ATE277930T1 - Verfahren zur herstellung basischer additionssalze eines antibiotikums mit einer anorganischen säure und oxalat-zwischenprodukte - Google Patents
Verfahren zur herstellung basischer additionssalze eines antibiotikums mit einer anorganischen säure und oxalat-zwischenprodukteInfo
- Publication number
- ATE277930T1 ATE277930T1 AT00948257T AT00948257T ATE277930T1 AT E277930 T1 ATE277930 T1 AT E277930T1 AT 00948257 T AT00948257 T AT 00948257T AT 00948257 T AT00948257 T AT 00948257T AT E277930 T1 ATE277930 T1 AT E277930T1
- Authority
- AT
- Austria
- Prior art keywords
- protecting group
- antibiotic
- inorganic acid
- producing
- group
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 5
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 150000007522 mineralic acids Chemical class 0.000 title abstract 3
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 239000013067 intermediate product Substances 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- -1 inorganic acid salt Chemical class 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP21680699 | 1999-07-30 | ||
| JP21680799 | 1999-07-30 | ||
| PCT/JP2000/005031 WO2001009135A1 (en) | 1999-07-30 | 2000-07-27 | Process for the preparation of basic antibiotic-inorganic acid addition salts and intermediate oxalates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE277930T1 true ATE277930T1 (de) | 2004-10-15 |
Family
ID=26521640
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00948257T ATE277930T1 (de) | 1999-07-30 | 2000-07-27 | Verfahren zur herstellung basischer additionssalze eines antibiotikums mit einer anorganischen säure und oxalat-zwischenprodukte |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6642377B1 (de) |
| EP (1) | EP1201665B1 (de) |
| JP (1) | JP4100908B2 (de) |
| KR (1) | KR100694685B1 (de) |
| CN (1) | CN1181072C (de) |
| AT (1) | ATE277930T1 (de) |
| CA (1) | CA2379650C (de) |
| DE (1) | DE60014390T2 (de) |
| HU (1) | HUP0202283A3 (de) |
| NO (1) | NO20020471L (de) |
| WO (1) | WO2001009135A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1426376A4 (de) * | 2001-08-13 | 2004-12-22 | Eisai Co Ltd | Verfahren zur herstellung von carbapenem-antibiotika |
| DE102004062303A1 (de) | 2004-12-23 | 2006-07-13 | BSH Bosch und Siemens Hausgeräte GmbH | Linearverdichter |
| DE102004062300A1 (de) * | 2004-12-23 | 2006-07-13 | BSH Bosch und Siemens Hausgeräte GmbH | Linearverdichter |
| US7932381B2 (en) * | 2005-02-15 | 2011-04-26 | Shionogi & Co., Ltd. | Process for producing carbapenem derivative and intermediate crystal therefor |
| DE102006009230A1 (de) * | 2006-02-28 | 2007-08-30 | BSH Bosch und Siemens Hausgeräte GmbH | Verfahren zum Justieren eines Kolbens in einem Linearverdichter |
| DE102006009231A1 (de) * | 2006-02-28 | 2007-08-30 | BSH Bosch und Siemens Hausgeräte GmbH | Verfahren und Steuergerät zum Betreiben eines Linearverdichters |
| CN100457759C (zh) * | 2007-01-12 | 2009-02-04 | 深圳信立泰药业股份有限公司 | 头孢吡肟氢卤酸盐的制备方法 |
| CN101041664B (zh) * | 2007-04-24 | 2010-05-26 | 深圳信立泰药业股份有限公司 | 钙盐沉淀法制备头孢吡肟氢卤酸盐 |
| JP2011520866A (ja) * | 2008-05-14 | 2011-07-21 | オーキッド ケミカルズ アンド ファーマシューティカルズ リミテッド | セフォゾプランの改良した製造方法 |
| AP2744A (en) | 2008-07-28 | 2013-09-30 | Pfizer | Phenanthrenone compounds, compositions and methods |
| CN102675343A (zh) * | 2011-03-15 | 2012-09-19 | 陈婧 | 一种以盐酸头孢替安制备盐酸头孢替安酯的方法 |
| CN104788470A (zh) * | 2015-04-30 | 2015-07-22 | 苗怡文 | 一种治疗敏感菌感染性疾病的盐酸头孢他美酯化合物 |
| CN109384800B (zh) * | 2018-11-20 | 2020-05-22 | 山东罗欣药业集团股份有限公司 | 一种盐酸头孢替安的制备方法 |
| CN119390710A (zh) * | 2024-10-09 | 2025-02-07 | 安徽益普克医药科技发展有限公司 | 一种高纯度盐酸匹美西林晶型的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1335718A (en) * | 1971-05-05 | 1973-10-31 | Leo Pharm Prod Ltd | Penicillin esters salts thereof and methods for their preparation |
| JP2949363B2 (ja) | 1990-06-05 | 1999-09-13 | サントリー株式会社 | アリル基の脱離方法 |
| US5302711A (en) | 1992-02-18 | 1994-04-12 | Eli Lilly And Company | Ester cleavage process for use with β-lactams |
| JPH08502513A (ja) | 1992-10-23 | 1996-03-19 | 藤沢薬品工業株式会社 | セフェム化合物、およびそれらの医薬組成物 |
| JP3848693B2 (ja) | 1994-07-06 | 2006-11-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 新規カルバペネム誘導体 |
| ATE263767T1 (de) | 1999-06-03 | 2004-04-15 | Eisai Co Ltd | Kristalline cabapenemderivate und pharmazeutische zubereitungen zur injektion |
-
2000
- 2000-07-27 CA CA002379650A patent/CA2379650C/en not_active Expired - Fee Related
- 2000-07-27 CN CNB008108900A patent/CN1181072C/zh not_active Expired - Fee Related
- 2000-07-27 US US10/030,909 patent/US6642377B1/en not_active Expired - Fee Related
- 2000-07-27 AT AT00948257T patent/ATE277930T1/de not_active IP Right Cessation
- 2000-07-27 HU HU0202283A patent/HUP0202283A3/hu unknown
- 2000-07-27 JP JP2001514338A patent/JP4100908B2/ja not_active Expired - Fee Related
- 2000-07-27 DE DE60014390T patent/DE60014390T2/de not_active Expired - Fee Related
- 2000-07-27 EP EP00948257A patent/EP1201665B1/de not_active Expired - Lifetime
- 2000-07-27 KR KR1020027000666A patent/KR100694685B1/ko not_active Expired - Fee Related
- 2000-07-27 WO PCT/JP2000/005031 patent/WO2001009135A1/ja not_active Ceased
-
2002
- 2002-01-29 NO NO20020471A patent/NO20020471L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100694685B1 (ko) | 2007-03-13 |
| EP1201665A4 (de) | 2002-10-23 |
| DE60014390D1 (de) | 2004-11-04 |
| CN1365362A (zh) | 2002-08-21 |
| KR20020033734A (ko) | 2002-05-07 |
| HUP0202283A3 (en) | 2003-10-28 |
| NO20020471D0 (no) | 2002-01-29 |
| HUP0202283A2 (en) | 2002-10-28 |
| DE60014390T2 (de) | 2005-10-06 |
| US6642377B1 (en) | 2003-11-04 |
| JP4100908B2 (ja) | 2008-06-11 |
| CN1181072C (zh) | 2004-12-22 |
| CA2379650A1 (en) | 2001-02-08 |
| NO20020471L (no) | 2002-03-22 |
| CA2379650C (en) | 2008-09-02 |
| EP1201665B1 (de) | 2004-09-29 |
| EP1201665A1 (de) | 2002-05-02 |
| WO2001009135A1 (en) | 2001-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1201665 Country of ref document: EP |
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| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |