ATE269079T1 - Stabilisierung pharmazeutischer zusammensetzungen durch besonderen einsatz eines antioxidans - Google Patents

Stabilisierung pharmazeutischer zusammensetzungen durch besonderen einsatz eines antioxidans

Info

Publication number
ATE269079T1
ATE269079T1 AT99920582T AT99920582T ATE269079T1 AT E269079 T1 ATE269079 T1 AT E269079T1 AT 99920582 T AT99920582 T AT 99920582T AT 99920582 T AT99920582 T AT 99920582T AT E269079 T1 ATE269079 T1 AT E269079T1
Authority
AT
Austria
Prior art keywords
antioxidant
stabilization
pharmaceutical compositions
special use
ophthalmic compositions
Prior art date
Application number
AT99920582T
Other languages
English (en)
Inventor
Gyoergy Lajos Kis
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE269079T1 publication Critical patent/ATE269079T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
AT99920582T 1998-04-02 1999-03-31 Stabilisierung pharmazeutischer zusammensetzungen durch besonderen einsatz eines antioxidans ATE269079T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98106046 1998-04-02
PCT/EP1999/002221 WO1999051230A1 (en) 1998-04-02 1999-03-31 Method for stabilizing pharmaceutical compositions by special use of an antioxidant

Publications (1)

Publication Number Publication Date
ATE269079T1 true ATE269079T1 (de) 2004-07-15

Family

ID=8231706

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99920582T ATE269079T1 (de) 1998-04-02 1999-03-31 Stabilisierung pharmazeutischer zusammensetzungen durch besonderen einsatz eines antioxidans

Country Status (21)

Country Link
US (2) US6576649B1 (de)
EP (1) EP1098649B1 (de)
JP (1) JP2002510627A (de)
KR (1) KR100617430B1 (de)
CN (1) CN1138542C (de)
AT (1) ATE269079T1 (de)
AU (1) AU756000B2 (de)
BR (1) BR9909329A (de)
CA (1) CA2326137C (de)
CZ (1) CZ301851B6 (de)
DE (1) DE69918122T2 (de)
DK (1) DK1098649T3 (de)
ES (1) ES2224651T3 (de)
HU (1) HU226588B1 (de)
ID (1) ID26033A (de)
IL (2) IL138476A0 (de)
NO (1) NO332004B1 (de)
NZ (1) NZ507026A (de)
PL (1) PL194914B1 (de)
WO (1) WO1999051230A1 (de)
ZA (1) ZA200005098B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0938896A1 (de) * 1998-01-15 1999-09-01 Novartis AG In Autoklaven behandelbare pharmazeutische Zusammensetzungen mit Komplexbildner
US6235781B1 (en) 1998-07-14 2001-05-22 Alcon Laboratories, Inc. Prostaglandin product
BR0016550A (pt) * 1999-12-21 2002-09-17 Dsm Nv Preservação da atividade de um fungicida em uma solução aquosa.
US6395756B2 (en) * 1999-12-23 2002-05-28 Novartis Ag Use of ophthalmic agent
KR100355892B1 (ko) * 2000-01-06 2002-10-12 주식회사 코리아나화장품 레티놀과 테트라디부틸 펜타에리스리틸히드록시히드로신나메이트를 함유하는 화장료 조성물
JP4822609B2 (ja) * 2000-05-22 2011-11-24 クラレメディカル株式会社 抗菌性組成物
WO2001090251A1 (fr) * 2000-05-22 2001-11-29 Kuraray Co., Ltd. Composition antimicrobienne
DE10041478A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung
DE10041479A1 (de) * 2000-08-24 2002-03-14 Sanol Arznei Schwarz Gmbh Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923
ES2396598T3 (es) * 2000-08-25 2013-02-22 Senju Pharmaceutical Co., Ltd. Preparaciones en forma de suspensiones acuosas
US20030027793A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal treatment of parkinson's disease
US20030026830A1 (en) * 2001-05-08 2003-02-06 Thomas Lauterback Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine
WO2002100436A2 (en) * 2001-06-08 2002-12-19 Novartis Ag Ophthalmic once-a-day composition
US7479507B2 (en) * 2003-01-14 2009-01-20 Adam Heller Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs
US6933289B2 (en) * 2003-07-01 2005-08-23 Allergan, Inc. Inhibition of irritating side effects associated with use of a topical ophthalmic medication
US20050220742A1 (en) * 2004-03-31 2005-10-06 Breen Ed V Compositions and methods for maintaining eyelid hygiene
US6969706B1 (en) * 2004-05-12 2005-11-29 Allergan, Inc. Preserved pharmaceutical compositions comprising cyclodextrins
CN1737047B (zh) * 2004-08-19 2010-05-05 住友化学株式会社 含填充材料的聚烯烃树脂组合物及其成形品
US20060089384A1 (en) * 2004-10-25 2006-04-27 Minno George E Ophthalmic compositions and methods of using the same
US20070208058A1 (en) * 2004-10-25 2007-09-06 Bryant Roy W Stable Pharmaceutical Compositions and Methods of Making and Using Same
EP1845983B1 (de) * 2004-10-25 2010-04-07 Bausch & Lomb Incorporated Ophthalmische zusammensetzungen und verfahren zu deren verwendung
US20070077302A1 (en) * 2005-09-30 2007-04-05 Azaam Alli Methods for stabilizing ophthalmic compositions
BRPI0709549A2 (pt) * 2006-03-17 2011-07-19 Johnson & Johnson Vision Care métodos para estabilizar composições instáveis oxidativamente
JP2009543736A (ja) * 2006-07-10 2009-12-10 ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッド 医薬品を含有する眼用レンズのためのパッケージ
ES2624960T3 (es) * 2006-09-29 2017-07-18 Johnson & Johnson Vision Care, Inc. Método de fabricación de dispositivos oftálmicos usados en el tratamiento de alergias oculares
US20090005362A1 (en) * 2007-06-26 2009-01-01 Vo Toan P Compositions Comprising Antihistamines or Mast Cell Stabilizers, and Methods of Making and Using Same
US8986728B2 (en) * 2008-05-30 2015-03-24 Abbott Cardiovascular Systems Inc. Soluble implantable device comprising polyelectrolyte with hydrophobic counterions
US8300252B2 (en) * 2008-06-18 2012-10-30 Livescribe, Inc. Managing objects with varying and repeated printed positioning information
CN102076340B (zh) * 2008-06-27 2013-01-23 祐德药品工业株式会社 含芬太尼或其盐的经皮吸收型贴剂
KR20100023538A (ko) * 2008-08-22 2010-03-04 삼성전자주식회사 고상 시약의 제조방법 및 고상 시약을 수용하는 미세유동장치
WO2010047681A1 (en) * 2008-10-24 2010-04-29 Bridge Pharma, Inc. Treating xerophthalmia with norketotifen
WO2010059894A1 (en) * 2008-11-21 2010-05-27 Bridge Pharma, Inc. Ocular formulations of norketotifen
KR101013102B1 (ko) * 2008-12-08 2011-02-14 주식회사 케이에스비 토너 카트리지의 블레이드 용접 장치
JP5675183B2 (ja) * 2009-06-16 2015-02-25 ロート製薬株式会社 水性組成物
FR2961694B1 (fr) * 2010-06-29 2013-01-25 Thea Lab Systeme de delivrance polymerique d'une solution non visqueuse a base de prostaglandine sans conservateur
US20180325854A1 (en) * 2015-11-06 2018-11-15 Accuitis Pharmaceuticals, Inc. Use of proteasome inhibitors to treat ocular disorders
CN114262476B (zh) * 2021-12-30 2023-09-05 沈阳兴齐眼药股份有限公司 提高妥布霉素滴眼液稳定性的包装容器
CN114262477B (zh) * 2021-12-30 2023-09-19 沈阳兴齐眼药股份有限公司 抑制妥布霉素滴眼液变色的包装容器及其制备方法
CN114441691B (zh) * 2022-04-12 2022-08-23 广州国标检验检测有限公司 一种眼用制剂容器中塑料添加剂的检测方法
US20240041869A1 (en) 2022-08-04 2024-02-08 Bausch + Lomb Ireland Limited Ophthalmic composition comprising an anti-allergen and a redness reduction agent
WO2024028816A1 (en) 2022-08-04 2024-02-08 Bausch + Lomb Ireland Limited Ophthalmic composition comprising pilocarpine and a redness reduction agent

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2231377B1 (de) * 1973-05-29 1977-11-04 Barnes Hind Pharm Inc
US3966905A (en) * 1973-05-29 1976-06-29 Barnes-Hind Pharmaceuticals, Inc. Stabilized catechol amine solutions
US4959208A (en) * 1987-10-19 1990-09-25 Ppg Industries, Inc. Active agent delivery device
JP3666884B2 (ja) * 1992-05-21 2005-06-29 日本ゼオン株式会社 医療用器材
JP3098895B2 (ja) * 1993-06-28 2000-10-16 三菱化学株式会社 液体用容器
JP3021312B2 (ja) * 1994-03-15 2000-03-15 千寿製薬株式会社 プラノプロフェンの安定化方法および安定なプラノプロフェン水性液剤
JP3055753B2 (ja) * 1994-07-05 2000-06-26 昭和薬品化工株式会社 フマル酸ケトチフェン含有点眼液
JP3693696B2 (ja) * 1994-12-15 2005-09-07 久光製薬株式会社 ケトチフェン含有経皮投与製剤
ES2144264T3 (es) * 1995-08-29 2000-06-01 Exxon Chemical Patents Inc Polipropileno tolerante a la radiacion y sus articulos utiles.
KR100228514B1 (ko) * 1996-09-05 1999-11-01 한승수 비스테로이드성 소염진통제를 활성성분으로 하는 경피흡수제제의 제조방법

Also Published As

Publication number Publication date
JP2002510627A (ja) 2002-04-09
ID26033A (id) 2000-11-16
KR100617430B1 (ko) 2006-08-31
IL138476A (en) 2006-04-10
US6576649B1 (en) 2003-06-10
HUP0101582A3 (en) 2002-10-28
CZ20003579A3 (cs) 2001-01-17
CA2326137C (en) 2009-06-02
AU3811999A (en) 1999-10-25
EP1098649B1 (de) 2004-06-16
KR20010042361A (ko) 2001-05-25
NZ507026A (en) 2003-09-26
EP1098649A1 (de) 2001-05-16
HU226588B1 (en) 2009-04-28
NO20004872L (no) 2000-11-09
ZA200005098B (en) 2001-05-21
CN1295474A (zh) 2001-05-16
PL343156A1 (en) 2001-07-30
AU756000B2 (en) 2003-01-02
DE69918122D1 (de) 2004-07-22
NO332004B1 (no) 2012-05-21
CZ301851B6 (cs) 2010-07-07
ES2224651T3 (es) 2005-03-01
DK1098649T3 (da) 2004-10-04
US6455547B1 (en) 2002-09-24
PL194914B1 (pl) 2007-07-31
DE69918122T2 (de) 2005-06-16
US20020103196A1 (en) 2002-08-01
NO20004872D0 (no) 2000-09-28
IL138476A0 (en) 2001-10-31
CA2326137A1 (en) 1999-10-14
WO1999051230A1 (en) 1999-10-14
BR9909329A (pt) 2000-12-12
CN1138542C (zh) 2004-02-18
HUP0101582A2 (hu) 2002-03-28

Similar Documents

Publication Publication Date Title
ATE269079T1 (de) Stabilisierung pharmazeutischer zusammensetzungen durch besonderen einsatz eines antioxidans
DE69728585D1 (de) Mittel gegen Juckreiz
TR199901191T2 (xx) Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�.
EA199900373A2 (ru) Фармацевтические композиции
BR0215405A (pt) Composições e processos de uso de collajolie
WO2003032966A1 (fr) Compositions destinees a potentialiser le glutathion
BR0317715A (pt) Composições e processos de uso de collajolie
SV2004001485A (es) Composicion de ziprasidona y controles sinteticos ref. pc23201
DE60232005D1 (de) Stabilisierte azithromycin-zusammensetzungen
BR0011030A (pt) Composições de cicloporina substancialmente livre de óleo
MXPA04001646A (es) Composicion oftalmica que comprende ascomicina.
EP0932613A4 (de) Expressionsblockierung von virulenten faktoren in s. aureus
AU6469401A (en) Pharmaceutically active compounds and methods of use
TWI256304B (en) Pharmaceutical compositions based on azetidine derivatives
PA8485701A1 (es) Derivados de indol
MXPA03011128A (es) Composicion de sabor y fragancia.
DE60219008D1 (de) Kosmetische und dermatologische zusammensetzung enthaltend n-acylaminoamid-derivate
EA200000522A1 (ru) 5-htагонисты
SE0302361D0 (sv) Inhibering av upptagning av monoamin
WO2002024727A3 (en) New inhibitors of iapp fibril formation and uses thereof
DK1163248T3 (da) 1,5-anhydro-D-fructose substitueret med en hydrofob gruppe til brug som en antioxidant og/eller emulgator
DE60220699D1 (de) Tibolonformulierungen
AUPP627398A0 (en) Novel peptides - II
BR0214244A (pt) Uso de uma ascomicina
IL147223A0 (en) The use of the protein uk 114 for inhibiting organ transplant rejection

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1098649

Country of ref document: EP

EEIH Change in the person of patent owner