese University Of Hong Kong Marker for prenatal diagnosis and monitoring
CA2603815C (en) 2005-04-15 2017-09-26 Epigenomics Ag A method for providing dna fragments derived from a remote sample
EP2477029A1 (de) * 2005-06-02 2012-07-18 Fluidigm Corporation Auswertung mit mikrofluiden Aufteilungsvorrichtungen
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) * 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
TR201910868T4 (tr) * 2006-02-02 2019-08-21 Univ Leland Stanford Junior Dijital analizle invazif olmayan fetal genetik tarama.
CN101421410A (zh) * 2006-03-06 2009-04-29 纽约市哥伦比亚大学托管会 从混合的胎儿-母体来源中特异性扩增胎儿dna序列
US7754428B2 (en) 2006-05-03 2010-07-13 The Chinese University Of Hong Kong Fetal methylation markers
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
EP2029777B1 (de) 2006-05-31 2017-03-08 Sequenom, Inc. Verfahren und zusammensetzungen zur nukleinsäureextraktion aus einer probe
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US20080070792A1 (en) * 2006-06-14 2008-03-20 Roland Stoughton Use of highly parallel snp genotyping for fetal diagnosis
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
TWI335354B (en) 2006-09-27 2011-01-01 Univ Hong Kong Chinese Methods for the detection of the degree of the methylation of a target dna and kits
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
JP5211790B2 (ja) * 2007-03-26 2013-06-12 住友化学株式会社 Dnaメチル化測定方法
ITTO20070307A1 (it) * 2007-05-04 2008-11-05 Silicon Biosystems Spa Metodo e dispositivo per la diagnosi prenatale non-invasiva
SI3101141T1 (sl) 2007-06-08 2020-03-31 Epigenomics Ag Postopek za metilacijsko analizo
AU2013202160B2 (en) * 2007-07-23 2015-07-23 The Chinese University Of Hong Kong Determining percentage of fetal dna in maternal sample
US20100112590A1 (en) 2007-07-23 2010-05-06 The Chinese University Of Hong Kong Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment
CA3176319A1 (en) 2007-07-23 2009-01-29 The Chinese University Of Hong Kong Analyzing tumor dna in a cell-free sample
EP2195452B1 (de) 2007-08-29 2012-03-14 Sequenom, Inc. Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion
AU2009205956B2 (en) 2008-01-18 2015-07-02 President And Fellows Of Harvard College Methods of detecting signatures of disease or conditions in bodily fluids
US8475641B2 (en) 2008-02-01 2013-07-02 The University Of British Columbia Methods and apparatus for particle introduction and recovery
EP2250497B1 (de) * 2008-02-18 2014-09-10 Genetic Technologies Limited Zellprozessierungs- und/oder -anreicherungsverfahren
EP2271772B1 (de) * 2008-03-11 2014-07-16 Sequenom, Inc. Tests auf nukleinsäurebasis zur pränatalen geschlechtsbestimmung
ES2599967T3 (es) 2008-09-16 2017-02-06 Sequenom, Inc. Procedimientos y composiciones para el enriquecimiento basado en metilación de ácido nucleico fetal de una muestra materna útiles para diagnósticos prenatales no invasivos
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP2334812B1 (de) * 2008-09-20 2016-12-21 The Board of Trustees of The Leland Stanford Junior University Nichtinvasive diagnose von fötaler aneuploidie mittels sequenzieren
CN102428191A (zh) * 2009-03-18 2012-04-25 塞昆纳姆股份有限公司 热稳定性内切核酸酶在产生报道分子中的应用
US8771948B2 (en) 2009-04-03 2014-07-08 Sequenom, Inc. Nucleic acid preparation compositions and methods
WO2010121381A1 (en) 2009-04-21 2010-10-28 The University Of British Columbia System and methods for detection of particles
US9447467B2 (en) 2009-04-21 2016-09-20 Genetic Technologies Limited Methods for obtaining fetal genetic material
