ATE35271T1 - Csf und verfahren zu seiner herstellung. - Google Patents
Csf und verfahren zu seiner herstellung.Info
- Publication number
- ATE35271T1 ATE35271T1 AT85109336T AT85109336T ATE35271T1 AT E35271 T1 ATE35271 T1 AT E35271T1 AT 85109336 T AT85109336 T AT 85109336T AT 85109336 T AT85109336 T AT 85109336T AT E35271 T1 ATE35271 T1 AT E35271T1
- Authority
- AT
- Austria
- Prior art keywords
- csf
- production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/14—Lymphokine; related peptides
- Y10S930/145—Colony stimulating factor
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP59153273A JPS61227526A (ja) | 1984-07-25 | 1984-07-25 | 新規なコロニー刺激因子 |
EP85109336A EP0169566B2 (de) | 1984-07-25 | 1985-07-25 | hG-CSF und Verfahren zu seiner Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE35271T1 true ATE35271T1 (de) | 1988-07-15 |
Family
ID=15558855
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT85109336T ATE35271T1 (de) | 1984-07-25 | 1985-07-25 | Csf und verfahren zu seiner herstellung. |
Country Status (17)
Country | Link |
---|---|
US (1) | US4833127A (de) |
EP (1) | EP0169566B2 (de) |
JP (1) | JPS61227526A (de) |
KR (1) | KR920009496B1 (de) |
AR (1) | AR242835A1 (de) |
AT (1) | ATE35271T1 (de) |
BG (1) | BG61494B2 (de) |
CA (1) | CA1312569C (de) |
DE (1) | DE3563444D1 (de) |
DK (1) | DK166731B1 (de) |
ES (1) | ES8609365A1 (de) |
FI (1) | FI83881C (de) |
HK (1) | HK50491A (de) |
NL (1) | NL930141I2 (de) |
NO (1) | NO168952C (de) |
SG (1) | SG41591G (de) |
ZA (1) | ZA855478B (de) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61227526A (ja) * | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | 新規なコロニー刺激因子 |
US5556620A (en) * | 1985-02-05 | 1996-09-17 | Cetus Oncology Corporation | Use of recombinant colony stimulating factor-1 to enhance wound healing |
US5422105A (en) * | 1985-02-05 | 1995-06-06 | Cetus Oncology Corporation | Use of recombinant colony stimulating factor 1 |
EP0209601B1 (de) * | 1985-02-05 | 1993-12-15 | Cetus Oncology Corporation | Rekombinanter koloniestimulierender faktor-1 |
US6156300A (en) * | 1985-02-05 | 2000-12-05 | Chiron Corporation | Point mutants of N∇2 CSF-1 and carboxy truncated fragments thereof |
US5837229A (en) * | 1985-02-05 | 1998-11-17 | Chiron Corporation | Uses of recombinant colony stimulating factor-1 |
US5792450A (en) * | 1985-02-05 | 1998-08-11 | Chiron Corporation | Purified human CSF-1 |
US6146851A (en) * | 1985-02-05 | 2000-11-14 | Chiron Corporation | DNA encoding NV2 (long form) and carboxy truncated fragments thereof |
US5573930A (en) * | 1985-02-05 | 1996-11-12 | Cetus Oncology Corporation | DNA encoding various forms of colony stimulating factor-1 |
EP0215126B1 (de) * | 1985-02-08 | 1991-07-31 | Chugai Seiyaku Kabushiki Kaisha | Menschlicher granuloxcyt-kolonie-stimulierungsfaktor |
US5532341A (en) | 1985-03-28 | 1996-07-02 | Sloan-Kettering Institute For Cancer Research | Human pluripotent hematopoietic colony stimulating factor |
US6004548A (en) * | 1985-08-23 | 1999-12-21 | Amgen, Inc. | Analogs of pluripotent granulocyte colony-stimulating factor |
US4810643A (en) * | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
JPS63500636A (ja) * | 1985-08-23 | 1988-03-10 | 麒麟麦酒株式会社 | 多分化能性顆粒球コロニー刺激因子をコードするdna |
ATE67517T1 (de) * | 1985-09-30 | 1991-10-15 | Chugai Pharmaceutical Co Ltd | Menschlicher granulozyten-colony stimulierender faktor. |
JPH0618778B2 (ja) * | 1985-10-04 | 1994-03-16 | 中外製薬株式会社 | 白血球減少症治療剤 |
