ATE293114T1 - Cephemverbindungen mit einem imidazo(4,5- b)pyridiniummethyl-rest, die ein breites antibakterielles wirkungsspektrum haben - Google Patents

Cephemverbindungen mit einem imidazo(4,5- b)pyridiniummethyl-rest, die ein breites antibakterielles wirkungsspektrum haben

Info

Publication number
ATE293114T1
ATE293114T1 AT99973033T AT99973033T ATE293114T1 AT E293114 T1 ATE293114 T1 AT E293114T1 AT 99973033 T AT99973033 T AT 99973033T AT 99973033 T AT99973033 T AT 99973033T AT E293114 T1 ATE293114 T1 AT E293114T1
Authority
AT
Austria
Prior art keywords
hydrogen
imidazo
compounds containing
broad spectrum
antibacterial action
Prior art date
Application number
AT99973033T
Other languages
English (en)
Inventor
Yasuhiro Nishitani
Hikaru Itani
Tadashi Irie
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Application granted granted Critical
Publication of ATE293114T1 publication Critical patent/ATE293114T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/48—Methylene radicals, substituted by hetero rings
    • C07D501/56—Methylene radicals, substituted by hetero rings with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
AT99973033T 1998-11-27 1999-11-25 Cephemverbindungen mit einem imidazo(4,5- b)pyridiniummethyl-rest, die ein breites antibakterielles wirkungsspektrum haben ATE293114T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33670798 1998-11-27
PCT/JP1999/006562 WO2000032606A1 (fr) 1998-11-27 1999-11-25 COMPOSÉS DE CÉPHÈME À BASE D'IMIDAZO[4,5-b]PYRIDINIUMMÉTHYLE À LARGE SPECTRE ANTIBACTÉRIEN

Publications (1)

Publication Number Publication Date
ATE293114T1 true ATE293114T1 (de) 2005-04-15

Family

ID=18301969

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99973033T ATE293114T1 (de) 1998-11-27 1999-11-25 Cephemverbindungen mit einem imidazo(4,5- b)pyridiniummethyl-rest, die ein breites antibakterielles wirkungsspektrum haben

Country Status (23)

