|
US3854480A
(en)
|
1969-04-01 |
1974-12-17 |
Alza Corp |
Drug-delivery system
|
|
US3906092A
(en)
|
1971-11-26 |
1975-09-16 |
Merck & Co Inc |
Stimulation of antibody response
|
|
US4469863A
(en)
|
1980-11-12 |
1984-09-04 |
Ts O Paul O P |
Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
|
|
US4675189A
(en)
|
1980-11-18 |
1987-06-23 |
Syntex (U.S.A.) Inc. |
Microencapsulation of water soluble active polypeptides
|
|
US5023243A
(en)
|
1981-10-23 |
1991-06-11 |
Molecular Biosystems, Inc. |
Oligonucleotide therapeutic agent and method of making same
|
|
WO1983001451A1
(en)
|
1981-10-23 |
1983-04-28 |
Molecular Biosystems Inc |
Oligonucleotide therapeutic agent and methods of making same
|
|
ES8301593A1
(es)
|
1981-11-16 |
1983-01-01 |
Union Ind Y Agro Ganader S A U |
Procedimiento de obtencion de una leche humanizada adiciona-da de nucleotidos con destino a la alimentacion infantil.
|
|
US4452775A
(en)
|
1982-12-03 |
1984-06-05 |
Syntex (U.S.A.) Inc. |
Cholesterol matrix delivery system for sustained release of macromolecules
|
|
US4627850A
(en)
|
1983-11-02 |
1986-12-09 |
Alza Corporation |
Osmotic capsule
|
|
US4806463A
(en)
|
1986-05-23 |
1989-02-21 |
Worcester Foundation For Experimental Biology |
Inhibition of HTLV-III by exogenous oligonucleotides
|
|
US5194428A
(en)
|
1986-05-23 |
1993-03-16 |
Worcester Foundation For Experimental Biology |
Inhibition of influenza virus replication by oligonucleotide phosphorothioates
|
|
US5075109A
(en)
|
1986-10-24 |
1991-12-24 |
Southern Research Institute |
Method of potentiating an immune response
|
|
US5264423A
(en)
|
1987-03-25 |
1993-11-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
|
US5276019A
(en)
|
1987-03-25 |
1994-01-04 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
|
ES2007350A6
(es)
|
1987-05-29 |
1989-06-16 |
Ganadera Union Ind Agro |
Productos alimenticios enriquecidos con nucleosidos yno nucleotidos para la nutricion infantil y de adultos, y procedimiento para su preparacion.
|
|
CA1339596C
(en)
|
1987-08-07 |
1997-12-23 |
New England Medical Center Hospitals, Inc. |
Viral expression inhibitors
|
|
US5004810A
(en)
|
1988-09-30 |
1991-04-02 |
Schering Corporation |
Antiviral oligomers
|
|
US6214804B1
(en)
|
1989-03-21 |
2001-04-10 |
Vical Incorporated |
Induction of a protective immune response in a mammal by injecting a DNA sequence
|
|
US5133974A
(en)
|
1989-05-05 |
1992-07-28 |
Kv Pharmaceutical Company |
Extended release pharmaceutical formulations
|
|
US5786189A
(en)
|
1989-11-29 |
1998-07-28 |
Smithkline Beecham Biologicals (S.A.) |
Vaccine
|
|
US5457189A
(en)
|
1989-12-04 |
1995-10-10 |
Isis Pharmaceuticals |
Antisense oligonucleotide inhibition of papillomavirus
|
|
US5514577A
(en)
|
1990-02-26 |
1996-05-07 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide therapies for modulating the effects of herpes viruses
|
|
US5248670A
(en)
|
1990-02-26 |
1993-09-28 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotides for inhibiting herpesviruses
|
|
US5166195A
(en)
|
1990-05-11 |
1992-11-24 |
Isis Pharmaceuticals, Inc. |
Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides
|
|
EP0468520A3
(en)
|
1990-07-27 |
1992-07-01 |
Mitsui Toatsu Chemicals, Inc. |
Immunostimulatory remedies containing palindromic dna sequences
|
|
US6042838A
(en)
*
|
1991-02-15 |
2000-03-28 |
Uab Research Foundation |
immunogenic compositions for mucosal administration of pneumococcal surface protein A (PspA)
|
|
US5407686A
(en)
|
1991-11-27 |
1995-04-18 |
Sidmak Laboratories, Inc. |
Sustained release composition for oral administration of active ingredient
|
|
DE69332045T2
(de)
|
1992-02-04 |
2002-10-17 |
Chiron Corp., Emeryville |
Hepatistherapeutikum
|
|
US6498147B2
(en)
|
1992-05-22 |
2002-12-24 |
The Scripps Research Institute |
Suppression of nuclear factor-κb dependent processes using oligonucleotides
|
|
US5585479A
(en)
|
1992-07-24 |
1996-12-17 |
The United States Of America As Represented By The Secretary Of The Navy |
Antisense oligonucleotides directed against human ELAM-I RNA
|
|
DK0664833T3
(da)
|
1992-10-05 |
1997-04-14 |