NZ218336A (en) * | 1985-12-09 | 1991-08-27 | Kirin Amgen Inc | Monoclonal antibodies to human pluripotent granulocyte colony stimulating factor (hpg-csf) |
DE3777845D1 (de) * | 1986-01-22 | 1992-05-07 | Chugai Pharmaceutical Co Ltd | Pharmazeutischer stoff fuer die behandlung von myelogener leukaemie. |
ES2039209T5 (es) * | 1986-01-22 | 1996-07-16 | Chugai Pharmaceutical Co Ltd | Compuesto farmaceutico que promueve el restablecimiento de la capacidad hemopoyetica. |
US5266480A (en) * | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
US4963489A (en) * | 1987-04-14 | 1990-10-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
US5160490A (en) * | 1986-04-18 | 1992-11-03 | Marrow-Tech Incorporated | Three-dimensional cell and tissue culture apparatus |
US5863531A (en) * | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
US5032508A (en) * | 1988-09-08 | 1991-07-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
US5510254A (en) * | 1986-04-18 | 1996-04-23 | Advanced Tissue Sciences, Inc. | Three dimensional cell and tissue culture system |
ZA872705B (en) * | 1986-04-22 | 1987-10-05 | Immunex Corporation | Human g-csf protein expression |
GR871067B (en) * | 1986-07-18 | 1987-11-19 | Chugai Pharmaceutical Co Ltd | Process for producing stable pharmaceutical preparation containing granulocyte colony stimulating factor |
JP2583770B2 (ja) * | 1986-09-17 | 1997-02-19 | 大塚製薬株式会社 | 遺伝子 |
JPH0725689B2 (ja) * | 1986-10-07 | 1995-03-22 | 中外製薬株式会社 | 顆粒球コロニ−刺激因子を含有する徐放性製剤 |
JPH0618781B2 (ja) * | 1986-10-18 | 1994-03-16 | 中外製薬株式会社 | 感染症治療剤 |
NO176799C (no) * | 1986-12-23 | 1995-05-31 | Kyowa Hakko Kogyo Kk | DNA som koder for et polypeptid, rekombinant plasmid som koder for og kan uttrykke et polypeptid og fremgangsmåte for fremstilling av dette polypeptid |
US5214132A (en) * | 1986-12-23 | 1993-05-25 | Kyowa Hakko Kogyo Co., Ltd. | Polypeptide derivatives of human granulocyte colony stimulating factor |
US5194592A (en) * | 1986-12-23 | 1993-03-16 | Kyowa Hakko Kogyo Co. Ltd. | Monoclonal antibodies to novel polypeptide derivatives of human granulocyte colony stimulating factor |
US20030232010A2 (en) * | 1988-03-29 | 2003-12-18 | Immunomedics, Inc. | Improved cytotoxic therapy |
CA1329119C (en) * | 1988-03-29 | 1994-05-03 | Milton David Goldenberg | Cytotoxic therapy |
US5202117A (en) * | 1988-08-24 | 1993-04-13 | Koichiro Tsuji | Method of treating thrombi with g-csf |
US5104651A (en) * | 1988-12-16 | 1992-04-14 | Amgen Inc. | Stabilized hydrophobic protein formulations of g-csf |
US6166183A (en) * | 1992-11-30 | 2000-12-26 | Kirin-Amgen, Inc. | Chemically-modified G-CSF |
JP2989002B2 (ja) * | 1988-12-22 | 1999-12-13 | キリン―アムジエン・インコーポレーテツド | 化学修飾顆粒球コロニー刺激因子 |
US20020177688A1 (en) * | 1988-12-22 | 2002-11-28 | Kirin-Amgen, Inc., | Chemically-modified G-CSF |
JPH0322973A (ja) * | 1989-01-19 | 1991-01-31 | Wan Shen-Yuan | ヒトヘパトーム細胞系によるコロニー形成促進因子(CSFs)の構成性産生 |
KR920701252A (ko) * | 1989-10-10 | 1992-08-11 | 스티븐 엠. 오드레 | 과립구 군체 자극인자 및 그를 이용하여 개 및 고양이과 동물의 전염병을 치료하거나 예방하는 방법 |
US5147799A (en) * | 1990-04-25 | 1992-09-15 | Isia Bursuker | Repopulation of macrophages and granulocytes using transforming growth factor-beta |
GB2253852B (en) * | 1991-02-26 | 1995-03-22 | Ici Plc | Vector for expression of heterologous polypeptide comprising inducible selection system |
WO1992016192A1 (en) * | 1991-03-15 | 1992-10-01 | Amgen Inc. | Pulmonary administration of granulocyte colony stimulating factor |
FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US20030053982A1 (en) * | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US6979442B1 (en) | 1998-08-17 | 2005-12-27 | Pfizer Inc. | Stabilized protein compositions |
CA2357811A1 (en) | 1999-01-06 | 2000-07-13 | Xencor, Inc. | Nucleic acids and proteins corresponding to mutants of g-csf with granulopoietic activity |
US7208473B2 (en) * | 1999-01-06 | 2007-04-24 | Xencor, Inc. | Nucleic acids and protein variants of hG-CSF with granulopoietic activity |
DK1157037T3 (da) * | 1999-01-29 | 2003-11-24 | Hoffmann La Roche | GCSF-konjugater |
US6831158B2 (en) * | 2000-01-10 | 2004-12-14 | Maxygen Holdings Ltd. | G-CSF conjugates |
US6555660B2 (en) * | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
US6646110B2 (en) * | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
US8435939B2 (en) | 2000-09-05 | 2013-05-07 | Biokine Therapeutics Ltd. | Polypeptide anti-HIV agent containing the same |
US7118737B2 (en) * | 2000-09-08 | 2006-10-10 | Amylin Pharmaceuticals, Inc. | Polymer-modified synthetic proteins |
FR2820979B1 (fr) | 2001-02-22 | 2004-03-12 | Didier Pourquier | Nouvelle application therapeutique du g-csf |
ATE468862T1 (de) * | 2001-07-11 | 2010-06-15 | Maxygen Inc | G-csf konjugate |
SI21102A (sl) | 2001-12-19 | 2003-06-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za izolacijo biološko aktivnega granulocitne kolonije stimulirajočega dejavnika |
ES2545090T3 (es) | 2001-12-21 | 2015-09-08 | Human Genome Sciences, Inc. | Proteínas de fusión de albúmina y GCSF |
ES2403932T3 (es) | 2002-08-27 | 2013-05-22 | Biokine Therapeutics Ltd. | Antagonista de CXCR4 y uso del mismo |
DE602006020562D1 (de) * | 2005-06-01 | 2011-04-21 | Maxygen Inc | Hren dafür |
EP2759302A3 (de) | 2006-12-21 | 2014-11-05 | Biokine Therapeutics LTD. | 4F-benzoyl-TN14003 kombiniert mit Rituximab für die Verwendung in der Behandlung eines Tumors |
US9155780B2 (en) | 2009-02-11 | 2015-10-13 | Yeda Research And Development Co. Ltd. | Short beta-defensin-derived peptides |
US20120114594A1 (en) | 2009-05-14 | 2012-05-10 | Keiichi Fukuda | Muscle repair promoter |
BRPI1009663A2 (pt) | 2009-06-14 | 2016-10-11 | Biokine Therapeutics Ltd | "método para elevação dos níveis plaquetários em um indivíduo com essa necessidade, método de inibição de hemorragia em um indivíduo que a necessite e composição farmacêutica" |
HUP1200171A1 (hu) | 2012-03-19 | 2013-09-30 | Richter Gedeon Nyrt | Módszerek polipeptidek elõállítására |
WO2013160895A1 (en) | 2012-04-24 | 2013-10-31 | Biokine Therapeutics Ltd. | Peptides and use thereof in the treatment of large cell lung cancer |
WO2017009842A2 (en) | 2015-07-16 | 2017-01-19 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
CN109310733A (zh) | 2016-02-23 | 2019-02-05 | 百欧林纳克斯有限公司 | 治疗急性骨髓性白血病的方法 |
KR102256542B1 (ko) * | 2019-07-12 | 2021-05-25 | 차원방 | 호안보강 및 확장을 위한 호안의 확장매립 시공방법 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4135975A (en) * | 1977-12-14 | 1979-01-23 | Lichtman Marshall A | Obtaining human cell lines that elaborate colony stimulating activity for marrow cells of man and other species and methods of preparing same |
JPS54140789A (en) * | 1978-04-22 | 1979-11-01 | Jitsuken Doubutsu Chuo Kenkiyu | Culturing of colony stimulating factor producing tumor cell |
US4230697A (en) * | 1978-07-03 | 1980-10-28 | Morinaga Milk Industry Co. Ltd. | Virus-inactivated HGI-glycoprotein capable of stimulating proliferation and differentiation of human granulocyte, process for preparing same and leukopenia curative containing same |
US4342828A (en) * | 1979-07-20 | 1982-08-03 | Morinaga Milk Industry Co., Ltd. | Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells |
JPS6030654B2 (ja) * | 1980-12-31 | 1985-07-17 | 株式会社林原生物化学研究所 | ヒトコロニ−刺激因子の製造方法 |
US4438032A (en) * | 1981-01-30 | 1984-03-20 | The Regents Of The University Of California | Unique T-lymphocyte line and products derived therefrom |
JPS5978122A (ja) * | 1982-10-27 | 1984-05-04 | Ajinomoto Co Inc | コロニ−刺激因子の製造法 |
JPS59169489A (ja) * | 1983-03-15 | 1984-09-25 | Otsuka Pharmaceut Co Ltd | ヒト培養株化細胞 |
AU594014B2 (en) * | 1984-03-21 | 1990-03-01 | Research Corporation Technologies, Inc. | Recombinant DNA molecules |
ATE67244T1 (de) * | 1984-07-06 | 1991-09-15 | Sandoz Ag | Herstellung und reinigung von lymphokinen. |
JPS61227526A (ja) * | 1984-07-25 | 1986-10-09 | Chugai Pharmaceut Co Ltd | 新規なコロニー刺激因子 |
AU588819B2 (en) * | 1984-10-29 | 1989-09-28 | Immunex Corporation | Cloning of human granulocyte-macrophage colony stimulating factor gene |
EP0215126B1 (de) * | 1985-02-08 | 1991-07-31 | Chugai Seiyaku Kabushiki Kaisha | Menschlicher granuloxcyt-kolonie-stimulierungsfaktor |
JPS62129298A (ja) * | 1985-12-02 | 1987-06-11 | Chugai Pharmaceut Co Ltd | 新規ポリペプチド |
-
1984
- 1984-07-25 JP JP59153273A patent/JPS61227526A/ja active Granted
-
1985
- 1985-07-12 US US06/754,287 patent/US4833127A/en not_active Expired - Fee Related
- 1985-07-18 CA CA000487077A patent/CA1312569C/en not_active Expired - Lifetime
- 1985-07-18 KR KR1019850005125A patent/KR920009496B1/ko not_active IP Right Cessation
- 1985-07-19 ZA ZA855478A patent/ZA855478B/xx unknown
- 1985-07-22 NO NO852915A patent/NO168952C/no not_active IP Right Cessation
- 1985-07-23 ES ES545502A patent/ES8609365A1/es not_active Expired
- 1985-07-24 DK DK337885A patent/DK166731B1/da not_active IP Right Cessation
- 1985-07-24 AR AR85301080A patent/AR242835A1/es active
- 1985-07-25 AT AT85109336T patent/ATE35271T1/de active
- 1985-07-25 DE DE8585109336T patent/DE3563444D1/de not_active Expired
- 1985-07-25 EP EP85109336A patent/EP0169566B2/de not_active Expired - Lifetime
- 1985-07-25 FI FI852903A patent/FI83881C/fi not_active IP Right Cessation
-
1991
- 1991-06-03 SG SG415/91A patent/SG41591G/en unknown
- 1991-07-04 HK HK504/91A patent/HK50491A/xx not_active IP Right Cessation
-
1993
- 1993-11-12 NL NL930141C patent/NL930141I2/nl unknown
-
1994
- 1994-02-28 BG BG98615A patent/BG61494B2/bg unknown
Also Published As
Publication number | Publication date |
---|---|
US4833127A (en) | 1989-05-23 |
ES8609365A1 (es) | 1986-07-16 |
NO168952B (no) | 1992-01-13 |
FI83881C (fi) | 1991-09-10 |
KR920009496B1 (ko) | 1992-10-17 |
AR242835A1 (es) | 1993-05-31 |
JPS61227526A (ja) | 1986-10-09 |
ZA855478B (en) | 1986-03-26 |
EP0169566B2 (de) | 2000-07-12 |
SG41591G (en) | 1993-02-19 |
NO168952C (no) | 1992-04-22 |
FI852903A0 (fi) | 1985-07-25 |
DK337885A (da) | 1986-01-26 |
HK50491A (en) | 1991-07-12 |
ES545502A0 (es) | 1986-07-16 |
KR860001185A (ko) | 1986-02-24 |
EP0169566B1 (de) | 1988-06-22 |
AU585518B2 (en) | 1989-06-22 |
FI83881B (fi) | 1991-05-31 |
CA1312569C (en) | 1993-01-12 |
DK166731B1 (da) | 1993-07-05 |
NL930141I1 (nl) | 1994-01-03 |
JPH0144200B2 (de) | 1989-09-26 |
AU4513185A (en) | 1986-01-30 |
NO852915L (no) | 1986-01-27 |
DE3563444D1 (en) | 1988-07-28 |
NL930141I2 (nl) | 1997-03-03 |
BG61494B2 (bg) | 1997-09-30 |
DK337885D0 (da) | 1985-07-24 |
EP0169566A1 (de) | 1986-01-29 |
FI852903L (fi) | 1986-01-26 |
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