ATE263185T1 - Verfahren zur herstellung von acylierten proteinpuder - Google Patents

Verfahren zur herstellung von acylierten proteinpuder

Info

Publication number
ATE263185T1
ATE263185T1 AT96303974T AT96303974T ATE263185T1 AT E263185 T1 ATE263185 T1 AT E263185T1 AT 96303974 T AT96303974 T AT 96303974T AT 96303974 T AT96303974 T AT 96303974T AT E263185 T1 ATE263185 T1 AT E263185T1
Authority
AT
Austria
Prior art keywords
protein
protein powder
acylated protein
producing acylated
isoelectric
Prior art date
Application number
AT96303974T
Other languages
English (en)
Inventor
Jeffrey Clayton Baker
Brian A Moser
Warren E Schrader
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE263185T1 publication Critical patent/ATE263185T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT96303974T 1995-06-07 1996-05-31 Verfahren zur herstellung von acylierten proteinpuder ATE263185T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/484,220 US5700904A (en) 1995-06-07 1995-06-07 Preparation of an acylated protein powder

Publications (1)

Publication Number Publication Date
ATE263185T1 true ATE263185T1 (de) 2004-04-15

Family

ID=23923252

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96303974T ATE263185T1 (de) 1995-06-07 1996-05-31 Verfahren zur herstellung von acylierten proteinpuder

Country Status (21)

Country Link
US (1) US5700904A (de)
EP (1) EP0747391B1 (de)
JP (1) JP3844504B2 (de)
KR (1) KR19990022590A (de)
CN (1) CN1192218A (de)
AT (1) ATE263185T1 (de)
AU (1) AU703032B2 (de)
BR (1) BR9608729A (de)
CA (1) CA2223389A1 (de)
CZ (1) CZ388197A3 (de)
DE (1) DE69631996T2 (de)
DK (1) DK0747391T3 (de)
EA (1) EA199800042A1 (de)
ES (1) ES2216039T3 (de)
HU (1) HUP9900877A3 (de)
IL (1) IL122460A0 (de)
NO (1) NO975583D0 (de)
NZ (1) NZ309371A (de)
PL (1) PL323994A1 (de)
TR (1) TR199701528T1 (de)
WO (1) WO1996040730A1 (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9316895D0 (en) 1993-08-13 1993-09-29 Guy S And St Thomas Hospitals Hepatoselective insulin analogues
US5986050A (en) * 1996-12-26 1999-11-16 Poly-Med, Inc. Peracylated proteins and synthetic polypeptides and process for making the same
US5898067A (en) * 1997-02-07 1999-04-27 Novo Nordisk A/S Crystallization of proteins
DE69829953T2 (de) * 1997-02-07 2006-03-02 Novo Nordisk A/S Kristallisation von proteinen
EP1005490B1 (de) * 1997-03-20 2006-03-29 Novo Nordisk A/S Zinkfreie insulinkristalle für die verwendung in medikamenten, die über die lunge verabreicht werden.
US6310038B1 (en) * 1997-03-20 2001-10-30 Novo Nordisk A/S Pulmonary insulin crystals
US5898028A (en) * 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
EP1039920A4 (de) * 1997-10-24 2003-05-28 Lilly Co Eli Mit fettsäuren acylierteinsulinanaloge
EP0911035A3 (de) * 1997-10-24 2002-08-21 Eli Lilly And Company Unlösliche insulinzusammensetzungen
ZA989744B (en) * 1997-10-31 2000-04-26 Lilly Co Eli Method for administering acylated insulin.
US6531448B1 (en) * 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
EP1396272A1 (de) * 1997-12-23 2004-03-10 Eli Lilly & Company Unlöslische Insulin Zusammensetzungen zur Regelung der Blutglukose
US6526675B1 (en) * 1999-06-07 2003-03-04 Roe-Hoan Yoon Methods of using natural products as dewatering aids for fine particles
US6855260B1 (en) * 1999-06-07 2005-02-15 Roe-Hoan Yoon Methods of enhancing fine particle dewatering
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6799682B1 (en) 2000-05-16 2004-10-05 Roe-Hoan Yoon Method of increasing flotation rate
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
AU2003226603A1 (en) * 2002-04-19 2003-11-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders
US7601688B2 (en) 2002-06-13 2009-10-13 Biocon Limited Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
AU2003278565A1 (en) * 2002-10-25 2004-05-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
ES2737835T3 (es) 2003-04-23 2020-01-16 Valeritas Inc Bomba accionada hidráulicamente para la administración de medicamentos de larga duración
HRP20130602T1 (en) 2003-07-30 2013-07-31 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine compounds for use in the treatment or prevention of autoimmune diseases
US9089636B2 (en) 2004-07-02 2015-07-28 Valeritas, Inc. Methods and devices for delivering GLP-1 and uses thereof
CN103223160B (zh) 2004-07-19 2015-02-18 比奥孔有限公司 胰岛素-低聚物共轭物,制剂及其用途
DE602005016952D1 (de) 2004-10-21 2009-11-12 Novo Nordisk As Wählmechanismus für einen drehstift
JP4022595B2 (ja) * 2004-10-26 2007-12-19 コニカミノルタオプト株式会社 撮影装置
US8007754B2 (en) 2005-02-04 2011-08-30 Mineral And Coal Technologies, Inc. Separation of diamond from gangue minerals
US20090043264A1 (en) 2005-04-24 2009-02-12 Novo Nordisk A/S Injection Device
CA2608367C (en) 2005-06-08 2014-08-19 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US20070203161A1 (en) * 2006-02-24 2007-08-30 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
US7741281B2 (en) * 2005-11-03 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
ES2622493T3 (es) 2006-02-24 2017-07-06 Rigel Pharmaceuticals, Inc. Composiciones y métodos para la inhibición de la ruta de JAK
US8361036B2 (en) 2006-03-10 2013-01-29 Novo Nordisk A/S Injection device having a gearing arrangement
WO2007104636A1 (en) 2006-03-10 2007-09-20 Novo Nordisk A/S An injection device and a method of changing a cartridge in the device
EP2004671B1 (de) 2006-03-30 2015-12-09 Novo Nordisk A/S Zwei-phasen fällung von proteinen
EP2005309B1 (de) 2006-03-30 2016-02-17 Valeritas, Inc. Flüssigkeitsausgabevorrichtung mit mehreren kartuschen
US7714025B2 (en) * 2006-05-10 2010-05-11 Arizona Biomedical Research Commission Modified chalcone compounds as antimitotic agents
WO2007132019A1 (en) 2006-05-16 2007-11-22 Novo Nordisk A/S A gearing mechanism for an injection device
AU2007253481B2 (en) 2006-05-18 2013-01-17 Novo Nordisk A/S An injection device with mode locking means
JP5230722B2 (ja) 2007-03-23 2013-07-10 ノボ・ノルデイスク・エー／エス ロックナットを備えた注射装置
PT2203181T (pt) 2007-10-16 2018-05-10 Biocon Ltd Uma composição farmacêutica sólida para administração por via oral e o seu processo de fabrico
CN102356075B (zh) 2009-01-23 2015-06-10 里格尔药品股份有限公司 抑制jak途径的组合物和方法
CN102770152B (zh) 2009-11-25 2016-07-06 阿瑞斯根股份有限公司 肽类的粘膜递送
RU2672100C2 (ru) 2010-07-28 2018-11-12 Райджел Фармасьютикалз, Инк. Композиции и способы ингибирования пути jak
JP6069351B2 (ja) 2011-12-29 2017-02-01 ノボ・ノルデイスク・エー／エス ダイアルアップ／ダイアルダウン投与機構を有するねじりバネ式ねじ巻き自動注射器
EP2828241B1 (de) 2012-03-23 2018-09-12 Mateon Therapeutics, Inc. Zusammensetzungen und verfahren zur hemmung von cathepsinen
US11206846B2 (en) 2017-05-02 2021-12-28 Leprino Foods Company High purity alpha lactalbumin and methods of making
MY200722A (en) 2017-09-26 2024-01-12 Biocon Biologics India Ltd Integrated automated filtration for separation, washing and drying of peptide crystals
US20220000880A1 (en) 2018-11-01 2022-01-06 Rigel Pharmaceuticals, Inc. Method and composition embodiments for treating acute myeloid leukemia
WO2020243612A1 (en) 2019-05-29 2020-12-03 Rigel Pharmaceuticals, Inc. Method of preventing and treating thrombosis
WO2021026451A1 (en) 2019-08-08 2021-02-11 Rigel Pharmaceuticals, Inc. Compounds and method for treating cytokine release syndrome
CN114286679A (zh) 2019-08-14 2022-04-05 里格尔药品股份有限公司 阻断或改善细胞因子释放综合征的方法
AU2023237737A1 (en) 2022-03-23 2024-10-03 Rigel Pharmaceuticals, Inc. Pyrimid-2-yl-pyrazole compounds as irak inhibitors

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1468831A (fr) * 1965-10-05 1967-02-10 Roussel Uclaf Procédé de préparation de nouveaux composés polypeptidiques et produits en résultant
DE1902865A1 (de) * 1968-02-01 1969-09-11 American Home Prod Substituierte Insulin-Derivate,Verfahren zu ihrer Herstellung und ihre Verwendung in pharmazeutischen Zubereitungen
US3591574A (en) * 1968-05-29 1971-07-06 American Home Prod Tri-n-phenylglycyl derivatives of insulin
US3528960A (en) * 1968-10-07 1970-09-15 Lilly Co Eli N-carboxyaroyl insulins
US3823125A (en) * 1969-10-14 1974-07-09 American Home Prod N-aminoacyl-substituted insulins
US3752798A (en) * 1969-12-02 1973-08-14 G Amird Tris-na1,nb1,nepsilonb29 - (3-x-3-oxo - 1-y-prop-1-en-1-yl)(ndelta-(4-z-6-r-pyrimidin - 2 - yl) ornithine b22)-insulins and their preparation
US3950517A (en) * 1970-05-08 1976-04-13 National Research Development Corporation Insulin derivatives
US3869437A (en) * 1970-05-08 1975-03-04 Nat Res Dev Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin
GB1381274A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
GB1381273A (en) * 1971-01-28 1975-01-22 Nat Res Dev Insulin derivatives
US3864325A (en) * 1971-11-18 1975-02-04 Nat Res Dev (N{HU Al{b , N{HU Bl{b , N{HU B29{B , carbamoyl)-(O{HU A14{B , O{HU B16{B , O{HU B26{B aryl) insulin derivatives
BE791949A (fr) * 1971-11-27 1973-05-28 Schering Ag Derives d'insuline, leur preparation et leur utilisation
US3843815A (en) * 1972-02-10 1974-10-22 Gen Foods Corp Inhibiting gel formation in meat-in-gravy products
US3755569A (en) * 1972-07-25 1973-08-28 American Home Prod Acyl substituted insulins
DE2252157C3 (de) * 1972-10-25 1976-03-18 Hoechst Ag Zwischenprodukte zur herstellung von insulin, insulin-analogen und -derivaten und verfahren zur herstellung von insulin, insulin analogen und derivaten
DE2253327A1 (de) * 1972-10-31 1974-05-09 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
NL7314766A (de) * 1972-10-31 1974-05-02
DE2428412A1 (de) * 1974-06-12 1976-01-15 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
DE2439296A1 (de) * 1974-08-16 1976-02-26 Hoechst Ag Verfahren zur herstellung von insulin, insulin-analogen und -derivaten
GB1492997A (en) * 1976-07-21 1977-11-23 Nat Res Dev Insulin derivatives
EP0014815A3 (de) * 1978-12-20 1980-10-29 Ciba-Geigy Ag Peptidderivate, Verfahren zu deren Herstellung und Zwischenprodukte sowie pharmazeutische Präparate mit einer dieser Verbindungen
US4486458A (en) * 1982-09-07 1984-12-04 A. E. Staley Manufacturing Company Non-gelling corn steep liquor
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
JPS6255096A (ja) * 1986-06-12 1987-03-10 Nippon Shinyaku Co Ltd 新規な脂肪酸アシル化合物
JPH01254699A (ja) * 1988-04-05 1989-10-11 Kodama Kk インスリン誘導体及びその用途
IL93282A (en) * 1989-02-09 1995-08-31 Lilly Co Eli Insulin analogues
AU8091091A (en) * 1990-07-26 1992-02-18 University Of Iowa Research Foundation, The Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule
US5304473A (en) * 1991-06-11 1994-04-19 Eli Lilly And Company A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
CA2150470A1 (en) * 1992-11-30 1994-06-09 S.P.I. Synthetic Peptides Incorporated Polyunsaturated fatty acyl-peptide composition

