ATE250424T1 - Zusammensetzungen und verfahren zur anregung des wachstums von neuriten - Google Patents

Zusammensetzungen und verfahren zur anregung des wachstums von neuriten

Info

Publication number
ATE250424T1
ATE250424T1 AT97947533T AT97947533T ATE250424T1 AT E250424 T1 ATE250424 T1 AT E250424T1 AT 97947533 T AT97947533 T AT 97947533T AT 97947533 T AT97947533 T AT 97947533T AT E250424 T1 ATE250424 T1 AT E250424T1
Authority
AT
Austria
Prior art keywords
stimulating
compositions
methods
neurites growth
neurites
Prior art date
Application number
AT97947533T
Other languages
German (de)
English (en)
Inventor
Robert E Zelle
Michael Su
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25009484&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE250424(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE250424T1 publication Critical patent/ATE250424T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Psychology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT97947533T 1996-11-13 1997-11-13 Zusammensetzungen und verfahren zur anregung des wachstums von neuriten ATE250424T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/748,447 US5840736A (en) 1996-11-13 1996-11-13 Methods and compositions for stimulating neurite growth
PCT/US1997/020866 WO1998020891A1 (en) 1996-11-13 1997-11-13 Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors

Publications (1)

Publication Number Publication Date
ATE250424T1 true ATE250424T1 (de) 2003-10-15

Family

ID=25009484

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97947533T ATE250424T1 (de) 1996-11-13 1997-11-13 Zusammensetzungen und verfahren zur anregung des wachstums von neuriten

Country Status (32)

Country Link
US (3) US5840736A (forum.php)
EP (1) EP0946190B1 (forum.php)
JP (1) JP2001504470A (forum.php)
KR (1) KR100544451B1 (forum.php)
CN (1) CN1168442C (forum.php)
AP (1) AP9901518A0 (forum.php)
AR (1) AR011278A1 (forum.php)
AT (1) ATE250424T1 (forum.php)
AU (1) AU724833B2 (forum.php)
BG (1) BG64670B1 (forum.php)
BR (1) BR9712765A (forum.php)
CA (1) CA2270634A1 (forum.php)
CO (1) CO4930260A1 (forum.php)
CZ (1) CZ296058B6 (forum.php)
DE (1) DE69725169T2 (forum.php)
DK (1) DK0946190T3 (forum.php)
EA (1) EA004247B1 (forum.php)
ES (1) ES2206753T3 (forum.php)
HU (1) HU226728B1 (forum.php)
IL (1) IL129555A (forum.php)
IN (1) IN183740B (forum.php)
IS (1) IS2057B (forum.php)
NO (1) NO328030B1 (forum.php)
NZ (1) NZ335394A (forum.php)
PL (1) PL190903B1 (forum.php)
PT (1) PT946190E (forum.php)
SK (1) SK284535B6 (forum.php)
TR (1) TR199901034T2 (forum.php)
TW (1) TW513302B (forum.php)
UA (1) UA63926C2 (forum.php)
WO (1) WO1998020891A1 (forum.php)
ZA (1) ZA9710256B (forum.php)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859031A (en) 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5780484A (en) * 1996-11-13 1998-07-14 Vertex Pharmaceuticals Incorporated Methods for stimulating neurite growth with piperidine compounds
US6242468B1 (en) 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
US6514686B2 (en) 1997-04-28 2003-02-04 The University Of British Columbia Method and composition for modulating amyloidosis
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US20010049381A1 (en) 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
US6852496B1 (en) 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
US5968921A (en) * 1997-10-24 1999-10-19 Orgegon Health Sciences University Compositions and methods for promoting nerve regeneration
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
AU1708099A (en) 1998-06-03 1999-12-20 Amgen, Inc. N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres
CN1318067A (zh) 1998-07-17 2001-10-17 阿古龙制药有限公司 用于刺激神经元生长和延伸的化合物、组合物和方法
GB9815880D0 (en) 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
US6395758B1 (en) 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US6218423B1 (en) 1998-08-14 2001-04-17 Gpi Nil Holdings, Inc. Pyrrolidine derivatives for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
US6228872B1 (en) * 1998-11-12 2001-05-08 Bristol-Myers Squibb Company Neurotrophic diamide and carbamate agents
DE69923998T2 (de) * 1998-12-09 2006-04-27 Chiron Corp., Emeryville Verwendung eines neurologischen wirkstoffes zur herstellung eines medikamentes zur behandlung von erkrankungen des zentralen nervensystems
JP2002534414A (ja) * 1999-01-08 2002-10-15 バーテックス ファーマシューティカルズ インコーポレイテッド 医薬の製造に有用な中間体の形成方法
WO2001002368A1 (en) * 1999-07-06 2001-01-11 Vertex Pharmaceuticals Incorporated N-heterocyclic derivatives with neuronal activity
US6734211B1 (en) 1999-07-09 2004-05-11 Oregon Health & Sciences University Compositions and methods for promoting nerve regeneration
NZ516888A (en) * 1999-07-30 2004-02-27 Vertex Pharma Acyclic and cyclic amine derivatives
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
BR0015486A (pt) * 1999-11-12 2002-07-02 Alcon Inc Ligandos de neurofilina para tratamento de condições oculares
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US6818643B1 (en) 1999-12-08 2004-11-16 Bristol-Myers Squibb Company Neurotrophic bicyclic diamides
US7060676B2 (en) 1999-12-20 2006-06-13 Trustees Of Tufts College T. cruzi-derived neurotrophic agents and methods of use therefor
WO2001046195A1 (en) 1999-12-21 2001-06-28 Gpi Nil Holdings, Inc. Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same
US6555573B2 (en) 2000-12-21 2003-04-29 The Quigley Corporation Method and composition for the topical treatment of diabetic neuropathy
DK1575477T3 (da) * 2001-05-25 2012-07-23 Cornell Res Foundation Inc Højaffinitetsligand til p75-neurotrofinreceptor
JP2005500270A (ja) * 2001-05-29 2005-01-06 ギルフォード ファーマシュウティカルズ インコーポレイテッド 手術の結果として発生した神経損傷を治療するための方法
FR2825273B1 (fr) * 2001-05-29 2006-11-24 Oreal Composition pour le traitement des signes cutanes du vieillissement
US7435725B2 (en) * 2001-11-06 2008-10-14 The Quigly Corporation Oral compositions and methods for prevention, reduction and treatment of radiation injury
US20030105027A1 (en) * 2001-11-06 2003-06-05 Rosenbloom Richard A. Nutritional supplements and methods for prevention, reduction and treatment of radiation injury
US20030118536A1 (en) * 2001-11-06 2003-06-26 Rosenbloom Richard A. Topical compositions and methods for treatment of adverse effects of ionizing radiation
AU2002363800A1 (en) * 2001-11-13 2003-05-26 Loi Tran Therapeutic agent composition and method of use
US20100247483A1 (en) * 2001-11-13 2010-09-30 Tran Loi H Therapeutic agent composition and method of use
US7232798B2 (en) 2001-11-13 2007-06-19 Tran Loi H Neuroprotection and neuroegenisis by administering cyclic prolyl glycine
US7083813B2 (en) * 2002-11-06 2006-08-01 The Quigley Corporation Methods for the treatment of peripheral neural and vascular ailments
US8841326B2 (en) 2004-02-12 2014-09-23 Stc.Unm Therapeutic curcumin derivatives
JP2009525319A (ja) * 2006-02-02 2009-07-09 ライナット ニューロサイエンス コーポレイション ｔｒｋＢアンタゴニストを投与することにより肥満を治療する方法
CN101400367A (zh) * 2006-02-02 2009-04-01 瑞纳神经科学公司 施用trkb激动剂治疗不希望的重量减轻或进食障碍的方法
CN101605556A (zh) * 2006-12-20 2009-12-16 瑞纳神经科学公司 治疗自体免疫疾病的trkb激动剂
US20090018151A1 (en) * 2007-02-23 2009-01-15 Ezekiel Fink Topical Treatment of Peripheral diabetic complications
JP7699378B2 (ja) 2018-05-15 2025-06-27 ハン ロイ トラン ロイド 軽度の認知障害、抑うつ、および精神障害の治療のための治療薬組成物およびその使用方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5798355A (en) 1995-06-07 1998-08-25 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity
US5543423A (en) * 1994-11-16 1996-08-06 Vertex Pharmaceuticals, Incorporated Amino acid derivatives with improved multi-drug resistance activity
IL115685A (en) * 1994-11-16 2000-08-31 Vertex Pharma Amino acid derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
US5696135A (en) * 1995-06-07 1997-12-09 Gpi Nil Holdings, Inc. Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
US6037370A (en) * 1995-06-08 2000-03-14 Vertex Pharmaceuticals Incorporated Methods and compositions for stimulating neurite growth
US5801197A (en) * 1995-10-31 1998-09-01 Gpi Nil Holdings, Inc. Rotamase enzyme activity inhibitors
US5811434A (en) * 1996-11-13 1998-09-22 Vertex Pharmacueticals Incorporated Methods and compositions for stimulating neurite growth
US9604852B2 (en) * 2012-09-28 2017-03-28 Dic Corporation α-alumina particles and method for manufacturing the same

Also Published As

Publication number Publication date
AP9901518A0 (en) 1999-06-30
IS2057B (is) 2005-10-14
DK0946190T3 (da) 2003-12-08
IL129555A (en) 2005-08-31
ZA9710256B (en) 1998-05-28
PT946190E (pt) 2004-02-27
WO1998020891A1 (en) 1998-05-22
US6284778B1 (en) 2001-09-04
IS5032A (is) 1999-04-21
JP2001504470A (ja) 2001-04-03
UA63926C2 (uk) 2004-02-16
SK284535B6 (sk) 2005-06-02
AU724833B2 (en) 2000-09-28
EP0946190B1 (en) 2003-09-24
BG64670B1 (bg) 2005-11-30
AU5258998A (en) 1998-06-03
AR011278A1 (es) 2000-08-16
NZ335394A (en) 2000-06-23
HK1022851A1 (en) 2000-08-25
KR100544451B1 (ko) 2006-01-24
KR20000068962A (ko) 2000-11-25
TW513302B (en) 2002-12-11
DE69725169D1 (de) 2003-10-30
IN183740B (forum.php) 2000-04-01
CA2270634A1 (en) 1998-05-22
BR9712765A (pt) 1999-10-26
PL333270A1 (en) 1999-11-22
IL129555A0 (en) 2000-02-29
NO992138D0 (no) 1999-05-03
HUP0001219A3 (en) 2001-12-28
CZ296058B6 (cs) 2006-01-11
PL190903B1 (pl) 2006-02-28
US6172086B1 (en) 2001-01-09
CN1239433A (zh) 1999-12-22
EP0946190A1 (en) 1999-10-06
US5840736A (en) 1998-11-24
HUP0001219A2 (hu) 2000-11-28
ES2206753T3 (es) 2004-05-16
EA004247B1 (ru) 2004-02-26
NO328030B1 (no) 2009-11-16
DE69725169T2 (de) 2004-07-15
EA199900464A1 (ru) 2000-02-28
NO992138L (no) 1999-07-13
SK62899A3 (en) 2000-04-10
HU226728B1 (en) 2009-08-28
CN1168442C (zh) 2004-09-29
TR199901034T2 (xx) 1999-07-21
CO4930260A1 (es) 2000-06-27
BG103429A (en) 2000-04-28
CZ168399A3 (cs) 1999-08-11

Similar Documents

Publication Publication Date Title
ATE250424T1 (de) Zusammensetzungen und verfahren zur anregung des wachstums von neuriten
DE69726289D1 (de) Verfahren und zusammensetzung zur behandlung von substraten bezüglich benetzbarkeit
DE69431714D1 (de) Verfahren und zusammensetzung zur verdauung von gewebe
DE69824312D1 (de) Verfahren und gerät zur beendigung von tachyarrhythmien
EP1006796A4 (en) COMPOSITIONS AND METHODS FOR ADMINISTERING BORRELIA DNA
ATE351910T1 (de) Ob-fusionsprotein enthaltende zusammensetzungen und verfahren
DE69700398D1 (de) Verfahren und Vorrichtungen zur Steuerung von Geruchsreizen
DE69519235D1 (de) Hämorrhoidenzusammensetzungen und verfahren zur verwendung
ATE233049T1 (de) Zusammensetzung und verfahren zur kontrolle von schädlichen bio-organismen
EP0929663A4 (en) METHOD FOR INCREASING GROWTH AND YIELD OF PLANTS
DE69820997D1 (de) Zusammensetzungen und verfahren zur behandlung des erhöhten augenindruckes
DE69535674D1 (de) Verfahren zur herstellung von l-valin und l-leucin
DE69725661D1 (de) Verfahren und gerät zur herstellung von nähfaden-nadel-zusammensetzung
DE69807538D1 (de) Vorrichtung und Verfahren zur Behandlung von Gewebe
DE69714828D1 (de) Verfahren zur Behandlung von Abfallstoffen
DE69810416D1 (de) Verfahren und Vorrichtung zur Verbesserung der Verpflanzung von Sämlingen
DE3860919D1 (de) Verbesserte detergens-bleichmittelzusammensetzung und verfahren zur reinigung von geweben.
DE69721322D1 (de) Zusammensetzung und verfahren zur keimungshemmung bei kartoffeln
DE69602847D1 (de) Tuberkilizide synergistische desinfizierende zusammensetzung und verfahren zur desinfektion
DE69613063D1 (de) Zusammensetzungen und Verfahren zur Wirkungsverstärkung von Antibiotika mit Polyphenolen
EP1109548A4 (en) Compositions and methods for treating and preventing bone diseases using tocotrienols
DE69812784D1 (de) Zusammensetzung zur Vorbeugung und Beseitigung von Pflanzenkrankheiten
DE69717675D1 (de) Verfahren und einrichtung zur kurzzeitigen trocknung von tabak
DE69735709D1 (de) Zusammensetzung und verfahren zur sanierung von zemenhaltigen materialien
DE69715922D1 (de) Verfahren und einrichtung zur behandlung von tabak

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0946190

Country of ref document: EP

REN Ceased due to non-payment of the annual fee