ATE297921T1 - Tetrazolylphenyl-acetamide als glukokinaseaktivatoren - Google Patents

Tetrazolylphenyl-acetamide als glukokinaseaktivatoren

Info

Publication number
ATE297921T1
ATE297921T1 AT01962926T AT01962926T ATE297921T1 AT E297921 T1 ATE297921 T1 AT E297921T1 AT 01962926 T AT01962926 T AT 01962926T AT 01962926 T AT01962926 T AT 01962926T AT E297921 T1 ATE297921 T1 AT E297921T1
Authority
AT
Austria
Prior art keywords
tetrazolylphenyl
acetamide
glucokinase activators
glucokinase
activators
Prior art date
Application number
AT01962926T
Other languages
German (de)
English (en)
Inventor
Achyutharao Sidduri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE297921T1 publication Critical patent/ATE297921T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01962926T 2000-08-15 2001-08-09 Tetrazolylphenyl-acetamide als glukokinaseaktivatoren ATE297921T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22549400P 2000-08-15 2000-08-15
PCT/EP2001/009207 WO2002014312A1 (en) 2000-08-15 2001-08-09 Tetrazolyl-phenyl acetamide glucokinase activators

Publications (1)

Publication Number Publication Date
ATE297921T1 true ATE297921T1 (de) 2005-07-15

Family

ID=22845106

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01962926T ATE297921T1 (de) 2000-08-15 2001-08-09 Tetrazolylphenyl-acetamide als glukokinaseaktivatoren

Country Status (20)

Country Link
US (3) US6369232B1 (cg-RX-API-DMAC7.html)
EP (1) EP1311504B1 (cg-RX-API-DMAC7.html)
JP (1) JP3961948B2 (cg-RX-API-DMAC7.html)
KR (1) KR100518061B1 (cg-RX-API-DMAC7.html)
CN (1) CN1209362C (cg-RX-API-DMAC7.html)
AR (1) AR031718A1 (cg-RX-API-DMAC7.html)
AT (1) ATE297921T1 (cg-RX-API-DMAC7.html)
AU (2) AU2001283998B2 (cg-RX-API-DMAC7.html)
BR (1) BR0113312A (cg-RX-API-DMAC7.html)
CA (1) CA2419416C (cg-RX-API-DMAC7.html)
DE (1) DE60111540T2 (cg-RX-API-DMAC7.html)
DK (1) DK1311504T3 (cg-RX-API-DMAC7.html)
ES (1) ES2243541T3 (cg-RX-API-DMAC7.html)
MX (1) MXPA03001275A (cg-RX-API-DMAC7.html)
PA (1) PA8525201A1 (cg-RX-API-DMAC7.html)
PE (1) PE20020386A1 (cg-RX-API-DMAC7.html)
PT (1) PT1311504E (cg-RX-API-DMAC7.html)
UY (1) UY26885A1 (cg-RX-API-DMAC7.html)
WO (1) WO2002014312A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200300904B (cg-RX-API-DMAC7.html)