Also Published As

Publication number Publication date
NO975583L (no) 1997-12-03
HUP9900877A3 (en) 1999-11-29
DE69631996D1 (de) 2004-05-06
DK0747391T3 (da) 2004-07-19
BR9608729A (pt) 1999-06-29
EA199800042A1 (ru) 1998-08-27
ES2216039T3 (es) 2004-10-16
CZ388197A3 (cs) 1998-05-13
EP0747391A3 (de) 1997-05-21
EP0747391A2 (de) 1996-12-11
CN1192218A (zh) 1998-09-02
EP0747391B1 (de) 2004-03-31
JPH11506738A (ja) 1999-06-15
JP3844504B2 (ja) 2006-11-15
IL122460A0 (en) 1998-06-15
PL323994A1 (en) 1998-04-27
NO975583D0 (no) 1997-12-03
WO1996040730A1 (en) 1996-12-19
AU5951396A (en) 1996-12-30
NZ309371A (en) 1999-09-29
MX9709657A (es) 1998-07-31
CA2223389A1 (en) 1996-12-19
US5700904A (en) 1997-12-23
HUP9900877A2 (hu) 1999-07-28
AU703032B2 (en) 1999-03-11
DE69631996T2 (de) 2005-01-27
KR19990022590A (ko) 1999-03-25
TR199701528T1 (xx) 1998-03-21

Similar Documents

Publication Publication Date Title
ATE263185T1 (de) Verfahren zur herstellung von acylierten proteinpuder
ATE195076T1 (de) Verfahren zur isolierung von haemopnilus influenzae protein-e
DE69941991D1 (de) Verfahren zur Herstellung von L-Aminosäure
IN181859B (de)
ATE138923T1 (de) Verfahren zur herstellung gereinigter glycolipide durch membrantrennverfahren
DE59609855D1 (de) Verfahren zur herstellung wässriger chlordioxid-lösungen
DE58905750D1 (de) Verfahren zur herstellung von konzentrierten fliessfaehigen waessrigen loesungen von betainen.
DE60125218D1 (de) Verfahren zur herstellung von humanem serumalbumin unter verwendung eines aufwarmschrittes
DE69403210D1 (de) Verfahren zur herstellung von n-acetylneuraminsäure
DE69316207D1 (de) Verfahren zur herstellung eines molkenproteinhydrolysates und hydrolysat
ATE129126T1 (de) Verfahren zur herstellung eines wässrigen viehfutterzusatzes und derart hergestellter futterzusatz.
DE69120946D1 (de) Co-hydrolytsches verfahren zur herstellung von extrakten aus hefe und nicht-hefe proteinen
ATE119886T1 (de) Verfahren zur herstellung von allantoin.
DE68917924D1 (de) Verfahren zur herstellung von wasserfreiem oxim aus wässrigen lösungen.
DE69003247D1 (de) Verfahren zur herstellung von glyoxylsäure durch enzymatische oxydation von glykolsäure.
ATE140366T1 (de) Verfahren zur herstellung von eines pflanzliches eiweisshydrolysat
ATE215784T1 (de) Verfahren zur herstellung eines kappa-casein- glykomakropeptides oder eines abkoemmlings davon
DE3673762D1 (de) Verfahren zur herstellung eines ammoniak-komplexes von zink-bis-dithiocarbamat.
ATA207094A (de) Verfahren zur herstellung von xanthangummi durch fermentation
DE3688201D1 (de) Verfahren zur herstellung von waessrigen loesungen von polysacchariden.
ATE307493T1 (de) Verfahren zur herstellung eines hochgereinigten pflanzlichen proteins mit niedriger ribonukleinsäure- konzentration
ATE377002T1 (de) Verfahren zur herstellung von 2- halogennikotinsäurederivaten und 2- chlornikotinsäure-n-butylester als zwischenprodukt
DE3670216D1 (de) Verfahren zur erzeugung von kugelfoermigen koerpern durch selektive agglomeration.
ATA70095A (de) Verfahren zur entkieselung von wässrigen, sauren, vorzugsweise salzsauren lösungen sowie herstellung von kieselsäurearmen metalloxid
DE59000542D1 (de) Verfahren zur herstellung kaeltestabiler alkanolisch-waessriger loesungen von polyethersulfonaten.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties