ATE268756T1 - Substituierte karbazole, verfahren zu ihrer herstellung und ihre verwendung als spla2- inhibitoren - Google Patents

Substituierte karbazole, verfahren zu ihrer herstellung und ihre verwendung als spla2- inhibitoren

Info

Publication number
ATE268756T1
ATE268756T1 AT99302941T AT99302941T ATE268756T1 AT E268756 T1 ATE268756 T1 AT E268756T1 AT 99302941 T AT99302941 T AT 99302941T AT 99302941 T AT99302941 T AT 99302941T AT E268756 T1 ATE268756 T1 AT E268756T1
Authority
AT
Austria
Prior art keywords
production
spla2 inhibitors
substituted carbazoles
carbazoles
substituted
Prior art date
Application number
AT99302941T
Other languages
German (de)
English (en)
Inventor
Benjamin Alan Anderson
Nicholas James Bach
Jolie Anne Bastian
Nancy Kay Harn
Richard Waltz Harper
Gary Alan Hite
Michael Dean Kinnick
Ho-Shen Lin
Richard James Loncharich
John Mcneill Mcgill
Edward David Mihelich
Jr John Michael Morin
Michael Leroy Phillips
Michael Enrico Richett
Daniel Jon Sall
Jason Scott Sawyer
Richard Walter Schevitz
Robert Theodore Vasileff
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE268756T1 publication Critical patent/ATE268756T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/70—[b]- or [c]-condensed containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT99302941T 1998-04-17 1999-04-16 Substituierte karbazole, verfahren zu ihrer herstellung und ihre verwendung als spla2- inhibitoren ATE268756T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6232898A 1998-04-17 1998-04-17

Publications (1)

Publication Number Publication Date
ATE268756T1 true ATE268756T1 (de) 2004-06-15

Family

ID=22041763

Family Applications (2)

Application Number Title Priority Date Filing Date
AT99302941T ATE268756T1 (de) 1998-04-17 1999-04-16 Substituierte karbazole, verfahren zu ihrer herstellung und ihre verwendung als spla2- inhibitoren
AT99302967T ATE271037T1 (de) 1998-04-17 1999-04-16 Substituierte karbazole, verfahren zu ihrer herstellung und ihre verwendung als spla2- inhibitoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99302967T ATE271037T1 (de) 1998-04-17 1999-04-16 Substituierte karbazole, verfahren zu ihrer herstellung und ihre verwendung als spla2- inhibitoren

Country Status (30)

Country Link
EP (2) EP0952149B1 (xx)
JP (2) JP4435330B2 (xx)
KR (2) KR19990083232A (xx)
CN (1) CN1149193C (xx)
AR (2) AR018186A1 (xx)
AT (2) ATE268756T1 (xx)
AU (2) AU753436B2 (xx)
BR (2) BR9901279A (xx)
CA (2) CA2269262A1 (xx)
CO (2) CO5011054A1 (xx)
CZ (2) CZ137099A3 (xx)
DE (2) DE69918590T2 (xx)
DK (1) DK0950657T3 (xx)
DZ (1) DZ2769A1 (xx)
EA (2) EA002816B1 (xx)
ES (2) ES2226286T3 (xx)
HU (2) HUP9901220A3 (xx)
ID (2) ID23761A (xx)
IL (2) IL129483A0 (xx)
NO (2) NO314400B1 (xx)
NZ (3) NZ335251A (xx)
PE (2) PE20000432A1 (xx)
PL (2) PL332565A1 (xx)
PT (1) PT950657E (xx)
SG (2) SG81976A1 (xx)
SI (1) SI0950657T1 (xx)
TR (2) TR199900853A3 (xx)
TW (1) TWI238160B (xx)
YU (2) YU19199A (xx)
ZA (2) ZA992771B (xx)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9123198A (en) * 1997-08-28 1999-03-16 Eli Lilly And Company Method for treatment of non-rheumatoid athritis
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.
JP2002542148A (ja) * 1998-12-21 2002-12-10 イーライ・リリー・アンド・カンパニー 敗血症の処置のための組み合わせ療法
CA2379208A1 (en) * 1999-07-19 2001-01-25 Eli Lilly & Company Spla2 inhibitors
US6706752B1 (en) 1999-07-19 2004-03-16 Eli Lilly And Company sPLA2 inhibitors
WO2002000257A1 (fr) * 2000-06-29 2002-01-03 Shionogi & Co., Ltd. Remedes a la maladie d'alzheimer
TW583000B (en) * 2000-06-29 2004-04-11 Shionogi & Co X-type sPLA2 inhibitor as a cancer therapeutical agent
US6967200B2 (en) 2000-06-29 2005-11-22 Shionogi & Co., Ltd. Remedies for cirrhosis
CA2413582A1 (en) * 2000-07-14 2002-01-24 Eli Lilly And Company Use of a spla2 inhibitor for the treatment of sepsis
EP1345898A2 (en) 2000-12-18 2003-09-24 Eli Lilly And Company Teracyclic carbazole derivates and their use as spla2 inhibitors
ATE353876T1 (de) * 2001-03-28 2007-03-15 Lilly Co Eli Substituierte carbazole als inhibitoren von spla2
AUPS282602A0 (en) 2002-06-07 2002-06-27 Garvan Institute Of Medical Research Method of inhibiting cell proliferation
DE10249055A1 (de) 2002-10-22 2004-05-06 Bayer Cropscience Ag 2-Phenyl-2-substituierte-1,3-diketone
JO3598B1 (ar) 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
EP1988098A1 (en) * 2007-04-27 2008-11-05 AEterna Zentaris GmbH Novel Tetrahydrocarbazole Derivatives as Ligands of G-protein Coupled Receptors
CN101981012A (zh) 2008-03-26 2011-02-23 第一三共株式会社 新的四氢异喹啉衍生物
TW201000107A (en) 2008-04-09 2010-01-01 Infinity Pharmaceuticals Inc Inhibitors of fatty acid amide hydrolase
WO2010084402A2 (en) * 2009-01-22 2010-07-29 Orchid Research Laboratories Ltd. Heterocyclic compounds as phosphodiesterase inhibitors
WO2010118159A1 (en) 2009-04-07 2010-10-14 Infinity Pharmaceuticals, Inc. Inhibitors of fatty acid amide hydrolase
ES2493916T3 (es) 2009-04-07 2014-09-12 Infinity Pharmaceuticals, Inc. Inhibidores de hidrolasa de amida de ácidos grasos
RU2569061C2 (ru) 2010-02-03 2015-11-20 Инфинити Фармасьютикалз, Инк. Ингибиторы амид-гидролазы жирных кислот
AR088377A1 (es) 2011-10-20 2014-05-28 Siena Biotech Spa Proceso para la preparacion de 6-cloro-2,3,4,9-tetrahidro-1h-carbazol-1-carboxamida y compuestos intermedios de esta
CN102816107B (zh) * 2012-08-20 2015-06-03 东南大学 咔唑衍生物及其制备方法与用途
JP2016501211A (ja) * 2012-11-30 2016-01-18 ジーイー・ヘルスケア・リミテッド 三環性インドールを得るためのハロゲン化亜鉛による環化プロセス
KR20150088802A (ko) 2012-11-30 2015-08-03 지이 헬쓰케어 리미티드 트리시클릭 인돌 유도체의 결정화 방법
WO2016116527A1 (de) * 2015-01-20 2016-07-28 Cynora Gmbh Organische moleküle, insbesondere zur verwendung in optoelektronischen bauelementen
CN108707104A (zh) * 2018-08-07 2018-10-26 北京恒信卓元科技有限公司 2-氯-1h-咔唑-1,4(9h)-二酮的合成方法

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Publication number Priority date Publication date Assignee Title
US3579534A (en) * 1969-05-09 1971-05-18 American Cyanamid Co Tetrahydrocarbazolecarboxylates
US3939177A (en) * 1972-11-22 1976-02-17 Sterling Drug Inc. 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
US3979391A (en) * 1972-11-22 1976-09-07 Sterling Drug Inc. 1,2,3,4-Tetrahydrocarbazoles
PT95692A (pt) * 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US5420289A (en) * 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
CA2110514A1 (en) * 1991-07-05 1993-01-21 Raymond Baker Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
MY110227A (en) * 1991-08-12 1998-03-31 Ciba Geigy Ag 1-acylpiperindine compounds.
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) * 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
ES2151993T3 (es) * 1995-06-23 2001-01-16 Lilly Co Eli 1,2,3,4-tetrahidro-9h-carbazoles 6-sustituidos y 10h-ciclohepta(7,6-b)indoles 7-sustituidos.
HUP9901984A3 (en) * 1995-12-13 2001-01-29 Lilly Co Eli Naphthyl acetamides as spla2 inhibitors, use thereof and pharmaceutical compositions containing these compounds
BR9713261A (pt) * 1996-10-30 2000-03-28 Lilly Co Eli Tricìclicos substituìdos
CA2304482A1 (en) * 1997-09-26 1999-04-08 Eli Lilly And Company Method for the treatment of cystic fibrosis
EP1043991A4 (en) * 1997-11-14 2005-02-02 Lilly Co Eli TREATMENT OF ALZHEIMER DISEASE
DZ2769A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Composés tricycliques substitués.

Also Published As

Publication number Publication date
TR199900853A2 (xx) 1999-11-22
EA199900301A3 (ru) 2000-04-24
NO991821L (no) 1999-10-18
EP0950657A2 (en) 1999-10-20
CZ137099A3 (cs) 1999-11-17
TWI238160B (en) 2005-08-21
PL332566A1 (en) 1999-10-25
AU2381799A (en) 1999-10-28
EA002816B1 (ru) 2002-10-31
TR199900853A3 (tr) 1999-11-22
KR19990083233A (ko) 1999-11-25
DE69918590D1 (de) 2004-08-19
ES2222663T3 (es) 2005-02-01
DZ2769A1 (fr) 2003-12-01
NO991821D0 (no) 1999-04-16
EA199900301A2 (ru) 1999-10-28
NO991822L (no) 1999-10-18
DK0950657T3 (da) 2004-11-22
EA199900303A2 (ru) 1999-10-28
JP2000026416A (ja) 2000-01-25
IL129485A0 (en) 2000-02-29
NO312240B1 (no) 2002-04-15
CA2269262A1 (en) 1999-10-17
ATE271037T1 (de) 2004-07-15
CO5031247A1 (es) 2001-04-27
NZ335253A (en) 2000-11-24
AU753547B2 (en) 2002-10-24
HU9901221A (hu) 2000-04-28
EA002347B1 (ru) 2002-04-25
JPH11322713A (ja) 1999-11-24
CA2269246A1 (en) 1999-10-17
HUP9901221A3 (en) 2001-11-28
ZA992772B (en) 2002-07-16
KR100586761B1 (ko) 2006-06-08
EP0952149A3 (en) 2001-08-16
AR018186A1 (es) 2001-10-31
EP0952149A2 (en) 1999-10-27
HUP9901220A3 (en) 2001-11-28
SI0950657T1 (en) 2005-02-28
HU9901220D0 (en) 1999-06-28
AR018593A1 (es) 2001-11-28
IL129483A0 (en) 2000-02-29
CZ136999A3 (cs) 1999-11-17
ID23287A (id) 2000-04-05
PE20000476A1 (es) 2000-06-02
SG81977A1 (en) 2001-07-24
NO314400B1 (no) 2003-03-17
HU9901220A (hu) 2000-04-28
CN1253948A (zh) 2000-05-24
EA199900303A3 (ru) 2000-04-24
NZ335251A (en) 2000-11-24
YU19199A (sh) 2002-08-12
PL332565A1 (en) 1999-10-25
EP0950657B1 (en) 2004-07-14
NO991822D0 (no) 1999-04-16
TR199900843A2 (xx) 2000-02-21
DE69917833T2 (de) 2005-07-14
ES2226286T3 (es) 2005-03-16
YU18999A (sh) 2002-08-12
EP0950657A3 (en) 2001-08-16
ID23761A (id) 2000-05-11
EP0952149B1 (en) 2004-06-09
DE69917833D1 (de) 2004-07-15
AU2381999A (en) 1999-10-28
CA2269246C (en) 2009-08-25
JP4435330B2 (ja) 2010-03-17
AU753436B2 (en) 2002-10-17
DE69918590T2 (de) 2005-07-21
PT950657E (pt) 2004-11-30
NZ507564A (en) 2002-10-25
CO5011054A1 (es) 2001-02-28
PE20000432A1 (es) 2000-05-23
KR19990083232A (ko) 1999-11-25
BR9902365A (pt) 2001-04-24
ZA992771B (en) 2002-04-18
CN1149193C (zh) 2004-05-12
SG81976A1 (en) 2001-07-24
HU9901221D0 (en) 1999-06-28
BR9901279A (pt) 2000-05-02

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