NO332004B1 - Fremgangsmate for a stabilisere en vandig farmasoytisk sammensetning, anvendelse av en antioksidant for a oppna nevnte stabilisering, samt en vandig oyensammensetning - Google Patents
Fremgangsmate for a stabilisere en vandig farmasoytisk sammensetning, anvendelse av en antioksidant for a oppna nevnte stabilisering, samt en vandig oyensammensetning Download PDFInfo
- Publication number
- NO332004B1 NO332004B1 NO20004872A NO20004872A NO332004B1 NO 332004 B1 NO332004 B1 NO 332004B1 NO 20004872 A NO20004872 A NO 20004872A NO 20004872 A NO20004872 A NO 20004872A NO 332004 B1 NO332004 B1 NO 332004B1
- Authority
- NO
- Norway
- Prior art keywords
- dimethylethyl
- composition
- antioxidant
- group
- hydroxyphenyl
- Prior art date
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- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 description 1
- 229960005016 naphazoline Drugs 0.000 description 1
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- 235000010298 natamycin Nutrition 0.000 description 1
- 239000004311 natamycin Substances 0.000 description 1
- NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 description 1
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- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
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- QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 1
- CMHHMUWAYWTMGS-UHFFFAOYSA-N oxybuprocaine Chemical compound CCCCOC1=CC(C(=O)OCCN(CC)CC)=CC=C1N CMHHMUWAYWTMGS-UHFFFAOYSA-N 0.000 description 1
- 229960003502 oxybuprocaine Drugs 0.000 description 1
- 229960001528 oxymetazoline Drugs 0.000 description 1
- 229960002740 oxyphenonium Drugs 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 229960001190 pheniramine Drugs 0.000 description 1
- 229940096826 phenylmercuric acetate Drugs 0.000 description 1
- VUXSPDNLYQTOSY-UHFFFAOYSA-N phenylmercuric borate Chemical class OB(O)O[Hg]C1=CC=CC=C1 VUXSPDNLYQTOSY-UHFFFAOYSA-N 0.000 description 1
- 229960000247 phenylmercuric borate Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229960001697 physostigmine Drugs 0.000 description 1
- PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
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- 229940068977 polysorbate 20 Drugs 0.000 description 1
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- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 229960003981 proparacaine Drugs 0.000 description 1
- 150000005599 propionic acid derivatives Chemical class 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000029219 regulation of pH Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000004289 sodium hydrogen sulphite Substances 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
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- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- LXANPKRCLVQAOG-NSHDSACASA-N sorbinil Chemical compound C12=CC(F)=CC=C2OCC[C@@]21NC(=O)NC2=O LXANPKRCLVQAOG-NSHDSACASA-N 0.000 description 1
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- 238000013112 stability test Methods 0.000 description 1
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- 229960002673 sulfacetamide Drugs 0.000 description 1
- SKIVFJLNDNKQPD-UHFFFAOYSA-N sulfacetamide Chemical compound CC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 SKIVFJLNDNKQPD-UHFFFAOYSA-N 0.000 description 1
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical class [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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- NBOMNTLFRHMDEZ-UHFFFAOYSA-N thiosalicylic acid Chemical class OC(=O)C1=CC=CC=C1S NBOMNTLFRHMDEZ-UHFFFAOYSA-N 0.000 description 1
- 229940103494 thiosalicylic acid Drugs 0.000 description 1
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- VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98106046 | 1998-04-02 | ||
| PCT/EP1999/002221 WO1999051230A1 (en) | 1998-04-02 | 1999-03-31 | Method for stabilizing pharmaceutical compositions by special use of an antioxidant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20004872D0 NO20004872D0 (no) | 2000-09-28 |
| NO20004872L NO20004872L (no) | 2000-11-09 |
| NO332004B1 true NO332004B1 (no) | 2012-05-21 |
Family
ID=8231706
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20004872A NO332004B1 (no) | 1998-04-02 | 2000-09-28 | Fremgangsmate for a stabilisere en vandig farmasoytisk sammensetning, anvendelse av en antioksidant for a oppna nevnte stabilisering, samt en vandig oyensammensetning |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6576649B1 (de) |
| EP (1) | EP1098649B1 (de) |
| JP (1) | JP2002510627A (de) |
| KR (1) | KR100617430B1 (de) |
| CN (1) | CN1138542C (de) |
| AT (1) | ATE269079T1 (de) |
| AU (1) | AU756000B2 (de) |
| BR (1) | BR9909329A (de) |
| CA (1) | CA2326137C (de) |
| CZ (1) | CZ301851B6 (de) |
| DE (1) | DE69918122T2 (de) |
| DK (1) | DK1098649T3 (de) |
| ES (1) | ES2224651T3 (de) |
| HU (1) | HU226588B1 (de) |
| ID (1) | ID26033A (de) |
| IL (2) | IL138476A0 (de) |
| NO (1) | NO332004B1 (de) |
| NZ (1) | NZ507026A (de) |
| PL (1) | PL194914B1 (de) |
| WO (1) | WO1999051230A1 (de) |
| ZA (1) | ZA200005098B (de) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0938896A1 (de) * | 1998-01-15 | 1999-09-01 | Novartis AG | In Autoklaven behandelbare pharmazeutische Zusammensetzungen mit Komplexbildner |
| US6235781B1 (en) | 1998-07-14 | 2001-05-22 | Alcon Laboratories, Inc. | Prostaglandin product |
| PT1239732E (pt) * | 1999-12-21 | 2004-08-31 | Dsm Ip Assets Bv | Conservacao da actividade de um fungicida numa solucao aquosa |
| US6395756B2 (en) * | 1999-12-23 | 2002-05-28 | Novartis Ag | Use of ophthalmic agent |
| KR100355892B1 (ko) * | 2000-01-06 | 2002-10-12 | 주식회사 코리아나화장품 | 레티놀과 테트라디부틸 펜타에리스리틸히드록시히드로신나메이트를 함유하는 화장료 조성물 |
| KR100457993B1 (ko) * | 2000-05-22 | 2004-11-26 | 가부시키가이샤 구라레 | 항균성 조성물 |
| JP4822609B2 (ja) * | 2000-05-22 | 2011-11-24 | クラレメディカル株式会社 | 抗菌性組成物 |
| DE10041478A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
| DE10041479A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung zur Verabreichung von N-0923 |
| JP5000835B2 (ja) * | 2000-08-25 | 2012-08-15 | 千寿製薬株式会社 | 水性懸濁液剤 |
| US20030026830A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine |
| US20030027793A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal treatment of parkinson's disease |
| WO2002100436A2 (en) * | 2001-06-08 | 2002-12-19 | Novartis Ag | Ophthalmic once-a-day composition |
| WO2004064781A2 (en) * | 2003-01-14 | 2004-08-05 | Adam Heller | Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs |
| US6933289B2 (en) * | 2003-07-01 | 2005-08-23 | Allergan, Inc. | Inhibition of irritating side effects associated with use of a topical ophthalmic medication |
| US20050220742A1 (en) * | 2004-03-31 | 2005-10-06 | Breen Ed V | Compositions and methods for maintaining eyelid hygiene |
| US6969706B1 (en) * | 2004-05-12 | 2005-11-29 | Allergan, Inc. | Preserved pharmaceutical compositions comprising cyclodextrins |
| CN1737047B (zh) * | 2004-08-19 | 2010-05-05 | 住友化学株式会社 | 含填充材料的聚烯烃树脂组合物及其成形品 |
| US20070208058A1 (en) * | 2004-10-25 | 2007-09-06 | Bryant Roy W | Stable Pharmaceutical Compositions and Methods of Making and Using Same |
| US20060089384A1 (en) * | 2004-10-25 | 2006-04-27 | Minno George E | Ophthalmic compositions and methods of using the same |
| BRPI0517451A (pt) * | 2004-10-25 | 2008-10-07 | Bausch & Lomb | composição oftámilca, e, métodos de tratar conjutivite alérgica e doença de olho seco |
| US20070077302A1 (en) * | 2005-09-30 | 2007-04-05 | Azaam Alli | Methods for stabilizing ophthalmic compositions |
| CA2908828C (en) | 2006-03-17 | 2018-01-16 | Johnson & Johnson Vision Care, Inc. | Methods for stabilizing oxidatively unstable compositions |
| CN101662966B (zh) * | 2006-07-10 | 2016-03-02 | 庄臣及庄臣视力保护公司 | 用于含药物眼用镜片的包装 |
| KR20090092763A (ko) * | 2006-09-29 | 2009-09-01 | 존슨 앤드 존슨 비젼 케어, 인코포레이티드 | 눈 알레르기의 치료에 사용되는 방법 및 안과용 장치 |
| US20090005362A1 (en) * | 2007-06-26 | 2009-01-01 | Vo Toan P | Compositions Comprising Antihistamines or Mast Cell Stabilizers, and Methods of Making and Using Same |
| US8986728B2 (en) * | 2008-05-30 | 2015-03-24 | Abbott Cardiovascular Systems Inc. | Soluble implantable device comprising polyelectrolyte with hydrophobic counterions |
| US8300252B2 (en) * | 2008-06-18 | 2012-10-30 | Livescribe, Inc. | Managing objects with varying and repeated printed positioning information |
| CN102076340B (zh) * | 2008-06-27 | 2013-01-23 | 祐德药品工业株式会社 | 含芬太尼或其盐的经皮吸收型贴剂 |
| KR20100023538A (ko) * | 2008-08-22 | 2010-03-04 | 삼성전자주식회사 | 고상 시약의 제조방법 및 고상 시약을 수용하는 미세유동장치 |
| US8741930B2 (en) * | 2008-10-24 | 2014-06-03 | Bridge Pharma, Inc. | Treating xerophthalmia with norketotifen |
| US8765787B2 (en) * | 2008-11-21 | 2014-07-01 | Bridge Pharma, Inc. | Methods of treatment of xerophthalmia with self-preserving ocular formulations of norketotifen |
| KR101013102B1 (ko) * | 2008-12-08 | 2011-02-14 | 주식회사 케이에스비 | 토너 카트리지의 블레이드 용접 장치 |
| JP5675183B2 (ja) * | 2009-06-16 | 2015-02-25 | ロート製薬株式会社 | 水性組成物 |
| FR2961694B1 (fr) * | 2010-06-29 | 2013-01-25 | Thea Lab | Systeme de delivrance polymerique d'une solution non visqueuse a base de prostaglandine sans conservateur |
| WO2017078953A1 (en) * | 2015-11-06 | 2017-05-11 | Accuitis Pharmaceuticals, Inc. | Use of proteasome inhibitors to treat ocular disorders |
| CN114262477B (zh) * | 2021-12-30 | 2023-09-19 | 沈阳兴齐眼药股份有限公司 | 抑制妥布霉素滴眼液变色的包装容器及其制备方法 |
| CN114262476B (zh) * | 2021-12-30 | 2023-09-05 | 沈阳兴齐眼药股份有限公司 | 提高妥布霉素滴眼液稳定性的包装容器 |
| CN114441691B (zh) * | 2022-04-12 | 2022-08-23 | 广州国标检验检测有限公司 | 一种眼用制剂容器中塑料添加剂的检测方法 |
| WO2024028815A1 (en) | 2022-08-04 | 2024-02-08 | Bausch + Lomb Ireland Limited | Ophthalmic composition comprising an anti-allergen and a redness reduction agent |
| WO2024028816A1 (en) | 2022-08-04 | 2024-02-08 | Bausch + Lomb Ireland Limited | Ophthalmic composition comprising pilocarpine and a redness reduction agent |
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| US3966905A (en) * | 1973-05-29 | 1976-06-29 | Barnes-Hind Pharmaceuticals, Inc. | Stabilized catechol amine solutions |
| FR2231377B1 (de) * | 1973-05-29 | 1977-11-04 | Barnes Hind Pharm Inc | |
| US4959208A (en) * | 1987-10-19 | 1990-09-25 | Ppg Industries, Inc. | Active agent delivery device |
| JP3666884B2 (ja) * | 1992-05-21 | 2005-06-29 | 日本ゼオン株式会社 | 医療用器材 |
| JP3098895B2 (ja) * | 1993-06-28 | 2000-10-16 | 三菱化学株式会社 | 液体用容器 |
| JP3021312B2 (ja) * | 1994-03-15 | 2000-03-15 | 千寿製薬株式会社 | プラノプロフェンの安定化方法および安定なプラノプロフェン水性液剤 |
| JP3055753B2 (ja) * | 1994-07-05 | 2000-06-26 | 昭和薬品化工株式会社 | フマル酸ケトチフェン含有点眼液 |
| JP3693696B2 (ja) * | 1994-12-15 | 2005-09-07 | 久光製薬株式会社 | ケトチフェン含有経皮投与製剤 |
| EP0847420B1 (de) * | 1995-08-29 | 2000-02-16 | Exxon Chemical Patents Inc. | Strahlungsbeständiges polypropylen und daraus herstellbare gegenstände |
| KR100228514B1 (ko) * | 1996-09-05 | 1999-11-01 | 한승수 | 비스테로이드성 소염진통제를 활성성분으로 하는 경피흡수제제의 제조방법 |
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