Hybridon Inc |
Terapeutisk anti-HIV oligonukletid og lægemiddel
|
|
US5567604A
(en)
|
1993-04-23 |
1996-10-22 |
Aronex Pharmaceuticals, Inc. |
Anti-viral guanosine-rich oligonucleotides
|
|
CA2165821C
(en)
|
1993-06-23 |
2002-01-08 |
Albert D. Friesen |
Antisense oligonucleotides and therapeutic use thereof in human immunodeficiency virus infection
|
|
US20030109469A1
(en)
|
1993-08-26 |
2003-06-12 |
Carson Dennis A. |
Recombinant gene expression vectors and methods for use of same to enhance the immune response of a host to an antigen
|
|
US5985847A
(en)
|
1993-08-26 |
1999-11-16 |
The Regents Of The University Of California |
Devices for administration of naked polynucleotides which encode biologically active peptides
|
|
US5679647A
(en)
|
1993-08-26 |
1997-10-21 |
The Regents Of The University Of California |
Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
|
|
US5804566A
(en)
|
1993-08-26 |
1998-09-08 |
The Regents Of The University Of California |
Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides
|
|
US5849719A
(en)
|
1993-08-26 |
1998-12-15 |
The Regents Of The University Of California |
Method for treating allergic lung disease
|
|
US5830877A
(en)
|
1993-08-26 |
1998-11-03 |
The Regents Of The University Of California |
Method, compositions and devices for administration of naked polynucleotides which encode antigens and immunostimulatory
|
|
US6133244A
(en)
*
|
1993-10-22 |
2000-10-17 |
Institut Pasteur |
Method for immunization against hepatitis B
|
|
WO1995024929A2
(en)
|
1994-03-15 |
1995-09-21 |
Brown University Research Foundation |
Polymeric gene delivery system
|
|
US6727230B1
(en)
|
1994-03-25 |
2004-04-27 |
Coley Pharmaceutical Group, Inc. |
Immune stimulation by phosphorothioate oligonucleotide analogs
|
|
WO1995026204A1
(en)
|
1994-03-25 |
1995-10-05 |
Isis Pharmaceuticals, Inc. |
Immune stimulation by phosphorothioate oligonucleotide analogs
|
|
US20030050263A1
(en)
|
1994-07-15 |
2003-03-13 |
The University Of Iowa Research Foundation |
Methods and products for treating HIV infection
|
|
US7935675B1
(en)
|
1994-07-15 |
2011-05-03 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6429199B1
(en)
|
1994-07-15 |
2002-08-06 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules for activating dendritic cells
|
|
US20030026782A1
(en)
|
1995-02-07 |
2003-02-06 |
Arthur M. Krieg |
Immunomodulatory oligonucleotides
|
|
EP0772619B2
(en)
*
|
1994-07-15 |
2010-12-08 |
The University of Iowa Research Foundation |
Immunomodulatory oligonucleotides
|
|
US5646262A
(en)
|
1994-07-28 |
1997-07-08 |
Georgetown University |
Antisense oligonucleotides against hepatitis B viral replication
|
|
US6630455B1
(en)
|
1995-01-13 |
2003-10-07 |
Vanderbilt University |
Methods for inducing mucosal immune responses
|
|
GB9503863D0
(en)
|
1995-02-25 |
1995-04-19 |
Smithkline Beecham Biolog |
Vaccine compositions
|
|
US5994315A
(en)
|
1995-06-07 |
1999-11-30 |
East Carolina University |
Low adenosine agent, composition, kit and method for treatment of airway disease
|
|
US6248720B1
(en)
|
1996-07-03 |
2001-06-19 |
Brown University Research Foundation |
Method for gene therapy using nucleic acid loaded polymeric microparticles
|
|
AU714584B2
(en)
|
1995-07-21 |
2000-01-06 |
Brown University Research Foundation |
A method for gene therapy using nucleic acid loaded polymeric microparticles
|
|
EA199800272A1
(ru)
|
1995-10-04 |
1998-10-29 |
Иммунекс Корпорейшн |
Фактор, стимулирующий дендритные клетки
|
|
US5736152A
(en)
|
1995-10-27 |
1998-04-07 |
Atrix Laboratories, Inc. |
Non-polymeric sustained release delivery system
|
|
US5780448A
(en)
|
1995-11-07 |
1998-07-14 |
Ottawa Civic Hospital Loeb Research |
DNA-based vaccination of fish
|
|
US5840332A
(en)
|
1996-01-18 |
1998-11-24 |
Perio Products Ltd. |
Gastrointestinal drug delivery system
|
|
EP1346649A3
(en)
|
1996-01-22 |
2003-12-10 |
Chr. Hansen A/S |
Water dispersible compositions containing natural hydrophobic pigment, method of preparing same and their use
|
|
CA2244946C
(en)
|
1996-01-30 |
2010-04-13 |
The Regents Of The University Of California |
Gene expression vectors which generate an antigen specific immune response and methods of using the same
|
|
US20030078223A1
(en)
|
1996-01-30 |
2003-04-24 |
Eyal Raz |
Compositions and methods for modulating an immune response
|
|
US6689757B1
(en)
*
|
1996-02-12 |
2004-02-10 |
M.L. Laboratories Plc |
Methods for vaccination and vaccines therefor
|
|
SE9600647D0
(sv)
*
|
1996-02-21 |
1996-02-21 |
Bror Morein |
Ny användning
|
|
US6030955A
(en)
|
1996-03-21 |
2000-02-29 |
The Trustees Of Columbia University In The City Of New York And Imclone Systems, Inc. |
Methods of affecting intracellular phosphorylation of tyrosine using phosphorothioate oligonucleotides, and antiangiogenic and antiproliferative uses thereof
|
|
AU705647B2
(en)
|
1996-07-10 |
1999-05-27 |
Immunex Corporation |
Method of activating dendritic cells
|
|
ATE292980T1
(de)
|
1996-10-11 |
2005-04-15 |
Univ California |
Immunostimulierende oligonucleotidekonjugate
|
|
EP0855184A1
(en)
|
1997-01-23 |
1998-07-29 |
Grayson B. Dr. Lipford |
Pharmaceutical composition comprising a polynucleotide and an antigen especially for vaccination
|
|
AU738513B2
(en)
|
1997-02-28 |
2001-09-20 |
University Of Iowa Research Foundation, The |
Use of nucleic acids containing unmethylated CpG dinucleotide in the treatment of LPS-associated disorders
|
|
US6406705B1
(en)
|
1997-03-10 |
2002-06-18 |
University Of Iowa Research Foundation |
Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant
|
|
EP1005368B1
(en)
|
1997-03-10 |
2009-09-02 |
Ottawa Hospital Research Institute |
Use of nucleic acids containing unmethylated CpG dinucleotide in combination with alum as adjuvants
|
|
US6426334B1
(en)
*
|
1997-04-30 |
2002-07-30 |
Hybridon, Inc. |
Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal
|
|
CA2286396C
(en)
|
1997-04-30 |
2010-07-06 |
Isis Pharmaceuticals Inc. |
Oligonucleotides for enhanced bioavailability
|
|
DE69841002D1
(de)
|
1997-05-14 |
2009-09-03 |
Univ British Columbia |
Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln
|
|
US20030104044A1
(en)
|
1997-05-14 |
2003-06-05 |
Semple Sean C. |
Compositions for stimulating cytokine secretion and inducing an immune response
|
|
EP0983289A4
(en)
*
|
1997-05-19 |
2001-04-25 |
Merck & Co Inc |
OLIGONUCLEOTIDE AIDS
|
|
DE69838294T2
(de)
|
1997-05-20 |
2009-08-13 |
Ottawa Health Research Institute, Ottawa |
Verfahren zur Herstellung von Nukleinsäurekonstrukten
|
|
US20040006034A1
(en)
|
1998-06-05 |
2004-01-08 |
Eyal Raz |
Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
|
|
US6589940B1
(en)
|
1997-06-06 |
2003-07-08 |
Dynavax Technologies Corporation |
Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof
|
|
ATE432348T1
(de)
|
1997-06-06 |
2009-06-15 |
Univ California |
Inhibitoren von immunstimulatorischen dna sequenz aktivität
|
|
WO1999001154A1
(en)
|
1997-07-03 |
1999-01-14 |
University Of Iowa Research Foundation |
Method for inhibiting immunostimulatory dna associated responses
|
|
US5877309A
(en)
|
1997-08-13 |
1999-03-02 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotides against JNK
|
|
EP1872786A1
(en)
|
1997-09-05 |
2008-01-02 |
The Regents of the University of California |
Use of immunostimulatory oligonucleotides for preventing or reducing antigen-stimulated, granulocyte-mediated inflammation
|
|
US6749856B1
(en)
*
|
1997-09-11 |
2004-06-15 |
The United States Of America, As Represented By The Department Of Health And Human Services |
Mucosal cytotoxic T lymphocyte responses
|
|
WO1999030686A1
(en)
|
1997-12-12 |
1999-06-24 |
Inex Pharmaceuticals Corp. |
Cationic drugs encapsulated in anionic liposomes
|
|
US20050031638A1
(en)
|
1997-12-24 |
2005-02-10 |
Smithkline Beecham Biologicals S.A. |
Vaccine
|
|
GB9727262D0
(en)
|
1997-12-24 |
1998-02-25 |
Smithkline Beecham Biolog |
Vaccine
|
|
JPH11209289A
(ja)
|
1998-01-22 |
1999-08-03 |
Taisho Pharmaceut Co Ltd |
粘膜免疫誘起剤
|
|
ES2284247T3
(es)
*
|
1998-04-03 |
2007-11-01 |
University Of Iowa Research Foundation |
Metodos y productos para estimular el sistema inmunitario usando oligonucleotidos y citoquinas inmunoterapeuticos.
|
|
WO1999052549A1
(en)
|
1998-04-09 |
1999-10-21 |
Smithkline Beecham Biologicals S.A. |
Adjuvant compositions
|
|
DE69932164D1
(de)
|
1998-04-28 |
2006-08-10 |
Inex Pharmaceuticals Corp |
Polyanionische polymere mit verbesserter fusogenfähigkeit
|
|
WO1999056755A1
(en)
|
1998-05-06 |
1999-11-11 |
University Of Iowa Research Foundation |
Methods for the prevention and treatment of parasitic infections and related diseases using cpg oligonucleotides
|
|
EP1078053B1
(en)
|
1998-05-14 |
2005-09-28 |
Coley Pharmaceutical GmbH |
METHODS FOR REGULATING HEMATOPOIESIS USING CpG-OLIGONUCLEOTIDES
|
|
ATE335510T1
(de)
|
1998-05-22 |
2006-09-15 |
Ottawa Health Research Inst |
Methoden und produkte zur induzierung mukosaler immunität
|
|
US6562798B1
(en)
|
1998-06-05 |
2003-05-13 |
Dynavax Technologies Corp. |
Immunostimulatory oligonucleotides with modified bases and methods of use thereof
|
|
AU748565B2
(en)
|
1998-06-23 |
2002-06-06 |
Board Of Trustees Of The Leland Stanford Junior University |
Adjuvant therapy
|
|
US6693086B1
(en)
|
1998-06-25 |
2004-02-17 |
National Jewish Medical And Research Center |
Systemic immune activation method using nucleic acid-lipid complexes
|
|
US20030022854A1
(en)
|
1998-06-25 |
2003-01-30 |
Dow Steven W. |
Vaccines using nucleic acid-lipid complexes
|
|
US20040247662A1
(en)
|
1998-06-25 |
2004-12-09 |
Dow Steven W. |
Systemic immune activation method using nucleic acid-lipid complexes
|
|
EP1096921B1
(en)
|
1998-07-20 |
2003-04-16 |
Protiva Biotherapeutics Inc. |
Liposomal encapsulated nucleic acid-complexes
|
|
WO2000006588A1
(en)
|
1998-07-27 |
2000-02-10 |
University Of Iowa Research Foundation |
STEREOISOMERS OF CpG OLIGONUCLEOTIDES AND RELATED METHODS
|
|
GB9817052D0
(en)
|
1998-08-05 |
1998-09-30 |
Smithkline Beecham Biolog |
Vaccine
|
|
DK1104306T3
(da)
|
1998-08-10 |
2006-05-22 |
Antigenics Inc |
Præparater af CpG- og saponinadjuvanser og fremgangsmåder til anvendelse deraf
|
|
US20010034330A1
(en)
|
1998-08-10 |
2001-10-25 |
Charlotte Kensil |
Innate immunity-stimulating compositions of CpG and saponin and methods thereof
|
|
US6210663B1
(en)
|
1998-08-20 |
2001-04-03 |
The Wistar Institute Of Anatomy And Biology |
Methods of augmenting mucosal immunity through systemic priming and mucosal boosting
|
|
AU777225B2
(en)
|
1998-09-03 |
2004-10-07 |
Coley Pharmaceutical Gmbh |
G-motif oligonucleotides and uses thereof
|
|
FR2783170B1
(fr)
|
1998-09-11 |
2004-07-16 |
Pasteur Merieux Serums Vacc |
Emulsion immunostimulante
|
|
AU6425999A
(en)
|
1998-10-09 |
2000-05-01 |
Dynavax Technologies Corporation |
Anti hiv compositions comprising immunostimulatory polynucleotides and hiv antigens
|
|
CZ301212B6
(cs)
|
1998-10-16 |
2009-12-09 |
Smithkline Beecham Biologicals S. A. |
Vakcinacní prostredek
|
|
AU760574B2
(en)
|
1999-01-12 |
2003-05-15 |
Smithkline Beecham Biologicals (Sa) |
Novel treatment
|
|
JP2003520568A
(ja)
|
1999-02-02 |
2003-07-08 |
バイオカシェ ファーマシューティカルズ， インコーポレイテッド |
高度な抗原提示プラットフォーム
|
|
EP1146907A2
(en)
|
1999-02-05 |
2001-10-24 |
Genzyme Corporation |
Use of cationic lipids to generate anti-tumor immunity
|
|
AU3760100A
(en)
|
1999-03-16 |
2000-10-04 |
Panacea Pharmaceuticals, Llc |
Immunostimulatory nucleic acids and antigens
|
|
FR2790955B1
(fr)
|
1999-03-19 |
2003-01-17 |
Assist Publ Hopitaux De Paris |
Utilisation d'oligonucleotides stabilises comme principe actif antitumoral
|
|
EP1162999B1
(en)
|
1999-03-19 |
2006-11-29 |
Glaxosmithkline Biologicals S.A. |
Vaccine against Streptococcus pneumoniae
|
|
US6977245B2
(en)
|
1999-04-12 |
2005-12-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Oligodeoxynucleotide and its use to induce an immune response
|
|
WO2000061151A2
(en)
|
1999-04-12 |
2000-10-19 |
The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Oligodeoxynucleotide and its use to induce an immune response
|
|
AU4642600A
(en)
|
1999-04-15 |
2000-11-02 |
Regents Of The University Of California, The |
Methods and compositions for use in potentiating antigen presentation by antigenpresenting cells
|
|
US6558670B1
(en)
|
1999-04-19 |
2003-05-06 |
Smithkline Beechman Biologicals S.A. |
Vaccine adjuvants
|
|
TR200103018T2
(tr)
|
1999-04-19 |
2002-02-21 |
Beecham Biologicals S.A. Smithkline |
İmmünostimülatör oligonükleotid ve saponin içeren katkı bileşikleri.
|
|
EP1177439B1
(en)
|
1999-04-29 |
2004-09-08 |
Coley Pharmaceutical GmbH |
Screening for immunostimulatory dna functional modifiers
|
|
US6737066B1
(en)
|
1999-05-06 |
2004-05-18 |
The Immune Response Corporation |
HIV immunogenic compositions and methods
|
|
BR0010323A
(pt)
|
1999-05-06 |
2002-01-08 |
Immune Response Corp Inc |
Composições imunogênicas, kit e método de confecção da mesma para uso na imunização de um mamìfero
|
|
EP1196558A1
(fr)
|
1999-06-08 |
2002-04-17 |
Aventis Pasteur |
Oligonucleotide immunostimulant
|
|
CA2412345A1
(en)
|
1999-06-16 |
2000-12-21 |
University Of Iowa Research Foundation |
Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases
|
|
GB9915204D0
(en)
|
1999-06-29 |
1999-09-01 |
Smithkline Beecham Biolog |
Vaccine
|
|
ES2250151T3
(es)
|
1999-06-29 |
2006-04-16 |
Glaxosmithkline Biologicals S.A. |
Uso de cpg como adyuvante de vacuna contra vih.
|
|
US6514948B1
(en)
|
1999-07-02 |
2003-02-04 |
The Regents Of The University Of California |
Method for enhancing an immune response
|
|
DE19935756A1
(de)
|
1999-07-27 |
2001-02-08 |
Mologen Forschungs Entwicklung |
Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation
|
|
US7479285B1
(en)
|
1999-08-19 |
2009-01-20 |
Dynavax Technologies Corporation |
Methods of modulating an immune response using immunostimulatory sequences and compositions for use therein
|
|
US20050249794A1
(en)
|
1999-08-27 |
2005-11-10 |
Semple Sean C |
Compositions for stimulating cytokine secretion and inducing an immune response
|
|
GB9921146D0
(en)
|
1999-09-07 |
1999-11-10 |
Smithkline Beecham Biolog |
Novel composition
|
|
UA77152C2
(en)
|
1999-09-25 |
2006-11-15 |
|
Method for stimulation of immune response using nucleic acid-containing immunostimulating compositions, method for treatment of cancer and method for treatment or prophylaxis of allergy or asthma
|
|
US6949520B1
(en)
|
1999-09-27 |
2005-09-27 |
Coley Pharmaceutical Group, Inc. |
Methods related to immunostimulatory nucleic acid-induced interferon
|
|
US7223398B1
(en)
|
1999-11-15 |
2007-05-29 |
Dynavax Technologies Corporation |
Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof
|
|
AU2593701A
(en)
|
1999-12-21 |
2001-07-03 |
Regents Of The University Of California, The |
Method for preventing an anaphylactic reaction
|
|
AU3108001A
(en)
|
2000-01-20 |
2001-12-24 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory nucleic acids for inducing a th2 immune response
|
|
US6852705B2
(en)
|
2000-01-21 |
2005-02-08 |
Merial |
DNA vaccines for farm animals, in particular bovines and porcines
|
|
AU783005B2
(en)
|
2000-01-31 |
2005-09-15 |
Smithkline Beecham Biologicals (Sa) |
Novel use
|
|
WO2001055341A2
(en)
|
2000-01-31 |
2001-08-02 |
The Regents Of The University Of California |
Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen
|
|
US7585847B2
(en)
|
2000-02-03 |
2009-09-08 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory nucleic acids for the treatment of asthma and allergy
|
|
FR2805265B1
(fr)
|
2000-02-18 |
2002-04-12 |
Aventis Pasteur |
Oligonucleotides immunostimulants
|
|
US20030130217A1
(en)
|
2000-02-23 |
2003-07-10 |
Eyal Raz |
Method for treating inflammatory bowel disease and other forms of gastrointestinal inflammation
|
|
WO2001062207A2
(en)
|
2000-02-23 |
2001-08-30 |
The Regents Of The University Of California |
Method for treating inflammatory bowel disease and other forms of gastrointestinal inflammation
|
|
WO2001062275A1
(en)
|
2000-02-24 |
2001-08-30 |
The Board Of Trustees Of The Leland Stanford Junior University |
Adjuvant treatment by in vivo activation of dendritic cells
|
|
US20020156033A1
(en)
|
2000-03-03 |
