ATE270288T1 - Heterocyclische subtituierte aminoazacyclische verbindungen mit zentraler nervensystemwirkung - Google Patents

Heterocyclische subtituierte aminoazacyclische verbindungen mit zentraler nervensystemwirkung

Info

Publication number
ATE270288T1
ATE270288T1 AT00932445T AT00932445T ATE270288T1 AT E270288 T1 ATE270288 T1 AT E270288T1 AT 00932445 T AT00932445 T AT 00932445T AT 00932445 T AT00932445 T AT 00932445T AT E270288 T1 ATE270288 T1 AT E270288T1
Authority
AT
Austria
Prior art keywords
compounds
aminoazocyclic
nervous system
central nervous
heterocyclic substituted
Prior art date
Application number
AT00932445T
Other languages
English (en)
Inventor
Michael R Schrimpf
Kevin B Sippy
Jerome F Daanen
Keith B Ryther
Jianguo Ji
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/559,881 external-priority patent/US6833370B1/en
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of ATE270288T1 publication Critical patent/ATE270288T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00932445T 1999-05-21 2000-05-15 Heterocyclische subtituierte aminoazacyclische verbindungen mit zentraler nervensystemwirkung ATE270288T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31670799A 1999-05-21 1999-05-21
US09/559,881 US6833370B1 (en) 1999-05-21 2000-04-26 Heterocycle substituted aminoazacycles useful as central nervous system agents
PCT/US2000/013339 WO2000071534A1 (en) 1999-05-21 2000-05-15 Heterocyclic substituted aminoazacycles useful as central nervous system agents

Publications (1)

Publication Number Publication Date
ATE270288T1 true ATE270288T1 (de) 2004-07-15

Family

ID=26980553

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00932445T ATE270288T1 (de) 1999-05-21 2000-05-15 Heterocyclische subtituierte aminoazacyclische verbindungen mit zentraler nervensystemwirkung

Country Status (24)

Country Link
EP (2) EP1178982B1 (de)
JP (1) JP2003500402A (de)
KR (2) KR100714122B1 (de)
CN (2) CN1192028C (de)
AT (1) ATE270288T1 (de)
AU (1) AU781241B2 (de)
BG (1) BG106192A (de)
BR (1) BR0007229A (de)
CA (1) CA2373793A1 (de)
CZ (1) CZ20014127A3 (de)
DE (1) DE60011895T2 (de)
DK (1) DK1178982T3 (de)
ES (1) ES2226844T3 (de)
HK (1) HK1045305B (de)
HU (1) HU225894B1 (de)
IL (2) IL146476A0 (de)
MX (1) MXPA01011897A (de)
NO (1) NO20015669L (de)
NZ (1) NZ515207A (de)
PL (1) PL200427B1 (de)
PT (1) PT1178982E (de)
SI (1) SI1178982T1 (de)
SK (1) SK16812001A3 (de)
WO (1) WO2000071534A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376472B1 (en) * 1996-07-08 2002-04-23 Aventis Pharmaceuticals, Inc. Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
MY145722A (en) * 2000-04-27 2012-03-30 Abbott Lab Diazabicyclic central nervous system active agents
US6809105B2 (en) 2000-04-27 2004-10-26 Abbott Laboratories Diazabicyclic central nervous system active agents
HUP0200849A2 (hu) * 2002-03-06 2004-08-30 Sanofi-Synthelabo N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
US20040242641A1 (en) * 2003-05-27 2004-12-02 Buckley Michael J. (1S,5S)-3-(5,6-dichloro-3-pyridinyl)-3,6-diazabicyclo[3.2.0]heptane is an effective analgesic agent
US7399765B2 (en) 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
US8580842B2 (en) 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US20080167286A1 (en) 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
US8486979B2 (en) 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
UY30846A1 (es) 2006-12-30 2008-07-31 Abbott Gmbh & Amp Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
US8703775B2 (en) 2007-12-07 2014-04-22 AbbVie Deutschland GmbH & Co. KG Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
NZ586651A (en) 2007-12-07 2012-06-29 Abbott Gmbh & Co Kg 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressine-dependent diseases
WO2010009775A1 (de) 2007-12-07 2010-01-28 Abbott Gmbh & Co. Kg Carbamat-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen
ES2455197T3 (es) 2007-12-07 2014-04-14 Abbvie Deutschland Gmbh & Co Kg Derivados de oxindol 5,6-disustituidos y el uso de los mismos para la preparación de un medicamento para el tratamiento de enfermedades dependientes de vasopresina
US8383657B2 (en) 2007-12-21 2013-02-26 Abbott Laboratories Thiazolylidine urea and amide derivatives and methods of use thereof
EP2248803A4 (de) * 2008-02-27 2012-03-28 Sumitomo Chemical Co Verfahren zur optischen auflösung von alkylpiperidin-3-yl carbamat und zwischenprodukt dafür
JP2009256298A (ja) * 2008-03-26 2009-11-05 Sumitomo Chemical Co Ltd ピペリジン−３−イルカーバメート化合物の光学分割方法およびその中間体
US9463190B2 (en) 2008-03-31 2016-10-11 University Of South Florida Methods of treating disease-induced ataxia and non-ataxic imbalance
US8383658B2 (en) 2008-06-04 2013-02-26 Abbott Laboratories Isoxazole based neuronal nicotinic receptor ligands and methods of use
TW201022233A (en) * 2008-11-04 2010-06-16 Organon Nv (Pyrrolidin-2-yl)phenyl derivatives
EP2435080A2 (de) 2009-05-29 2012-04-04 Abbott Laboratories Pharmazeutische zusammensetzungen zur schmerzbehandlung
WO2010151815A2 (en) 2009-06-25 2010-12-29 Abbott Laboratories 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof
US20110034469A1 (en) 2009-08-04 2011-02-10 Takeda Pharmaceutical Company Limited Heterocyclic Compound
CN102936220B (zh) * 2012-11-15 2014-07-02 河北桑迪亚医药技术有限责任公司 一种氨基吡啶boc保护的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4302456A (en) 1977-04-13 1981-11-24 The Upjohn Company Process for therapeutic treatment
FR2459240A1 (fr) * 1979-06-21 1981-01-09 Cm Ind Aminopiperidines anorexigenes, procede pour leur preparation, intermediaires dans ledit procede et medicaments qui les contiennent
US4302455A (en) * 1980-04-14 1981-11-24 Merck & Co., Inc. 2-(4-Aminopiperidino)pyrazines
CA2133855A1 (en) * 1993-10-11 1995-04-12 Marco Baroni Heteroarylpiperidines, process for their preparation and pharmaceutical compositions in which they are present
EP0647639A1 (de) * 1993-10-11 1995-04-12 Sanofi Heteroarylpiperidinen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammenstellungen
US5585388A (en) * 1995-04-07 1996-12-17 Sibia Neurosciences, Inc. Substituted pyridines useful as modulators of acetylcholine receptors

Also Published As

Publication number Publication date
NZ515207A (en) 2003-09-26
AU781241B2 (en) 2005-05-12
HU225894B1 (en) 2007-12-28
IL190780A0 (en) 2008-11-03
CA2373793A1 (en) 2000-11-30
PT1178982E (pt) 2004-11-30
ES2226844T3 (es) 2005-04-01
WO2000071534A1 (en) 2000-11-30
HUP0202034A3 (en) 2006-04-28
KR100714121B1 (ko) 2007-05-04
SK16812001A3 (sk) 2002-05-09
EP1178982B1 (de) 2004-06-30
CN1361774A (zh) 2002-07-31
BR0007229A (pt) 2002-09-10
BG106192A (bg) 2002-08-30
JP2003500402A (ja) 2003-01-07
NO20015669D0 (no) 2001-11-20
KR100714122B1 (ko) 2007-05-04
DE60011895D1 (de) 2004-08-05
HUP0202034A2 (en) 2002-10-28
SI1178982T1 (en) 2004-12-31
KR20060118618A (ko) 2006-11-23
NO20015669L (no) 2001-11-23
DE60011895T2 (de) 2005-08-04
IL146476A0 (en) 2002-07-25
DK1178982T3 (da) 2004-11-08
AU5016600A (en) 2000-12-12
PL352066A1 (en) 2003-07-28
KR20060110877A (ko) 2006-10-25
EP1178982A1 (de) 2002-02-13
CN1636990A (zh) 2005-07-13
PL200427B1 (pl) 2009-01-30
HK1045305B (en) 2005-04-01
CZ20014127A3 (cs) 2002-06-12
CN1192028C (zh) 2005-03-09
HK1045305A1 (en) 2002-11-22
MXPA01011897A (es) 2002-06-21
EP1428824A1 (de) 2004-06-16

Similar Documents

Publication Publication Date Title
ATE270288T1 (de) Heterocyclische subtituierte aminoazacyclische verbindungen mit zentraler nervensystemwirkung
BR0013237A (pt) Fenil oxazolidinonas substituìdas heterobiciclicas antibacterianas
ATE168373T1 (de) Benzofuranyl- und thiophenylalkancarbonsäurederivate
DE69838172D1 (de) Oxindolylchinazolinderivate als angiogenesehemmer
PT778277E (pt) Derivados heterociclicos substituidos como antagonistas do crf
ATE154354T1 (de) Azabicyclische verbindungen, diese enthaltende pharmazeutische zubereitungen und ihre therapeutische verwendung
ECSP045359A (es) Isoxazolinas 5 metiloximetil sustituidas por 3-heteroarilo utilizadas con herbicidas
ES2191076T3 (es) Nuevos derivados de 1-aril-pirazol y su empleo como plaguicidas.
ATE370735T1 (de) Phenylpyridazinderivate und diese enthaltende arzneimittel
DE69322188D1 (de) Antimikrobielle Carbapenem-Derivate, ihre Herstellung und ihre therapeutische Verwendung
ATE247660T1 (de) Furopyridinderivate und ihre therapeutische verwendung
FI902291A0 (fi) Heterocykliska guanider som 5ht3 -antagonister.
ATE194338T1 (de) Diphenylthiazolderivate mit antiinflammatorischer aktivität
ATE160146T1 (de) Hetero-tricyclisch-substituierte phenyl- cyclohexan-carbonsäurederivate
BR0108002A (pt) Derivados de amidas heterocìclicas
UY26416A1 (es) Compuestos
PT889044E (pt) Derivados do 5-(heteroaril)alquil-3-oxo-pirido-(1,2-a)benzimidazole-4-carboxamida (pbi) uteis no tratamento de perturbacoes do sistema nervoso central
ATE146469T1 (de) Heterocyclische alkoxyacrylsäurederivate mit fungizider aktivität
DE69018741D1 (de) Konjugierte gamma-Hydroxybutenolid-Derivate und sie als aktiver Wirkstoff enthaltende Mittel gegen Magengeschwüre.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1178982

Country of ref document: EP

REN Ceased due to non-payment of the annual fee