ATE281153T1 - Implantierbares system mit verzögerter wirkstofffreisetzung - Google Patents

Implantierbares system mit verzögerter wirkstofffreisetzung

Info

Publication number
ATE281153T1
ATE281153T1 AT02076866T AT02076866T ATE281153T1 AT E281153 T1 ATE281153 T1 AT E281153T1 AT 02076866 T AT02076866 T AT 02076866T AT 02076866 T AT02076866 T AT 02076866T AT E281153 T1 ATE281153 T1 AT E281153T1
Authority
AT
Austria
Prior art keywords
implantable
delayed release
release system
delayed
release
Prior art date
Application number
AT02076866T
Other languages
English (en)
Inventor
Bonnie J Eckenhoff
John R Peery
Keith E Dionne
Felix A Landrau
Scott D Lautenbach
Judy A Magruder
Jeromy C Wright
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24384575&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE281153(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of ATE281153T1 publication Critical patent/ATE281153T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • A61K38/09Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/14526Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons the piston being actuated by fluid pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00Characteristics of a physical parameter; associated device therefor
    • A61M2206/10Flow characteristics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
AT02076866T 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung ATE281153T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59576196A 1996-02-02 1996-02-02

Publications (1)

Publication Number Publication Date
ATE281153T1 true ATE281153T1 (de) 2004-11-15

Family

ID=24384575

Family Applications (5)

Application Number Title Priority Date Filing Date
AT02076868T ATE277595T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung
AT02076869T ATE303792T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung
AT02076867T ATE284202T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung
AT97902971T ATE235224T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter freisetzung von leuprolid
AT02076866T ATE281153T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung

Family Applications Before (4)

Application Number Title Priority Date Filing Date
AT02076868T ATE277595T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung
AT02076869T ATE303792T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung
AT02076867T ATE284202T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter wirkstofffreisetzung
AT97902971T ATE235224T1 (de) 1996-02-02 1997-01-15 Implantierbares system mit verzögerter freisetzung von leuprolid

Country Status (27)

Country Link
US (2) US5728396A (de)
EP (7) EP1238659B1 (de)
JP (1) JP4176832B2 (de)
KR (1) KR100540090B1 (de)
CN (3) CN100493647C (de)
AR (1) AR006079A1 (de)
AT (5) ATE277595T1 (de)
BR (1) BR9707336B1 (de)
CO (1) CO4761076A1 (de)
CZ (2) CZ293808B6 (de)
DE (5) DE69731498T2 (de)
DK (5) DK1238659T3 (de)
ES (5) ES2229051T3 (de)
HU (1) HU221919B1 (de)
ID (1) ID17704A (de)
IL (2) IL125596A (de)
MY (1) MY122081A (de)
NO (1) NO327194B1 (de)
NZ (1) NZ331186A (de)
PL (2) PL189137B1 (de)
PT (5) PT1238659E (de)
RO (1) RO119929B1 (de)
RU (1) RU2189221C2 (de)
SK (2) SK284136B6 (de)
TW (1) TW466121B (de)
WO (1) WO1997027840A1 (de)
ZA (1) ZA97831B (de)

Families Citing this family (339)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6132420A (en) * 1996-02-02 2000-10-17 Alza Corporation Osmotic delivery system and method for enhancing start-up and performance of osmotic delivery systems
US6156331A (en) * 1996-02-02 2000-12-05 Alza Corporation Sustained delivery of an active agent using an implantable system
US6395292B2 (en) * 1996-02-02 2002-05-28 Alza Corporation Sustained delivery of an active agent using an implantable system
US5916582A (en) * 1996-07-03 1999-06-29 Alza Corporation Aqueous formulations of peptides
US5932547A (en) * 1996-07-03 1999-08-03 Alza Corporation Non-aqueous polar aprotic peptide formulations
US5981489A (en) * 1996-07-18 1999-11-09 Alza Corporation Non-aqueous protic peptide formulations
US6676127B2 (en) 1997-03-13 2004-01-13 Shuffle Master, Inc. Collating and sorting apparatus
ZA981610B (en) * 1997-03-24 1999-08-26 Alza Corp Self adjustable exit port.
DE69816980T2 (de) * 1997-03-31 2004-07-22 Alza Corp., Palo Alto Implantierbares diffusionabgabesystem
JPH10279499A (ja) * 1997-04-04 1998-10-20 Takeda Chem Ind Ltd 子宮粘膜適用製剤
DE69833375D1 (de) * 1997-06-04 2006-04-13 Debio Rech Pharma Sa Implantate zur gesteuerten freisetzung von pharmazeutischen wirkstoffen und verfahren zur herstellung
MY125870A (en) * 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system flow modulator apparatus and method
EP1779847B1 (de) * 1997-07-25 2009-03-18 Intarcia Therapeutics, Inc. Osmotisches Abgabesystem mit halbdurchlässigem Stöpsel
MY125849A (en) 1997-07-25 2006-08-30 Alza Corp Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems
DK1041975T3 (da) * 1997-12-22 2002-11-04 Alza Corp Hastighedskontrollerende membraner til anordninger til kontrolleret indførsel af medikament
WO1999033446A1 (en) 1997-12-29 1999-07-08 Alza Corporation Osmotic delivery system with membrane plug retention mechanism
EP1736145B1 (de) * 1997-12-30 2011-12-21 Intarcia Therapeutics, Inc Verabreichungssystem für Wirkstoffe mit einem Membranstöpsel
DE69834213T2 (de) 1997-12-31 2007-01-25 Alza Corp., Mountain View Osmotisches Abgabesystem für ein nützliches Mittel
US6183461B1 (en) 1998-03-11 2001-02-06 Situs Corporation Method for delivering a medication
US6254096B1 (en) 1998-04-15 2001-07-03 Shuffle Master, Inc. Device and method for continuously shuffling cards
US6655684B2 (en) 1998-04-15 2003-12-02 Shuffle Master, Inc. Device and method for forming and delivering hands from randomly arranged decks of playing cards
US7890176B2 (en) * 1998-07-06 2011-02-15 Boston Scientific Neuromodulation Corporation Methods and systems for treating chronic pelvic pain
US6565874B1 (en) * 1998-10-28 2003-05-20 Atrix Laboratories Polymeric delivery formulations of leuprolide with improved efficacy
HK1040916B (en) * 1998-12-31 2003-10-03 Intarcia Therapeutics, Inc. Osmotic delivery system having space efficient piston
US7258869B1 (en) 1999-02-08 2007-08-21 Alza Corporation Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicle
US7919109B2 (en) 1999-02-08 2011-04-05 Intarcia Therapeutics, Inc. Stable non-aqueous single phase viscous vehicles and formulations utilizing such vehicles
WO2002043800A2 (en) 2000-11-29 2002-06-06 Durect Corporation Devices and methods for controlled delivery from a drug delivery device
US6541021B1 (en) * 1999-03-18 2003-04-01 Durect Corporation Devices and methods for pain management
US6835194B2 (en) 1999-03-18 2004-12-28 Durect Corporation Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners
US6139535A (en) * 1999-05-27 2000-10-31 Situs Corporation Method and apparatus for placement and activation of a medical device within a body cavity
US6468264B1 (en) 1999-10-12 2002-10-22 Durect Corporation Closed exchange system
US6436091B1 (en) 1999-11-16 2002-08-20 Microsolutions, Inc. Methods and implantable devices and systems for long term delivery of a pharmaceutical agent
EP1235610A2 (de) 1999-12-08 2002-09-04 Durect Corporation Katheter mit stilettlumen
EP1328256B1 (de) 1999-12-21 2005-10-19 Alza Corporation Ventil für osmotische vorrichtungen
CN1230224C (zh) * 1999-12-27 2005-12-07 阿尔萨公司 渗透促进剂输送系统
US6616652B1 (en) 2000-02-15 2003-09-09 Microsolutions, Inc. Osmotic pump delivery system with pre-hydrated membrane(s) and/or primable catheter
US6464688B1 (en) 2000-02-15 2002-10-15 Microsolutions, Inc. Osmotic pump delivery system with flexible drug compartment
US6471688B1 (en) 2000-02-15 2002-10-29 Microsolutions, Inc. Osmotic pump drug delivery systems and methods
US6582441B1 (en) 2000-02-24 2003-06-24 Advanced Bionics Corporation Surgical insertion tool
US7074803B2 (en) * 2001-03-02 2006-07-11 Durect Corporation Opioid formulations
US8024048B2 (en) * 2000-03-13 2011-09-20 Ionix Medical Inc. Method and device for treating cancer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
US7742811B2 (en) * 2000-03-13 2010-06-22 Onco Stim Implantable device and method for the electrical treatment of cancer
US8511684B2 (en) 2004-10-04 2013-08-20 Shfl Entertainment, Inc. Card-reading shoe with inventory correction feature and methods of correcting inventory
US8590896B2 (en) 2000-04-12 2013-11-26 Shuffle Master Gmbh & Co Kg Card-handling devices and systems
CN1438861A (zh) 2000-04-26 2003-08-27 沃特森药物公司 最小化与奥昔布宁疗法有关的副作用
US20030124177A1 (en) * 2000-04-26 2003-07-03 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
US7029694B2 (en) 2000-04-26 2006-04-18 Watson Laboratories, Inc. Compositions and methods for transdermal oxybutynin therapy
US7179483B2 (en) 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
US20060034828A1 (en) * 2000-06-28 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a GlcNAcMAN5GLCNAC2 glycoform
JP2002089978A (ja) 2000-09-11 2002-03-27 Daikin Ind Ltd ペア型の冷凍装置およびマルチ型の冷凍装置
US20020197235A1 (en) * 2000-11-03 2002-12-26 Moran Stanford Mark Method for short-term and long-term drug dosimetry
US8470359B2 (en) * 2000-11-13 2013-06-25 Qlt Usa, Inc. Sustained release polymer
US7776029B2 (en) * 2001-01-30 2010-08-17 The Alfred E. Mann Foundation For Scientific Research Microminiature infusion pump
US20050143789A1 (en) * 2001-01-30 2005-06-30 Whitehurst Todd K. Methods and systems for stimulating a peripheral nerve to treat chronic pain
US7493172B2 (en) * 2001-01-30 2009-02-17 Boston Scientific Neuromodulation Corp. Methods and systems for stimulating a nerve originating in an upper cervical spine area to treat a medical condition
US20060064140A1 (en) * 2001-01-30 2006-03-23 Whitehurst Todd K Methods and systems for stimulating a trigeminal nerve to treat a psychiatric disorder
EP1365770A2 (de) * 2001-02-07 2003-12-03 Durect Corporation Vorrichtungen und verfahren zur erhaltung der knochendichte
EP1379197A4 (de) * 2001-03-23 2009-06-03 Durect Corp Abgabe von arzneimitteln von vorrichtungen mit verzögerter freisetzung, die in myokardgewebe oder im perikardraum implantiert sind
US6632217B2 (en) * 2001-04-19 2003-10-14 Microsolutions, Inc. Implantable osmotic pump
US7163688B2 (en) * 2001-06-22 2007-01-16 Alza Corporation Osmotic implant with membrane and membrane retention means
GB0121709D0 (en) * 2001-09-07 2001-10-31 Imp College Innovations Ltd Food inhibition agent
AU2002327596A1 (en) 2001-09-17 2003-04-01 Durect Corporation Device and method for accurate delivery of an active agent
PL205971B1 (pl) * 2001-09-24 2010-06-30 Imp Innovations Ltd Zastosowanie PYY₃-₃₆ do wytwarzania leku na ograniczanie apetytu, zmniejszenie otyłości lub do zapobiegania otyłości
US20080111300A1 (en) * 2006-11-10 2008-05-15 Zbigniew Czyzewski Casino card shoes, systems, and methods for a no peek feature
US7677565B2 (en) 2001-09-28 2010-03-16 Shuffle Master, Inc Card shuffler with card rank and value reading capability
US8616552B2 (en) 2001-09-28 2013-12-31 Shfl Entertainment, Inc. Methods and apparatuses for an automatic card handling device and communication networks including same
US8011661B2 (en) 2001-09-28 2011-09-06 Shuffle Master, Inc. Shuffler with shuffling completion indicator
US8337296B2 (en) 2001-09-28 2012-12-25 SHFL entertaiment, Inc. Method and apparatus for using upstream communication in a card shuffler
US7753373B2 (en) 2001-09-28 2010-07-13 Shuffle Master, Inc. Multiple mode card shuffler and card reading device
CA2466228A1 (en) * 2001-11-09 2003-08-07 Biomedicines, Inc. Method for treating diseases with omega interferon
AU2003201998C1 (en) 2002-01-10 2012-10-25 Imperial Innovations Limited Modification of feeding behavior
US8058233B2 (en) * 2002-01-10 2011-11-15 Oregon Health And Science University Modification of feeding behavior using PYY and GLP-1
US6886829B2 (en) 2002-02-08 2005-05-03 Vendingdata Corporation Image capturing card shuffler
US8774922B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having expandable balloons for renal neuromodulation and associated systems and methods
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US7620451B2 (en) * 2005-12-29 2009-11-17 Ardian, Inc. Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach
US6978174B2 (en) 2002-04-08 2005-12-20 Ardian, Inc. Methods and devices for renal nerve blocking
US9308043B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US8145316B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods and apparatus for renal neuromodulation
US20070129761A1 (en) 2002-04-08 2007-06-07 Ardian, Inc. Methods for treating heart arrhythmia
US8150519B2 (en) 2002-04-08 2012-04-03 Ardian, Inc. Methods and apparatus for bilateral renal neuromodulation
US8175711B2 (en) 2002-04-08 2012-05-08 Ardian, Inc. Methods for treating a condition or disease associated with cardio-renal function
US8131371B2 (en) 2002-04-08 2012-03-06 Ardian, Inc. Methods and apparatus for monopolar renal neuromodulation
US8145317B2 (en) 2002-04-08 2012-03-27 Ardian, Inc. Methods for renal neuromodulation
US20070135875A1 (en) 2002-04-08 2007-06-14 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US7853333B2 (en) 2002-04-08 2010-12-14 Ardian, Inc. Methods and apparatus for multi-vessel renal neuromodulation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US9636174B2 (en) 2002-04-08 2017-05-02 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US9308044B2 (en) 2002-04-08 2016-04-12 Medtronic Ardian Luxembourg S.A.R.L. Methods for therapeutic renal neuromodulation
US8347891B2 (en) 2002-04-08 2013-01-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for performing a non-continuous circumferential treatment of a body lumen
US7162303B2 (en) 2002-04-08 2007-01-09 Ardian, Inc. Renal nerve stimulation method and apparatus for treatment of patients
US7756583B2 (en) 2002-04-08 2010-07-13 Ardian, Inc. Methods and apparatus for intravascularly-induced neuromodulation
US20080213331A1 (en) 2002-04-08 2008-09-04 Ardian, Inc. Methods and devices for renal nerve blocking
US7617005B2 (en) 2002-04-08 2009-11-10 Ardian, Inc. Methods and apparatus for thermally-induced renal neuromodulation
WO2004037341A2 (en) * 2002-05-07 2004-05-06 Schroeppel Edward A Method and device for treating concer with electrical therapy in conjunction with chemotherapeutic agents and radiation therapy
EP1536767B1 (de) * 2002-06-17 2007-08-08 Alza Corporation Osmotisches abgabesystem mit schubmotor früher nullter ordnung mit einem osmotischen mittel, das in dem flüssigen vehikel dispergiert ist
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
ES2295642T3 (es) * 2002-06-26 2008-04-16 Intarcia Therapeutics, Inc. Piston de volumen eficaz de ocupacion minima para sistemas de administracion de medicamentos.
US7254449B2 (en) * 2002-07-31 2007-08-07 Advanced Bionics Corp Systems and methods for providing power to one or more implantable devices
CA2497867A1 (en) 2002-09-06 2004-03-18 Durect Corporation Delivery of modulators of glutamate-mediated neurotransmission to the inner ear
US20060009739A1 (en) * 2002-09-06 2006-01-12 Durect Corporation Implantable flow regulator with failsafe mode and reserve drug supply
US20060198894A1 (en) * 2002-10-29 2006-09-07 Johanna Bentz Stabilized, solid-state polypeptide particles
US7014636B2 (en) * 2002-11-21 2006-03-21 Alza Corporation Osmotic delivery device having a two-way valve and a dynamically self-adjusting flow channel
US20040102476A1 (en) * 2002-11-25 2004-05-27 Chan Tai Wah High concentration formulations of opioids and opioid derivatives
ATE482695T1 (de) * 2002-12-13 2010-10-15 Durect Corp Orale darreichungsform mit flüssigen hochviskosen trägersystemen
EP1578398A2 (de) * 2002-12-19 2005-09-28 ALZA Corporation Stabilisierte nicht-wässrige einphasige gele und diese enthaltende zusammensetzungen zur verabreichung aus einer implantierbaren vorrichtung
US7731947B2 (en) * 2003-11-17 2010-06-08 Intarcia Therapeutics, Inc. Composition and dosage form comprising an interferon particle formulation and suspending vehicle
GB0300571D0 (en) * 2003-01-10 2003-02-12 Imp College Innovations Ltd Modification of feeding behaviour
BRPI0408925A (pt) * 2003-03-31 2006-04-04 Alza Corp veìculos de fase simples não-aquosos e formulações utilizando tais veìculos
EP1610761A2 (de) * 2003-03-31 2006-01-04 Alza Corporation Osmotisches verabreichungssystem und methode zur verkürzung der startzeit von osmotischen verabreichungssystemen
CA2520610A1 (en) * 2003-03-31 2004-10-21 Alza Corporation Osmotic pump with means for dissipating internal pressure
AU2004235744A1 (en) * 2003-05-01 2004-11-18 Archimedes Development Limited Nasal administration of the LH-RH analog leuprolide
US20070083240A1 (en) * 2003-05-08 2007-04-12 Peterson David K L Methods and systems for applying stimulation and sensing one or more indicators of cardiac activity with an implantable stimulator
US7429378B2 (en) * 2003-05-13 2008-09-30 Depuy Spine, Inc. Transdiscal administration of high affinity anti-MMP inhibitors
US7344716B2 (en) * 2003-05-13 2008-03-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
US20040229878A1 (en) * 2003-05-13 2004-11-18 Depuy Spine, Inc. Transdiscal administration of specific inhibitors of P38 kinase
US8273347B2 (en) 2003-05-13 2012-09-25 Depuy Spine, Inc. Autologous treatment of degenerated disc with cells
MXPA05012275A (es) 2003-05-13 2006-02-10 Depuy Spine Inc Un metodo para tratar enfermedad degenerativa del disco.
US7553827B2 (en) * 2003-08-13 2009-06-30 Depuy Spine, Inc. Transdiscal administration of cycline compounds
JP2007525188A (ja) 2003-05-16 2007-09-06 インターミューン インコーポレイテッド 合成ケモカイン受容体リガンドおよびその使用方法
US7108762B2 (en) * 2003-06-12 2006-09-19 Cordis Corporation Method for manufacturing an orifice mechanism capable of low fluid flow rates
US6976983B2 (en) 2003-06-12 2005-12-20 Cordis Corporation Implantable device for delivering drugs using orifice mechanism capable of low fluid flow rates
US8109922B2 (en) * 2003-06-12 2012-02-07 Cordis Corporation Orifice device having multiple channels and multiple layers for drug delivery
US7211076B2 (en) * 2003-06-12 2007-05-01 Cordis Corporation Medical device for fluid delivery having low fluid flow rate
US7678103B2 (en) * 2003-06-12 2010-03-16 Cordis Corporation Orifice device for delivering drugs at low fluid flow rates
US8491571B2 (en) 2003-06-12 2013-07-23 Cordis Corporation Orifice device having multiple channels with varying flow rates for drug delivery
US8361467B2 (en) * 2003-07-30 2013-01-29 Depuy Spine, Inc. Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints
US7858110B2 (en) 2003-08-11 2010-12-28 Endo Pharmaceuticals Solutions, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
CA2437639C (en) 2003-08-11 2016-07-05 Valera Pharmaceuticals, Inc. Long term drug delivery devices with polyurethane based polymers and their manufacture
AU2004277980A1 (en) 2003-09-30 2005-04-14 Alza Corporation Osmotically driven active agent delivery device providing an ascending release profile
US7407973B2 (en) 2003-10-24 2008-08-05 Intermune, Inc. Use of pirfenidone in therapeutic regimens
MXPA06002030A (es) * 2003-10-31 2006-05-17 Alza Corp Bomba osmotica con tapon de membrana de auto-retencion, de rapido inicio.
WO2005046639A2 (en) * 2003-11-06 2005-05-26 Alza Corporation Modular imbibition rate reducer for use with implantable osmotic pump
US8895540B2 (en) * 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
US7769461B2 (en) * 2003-12-19 2010-08-03 Boston Scientific Neuromodulation Corporation Skull-mounted electrical stimulation system and method for treating patients
EP1703895A2 (de) * 2004-01-13 2006-09-27 Vasogenix Pharmaceuticals, Inc. Zusammensetzung zur cgrp anwendung mit kontrollierter freigabe zur behandlung von kardiovaskulären oder nieren indikationen
CA2552758A1 (en) * 2004-01-13 2005-08-04 Vasogenix Pharmaceuticals, Inc. Methods for treating acute myocardial infarction by administering calcitonin gene related peptide and compositions containing the same
WO2005070444A2 (en) * 2004-01-13 2005-08-04 Vasogenix Pharmaceuticals, Inc. Methods for treating acute myocardial infarction by calcitonin gene related peptide and compositions containing the same
US20050175701A1 (en) * 2004-02-10 2005-08-11 Alza Corporation Capillary moderator for osmotic delivery system
US20050222646A1 (en) * 2004-04-06 2005-10-06 Kai Kroll Method and device for treating cancer with modified output electrical therapy
US7720549B2 (en) * 2004-04-06 2010-05-18 Oncostim, Inc. Partially implantable system for the electrical treatment of abnormal tissue growth
US20050240166A1 (en) * 2004-04-26 2005-10-27 Microsolutions, Inc. Implantable device, formulation and method for anti-psychotic therapy using risperidone
US20050249782A1 (en) * 2004-05-04 2005-11-10 Victor Perry Drug delivery device
US20050266087A1 (en) * 2004-05-25 2005-12-01 Gunjan Junnarkar Formulations having increased stability during transition from hydrophobic vehicle to hydrophilic medium
US20050267555A1 (en) * 2004-05-28 2005-12-01 Marnfeldt Goran N Engagement tool for implantable medical devices
US20080027513A1 (en) * 2004-07-09 2008-01-31 Advanced Bionics Corporation Systems And Methods For Using A Butterfly Coil To Communicate With Or Transfer Power To An Implantable Medical Device
EP3417895A1 (de) 2004-07-28 2018-12-26 Medtronic Ardian Luxembourg S.à.r.l. Verfahren und vorrichtungen für die nierennervenblockade
EP2594259A1 (de) 2004-08-04 2013-05-22 Brookwood Pharmaceuticals, Inc. Verfahren zur Herstellung von Abgabevorrichtungen und damit erhaltene Vorrichtungen
US8452407B2 (en) * 2004-08-16 2013-05-28 Boston Scientific Neuromodulation Corporation Methods for treating gastrointestinal disorders
US20060045891A1 (en) * 2004-08-24 2006-03-02 Lovalenti Phillip M Density-matched suspension vehicles and pharmaceutical suspensions
WO2006024038A2 (en) * 2004-08-27 2006-03-02 Codman & Shurtleff Light-based implant for treating alzheimer’s disease
US20060066048A1 (en) 2004-09-14 2006-03-30 Shuffle Master, Inc. Magnetic jam detection in a card shuffler
BRPI0515372B8 (pt) * 2004-09-17 2021-05-25 Durect Corp composição líquida para fornecer anestesia local prolongada após administração a um indivíduo, e, uso de bupivacaína, acetato isobutirato de sacarose e álcool benzílico
US7766332B2 (en) 2006-07-05 2010-08-03 Shuffle Master, Inc. Card handling devices and methods of using the same
US20070083239A1 (en) * 2005-09-23 2007-04-12 Denise Demarais Methods and apparatus for inducing, monitoring and controlling renal neuromodulation
US7937143B2 (en) * 2004-11-02 2011-05-03 Ardian, Inc. Methods and apparatus for inducing controlled renal neuromodulation
US9358393B1 (en) 2004-11-09 2016-06-07 Andres M. Lozano Stimulation methods and systems for treating an auditory dysfunction
US7483746B2 (en) * 2004-12-06 2009-01-27 Boston Scientific Neuromodulation Corp. Stimulation of the stomach in response to sensed parameters to treat obesity
US9095713B2 (en) * 2004-12-21 2015-08-04 Allison M. Foster Methods and systems for treating autism by decreasing neural activity within the brain
US20060161217A1 (en) * 2004-12-21 2006-07-20 Jaax Kristen N Methods and systems for treating obesity
US9327069B2 (en) 2004-12-21 2016-05-03 Boston Scientific Neuromodulation Corporation Methods and systems for treating a medical condition by promoting neural remodeling within the brain
US20070038264A1 (en) * 2004-12-21 2007-02-15 Jaax Kristen N Methods and systems for treating autism
US9352145B2 (en) * 2004-12-22 2016-05-31 Boston Scientific Neuromodulation Corporation Methods and systems for treating a psychotic disorder
US8515541B1 (en) 2004-12-22 2013-08-20 Boston Scientific Neuromodulation Corporation Methods and systems for treating post-stroke disorders
WO2006079055A2 (en) * 2005-01-24 2006-07-27 Neurosystec Corporation Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues
JP2008528698A (ja) * 2005-02-03 2008-07-31 インターシア セラピューティクス,インコーポレイティド 埋め込み可能なインターフェロン含有デバイス
US20060216242A1 (en) * 2005-02-03 2006-09-28 Rohloff Catherine M Suspending vehicles and pharmaceutical suspensions for drug dosage forms
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
WO2006083761A2 (en) 2005-02-03 2006-08-10 Alza Corporation Solvent/polymer solutions as suspension vehicles
US20060194724A1 (en) * 2005-02-25 2006-08-31 Whitehurst Todd K Methods and systems for nerve regeneration
US20060200205A1 (en) * 2005-03-01 2006-09-07 Haller Matthew I Systems and methods for treating a patient with multiple stimulation therapies
US7702385B2 (en) * 2005-11-16 2010-04-20 Boston Scientific Neuromodulation Corporation Electrode contact configurations for an implantable stimulator
US7853321B2 (en) * 2005-03-14 2010-12-14 Boston Scientific Neuromodulation Corporation Stimulation of a stimulation site within the neck or head
US8423155B1 (en) 2005-03-14 2013-04-16 Boston Scientific Neuromodulation Corporation Methods and systems for facilitating stimulation of one or more stimulation sites
US7848803B1 (en) 2005-03-14 2010-12-07 Boston Scientific Neuromodulation Corporation Methods and systems for facilitating stimulation of one or more stimulation sites
US7288108B2 (en) * 2005-03-14 2007-10-30 Codman & Shurtleff, Inc. Red light implant for treating Parkinson's disease
USRE47266E1 (en) 2005-03-14 2019-03-05 DePuy Synthes Products, Inc. Light-based implants for treating Alzheimer's disease
US7627383B2 (en) * 2005-03-15 2009-12-01 Boston Scientific Neuromodulation Corporation Implantable stimulator
US7959938B2 (en) 2005-03-15 2011-06-14 Intarcia Therapeutics, Inc. Polyoxaester suspending vehicles for use with implantable delivery systems
US20110077579A1 (en) * 2005-03-24 2011-03-31 Harrison William V Cochlear implant with localized fluid transport
US7200504B1 (en) 2005-05-16 2007-04-03 Advanced Bionics Corporation Measuring temperature change in an electronic biomedical implant
GB0511986D0 (en) * 2005-06-13 2005-07-20 Imp College Innovations Ltd Novel compounds and their effects on feeding behaviour
US7764836B2 (en) 2005-06-13 2010-07-27 Shuffle Master, Inc. Card shuffler with card rank and value reading capability using CMOS sensor
US7351253B2 (en) * 2005-06-16 2008-04-01 Codman & Shurtleff, Inc. Intranasal red light probe for treating Alzheimer's disease
US20070015689A1 (en) 2005-06-23 2007-01-18 Alza Corporation Complexation of metal ions with polypeptides
US20070027105A1 (en) * 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US20070031341A1 (en) * 2005-08-08 2007-02-08 Dimauro Thomas M Methods of delivering therapeutics to the brain
US7684858B2 (en) * 2005-09-21 2010-03-23 Boston Scientific Neuromodulation Corporation Methods and systems for placing an implanted stimulator for stimulating tissue
US7790671B2 (en) * 2005-10-07 2010-09-07 Codman & Shurtleff, Inc. Implantable pump for protein delivery for obesity control by drug infusion into the brain
US7819907B2 (en) * 2005-10-31 2010-10-26 Codman & Shurtleff, Inc. Device and method for fixing adjacent bone plates
JP2009517343A (ja) 2005-11-14 2009-04-30 エンタープライズ パートナーズ ベンチャー キャピタル 組織損傷のための幹細胞因子療法
US7729758B2 (en) * 2005-11-30 2010-06-01 Boston Scientific Neuromodulation Corporation Magnetically coupled microstimulators
US7610100B2 (en) * 2005-12-30 2009-10-27 Boston Scientific Neuromodulation Corporation Methods and systems for treating osteoarthritis
US7835803B1 (en) 2006-01-17 2010-11-16 Boston Scientific Neuromodulation Corporation Lead assemblies with one or more switching networks
US8175710B2 (en) * 2006-03-14 2012-05-08 Boston Scientific Neuromodulation Corporation Stimulator system with electrode array and the method of making the same
US7556266B2 (en) 2006-03-24 2009-07-07 Shuffle Master Gmbh & Co Kg Card shuffler with gravity feed system for playing cards
US7777641B2 (en) * 2006-03-29 2010-08-17 Advanced Bionics, Llc Systems and methods of facilitating communication between a first and second device
US20070232660A1 (en) * 2006-04-04 2007-10-04 Allergan, Inc. Therapeutic and delivery methods of prostaglandin ep4 agonists
US8267905B2 (en) 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
KR101106510B1 (ko) 2006-05-30 2012-01-20 인타르시아 세라퓨틱스 인코포레이티드 투피스, 내부채널 삼투압 전달 시스템 유동 조절기
US8353513B2 (en) 2006-05-31 2013-01-15 Shfl Entertainment, Inc. Card weight for gravity feed input for playing card shuffler
US8579289B2 (en) 2006-05-31 2013-11-12 Shfl Entertainment, Inc. Automatic system and methods for accurate card handling
US8342525B2 (en) 2006-07-05 2013-01-01 Shfl Entertainment, Inc. Card shuffler with adjacent card infeed and card output compartments
US7803148B2 (en) * 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
WO2007148238A1 (en) * 2006-06-20 2007-12-27 Koninklijke Philips Electronics, N.V. Electronic capsule for treating gastrointestinal disease
US8504163B1 (en) 2006-06-30 2013-08-06 Boston Scientific Neuromodulation Corporation Cranially mounted stimulation systems and methods
US8401654B1 (en) 2006-06-30 2013-03-19 Boston Scientific Neuromodulation Corporation Methods and systems for treating one or more effects of deafferentation
US8070574B2 (en) 2007-06-06 2011-12-06 Shuffle Master, Inc. Apparatus, system, method, and computer-readable medium for casino card handling with multiple hand recall feature
WO2008011125A2 (en) * 2006-07-20 2008-01-24 Neurosystec Corporation Devices, systems and methods for ophthalmic drug delivery
EP2056793A4 (de) * 2006-07-31 2011-08-17 Neurosystec Corp Nanopartikel mit freier base aus gacyclidine
CA2670821C (en) * 2006-08-09 2012-05-15 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies
DE102006038940A1 (de) * 2006-08-18 2008-02-21 Bayer Materialscience Ag Dispersionen von Nanoharnstoffen, enthaltend Wirkstoffe
JP2010510171A (ja) * 2006-08-21 2010-04-02 ユナイテッド セラピューティクス コーポレーション ウイルス感染症の治療のための併用療法
US20080065002A1 (en) * 2006-09-07 2008-03-13 Neurosystec Corporation Catheter for Localized Drug Delivery and/or Electrical Stimulation
US7445528B1 (en) 2006-09-29 2008-11-04 Boston Scientific Neuromodulation Corporation Connector assemblies
AU2007319576B2 (en) 2006-10-06 2014-01-16 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Prevention of tissue ischemia, related methods and compositions
US7347746B1 (en) 2006-10-27 2008-03-25 Boston Scientific Neuromodulation Corporation Receptacle connector assembly
WO2008053396A2 (en) * 2006-10-31 2008-05-08 Koninklijke Philips Electronics N.V. Design of swallowable multi-nozzle, dosing device for releasing medicines in the gastrointesinal tract
PL2117521T3 (pl) 2006-11-03 2012-11-30 Durect Corp Transdermalne systemy dostarczania zawierające bupiwakainę
US8919775B2 (en) 2006-11-10 2014-12-30 Bally Gaming, Inc. System for billing usage of an automatic card handling device
TWI428346B (zh) * 2006-12-13 2014-03-01 Imp Innovations Ltd 新穎化合物及其等對進食行為影響
CA2683610C (en) * 2007-04-23 2013-01-08 Intarcia Therapeutics, Inc. Suspension formulations of insulinotropic peptides and uses thereof
WO2009075782A1 (en) * 2007-12-06 2009-06-18 Durect Corporation Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition
CA2709712C (en) 2007-12-20 2016-05-10 Surmodics Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
US8986696B2 (en) * 2007-12-21 2015-03-24 Depuy Mitek, Inc. Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints
US20090162351A1 (en) * 2007-12-21 2009-06-25 Depuy Spine, Inc. Transdiscal administration of inhibitors of p38 MAP kinase
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
WO2009102467A2 (en) 2008-02-13 2009-08-20 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US9320914B2 (en) 2008-03-03 2016-04-26 DePuy Synthes Products, Inc. Endoscopic delivery of red/NIR light to the subventricular zone
US20090259217A1 (en) * 2008-04-09 2009-10-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems associated with delivery of one or more agents to an individual
US20090259215A1 (en) * 2008-04-09 2009-10-15 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods and systems associated with delivery of one or more agents to an individual
JP5670326B2 (ja) * 2008-06-25 2015-02-18 メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ 複数の薬剤リザーバを有する電子ピル
US10736689B2 (en) 2008-08-20 2020-08-11 Prostacare Pty Ltd Low-corrosion electrode for treating tissue
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
CA2737461A1 (en) 2008-09-19 2010-03-25 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
AU2009298637B2 (en) * 2008-09-30 2015-08-13 Braeburn Pharmaceuticals, Inc. Implantable device for the delivery of risperidone and methods of use thereof
WO2010039801A2 (en) 2008-10-02 2010-04-08 The J. David Gladstone Institutes Methods of treating hepatitis c virus infection
KR101419583B1 (ko) * 2008-10-15 2014-07-25 인타르시아 세라퓨틱스 인코포레이티드 고농축 약물 입자, 제형, 현탁액 및 이들의 용도
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CN102271732B (zh) * 2008-11-14 2014-12-31 得克萨斯大学体系董事会 纳米通道装置和相关方法
US8652129B2 (en) 2008-12-31 2014-02-18 Medtronic Ardian Luxembourg S.A.R.L. Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation
WO2010105093A2 (en) 2009-03-12 2010-09-16 Delpor, Inc. Implantable device for long-term delivery of drugs
US8975247B2 (en) 2009-03-18 2015-03-10 The Board Of Trustees Of The Leland Stanford Junion University Methods and compositions of treating a flaviviridae family viral infection
US8967621B2 (en) 2009-04-07 2015-03-03 Bally Gaming, Inc. Card shuffling apparatuses and related methods
JP5763049B2 (ja) * 2009-04-07 2015-08-12 メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ 無弁薬物送達装置
US7988152B2 (en) 2009-04-07 2011-08-02 Shuffle Master, Inc. Playing card shuffler
EP2419091B1 (de) 2009-04-13 2019-06-26 The Board of Regents of The University of Texas System Nanokanalvorrichtung und zugehörige verfahren
EP2724739B1 (de) 2009-07-30 2015-07-01 Tandem Diabetes Care, Inc. Tragbares Infusionspumpensystem
JP5497176B2 (ja) 2009-08-12 2014-05-21 コーニンクレッカ フィリップス エヌ ヴェ 圧縮可能な薬品貯槽を備える薬品送出装置
MX378797B (es) 2009-09-28 2025-03-10 Intarcia Therapeutics Inc Establecimiento y/o terminacion rapidos de suministro de estado estable sustancial de farmaco.
US8916186B2 (en) * 2009-10-23 2014-12-23 DePuy Synthes Products, LLC Methods and devices for correcting spinal deformity with pharmaceutical-eluting pedicle screws
US9327015B2 (en) * 2009-10-23 2016-05-03 DePuy Synthes Products, Inc. Methods and devices for correcting spinal deformity with pharmaceutical-eluting pedicle screws
BR112012009801A8 (pt) 2009-10-30 2016-08-30 Cns Therapeutics Inc Polipeptídeo neurturina e variante de neurturina
AU2011248625B2 (en) 2010-04-26 2017-01-05 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase
JP6294074B2 (ja) 2010-04-27 2018-03-14 エータイアー ファーマ, インコーポレイテッド イソロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
CN103097524B (zh) 2010-04-28 2016-08-03 Atyr医药公司 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2797374C (en) 2010-04-29 2021-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases
AU2011248457B2 (en) 2010-04-29 2017-02-16 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl tRNA synthetases
WO2011150279A2 (en) 2010-05-27 2011-12-01 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-trna synthetases
CA2797977C (en) 2010-05-03 2019-08-20 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-trna synthetases
WO2011139986A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases
WO2011140135A2 (en) 2010-05-03 2011-11-10 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases
CA2798139C (en) 2010-05-04 2019-09-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
CN103200953B (zh) 2010-05-14 2017-02-15 Atyr 医药公司 与苯丙氨酰‑β‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CN103096914B (zh) 2010-05-17 2015-08-12 Atyr医药公司 与亮氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2796791C (en) 2010-05-19 2020-08-04 Nanomedical Systems, Inc. Nano-scale coatings and related methods suitable for in-vivo use
CA2800281C (en) 2010-06-01 2021-01-12 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-trna synthetases
AU2011289831C1 (en) 2010-07-12 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
CN103108650A (zh) 2010-08-25 2013-05-15 Atyr医药公司 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CN103118610B (zh) 2010-08-30 2016-03-02 西努赛斯公司 用于扩张鼻旁窦开口和用于治疗鼻窦炎的装置
US8800993B2 (en) 2010-10-14 2014-08-12 Shuffle Master Gmbh & Co Kg Card handling systems, devices for use in card handling systems and related methods
CN107007348B (zh) 2010-10-25 2019-05-31 美敦力Af卢森堡有限责任公司 用于神经调节治疗的估算及反馈的装置、系统及方法
US8801768B2 (en) * 2011-01-21 2014-08-12 Endologix, Inc. Graft systems having semi-permeable filling structures and methods for their use
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
CA2832589A1 (en) 2011-04-07 2012-10-11 Allergan, Inc. Devices, compositions and methods utilizing ep4 and ep2 receptor agonists for preventing, reducing or treating capsular contracture
WO2012175698A1 (en) 2011-06-23 2012-12-27 Université Libre de Bruxelles Therapeutic use of all-trans retinoic acid (atra) in patients suffering from alcoholic liver disease
US8485527B2 (en) 2011-07-29 2013-07-16 Savant Shuffler LLC Card shuffler
US9731190B2 (en) 2011-07-29 2017-08-15 Bally Gaming, Inc. Method and apparatus for shuffling and handling cards
WO2013033636A2 (en) 2011-09-01 2013-03-07 University Of Southern California Methods for preparing high throughput peptidomimetics, orally bioavailable drugs and compositions containing same
AU2012347785B2 (en) 2011-12-06 2017-03-16 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating viral diseases
EP2819740A4 (de) 2012-02-29 2015-11-25 Sinusys Corp Vorrichtungen und verfahren zur dilatation einer paranasalen sinusöffnung und zur behandlung von sinusitis
EP3348220B1 (de) 2012-03-08 2024-10-23 Medtronic Ardian Luxembourg S.à.r.l. Biomarkerprobenahme in zusammenhang mit neuromodulationsvorrichtungen sowie entsprechende systeme
AU2013230781B2 (en) 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Ovarian neuromodulation and associated systems and methods
US9335910B2 (en) 2012-04-23 2016-05-10 Tandem Diabetes Care, Inc. System and method for reduction of inadvertent activation of medical device during manipulation
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9715327B2 (en) 2012-06-07 2017-07-25 Tandem Diabetes Care, Inc. Preventing inadvertent changes in ambulatory medical devices
US9238100B2 (en) 2012-06-07 2016-01-19 Tandem Diabetes Care, Inc. Device and method for training users of ambulatory medical devices
US8960674B2 (en) 2012-07-27 2015-02-24 Bally Gaming, Inc. Batch card shuffling apparatuses including multi-card storage compartments, and related methods
US9378766B2 (en) 2012-09-28 2016-06-28 Bally Gaming, Inc. Card recognition system, card handling device, and method for tuning a card handling device
US9511274B2 (en) 2012-09-28 2016-12-06 Bally Gaming Inc. Methods for automatically generating a card deck library and master images for a deck of cards, and a related card processing apparatus
US20140110296A1 (en) 2012-10-19 2014-04-24 Medtronic Ardian Luxembourg S.A.R.L. Packaging for Catheter Treatment Devices and Associated Devices, Systems, and Methods
CN104001261A (zh) * 2013-02-27 2014-08-27 重庆市北碚区精神卫生中心 一种皮下给药装置
WO2014160183A1 (en) 2013-03-13 2014-10-02 The United States Of America,As Represented By The Secretary,Department Of Health And Human Services Methods for modulating chemotherapeutic cytotoxicity
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
CA2905131A1 (en) 2013-03-15 2014-09-18 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
US9687263B2 (en) 2013-05-30 2017-06-27 SinuSys Corporation Devices and methods for inserting a sinus dilator
IL299897B2 (en) 2013-08-19 2024-02-01 Taris Biomedical Llc Devices and methods for administering multiple units of drug
WO2015085312A1 (en) * 2013-12-06 2015-06-11 Durect Corporation Compositions comprising antioxidant, fluid dispensers, and methods involving the same
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
US9980766B1 (en) 2014-03-28 2018-05-29 Medtronic Ardian Luxembourg S.A.R.L. Methods and systems for renal neuromodulation
US10194979B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US10194980B1 (en) 2014-03-28 2019-02-05 Medtronic Ardian Luxembourg S.A.R.L. Methods for catheter-based renal neuromodulation
US9474957B2 (en) 2014-05-15 2016-10-25 Bally Gaming, Inc. Playing card handling devices, systems, and methods for verifying sets of cards
USD764599S1 (en) 2014-08-01 2016-08-23 Bally Gaming, Inc. Card shuffler device
US9566501B2 (en) 2014-08-01 2017-02-14 Bally Gaming, Inc. Hand-forming card shuffling apparatuses including multi-card storage compartments, and related methods
US9504905B2 (en) 2014-09-19 2016-11-29 Bally Gaming, Inc. Card shuffling device and calibration method
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US20160243288A1 (en) * 2015-02-23 2016-08-25 Tissuetech, Inc. Apparatuses and methods for treating ophthalmic diseases and disorders
WO2016144995A1 (en) 2015-03-09 2016-09-15 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compositions and methods for the treatment of glioblastoma
US10246463B2 (en) 2015-04-07 2019-04-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Hypoxia-inducible factor 1 (HIF-1) inhibitors
CN113598842A (zh) 2015-06-03 2021-11-05 因塔西亚制药公司 植入物放置和移除系统
CA2993009A1 (en) 2015-07-31 2017-02-09 Research Institute At Nationwide Children's Hospital Peptides and antibodies for the removal of biofilms
WO2017066719A2 (en) 2015-10-14 2017-04-20 Research Institute At Nationwide Children's Hospital Hu specific interfering agents
CA3003747A1 (en) 2015-11-05 2017-05-11 The General Hospital Corporation Intrathecal delivery of nucleic acid sequences encoding abcd1 for treatment of adrenomyeloneuropathy
KR102574993B1 (ko) 2016-05-16 2023-09-06 인타르시아 세라퓨틱스 인코포레이티드 글루카곤-수용체 선택적 폴리펩티드 및 이들의 이용 방법
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
US12274794B2 (en) 2016-07-06 2025-04-15 Orient Pharma Co., Ltd. Oral dosage form with drug composition, barrier layer and drug layer
KR20190086460A (ko) 2016-10-20 2019-07-22 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 신경보호 폴리펩티드를 중추 신경계에 전달하는 방법
WO2018129058A1 (en) 2017-01-03 2018-07-12 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a glp-1 receptor agonist and co-adminstration of a drug
CA3049114A1 (en) 2017-01-04 2018-07-12 Lauren O. Bakaletz Antibody fragments for the treatment of biofilm-related disorders
JP7514621B2 (ja) 2017-01-04 2024-07-11 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル Dnabiiワクチンおよび強化された活性を有する抗体
JP2020510028A (ja) 2017-03-08 2020-04-02 インターシア セラピューティクス,インコーポレイティド 薬物送達デバイスから吐き気誘発性化合物の投与のための装置及び方法
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
CA3063711A1 (en) 2017-05-17 2018-11-22 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
KR102659146B1 (ko) 2017-11-27 2024-04-22 프로스타캐어 피티와이 엘티디 전립선 질환의 치료를 위한 장치 및 방법
US11224474B2 (en) 2018-02-28 2022-01-18 Prostacare Pty Ltd System for managing high impedance changes in a non-thermal ablation system for BPH
EP3793667A1 (de) 2018-05-17 2021-03-24 Massachusetts Institute of Technology Systeme zur elektrischen stimulation
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
KR102911883B1 (ko) 2018-10-11 2026-01-13 인타르시아 세라퓨틱스 인코포레이티드 인간 아밀린 유사체 폴리펩타이드 및 사용 방법
CN109045454B (zh) * 2018-10-25 2021-02-02 北京光捷扬基健康科技有限公司 一种中耳重复给药装置及人工耳蜗植入电极
JP7627255B2 (ja) 2019-07-08 2025-02-05 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル バイオフィルムを破壊するための抗体組成物
CA3167217A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
CN112107742B (zh) * 2020-10-22 2024-05-14 南京佑羲医药科技有限公司 一种长效智能植入式载药装置及其制造方法
CN116940358A (zh) 2021-01-12 2023-10-24 度勒科特公司 持续释放药物递送系统和有关的方法
EP4595997A4 (de) 2022-10-07 2025-12-17 Terumo Corp Vorrichtung zur verabreichung von arzneimitteln
WO2025085868A2 (en) 2023-10-20 2025-04-24 Radiation Control Technologies, Inc. Cd47-targeting morpholinos
WO2025160155A1 (en) 2024-01-22 2025-07-31 The Broad Institute, Inc. Epigenetic targeting of prion diseases

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2028145C1 (ru) * 1975-07-21 1995-02-09 Украинский научно-исследовательский институт эндокринологии и обмена веществ Средство для лечения аденомы и рака предстательной железы
US3987790A (en) * 1975-10-01 1976-10-26 Alza Corporation Osmotically driven fluid dispenser
US4865845A (en) * 1986-03-21 1989-09-12 Alza Corporation Release rate adjustment of osmotic or diffusional delivery devices
US5034229A (en) * 1988-12-13 1991-07-23 Alza Corporation Dispenser for increasing feed conversion of hog
US5059423A (en) * 1988-12-13 1991-10-22 Alza Corporation Delivery system comprising biocompatible beneficial agent formulation
US5057318A (en) * 1988-12-13 1991-10-15 Alza Corporation Delivery system for beneficial agent over a broad range of rates
US5112614A (en) * 1989-09-14 1992-05-12 Alza Corporation Implantable delivery dispenser
US5213809A (en) * 1990-01-24 1993-05-25 Alza Corporation Delivery system comprising means for controlling internal pressure
US5324280A (en) * 1990-04-02 1994-06-28 Alza Corporation Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
US5234693A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5234692A (en) * 1990-07-11 1993-08-10 Alza Corporation Delivery device with a protective sleeve
US5137727A (en) * 1991-06-12 1992-08-11 Alza Corporation Delivery device providing beneficial agent stability
US5308348A (en) * 1992-02-18 1994-05-03 Alza Corporation Delivery devices with pulsatile effect
US5540665A (en) * 1994-01-31 1996-07-30 Alza Corporation Gas driven dispensing device and gas generating engine therefor
CN2230173Y (zh) * 1995-08-18 1996-07-03 赵先鲁 鼻腔给药装置

Also Published As

Publication number Publication date
PL328202A1 (en) 1999-01-18
HU221919B1 (hu) 2003-02-28
EP1249229A3 (de) 2005-02-02
IL125596A (en) 2004-07-25
SK104098A3 (en) 1998-12-02
CZ236598A3 (cs) 1998-10-14
DE69731498D1 (de) 2004-12-09
EP1238658A1 (de) 2002-09-11
CN1520895A (zh) 2004-08-18
CN100506311C (zh) 2009-07-01
PT1238658E (pt) 2005-04-29
NZ331186A (en) 2000-04-28
ES2233768T3 (es) 2005-06-16
US5728396A (en) 1998-03-17
HK1093449A1 (zh) 2007-03-02
ID17704A (id) 1998-01-22
TW466121B (en) 2001-12-01
KR100540090B1 (ko) 2006-03-23
IL125596A0 (en) 1999-03-12
NO983544L (no) 1998-09-28
DK1238659T3 (da) 2005-01-24
DE69734168D1 (de) 2005-10-13
CN1146403C (zh) 2004-04-21
JP4176832B2 (ja) 2008-11-05
PL189289B1 (pl) 2005-07-29
EP0877599B1 (de) 2003-03-26
CN1795940A (zh) 2006-07-05
CN100493647C (zh) 2009-06-03
HUP9902477A2 (hu) 1999-11-29
CO4761076A1 (es) 1999-04-27
IL156090A (en) 2011-12-29
RU2189221C2 (ru) 2002-09-20
CN1210459A (zh) 1999-03-10
ATE284202T1 (de) 2004-12-15
RO119929B1 (ro) 2005-06-30
PT1238659E (pt) 2005-01-31
US5985305A (en) 1999-11-16
DE69731902D1 (de) 2005-01-13
SK285803B6 (sk) 2007-08-02
AU1701797A (en) 1997-08-22
BR9707336B1 (pt) 2009-01-13
DK0877599T3 (da) 2003-07-21
DK1238660T3 (da) 2006-01-16
AR006079A1 (es) 1999-08-11
AU724061B2 (en) 2000-09-14
SK284136B6 (sk) 2004-09-08
DE69734168T2 (de) 2006-01-19
DK1238657T3 (da) 2005-01-17
ATE235224T1 (de) 2003-04-15
ES2191165T3 (es) 2003-09-01
ES2246004T3 (es) 2006-02-01
NO327194B1 (no) 2009-05-11
NO983544D0 (no) 1998-07-31
EP1238659A1 (de) 2002-09-11
ATE303792T1 (de) 2005-09-15
EP1238656A1 (de) 2002-09-11
EP0877599A1 (de) 1998-11-18
EP1238658B1 (de) 2004-12-08
CZ293808B6 (cs) 2004-08-18
WO1997027840A1 (en) 1997-08-07
PT1238657E (pt) 2005-01-31
EP1238660A1 (de) 2002-09-11
PT877599E (pt) 2003-08-29
DE69720190D1 (de) 2003-04-30
DE69731498T2 (de) 2005-11-03
ES2229051T3 (es) 2005-04-16
EP1238659B1 (de) 2004-09-29
BR9707336A (pt) 1999-07-20
DE69731013D1 (de) 2004-11-04
DK1238658T3 (da) 2005-04-04
EP1238660B1 (de) 2005-09-07
JP2000504011A (ja) 2000-04-04
HK1068821A1 (zh) 2005-05-06
ES2232713T3 (es) 2005-06-01
EP1238657B1 (de) 2004-11-03
PT1238660E (pt) 2005-10-31
ZA97831B (en) 1997-10-31
MY122081A (en) 2006-03-31
DE69731013T2 (de) 2005-11-17
HK1018396A1 (en) 1999-12-24
HUP9902477A3 (en) 2001-02-28
ATE277595T1 (de) 2004-10-15
PL189137B1 (pl) 2005-06-30
EP1238657A1 (de) 2002-09-11
CZ300994B6 (cs) 2009-10-07
EP1249229A2 (de) 2002-10-16
DE69720190T2 (de) 2003-12-11
KR19990082193A (ko) 1999-11-25
DE69731902T2 (de) 2005-12-22

Similar Documents

Publication Publication Date Title
ATE303792T1 (de) Implantierbares system mit verzögerter wirkstofffreisetzung
DE69728173D1 (de) Selbsteinstellendes cochleares implantatsystem
DE69839063D1 (de) Einstufiges Implantatsystem
DE69729472D1 (de) Phonopneumograph system
DE69713466D1 (de) Aktionsanalyse-/-aufnahmesystem
DE69726292D1 (de) Erdnahen-orbit-startsystem
DE69733624D1 (de) Bildgesteuertes chirurgisches System
NO985854D0 (no) Sammenkoblende stroppefestesystem
DE69720150D1 (de) Bildschirmgesteuertes chirurgisches system
DE69729021D1 (de) Flächiges Implantat
FI974458A0 (fi) Röntgenkuvauslaitteisto
DE69620003D1 (de) Freisetzungssysteme
DE59710859D1 (de) Implantat
DE69731134D1 (de) Kamerasystem
DE69716133D1 (de) Harnisch
ID17405A (id) Sistim elektrokromik
FI974420A0 (fi) Röntgenkuvauslaitteisto
NO983086D0 (no) Fjernstyringssystem
NO983743D0 (no) Forankringssystem
DE59702083D1 (de) Elektronisch steuerbare bremsanlage
FR2767394B3 (fr) Systeme porte-montre
DE59710258D1 (de) Verbindungsbeschlag
DE69735222T8 (de) Bremsanlage
DE69735754D1 (de) Impedanz-abhängiger implantierbarer kardiovertierer defribillator
NO985866D0 (no) Fortoejnings-system

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1238657

Country of ref document: EP

REN Ceased due to non-payment of the annual fee