US9752191B2 (en) 2009-07-09 2017-09-05 The Scripps Research Institute Gene expression profiles associated with chronic allograft nephropathy
HUE034854T2 (en) 2009-11-05 2018-03-28 Univ Hong Kong Chinese Fetal genomic analysis from maternal biological samples
EP3406737B1 (de) 2009-11-06 2023-05-31 The Chinese University of Hong Kong Grössen-abhängige genomanalyse
PL2496720T3 (pl) 2009-11-06 2021-01-11 The Board Of Trustees Of The Leland Stanford Junior University Nieinwazyjna diagnoza odrzucenia przeszczepu u pacjentów z przeszczepem narządu
JP2013511991A (ja) * 2009-11-25 2013-04-11 クアンタライフ, インコーポレイテッド 遺伝子材料を検出する方法および組成物
ES2577017T3 (es) 2009-12-22 2016-07-12 Sequenom, Inc. Procedimientos y kits para identificar la aneuploidia
EP2848703A1 (de) 2010-01-19 2015-03-18 Verinata Health, Inc Gleichzeitige Bestimmung von Aneupolidie- und Fötus-DNA-Fraktion
AU2011207561B2 (en) 2010-01-19 2014-02-20 Verinata Health, Inc. Partition defined detection methods
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
US20120010085A1 (en) 2010-01-19 2012-01-12 Rava Richard P Methods for determining fraction of fetal nucleic acids in maternal samples
AU2011207544A1 (en) * 2010-01-19 2012-09-06 Verinata Health, Inc. Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
EP2572003A4 (de) 2010-05-18 2016-01-13 Natera Inc Verfahren zur nichtinvasiven pränatalen ploidiezuordnung
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
SG10201505724SA (en) 2010-07-23 2015-09-29 Harvard College Methods of detecting diseases or conditions using phagocytic cells
AU2011280997A1 (en) 2010-07-23 2013-02-28 President And Fellows Of Harvard College Methods of detecting autoimmune or immune-related diseases or conditions
EP2596353A4 (de) 2010-07-23 2014-01-15 Harvard College Verfahren zum nachweis pränataler oder schwangerschaftsvermittelter krankheiten oder leiden
MX361944B (es) 2010-07-23 2018-12-19 President And Fellows Of Harvard College Star Metodos para detectar firmas de enfermedad o condiciones en fluidos corporales.
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US10167508B2 (en) 2010-08-06 2019-01-01 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
US20130040375A1 (en) 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US11031095B2 (en) 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
EP2633311A4 (de) 2010-10-26 2014-05-07 Univ Stanford Nichtinvasives fötales genetisches screening durch sequenzierungsanalyse
US10131947B2 (en) 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
US8756020B2 (en) 2011-01-25 2014-06-17 Ariosa Diagnostics, Inc. Enhanced risk probabilities using biomolecule estimations
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
JP2014506465A (ja) 2011-02-09 2014-03-17 バイオ−ラド ラボラトリーズ,インコーポレイティド 核酸の分析
CN103492589B (zh) 2011-02-24 2016-06-15 香港中文大学 多胎妊娠的分子测试
CN103797129B (zh) * 2011-04-12 2016-08-17 维里纳塔健康公司 使用多态计数来解析基因组分数
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
US8450061B2 (en) 2011-04-29 2013-05-28 Sequenom, Inc. Quantification of a minority nucleic acid species
WO2012177792A2 (en) 2011-06-24 2012-12-27 Sequenom, Inc. Methods and processes for non-invasive assessment of a genetic variation
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
EP3922731A3 (de) 2011-10-06 2022-01-05 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US20140242588A1 (en) 2011-10-06 2014-08-28 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2851537C (en) 2011-10-11 2020-12-29 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2805280B1 (de) 2012-01-20 2022-10-05 Sequenom, Inc. Diagnostische verfahren zur evaluierung von versuchsbedingungen
EP3401399B1 (de) 2012-03-02 2020-04-22 Sequenom, Inc. Verfahren und prozesse zur nicht-invasiven beurteilung genetischer variationen
EP3573066B1 (de) 2012-03-13 2023-09-27 The Chinese University Of Hong Kong Verfahren zur analyse von massiv parallelen sequenzierungsdaten zur nichtinvasiven pränatalen diagnose
US9512477B2 (en) 2012-05-04 2016-12-06 Boreal Genomics Inc. Biomarker anaylsis using scodaphoresis
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9840732B2 (en) 2012-05-21 2017-12-12 Fluidigm Corporation Single-particle analysis of particle populations
US10289800B2 (en) 2012-05-21 2019-05-14 Ariosa Diagnostics, Inc. Processes for calculating phased fetal genomic sequences
CA2874195C (en) 2012-05-21 2020-08-25 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014011928A1 (en) 2012-07-13 2014-01-16 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
JP2015522293A (ja) 2012-07-19 2015-08-06 アリオサ ダイアグノスティックス インコーポレイテッドAriosa Diagnostics,Inc. 多重化連続ライゲーションに基づく遺伝子変異体の検出
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
EP3354747B1 (de) 2012-09-20 2021-02-17 The Chinese University Of Hong Kong Nicht-invasive bestimmung des methyloms eines tumors aus plasma
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014055790A2 (en) 2012-10-04 2014-04-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10494675B2 (en) 2013-03-09 2019-12-03 Cell Mdx, Llc Methods of detecting cancer
EP2965086A4 (de) 2013-03-09 2017-02-08 Harry Stylli Verfahren zum nachweis von prostatakrebs
US20130189684A1 (en) 2013-03-12 2013-07-25 Sequenom, Inc. Quantification of cell-specific nucleic acid markers
US11060145B2 (en) 2013-03-13 2021-07-13 Sequenom, Inc. Methods and compositions for identifying presence or absence of hypermethylation or hypomethylation locus
EP3415626B1 (de) 2013-03-15 2020-01-22 Lineage Biosciences, Inc. Verfahren und zusammensetzungen zum markieren und analysieren von proben
CN105121660B (zh) 2013-03-15 2018-09-28 香港中文大学 确定多胎妊娠的胎儿基因组
US9340835B2 (en) 2013-03-15 2016-05-17 Boreal Genomics Corp. Method for separating homoduplexed and heteroduplexed nucleic acids
ES2939547T3 (es) 2013-04-03 2023-04-24 Sequenom Inc Métodos y procedimientos para la evaluación no invasiva de variaciones genéticas
AU2014268377B2 (en) 2013-05-24 2020-10-08 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
KR102299305B1 (ko) 2013-06-21 2021-09-06 시쿼넘, 인코포레이티드 유전적 변이의 비침습 평가를 위한 방법 및 프로세스
CN105555965B (zh) * 2013-07-30 2020-06-05 深圳华大基因股份有限公司 确定核酸混合物中核酸组成的方法
IL304949A (en) 2013-10-04 2023-10-01 Sequenom Inc Methods and processes for non-invasive evaluation of genetic variations
US10438691B2 (en) 2013-10-07 2019-10-08 Sequenom, Inc. Non-invasive assessment of chromosome alterations using change in subsequence mappability
EP3736344A1 (de) 2014-03-13 2020-11-11 Sequenom, Inc. Verfahren und prozesse zur nichtinvasiven beurteilung genetischer variationen
CN106460070B (zh) 2014-04-21 2021-10-08 纳特拉公司 检测染色体片段中的突变和倍性
EP2942400A1 (de) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex-Nachweis von DNA, die aus einem spezifischen Zelltyp herrührt
CN107223159A (zh) 2014-05-09 2017-09-29 科戴克斯生命股份公司 源自特定细胞类型的dna的检测及相关方法
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
EP3598452B1 (de) 2014-05-30 2023-07-26 Sequenom, Inc. Chromosomendarstellungsbestimmungen
AU2015292311B2 (en) 2014-07-25 2022-01-20 University Of Washington Methods of determining tissues and/or cell types giving rise to cell-free DNA, and methods of identifying a disease or disorder using same
EP3175000B1 (de) 2014-07-30 2020-07-29 Sequenom, Inc. Verfahren und prozesse zur nicht-invasiven beurteilung genetischer variationen
WO2016040843A1 (en) 2014-09-11 2016-03-17 Harry Stylli Methods of detecting prostate cancer
CA2964158A1 (en) 2014-10-10 2016-04-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
WO2016183106A1 (en) 2015-05-11 2016-11-17 Natera, Inc. Methods and compositions for determining ploidy
WO2016185284A1 (en) 2015-05-20 2016-11-24 Boreal Genomics, Inc. Method for isolating target nucleic acid using heteroduplex binding proteins
CA2986200A1 (en) 2015-05-22 2016-12-01 Nipd Genetics Public Company Limited Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing
DK3168309T3 (da) 2015-11-10 2020-06-22 Eurofins Lifecodexx Gmbh Detektion af føtale kromosomale aneuploidier under anvendelse af dna-regioner med forskellig metylering mellem fosteret og det gravide hunkøn
WO2017205826A1 (en) 2016-05-27 2017-11-30 Sequenom, Inc. Methods for detecting genetic variations
WO2018013837A1 (en) 2016-07-15 2018-01-18 The Regents Of The University Of California Methods of producing nucleic acid libraries
CA3030894A1 (en) 2016-07-27 2018-02-01 Sequenom, Inc. Methods for non-invasive assessment of genomic instability
US11200963B2 (en) 2016-07-27 2021-12-14 Sequenom, Inc. Genetic copy number alteration classifications
WO2018064486A1 (en) 2016-09-29 2018-04-05 Counsyl, Inc. Noninvasive prenatal screening using dynamic iterative depth optimization
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
EP3571614A1 (de) 2017-01-20 2019-11-27 Sequenom, Inc. Verfahren zur nichtinvasiven beurteilung von kopienzahländerungen
WO2018136881A1 (en) 2017-01-20 2018-07-26 Sequenom, Inc. Sequencing adapter manufacture and use
EP4235676A3 (de) 2017-01-20 2023-10-18 Sequenom, Inc. Verfahren zur nichtinvasiven beurteilung genetischer veränderungen
JP7237003B2 (ja) 2017-01-24 2023-03-10 セクエノム, インコーポレイテッド 遺伝子片の評価のための方法およびプロセス
EP3596233B1 (de) 2017-03-17 2022-05-18 Sequenom, Inc. Verfahren und vorgänge zur beurteilung von genetischem mosaizismus
AU2019207900A1 (en) 2018-01-12 2020-07-09 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
WO2019236726A1 (en) 2018-06-06 2019-12-12 The Regents Of The University Of California Methods of producing nucleic acid libraries and compositions and kits for practicing same
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
SG11202110468YA (en) 2019-04-05 2021-10-28 Claret Bioscience Llc Methods and compositions for analyzing nucleic acid
CN110734966B (zh) * 2019-09-19 2021-06-25 广州医科大学附属肿瘤医院 一种用于检测sav1基因启动子区甲基化位点的检测体系及试剂盒
AU2020363787A1 (en) 2019-10-09 2022-04-21 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
EP4052259A1 (de) 2019-10-31 2022-09-07 Sequenom, Inc. Anwendung eines mosaikbildungsverhältnisses bei mehrlingsschwangerschaften und personalisierter risikobeurteilung
WO2021262805A1 (en) 2020-06-24 2021-12-30 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
WO2022076574A1 (en) 2020-10-08 2022-04-14 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
CA3209074A1 (en) * 2021-03-09 2022-09-15 Andrew Kennedy Genomic library preparation and targeted epigenetic assays using cas-grna ribonucleoproteins

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
AU7829398A (en) * 1997-06-09 1998-12-30 University Of Southern California A cancer diagnostic method based upon dna methylation differences
DE19754482A1 (de) * 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
JP2004505612A (ja) * 2000-03-31 2004-02-26 ユニバーシティ・オブ・サザン・カリフォルニア 食道腺ガンに関する後成的配列
US6927028B2 (en) * 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
US7709194B2 (en) * 2004-06-04 2010-05-04 The Chinese University Of Hong Kong Marker for prenatal diagnosis and monitoring
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring

Also Published As

Publication number Publication date
DE60218182D1 (de) 2007-03-29
HK1076840A1 (en) 2006-01-27
CA2973165A1 (en) 2003-03-13
US20030044388A1 (en) 2003-03-06
CA2887218A1 (en) 2003-03-13
US8431343B2 (en) 2013-04-30
US20120190029A1 (en) 2012-07-26
WO2003020974A2 (en) 2003-03-13
US20150232949A1 (en) 2015-08-20
CA3012120A1 (en) 2003-03-13
CN1665936A (zh) 2005-09-07
EP1421211A2 (de) 2004-05-26
WO2003020974A3 (en) 2003-09-18
DE60218182T2 (de) 2008-02-07
CN100352939C (zh) 2007-12-05
PT1421211E (pt) 2007-03-30
US20200208225A1 (en) 2020-07-02
US8168382B2 (en) 2012-05-01
US20130337443A1 (en) 2013-12-19
CA2887218C (en) 2017-08-22
US20050282185A1 (en) 2005-12-22
US8962280B2 (en) 2015-02-24
EP1421211B1 (de) 2007-02-14
DK1421211T3 (da) 2007-05-29
ES2280562T3 (es) 2007-09-16
JP2005501566A (ja) 2005-01-20
US20090170102A1 (en) 2009-07-02
CA2456140A1 (en) 2003-03-13
US6927028B2 (en) 2005-08-09
CA2973165C (en) 2018-08-28
CA2456140C (en) 2015-06-23
CA3012120C (en) 2021-08-10
AU2002324135A1 (en) 2003-03-18

Similar Documents

Publication Publication Date Title
DE60218182D1 (de) Methoden um dns von verschiedenen individuen nachzuweisen
CY1122112T1 (el) Μη-επεμβατικη εμβρυικη γενετικη σαρωση με ψηφιακη αναλυση
WO2005023091A3 (en) Method for non-invasive prenatal diagnosis
WO2010065470A3 (en) Compositions and methods for detecting background male dna during fetal sex determination
BR112022016493A2 (pt) Composições, kits e métodos para detecção de sequências virais
ATE351923T1 (de) Diagnostische methode zur identifizierung von fötaler dna in einer maternalen probe
ATE362995T1 (de) Verfahren zum nachweis von cytosinmethylierungsmustern mit hoher sensitivität
NZ601079A (en) Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies
WO2006110855A3 (en) Methods for determining sequence variants using ultra-deep sequencing
ATE515575T1 (de) Verfahren und sonden für den nachweis von krebs
ATE547537T1 (de) Verfahren zur bestimmung der dna-methylierung in blut- oder urinproben
WO2004099434A3 (en) Homogeneous multiplex screening assays and kits
DE60035691D1 (de) Verfahren zur Erkennung von Einzel-Nukleotid-Polymorphismen
MXPA03007786A (es) Amplificacion de sonda circular usando iniciadores de transferencia de energia.
WO2009039507A3 (en) Identification and isolation of fetal cells and nucleic acid
BRPI0518405A2 (pt) detecÇço de vÍrus papiloma humano (hpv) utilizando sondas de Ácido nuclÉico, microcontas e separador de cÉlulas ativado fluorescente (facs)
Rana Crime investigation through DNA methylation analysis: methods and applications in forensics
DE60325382D1 (de) Verfahren zur diagnose von gebärmutterhalskrebs
Hibbitts et al. Human papilloma virus genotyping by surface-enhanced Raman scattering
ATE449868T1 (de) Methoden, testsätze und kompositionen zur detektion und quantifizierung von zielsequenzen
ES2875758T3 (es) Conjunto de cebadores y método para la detección e identificación de especies de mejillón del genero mytilus
WO2005017488A3 (en) Method and system for identifying biological entities in biological and environmental samples
DE50107569D1 (de) Nachweis von humanen papillomviren
ATE525485T1 (de) Nukleinsäureanalyseverfahren zur analyse des methylierungsmusters von cpg-inseln in unterschiedlichen proben
ATE518006T1 (de) Verfahren zur quantitativen analyse von methylcytosin in dna und verwendungen davon

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1421211

Country of ref document: EP