2002-10-24 |
Bratzler Robert L. |
Immunostimulatory nucleic acids and cancer medicament combination therapy for the treatment of cancer
|
|
US20040131628A1
(en)
|
2000-03-08 |
2004-07-08 |
Bratzler Robert L. |
Nucleic acids for the treatment of disorders associated with microorganisms
|
|
US20020107212A1
(en)
|
2000-03-10 |
2002-08-08 |
Nest Gary Van |
Methods of reducing papillomavirus infection using immunomodulatory polynucleotide sequences
|
|
US20030129251A1
(en)
|
2000-03-10 |
2003-07-10 |
Gary Van Nest |
Biodegradable immunomodulatory formulations and methods for use thereof
|
|
US20020028784A1
(en)
|
2000-03-10 |
2002-03-07 |
Nest Gary Van |
Methods of preventing and treating viral infections using immunomodulatory polynucleotide sequences
|
|
US7157437B2
(en)
|
2000-03-10 |
2007-01-02 |
Dynavax Technologies Corporation |
Methods of ameliorating symptoms of herpes infection using immunomodulatory polynucleotide sequences
|
|
US20010046967A1
(en)
|
2000-03-10 |
2001-11-29 |
Gary Van Nest |
Methods of preventing and treating respiratory viral infection using immunomodulatory polynucleotide
|
|
US7129222B2
(en)
|
2000-03-10 |
2006-10-31 |
Dynavax Technologies Corporation |
Immunomodulatory formulations and methods for use thereof
|
|
US20020098199A1
(en)
|
2000-03-10 |
2002-07-25 |
Gary Van Nest |
Methods of suppressing hepatitis virus infection using immunomodulatory polynucleotide sequences
|
|
EP1267618A1
(en)
|
2000-03-28 |
2003-01-02 |
The Regents Of The University Of California |
Methods for increasing a cytotoxic t lymphocyte response in vivo
|
|
EP1278550A4
(en)
|
2000-04-07 |
2004-05-12 |
Univ California |
SYNERGISTIC IMPROVEMENTS OF POLYNUCLEOTIDE VACCINE
|
|
US7534772B2
(en)
|
2000-06-22 |
2009-05-19 |
University Of Iowa Research Foundation |
Methods for enhancing antibody-induced cell lysis and treating cancer
|
|
US20020165178A1
(en)
|
2000-06-28 |
2002-11-07 |
Christian Schetter |
Immunostimulatory nucleic acids for the treatment of anemia, thrombocytopenia, and neutropenia
|
|
WO2002009748A1
(en)
|
2000-07-31 |
2002-02-07 |
Yale University |
Innate immune system-directed vaccines
|
|
US20020198165A1
(en)
|
2000-08-01 |
2002-12-26 |
Bratzler Robert L. |
Nucleic acids for the prevention and treatment of gastric ulcers
|
|
US20020091097A1
(en)
|
2000-09-07 |
2002-07-11 |
Bratzler Robert L. |
Nucleic acids for the prevention and treatment of sexually transmitted diseases
|
|
CA2419894A1
(en)
|
2000-09-15 |
2002-03-21 |
Coley Pharmaceutical Gmbh |
Process for high throughput screening of cpg-based immuno-agonist/antagonist
|
|
GB0023008D0
(en)
|
2000-09-20 |
2000-11-01 |
Glaxo Group Ltd |
Improvements in vaccination
|
|
FR2814958B1
(fr)
|
2000-10-06 |
2003-03-07 |
Aventis Pasteur |
Composition vaccinale
|
|
SI2266603T1
(sl)
|
2000-10-18 |
2012-12-31 |
Glaxosmithkline Biologicals S.A. |
Tumorska cepiva
|
|
CA2426047A1
(en)
|
2000-11-02 |
2002-05-10 |
Inex Pharmaceuticals Corporation |
Therapeutic oligonucleotides of reduced toxicity
|
|
WO2002069369A2
(en)
|
2000-12-08 |
2002-09-06 |
Coley Pharmaceutical Gmbh |
Cpg-like nucleic acids and methods of use thereof
|
|
AU2002248185A1
(en)
|
2000-12-14 |
2002-07-16 |
Coley Pharmaceutical Group, Inc. |
Inhibition of angiogenesis by nucleic acids
|
|
AU2002231336B2
(en)
|
2000-12-27 |
2007-06-28 |
Surefire Medical, Inc. D/B/A Trisalus Life Sciences |
Immunomodulatory polynucleotides and methods of using the same
|
|
WO2002074922A2
(en)
|
2001-03-16 |
2002-09-26 |
The Regents Of The University Of California |
Compositions and methods for modulating an immune response
|
|
US20030050268A1
(en)
|
2001-03-29 |
2003-03-13 |
Krieg Arthur M. |
Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases
|
|
WO2002102307A2
(en)
|
2001-06-15 |
2002-12-27 |
Ribapharm |
Nucleoside vaccine adjuvants
|
|
WO2003012061A2
(en)
|
2001-08-01 |
2003-02-13 |
Coley Pharmaceutical Gmbh |
Methods and compositions relating to plasmacytoid dendritic cells
|
|
JP4607452B2
(ja)
|
2001-08-07 |
2011-01-05 |
ダイナバックス テクノロジーズ コーポレイション |
免疫調節性組成物、製剤およびその使用方法
|
|
US8834900B2
(en)
|
2001-08-17 |
2014-09-16 |
University Of Iowa Research Foundation |
Combination motif immune stimulatory oligonucleotides with improved activity
|
|
JP2005501550A
(ja)
|
2001-08-30 |
2005-01-20 |
スリーエム イノベイティブ プロパティズ カンパニー |
免疫反応調整剤分子を用いた形質細胞様樹状細胞を成熟させる方法
|
|
US20030119774A1
(en)
|
2001-09-25 |
2003-06-26 |
Marianna Foldvari |
Compositions and methods for stimulating an immune response
|
|
CA2461315A1
(en)
|
2001-10-05 |
2003-04-17 |
Coley Pharmaceutical Gmbh |
Toll-like receptor 3 signaling agonists and antagonists
|
|
CA2471968C
(en)
|
2001-10-06 |
2013-07-23 |
Merial Limited |
Immunostimulatory nucleic acids and use thereof
|
|
EP1478371A4
(en)
|
2001-10-12 |
2007-11-07 |
Univ Iowa Res Found |
METHOD AND PRODUCTS FOR IMPROVING IMMUNE RESPONSES WITH IMIDAZOCHINOLINE COMPOUNDS
|
|
AU2002340662B2
(en)
|
2001-11-07 |
2008-07-03 |
Tekmira Pharmaceuticals Corporation |
Mucosal adjuvants comprising an oligonucleotide and a cationic lipid
|
|
TW200303759A
(en)
|
2001-11-27 |
2003-09-16 |
Schering Corp |
Methods for treating cancer
|
|
US8088388B2
(en)
|
2002-02-14 |
2012-01-03 |
United Biomedical, Inc. |
Stabilized synthetic immunogen delivery system
|
|
US20030232443A1
(en)
|
2002-06-18 |
2003-12-18 |
Isis Pharmaceuticals Inc. |
Antisense modulation of centromere protein B expression
|
|
US8153141B2
(en)
|
2002-04-04 |
2012-04-10 |
Coley Pharmaceutical Gmbh |
Immunostimulatory G, U-containing oligoribonucleotides
|
|
CN1665531A
(zh)
|
2002-05-10 |
2005-09-07 |
伊内克斯药物公司 |
甲基化的免疫刺激性寡核苷酸和利用这些寡核苷酸的方法
|
|
AU2003246396B2
(en)
|
2002-05-28 |
2008-08-21 |
Merck Patent Gmbh |
A method for generating antigen-presenting cells
|
|
AU2003243409A1
(en)
|
2002-06-05 |
2003-12-22 |
Coley Pharmaceutical Group, Inc. |
Method for treating autoimmune or inflammatory diseases with combinations of inhibitory oligonucleotides and small molecule antagonists of immunostimulatory cpg nucleic acids
|
|
US7569553B2
(en)
|
2002-07-03 |
2009-08-04 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
|
US7807803B2
(en)
|
2002-07-03 |
2010-10-05 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
|
US7605138B2
(en)
|
2002-07-03 |
2009-10-20 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
|
US20040053880A1
(en)
|
2002-07-03 |
2004-03-18 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
|
US7576066B2
(en)
|
2002-07-03 |
2009-08-18 |
Coley Pharmaceutical Group, Inc. |
Nucleic acid compositions for stimulating immune responses
|
|
WO2004004654A2
(en)
|
2002-07-03 |
2004-01-15 |
Cambridge Scientific, Inc. |
Vaccines to induce mucosal immunity
|
|
WO2004007743A2
(en)
|
2002-07-17 |
2004-01-22 |
Coley Pharmaceutical Gmbh |
Use of cpg nucleic acids in prion-disease
|
|
CN1468957A
(zh)
|
2002-07-19 |
2004-01-21 |
中国人民解放军第二军医大学 |
一种用作人用治疗性疫苗佐剂的质粒
|
|
AR040996A1
(es)
|
2002-08-19 |
2005-04-27 |
Coley Pharm Group Inc |
Acidos nucleicos inmunoestimuladores
|
|
AU2003278845A1
(en)
|
2002-09-19 |
2004-04-08 |
Coley Pharmaceutical Gmbh |
Toll-like receptor 9 (tlr9) from various mammalian species
|
|
MXPA05004588A
(es)
|
2002-10-29 |
2005-12-14 |
Coley Pharmaceutical Group Ltd |
Metodos y productos relacionados con el tratamiento y prevencion de infeccion de virus de hepatitis c.
|
|
WO2004053104A2
(en)
|
2002-12-11 |
2004-06-24 |
Coley Pharmaceutical Group, Inc. |
5’ cpg nucleic acids and methods of use
|
|
KR100525321B1
(ko)
|
2002-12-13 |
2005-11-02 |
안웅식 |
파필로마바이러스 항원 단백질 및ＣｐＧ-올리고데옥시뉴클레오타이드를 포함하는파필로마바이러스 유발 질환의 예방 또는 치료용 약제학적조성물
|
|
WO2004087203A2
(en)
|
2003-04-02 |
2004-10-14 |
Coley Pharmaceutical Group, Ltd. |
Immunostimulatory nucleic acid oil-in-water formulations for topical application
|
|
WO2004094671A2
(en)
|
2003-04-22 |
2004-11-04 |
Coley Pharmaceutical Gmbh |
Methods and products for identification and assessment of tlr ligands
|
|
MXPA05013922A
(es)
|
2003-06-20 |
2006-02-24 |
Coley Pharm Group Inc |
Antagonistas de receptor tipo toll de molecula pequena.
|
|
AU2004275876B2
(en)
|
2003-09-25 |
2011-03-31 |
Coley Pharmaceutical Gmbh |
Nucleic acid-lipophilic conjugates
|
|
US20050215501A1
(en)
|
2003-10-24 |
2005-09-29 |
Coley Pharmaceutical Group, Inc. |
Methods and products for enhancing epitope spreading
|
|
BRPI0416079A
(pt)
|
2003-10-30 |
2007-01-02 |
Coley Pharm Gmbh |
análogos de oligonucleotìdeos de classe c com uma potência imunoestimuladora aumentada
|
|
US20050239733A1
(en)
|
2003-10-31 |
2005-10-27 |
Coley Pharmaceutical Gmbh |
Sequence requirements for inhibitory oligonucleotides
|
|
US20050100983A1
(en)
|
2003-11-06 |
2005-05-12 |
Coley Pharmaceutical Gmbh |
Cell-free methods for identifying compounds that affect toll-like receptor 9 (TLR9) signaling
|
|
TW200533750A
(en)
|
2004-02-19 |
2005-10-16 |
Coley Pharm Group Inc |
Immunostimulatory viral RNA oligonucleotides
|
|
WO2005111057A2
(en)
|
2004-04-02 |
2005-11-24 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory nucleic acids for inducing il-10 responses
|
|
JP2008501807A
(ja)
|
2004-06-08 |
2008-01-24 |
コーリー ファーマシューティカル ゲーエムベーハー |
抗原ならびに免疫活性化アゴニストおよび免疫活性化アンタゴニストのための担体基本骨格としての無塩基オリゴヌクレオチド
|
|
KR20100018029A
(ko)
|
2004-07-18 |
2010-02-16 |
씨에스엘 리미티드 |
면역자극 복합체 및 향상된 인터페론-감마 반응을 유도하기 위한 올리고뉴클레오티드 제제
|
|
JP2008506683A
(ja)
|
2004-07-18 |
2008-03-06 |
コーリー ファーマシューティカル グループ， リミテッド |
先天免疫応答を誘導するための方法および組成物
|
|
MY159370A
(en)
|
2004-10-20 |
2016-12-30 |
Coley Pharm Group Inc |
Semi-soft-class immunostimulatory oligonucleotides
|
|
WO2006091915A2
(en)
|
2005-02-24 |
2006-08-31 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory oligonucleotides
|
|
EP1874325A2
(en)
|
2005-04-08 |
2008-01-09 |
Coley Pharmaceutical Group, Inc. |
Methods for treating infectious disease exacerbated asthma
|
|
WO2006116458A2
(en)
|
2005-04-26 |
2006-11-02 |
Coley Pharmaceutical Gmbh |
Modified oligoribonucleotide analogs with enhances immunostimulatory activity
|
|
US20090306177A1
(en)
|
2005-09-16 |
2009-12-10 |
Coley Pharmaceutical Gmbh |
Modulation of Immunostimulatory Properties of Short Interfering Ribonucleic Acid (Sirna) by Nucleotide Modification
|
|
AU2006294528A1
(en)
|
2005-09-27 |
2007-04-05 |
Coley Pharmaceutical Gmbh |
Modulation of TLR-mediated immune responses using adaptor oligonucleotides
|
|
WO2007062107A2
(en)
|
2005-11-25 |
2007-05-31 |
Coley Pharmaceutical Gmbh |
Immunostimulatory oligoribonucleotides
|
|
EP1991678B2
(en)
|
2006-02-15 |
2020-07-15 |
Rechtsanwalt Thomas Beck |
Compositions and methods for oligonucleotide formulations
|
|
US8027888B2
(en)
|
2006-08-31 |
2011-09-27 |
Experian Interactive Innovation Center, Llc |
Online credit card prescreen systems and methods
|
|
WO2008033432A2
(en)
|
2006-09-12 |
2008-03-20 |
Coley Pharmaceutical Group, Inc. |
Immune modulation by chemically modified ribonucleosides and oligoribonucleotides
|
|
CN101541965A
(zh)
|
2006-09-27 |
2009-09-23 |
科勒制药集团股份有限公司 |
Tlr配体与抗病毒剂的组合物
|
|
MX2009003398A
(es)
|
2006-09-27 |
2009-08-12 |
Coley Pharm Gmbh |
Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada.
|
|
US20100144846A1
(en)
|
2006-10-26 |
2010-06-10 |
Coley Pharmaceutical Gmbh |
Oligoribonucleotides and uses thereof
|