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SE0102299D0 (sv) 2001-06-26 2001-06-26 Astrazeneca Ab Compounds
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
US7078423B2 (en) * 2002-07-18 2006-07-18 Inotek Pharmaceuticals Corporation 5-Aryltetrazole compounds, compositions thereof, and uses therefor
US7087631B2 (en) * 2002-07-18 2006-08-08 Inotek Pharmaceuticals Corporation Aryltetrazole compounds, and compositions thereof
WO2004050645A1 (en) * 2002-10-03 2004-06-17 Novartis Ag Substituted (thiazol-2-yl) -amide or sulfonamide as glycokinase activators useful in the treatment of type 2 diabetes
GB0226931D0 (en) 2002-11-19 2002-12-24 Astrazeneca Ab Chemical compounds
MY141521A (en) 2002-12-12 2010-05-14 Hoffmann La Roche 5-substituted-six-membered heteroaromatic glucokinase activators
WO2004063194A1 (en) * 2003-01-06 2004-07-29 Eli Lilly And Company Heteroaryl compounds
US7262196B2 (en) * 2003-02-11 2007-08-28 Prosidion Limited Tri(cyclo) substituted amide glucokinase activator compounds
PL378117A1 (pl) * 2003-02-11 2006-03-06 Prosidion Limited Tricyklopodstawione związki amidowe
BRPI0509543A (pt) * 2004-04-02 2007-09-18 Novartis Ag derivados de tiazolopiridina, condições farmacêuticas que contêm os mesmos e métodos para tratar condições mediadas por glucocinase
EP1735322B1 (en) * 2004-04-02 2011-09-14 Novartis AG Sulfonamide-thiazolpyridine derivatives as glucokinase activators useful for the treatment of type 2 diabetes
EP2301935A1 (en) 2005-07-09 2011-03-30 AstraZeneca AB (Publ) Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
KR100965040B1 (ko) * 2005-07-11 2010-06-21 미쓰비시 타나베 파마 코퍼레이션 옥심 유도체 및 그의 제조 방법
CA2621227A1 (en) 2005-08-31 2007-03-08 Astellas Pharma Inc. Thiazole derivative
JP2007063225A (ja) * 2005-09-01 2007-03-15 Takeda Chem Ind Ltd イミダゾピリジン化合物
CN101272784A (zh) 2005-09-29 2008-09-24 塞诺菲-安万特股份有限公司 苯基-和吡啶基-1,2,4-噁二唑酮衍生物、它们的制备方法和它们作为药物的用途
GT200600428A (es) * 2005-09-30 2007-05-21 Compuestos organicos
GT200600429A (es) * 2005-09-30 2007-04-30 Compuestos organicos
BRPI0618062A2 (pt) * 2005-11-03 2011-08-16 Prosidion Ltd composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, processo para a preparação de um composto
US20070197532A1 (en) * 2005-11-18 2007-08-23 Cao Sheldon X Glucokinase activators
ES2381864T3 (es) * 2005-12-15 2012-06-01 Nihon Nohyaku Co., Ltd. Derivado de ftalamida, pesticida agrícola u hortícola y utilización del pesticida
WO2007104034A2 (en) 2006-03-08 2007-09-13 Takeda San Diego, Inc. Glucokinase activators
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
EP2049518B1 (en) * 2006-05-31 2011-08-31 Takeda San Diego, Inc. Indazole and isoindole derivatives as glucokinase activating agents.
US7910747B2 (en) * 2006-07-06 2011-03-22 Bristol-Myers Squibb Company Phosphonate and phosphinate pyrazolylamide glucokinase activators
US7902248B2 (en) 2006-12-14 2011-03-08 Hoffmann-La Roche Inc. Oxime glucokinase activators
WO2008079787A2 (en) 2006-12-20 2008-07-03 Takeda San Diego, Inc. Glucokinase activators
TW200831081A (en) * 2006-12-25 2008-08-01 Kyorin Seiyaku Kk Glucokinase activator
EP2105435A4 (en) * 2007-01-10 2011-06-15 Mitsubishi Tanabe Pharma Corp Hydrazone derivative
WO2008111473A1 (ja) * 2007-03-07 2008-09-18 Kyorin Pharmaceutical Co., Ltd. グルコキナーゼ活性化物質
WO2008116107A2 (en) * 2007-03-21 2008-09-25 Takeda San Diego, Inc. Piperazine derivatives as glucokinase activators
AU2008310519B2 (en) * 2007-10-08 2013-05-02 Advinus Therapeutics Private Limited Acetamide derivatives as glucokinase activators, their process and medicinal applications
AR070107A1 (es) * 2008-01-15 2010-03-17 Lilly Co Eli R-2-(4-ciclopropansulfonil-fenil)-n-pirazin-2-il-3-(tetrahidropiran-4-il)-propionamida en forma cristalina, composicion farmaceutica que la comprende y su uso para la manufactura de un medicamento util para la prevencion o tratamiento de hiperglicemia
KR20100113518A (ko) * 2008-01-18 2010-10-21 아스텔라스세이야쿠 가부시키가이샤 페닐아세트아미드 유도체
JP5449144B2 (ja) * 2008-04-28 2014-03-19 杏林製薬株式会社 シクロペンチルアクリル酸アミド誘導体
ES2893699T3 (es) 2010-03-31 2022-02-09 Scripps Research Inst Reprogramación de células

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US3776917A (en) * 1972-06-05 1973-12-04 Schering Corp 2-amino-6-phenalkyl-aminopyridines and derivatives thereof
GB8909574D0 (en) 1989-04-26 1989-06-14 Ici Plc Chemical process
US5859052A (en) * 1993-01-14 1999-01-12 G. D. Searle & Co. Fatty acid analogs and prodrugs
US5461049A (en) * 1994-05-27 1995-10-24 Warner-Lambert Company Amide tetrazole ACAT inhibitors
US5468867A (en) * 1994-05-27 1995-11-21 Syntex (U.S.A.) Inc. Process for preparing1-butyl-2-[2'-(2H-tetrazol-5-yl)biphenyl-4-ylmethyl1-1H-indole-3-carboxylic acid
JP2001509166A (ja) * 1997-01-28 2001-07-10 メルク エンド カンパニー インコーポレーテッド 糖尿病および肥満の治療のためのβ▲下３▼作動薬としてのチアゾールベンゼンスルホンアミド
PT1169312E (pt) * 1999-03-29 2005-01-31 Hoffmann La Roche Activadores de glicocinase

Also Published As

Publication number Publication date
AU8399801A (en) 2002-02-25
JP3961948B2 (ja) 2007-08-22
PT1311504E (pt) 2005-10-31
MXPA03001275A (es) 2003-06-30
EP1311504B1 (en) 2005-06-15
UY26885A1 (es) 2002-02-28
ZA200300904B (en) 2004-04-30
DE60111540T2 (de) 2006-03-16
CN1466584A (zh) 2004-01-07
PE20020386A1 (es) 2002-05-13
BR0113312A (pt) 2003-07-01
ES2243541T3 (es) 2005-12-01
CN1209362C (zh) 2005-07-06
EP1311504A1 (en) 2003-05-21
US20020035266A1 (en) 2002-03-21
US20020065275A1 (en) 2002-05-30
US6441180B1 (en) 2002-08-27
KR20030022408A (ko) 2003-03-15
PA8525201A1 (es) 2002-07-30
CA2419416A1 (en) 2002-02-21
JP2004506632A (ja) 2004-03-04
WO2002014312A1 (en) 2002-02-21
DK1311504T3 (da) 2005-10-17
DE60111540D1 (de) 2005-07-21
AU2001283998B2 (en) 2005-10-20
KR100518061B1 (ko) 2005-09-28
US6369232B1 (en) 2002-04-09
US6388088B1 (en) 2002-05-14
CA2419416C (en) 2009-10-13
US20020035267A1 (en) 2002-03-21
AR031718A1 (es) 2003-10-01

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