Country Link
US (2) US6518263B1 (de)
EP (1) EP1134222B1 (de)
JP (1) JP3636663B2 (de)
KR (1) KR100692169B1 (de)
CN (1) CN100436456C (de)
AT (1) ATE293114T1 (de)
AU (1) AU758662B2 (de)
BR (1) BR9915743A (de)
CA (1) CA2350905C (de)
CZ (1) CZ20011719A3 (de)
DE (1) DE69924751T2 (de)
ES (1) ES2241374T3 (de)
HU (1) HUP0200450A3 (de)
ID (1) ID28740A (de)
IL (1) IL143314A0 (de)
NO (1) NO20012554L (de)
NZ (1) NZ511619A (de)
PL (1) PL347897A1 (de)
RU (1) RU2223964C2 (de)
TR (1) TR200101507T2 (de)
TW (1) TW526202B (de)
WO (1) WO2000032606A1 (de)
ZA (1) ZA200103850B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW526202B (en) * 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
CA2387016C (en) 1999-10-08 2010-09-28 William H. Miller Acrylamide derivatives as fab i inhibitors
JP2003012647A (ja) * 2000-10-04 2003-01-15 Shionogi & Co Ltd ２，３−ジアミノピリジンの製造方法
DK1560584T3 (da) * 2001-04-06 2009-05-18 Affinium Pharm Inc Fab I inhibitorer
WO2002088147A1 (fr) * 2001-04-23 2002-11-07 Shionogi & Co., Ltd. Sulfate d'un compose cepheme
AU2003211942A1 (en) * 2002-02-14 2003-09-04 Shionogi And Co., Ltd. Process for production of 2,3-diaminopyridine derivatives
ATE398105T1 (de) * 2002-03-13 2008-07-15 Janssen Pharmaceutica Nv Carbonylamino- derivativate als neue inhibitoren von histone deacetylase
AU2003241675A1 (en) * 2002-06-21 2004-01-06 Shionogi And Co., Ltd. Medicinal cephem compound composition for injection
JPWO2004026882A1 (ja) * 2002-09-20 2006-01-19 塩野義製薬株式会社 セフェム剤の製法
AU2003275682A1 (en) * 2002-10-29 2004-05-25 Shionogi And Co., Ltd. Crystal of inorganic acid salt of cephem compound
AU2002952355A0 (en) * 2002-10-30 2002-11-14 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
CA2504730C (en) * 2002-10-30 2011-04-12 Astellas Pharma Inc. Cephem compounds
JP4859460B2 (ja) * 2002-12-06 2012-01-25 アフィニウム ファーマシューティカルズ， インク． ヘテロ環化合物、その製造方法および治療におけるその使用
CA2519429C (en) * 2003-03-17 2013-08-06 Affinium Pharmaceuticals, Inc. Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics
AU2003902380A0 (en) * 2003-05-16 2003-06-05 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
MXPA06003068A (es) * 2003-09-18 2006-08-25 Astellas Pharma Inc Compuestos de cefem.
JP4535366B2 (ja) * 2003-12-03 2010-09-01 塩野義製薬株式会社 セフェム剤の製造方法
CN1922190A (zh) * 2004-03-05 2007-02-28 盐野义制药株式会社 3－吡啶甲基头胞化合物
DK1828167T3 (da) 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
JP2006206529A (ja) * 2005-01-31 2006-08-10 Shionogi & Co Ltd Ｎ−（４−ピリジル）エチレンジアミン誘導体
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
EP2054422B1 (de) 2006-07-20 2017-06-14 Debiopharm International SA Acrylamidderivate als fab-i-inhibitoren
EP2125802A4 (de) * 2007-02-16 2014-08-20 Debiopharm Int Sa Salze, prodrugs und polymorphe von fab-i-inhibitoren
US8198434B2 (en) * 2008-05-07 2012-06-12 Idexx Laboratories, Inc. Process for preparing cefsulodin sodium
CN102443017B (zh) * 2010-10-13 2014-10-29 石药集团中奇制药技术（石家庄）有限公司 一种盐酸头孢唑兰的制备方法
WO2013036783A2 (en) 2011-09-09 2013-03-14 Cubist Pharmaceuticals, Inc. Methods for treating intrapulmonary infections
IN2014KN02915A (de) 2012-06-19 2015-05-08 Debiopharm Int Sa
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
RS58700B1 (sr) 2012-10-12 2019-06-28 Broad Inst Inc Gsk3 inhibitori i postupci njihove primene
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
MX2020004205A (es) 2013-03-15 2021-11-16 Merck Sharp & Dohme Llc Composiciones antibioticas de ceftolozano.
EP3043797B1 (de) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Behandlung von infektionen mit ceftolozan/tazobactam bei personen mit beeinträchtigter nierenfunktion
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
ES2729026T3 (es) * 2015-06-29 2019-10-29 Sandoz Ag Procedimiento para la preparación de derivados de carbamoilamino pirazol
CA3005779C (en) * 2015-12-10 2020-04-07 Naeja-Rgm Pharmaceuticals Ulc Cephem compounds, their production and use
TN2018000293A1 (en) 2016-02-26 2020-01-16 Debiopharm Int Sa Medicament for treatment of diabetic foot infections
EA201992359A1 (ru) 2017-04-05 2020-03-12 Дзе Брод Инститьют Инк. Трициклические соединения в качестве ингибиторов киназы гликогенсинтазы-3 (gsk3) и их применение

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3585199A (en) * 1967-05-25 1971-06-15 Merck & Co Inc (4-(3-(polyazaheterocyclic)alkanoyl)phenoxy)alkanoic acids
US4002623A (en) * 1974-08-07 1977-01-11 Pfizer Inc. Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines
GR75644B (de) 1980-06-18 1984-08-02 Fujisawa Pharmaceutical Co
ES8306160A1 (es) 1981-04-03 1983-05-01 Fujisawa Pharmaceutical Co "procedimiento para preparar un nuevo compuesto de cefem".
SU1169542A3 (ru) 1981-09-08 1985-07-23 Эли Лилли Энд Компани (Фирма) Способ получени тиенопиридиний- или фуропиридиний-замещенных производных цефалоспорина
US4406899A (en) 1982-03-04 1983-09-27 Bristol-Myers Company Cephalosporins
ZA838864B (en) * 1982-12-17 1984-11-28 Ici Pharma Process for the manufacture of cephalosporin derivatives
DE3248281A1 (de) 1982-12-28 1984-06-28 Hoechst Ag, 6230 Frankfurt Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung
US4525473A (en) 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
DE3409431A1 (de) 1983-10-08 1985-04-18 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3336757A1 (de) 1983-10-08 1985-04-25 Hoechst Ag, 6230 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
EP0138552A3 (de) 1983-10-17 1986-03-19 Eli Lilly And Company Herstellung von 3-biclyclipyridinium-methyl Cephalosporinen
US4692443A (en) * 1983-10-17 1987-09-08 Eli Lilly And Company 3-bicyclicpyridinium-methyl cephalosporins
JPS60120889A (ja) 1983-11-30 1985-06-28 Meiji Seika Kaisha Ltd 新規セファロスポリン化合物及びその製造法
US4547573A (en) 1983-12-02 1985-10-15 Ici Pharma Process for preparing cephalosporin derivatives
GB8401093D0 (en) 1984-01-16 1984-02-15 Fujisawa Pharmaceutical Co Cephem compounds
NO165842C (no) 1984-04-23 1991-04-17 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive cefem-forbindelser.
IL77458A (en) 1985-01-14 1990-07-26 Eisai Co Ltd Cephem derivatives,their production and antibacterial compositions containing them and certain novel intermediates therefor
NO166283C (no) 1985-03-01 1991-06-26 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive 7beta-(2-(5-amino-1,2,4-tiadiazol-3-yl)-2(z)-substituertoksyiminoacetamido)-3-(heterocyclylmetyl)-3-cefem-4-karboksylsyrederivater.
ATE89826T1 (de) 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
US4804658A (en) 1986-09-15 1989-02-14 G. D. Searle & Co. Imidazopyridine derivatives and pharmaceutical compositions
GB8712747D0 (en) * 1987-05-30 1987-07-01 Pfizer Ltd Therapeutic agents
JPH0248587A (ja) * 1988-08-10 1990-02-19 Yamanouchi Pharmaceut Co Ltd 複素環置換ビスフォスフォン酸誘導体及びその医薬
JPH02286679A (ja) * 1989-04-28 1990-11-26 Grelan Pharmaceut Co Ltd イミダゾピリジン誘導体
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
US5332744A (en) 1989-05-30 1994-07-26 Merck & Co., Inc. Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
US5298518A (en) 1989-09-29 1994-03-29 Eisai Co., Ltd. Biphenylmethane derivative and pharmacological use
IE70593B1 (en) * 1989-09-29 1996-12-11 Eisai Co Ltd Biphenylmethane derivative the use of it and pharmacological compositions containing same
EP0434038A1 (de) 1989-12-22 1991-06-26 Takeda Chemical Industries, Ltd. Kondensierte Imidazolderivate, ihre Herstellung und Verwendung
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.
DE4005970A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
EP0461040A1 (de) * 1990-06-08 1991-12-11 Roussel Uclaf Imidazolderivate, Verfahren zu deren Herstellung, Zwischenprodukte, deren Anwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen
WO1992006086A1 (en) 1990-10-01 1992-04-16 Janssen Pharmaceutica N.V. Novel 4-piperidinylcarbonyl derivatives
US5281589A (en) 1991-06-15 1994-01-25 Cheil Foods & Chemicals, Inc. 3-fused pyridiniummethyl cephalosporins
JPH05201991A (ja) * 1991-07-10 1993-08-10 Dainippon Pharmaceut Co Ltd アミノ酸誘導体
JPH05222058A (ja) 1992-02-17 1993-08-31 Fujisawa Pharmaceut Co Ltd 新規セフェム化合物およびその塩
JPH0641149A (ja) * 1992-05-28 1994-02-15 Toyama Chem Co Ltd 新規なセファロスポリン誘導体およびその塩
JP3269658B2 (ja) * 1992-06-02 2002-03-25 エーザイ株式会社 フェノール誘導体
GB9216287D0 (en) 1992-07-31 1992-09-16 Fujisawa Pharmaceutical Co New cephem compounds
JPH07101958A (ja) 1992-10-16 1995-04-18 Takeda Chem Ind Ltd セフェム化合物、その製造法および抗菌組成物
US5334598A (en) 1993-03-19 1994-08-02 Merck & Co., Inc. Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives
DE4309969A1 (de) * 1993-03-26 1994-09-29 Bayer Ag Substituierte heteroanellierte Imidazole
JPH07101960A (ja) 1993-10-05 1995-04-18 Takeda Chem Ind Ltd セフェム化合物、その製造法および抗菌組成物
US5486525A (en) 1993-12-16 1996-01-23 Abbott Laboratories Platelet activating factor antagonists: imidazopyridine indoles
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
DE4416433A1 (de) * 1994-05-10 1995-11-16 Hoechst Ag Cyclohexan-Derivate, Verfahren zu ihrer Herstellung und die Verwendung der Verbindungen zur Behandlung von Krankheiten
US5585492A (en) 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
US5635514A (en) 1994-10-25 1997-06-03 G. D. Searle & Company Heteroaralkyl and heteroarylthioalkyl thiophenolic compounds as 5-lipoxgenase inhibitors
US5846990A (en) 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
JPH09165371A (ja) * 1995-10-09 1997-06-24 Sankyo Co Ltd 複素環化合物を含有する医薬
JPH09110877A (ja) * 1995-10-17 1997-04-28 Katayama Seiyakushiyo:Kk セフェム化合物、その製造法及びそれを含有する抗菌剤
FR2742052B1 (fr) * 1995-12-12 1998-04-10 Esteve Labor Dr Utilisation des derives 1-(4-(4-aryl (ou heteroaryl)-1-piper azinyl)-buty)-1h-azole pour le traitement de la depression, des troubles obsessifs compulsifs, l'apnee du sommeil, les dysfonctions sexuelles, l'emese et le mal des transports
AUPN955596A0 (en) 1996-04-30 1996-05-23 Fujisawa Pharmaceutical Co., Ltd. New compound
JP4028894B2 (ja) 1996-08-09 2007-12-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 ベンゾピペリジン誘導体
TW526202B (en) * 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity

Also Published As

Publication number Publication date
KR100692169B1 (ko) 2007-03-12
US6518263B1 (en) 2003-02-11
US20030149014A1 (en) 2003-08-07
NO20012554L (no) 2001-07-27
JP3636663B2 (ja) 2005-04-06
AU758662B2 (en) 2003-03-27
TR200101507T2 (tr) 2001-09-21
IL143314A0 (en) 2002-04-21
ES2241374T3 (es) 2005-10-16
NO20012554D0 (no) 2001-05-23
HUP0200450A3 (en) 2004-04-28
RU2223964C2 (ru) 2004-02-20
ID28740A (id) 2001-06-28
PL347897A1 (en) 2002-04-22
CA2350905A1 (en) 2000-06-08
CZ20011719A3 (cs) 2001-12-12
ZA200103850B (en) 2002-05-13
CA2350905C (en) 2007-10-23
HUP0200450A2 (hu) 2002-07-29
EP1134222A1 (de) 2001-09-19
US6800621B2 (en) 2004-10-05
CN100436456C (zh) 2008-11-26
CN1333776A (zh) 2002-01-30
EP1134222A4 (de) 2003-01-29
NZ511619A (en) 2002-11-26
WO2000032606A1 (fr) 2000-06-08
TW526202B (en) 2003-04-01
AU1409000A (en) 2000-06-19
KR20010086058A (ko) 2001-09-07
DE69924751D1 (de) 2005-05-19
EP1134222B1 (de) 2005-04-13
BR9915743A (pt) 2001-08-21
DE69924751T2 (de) 2006-03-09

Similar Documents

Publication Publication Date Title
ATE293114T1 (de) Cephemverbindungen mit einem imidazo(4,5- b)pyridiniummethyl-rest, die ein breites antibakterielles wirkungsspektrum haben
HK1087112A1 (en) Tricyclic compounds, their production and use
SG47520A1 (en) New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
TW349097B (en) Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
PL300063A1 (en) 7-(substituted)-9-[(substituted glycil) amido]-6-demethyl-6-deoxy-tetracyclines, methods of obtaining such compounds as well as their organic and inorganic salts and metal complex, pharmaceutical agent and veterinary agent
ATE339409T1 (de) Trizyklische verbindungen
DE69901717D1 (de) Phosphohalohydrine, verfahren zu deren herstellung und verwendungen
ATE201195T1 (de) Tricyclische verbindungen
ES2157199T3 (es) Nuevo procedimiento para la produccion de cefalosporinas y nuevos compuestos intermedios para este procedimiento.
ATE202354T1 (de) Tetracyclische kondensierte heterocyclische verbindungen zur behandlung von seniler demenz
WO2000063182A3 (de) 2,4-diamino-pyrimidin-derivate und ihre verwendung als mikrobizide und heribizide
DE69121259T2 (de) Beta-Lactam-Verbindungen und ihre Herstellung
AU9025601A (en) Cephem compounds and esbl-detecting reagents containing the same
PT1338596E (pt) Processos para a preparacao de agentes antibacterianos do tipo carbapenem
DE69332366D1 (de) Arylsubstituierte heterocyclische Verbindungen
DK0604355T3 (da) Arylsubstituerede heterocykliske forbindelser
HK1064673A1 (en) Fused-polycyclic compounds
AR028744A1 (es) Un proceso para la preparacion de compuestos de 7-[2-(2-aminotiazol-4-il)-2-alcoxicarbonilmetoxiiminoacetamido inferior]-3-cefem y los intermediarios en dicho proceso
ATE448198T1 (de) Neue alpha-ketoamidderivate und deren verwendung
TH15136EX (th) อนุพันธ์ของไพราโซลซึ่งถูกแทนที่
SU1829358A1 (ru) Гидрохлорид-3-[3-(4-метилпиперазин-1-ил)пропилтио]-1,2,4-триазино[5,6-b]индола, защищающий печень от отравления четыреххлористым углеродом

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties