ATE229940T1 - 3-spiro-indolin-2-onderivate als liganden der vasopressin und/oder der ocytocin rezeptoren - Google Patents
3-spiro-indolin-2-onderivate als liganden der vasopressin und/oder der ocytocin rezeptorenInfo
- Publication number
- ATE229940T1 ATE229940T1 AT96934967T AT96934967T ATE229940T1 AT E229940 T1 ATE229940 T1 AT E229940T1 AT 96934967 T AT96934967 T AT 96934967T AT 96934967 T AT96934967 T AT 96934967T AT E229940 T1 ATE229940 T1 AT E229940T1
- Authority
- AT
- Austria
- Prior art keywords
- indolin
- vasopressin
- spiro
- ligands
- derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/96—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9512533A FR2740136B1 (fr) | 1995-10-24 | 1995-10-24 | Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant |
PCT/FR1996/001666 WO1997015556A1 (fr) | 1995-10-24 | 1996-10-24 | Derives 3-spiro-indolin-2-one comme ligands des recepteurs de la vasopressine et/ou de l'ocytocine |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE229940T1 true ATE229940T1 (de) | 2003-01-15 |
Family
ID=9483867
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96934967T ATE229940T1 (de) | 1995-10-24 | 1996-10-24 | 3-spiro-indolin-2-onderivate als liganden der vasopressin und/oder der ocytocin rezeptoren |
Country Status (31)
Country | Link |
---|---|
US (2) | US5994350A (de) |
EP (1) | EP0873309B1 (de) |
JP (2) | JP3274471B2 (de) |
KR (1) | KR100298925B1 (de) |
CN (1) | CN1106384C (de) |
AR (1) | AR004225A1 (de) |
AT (1) | ATE229940T1 (de) |
AU (1) | AU715841B2 (de) |
BR (1) | BR9611198A (de) |
CZ (1) | CZ295585B6 (de) |
DE (1) | DE69625517T2 (de) |
DK (1) | DK0873309T3 (de) |
EE (1) | EE04433B1 (de) |
ES (1) | ES2191769T3 (de) |
FR (1) | FR2740136B1 (de) |
HK (1) | HK1016596A1 (de) |
HU (1) | HUP9900331A3 (de) |
IL (1) | IL124002A (de) |
IN (1) | IN185328B (de) |
IS (1) | IS1949B (de) |
MY (1) | MY115864A (de) |
NO (1) | NO310974B1 (de) |
NZ (1) | NZ320352A (de) |
PL (1) | PL187093B1 (de) |
RU (1) | RU2167864C2 (de) |
SK (1) | SK284546B6 (de) |
TR (1) | TR199800719T2 (de) |
TW (1) | TW474917B (de) |
UA (1) | UA59345C2 (de) |
WO (1) | WO1997015556A1 (de) |
ZA (1) | ZA968945B (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2757157B1 (fr) * | 1996-12-13 | 1999-12-31 | Sanofi Sa | Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant |
FR2775598A1 (fr) | 1998-03-06 | 1999-09-10 | Sanofi Sa | Compositions pharmaceutiques contenant en association un antagoniste selectif des recepteurs v1a de l'arginine-vasopressine et un antagoniste selectif des recepteur v2 de l'arginine-vasopressine |
FR2778103A1 (fr) * | 1998-04-29 | 1999-11-05 | Sanofi Sa | Compositions pharmaceutiques contenant en association un antagoniste v1a de l'arginine-vasopressine et un antagoniste des recepteurs at1 de l'angiotensine ii |
HU225703B1 (en) * | 1999-07-15 | 2007-06-28 | Sanofi Aventis | Process for producing spiro[cis-4-(betha-hydroxy-ethyloxi)-cyclohexane-[3h]indole]-2'[1'h]-one derivatives |
HU225150B1 (en) * | 1999-07-15 | 2006-07-28 | Sanofi Aventis | Novel process for producing 2-methoxy-4-(t-butylaminocarbonyl)-benzenesulfonyl chloride |
HUP9902376A3 (en) | 1999-07-15 | 2002-11-28 | Sanofi Aventis | Process for producing n-(1,1-dimethyl)-4-[[s'-ethoxi-4-cis-[2-(4-morpholino)-ethoxi]-2'-oxospiro[cyclohexane-1,3'-[3h]indole]-1'(2'h)yl]-sulfonyl]-3-methoxybenzamide and its salts |
HUP9902374A3 (en) * | 1999-07-15 | 2002-11-28 | Sanofi Aventis | Process for producing spiro[(4-cyclohexanone)-[3h]indol-2'[1'h]-on derivatives and intermediates |
US20030103983A1 (en) * | 2002-05-09 | 2003-06-05 | Pressler Milton Lethan | Ace inhibitor-vasopressin antagonist combinations |
CA2425892A1 (en) * | 2000-11-28 | 2003-04-11 | Hiroyuki Koshio | 1,4,5,6-tetrahydroimidazo[4,5-d]diazepine derivative or salt thereof |
AU2002231098A1 (en) * | 2000-12-15 | 2002-06-24 | Emory University | Nonpeptide agonists and antagonists of vasopressin receptors |
AU2002247127A1 (en) * | 2001-02-14 | 2002-08-28 | Duke University | Therapy for cerebral vasospasm |
EP1421064B1 (de) * | 2001-07-31 | 2005-05-11 | Sanofi-Aventis | Verfahren zur herstellung von 3 spiro'cyclohexan-1,3'-'3h!indolin-2'-on!derivaten |
US7517899B2 (en) | 2004-03-30 | 2009-04-14 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
US7414052B2 (en) | 2004-03-30 | 2008-08-19 | Wyeth | Phenylaminopropanol derivatives and methods of their use |
PL1750862T3 (pl) | 2004-06-04 | 2011-06-30 | Teva Pharma | Kompozycja farmaceutyczna zawierająca irbesartan |
FR2874921B1 (fr) * | 2004-09-09 | 2006-10-20 | Sanofi Aventis Sa | Derives de 3-spiro-indolin-2-one, leur preparation et leur application en therapeutique |
FR2874920B1 (fr) * | 2004-09-09 | 2006-10-20 | Sanofi Aventis Sa | Derives de 3-spiro-indolin-2-one comme ligand des recepteurs de la vasopressine |
MX2007007103A (es) * | 2004-12-13 | 2008-03-10 | Lilly Co Eli | Derivados espiro como inhibidores de lipoxigenasa. |
CA2593044A1 (en) * | 2004-12-31 | 2006-07-13 | Abbott Gmbh & Co. Kg | Substituted oxindole derivatives, medicaments containing said derivatives and use thereof |
DE102005014936A1 (de) * | 2005-03-24 | 2006-12-14 | Abbott Gmbh & Co. Kg | Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung |
AR056968A1 (es) * | 2005-04-11 | 2007-11-07 | Xenon Pharmaceuticals Inc | Compuestos espiro-oxindol y composiciones farmacéuticas |
AR053710A1 (es) * | 2005-04-11 | 2007-05-16 | Xenon Pharmaceuticals Inc | Compuestos espiroheterociclicos y sus usos como agentes terapeuticos |
AR056317A1 (es) * | 2005-04-20 | 2007-10-03 | Xenon Pharmaceuticals Inc | Compuestos de oxindol y composicion farmaceutica |
CL2007002953A1 (es) * | 2006-10-12 | 2008-02-01 | Xenon Pharmaceuticals Inc | Compuestos derivados de espiro-oxindol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento del dolor, cancer, prurito, hiperplasia prostatica benigna, hipercolesterolemia. |
TW200833695A (en) * | 2006-10-12 | 2008-08-16 | Xenon Pharmaceuticals Inc | Use of spiro-oxindole compounds as therapeutic agents |
CN101522685A (zh) * | 2006-10-12 | 2009-09-02 | 泽农医药公司 | 三环螺-吲哚酮衍生物及其作为治疗剂的用途 |
FR2927625B1 (fr) | 2008-02-19 | 2010-03-12 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique |
US7723372B2 (en) | 2008-03-19 | 2010-05-25 | Hoffman-La Roche Inc. | Spiroindolinone derivatives |
FR2930249B1 (fr) | 2008-04-21 | 2010-05-14 | Sanofi Aventis | Nouveaux derives de 3-aminoalkyl-1,3-dihydro-2h-indol-2-one, leur preparation et leur application en therapeutique. |
JP5570172B2 (ja) * | 2008-10-08 | 2014-08-13 | 持田製薬株式会社 | 喫煙による循環機能不全の予防/改善または治療剤 |
RU2011119626A (ru) * | 2008-10-17 | 2012-11-27 | Ксенон Фармасьютикалз Инк. | Спирооксиндольные соединения и их применение в качестве терапевтичеких средств |
US8101647B2 (en) | 2008-10-17 | 2012-01-24 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
EP2488531B1 (de) | 2009-10-14 | 2014-03-26 | Xenon Pharmaceuticals Inc. | Verfahren zur herstellung von spiro-oxindol derivaten |
WO2011047173A2 (en) * | 2009-10-14 | 2011-04-21 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions for oral administration |
US8088815B2 (en) | 2009-12-02 | 2012-01-03 | Hoffman-La Roche Inc. | Spiroindolinone pyrrolidines |
US8288431B2 (en) | 2010-02-17 | 2012-10-16 | Hoffmann-La Roche Inc. | Substituted spiroindolinones |
WO2011106729A2 (en) | 2010-02-26 | 2011-09-01 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
US8217044B2 (en) | 2010-04-28 | 2012-07-10 | Hoffmann-La Roche Inc. | Spiroindolinone pyrrolidines |
MD4202C1 (ro) * | 2012-03-21 | 2013-09-30 | Институт Химии Академии Наук Молдовы | Procedeu de obţinere a derivaţilor carbometoxi ai spiro[ciclopropan-oxindolilor] |
MD4201C1 (ro) * | 2012-03-21 | 2013-09-30 | Институт Химии Академии Наук Молдовы | Procedeu de obţinere a derivaţilor carbonitrilici ai spiro[ciclopropan-oxindolilor] |
MX2015011722A (es) * | 2013-03-08 | 2015-12-03 | Wockhardt Ltd | Proceso para la preparacion de (2s, 5r)-7-oxo-6-sulfooxi-2-[((3r)- piperidin-3-carbonil)carbonil hidrazino]-1,6-diaza-biciclo[3.2.1] octano. |
WO2016127068A1 (en) | 2015-02-05 | 2016-08-11 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
TW201938171A (zh) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | 作為血管升壓素V1a受體拮抗劑之三環化合物 |
HU231206B1 (hu) | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepinek |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
US5663431A (en) * | 1992-01-30 | 1997-09-02 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
FR2686878B1 (fr) * | 1992-01-30 | 1995-06-30 | Sanofi Elf | Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant. |
US5686624A (en) * | 1992-01-30 | 1997-11-11 | Sanofi | 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present |
FR2708606B1 (fr) * | 1993-07-30 | 1995-10-27 | Sanofi Sa | Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
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1995
- 1995-10-24 FR FR9512533A patent/FR2740136B1/fr not_active Expired - Fee Related
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1996
- 1996-10-22 TW TW085112955A patent/TW474917B/zh not_active IP Right Cessation
- 1996-10-23 IN IN2288DE1996 patent/IN185328B/en unknown
- 1996-10-23 MY MYPI96004404A patent/MY115864A/en unknown
- 1996-10-23 AR ARP960104863A patent/AR004225A1/es active IP Right Grant
- 1996-10-24 ES ES96934967T patent/ES2191769T3/es not_active Expired - Lifetime
- 1996-10-24 NZ NZ320352A patent/NZ320352A/xx not_active IP Right Cessation
- 1996-10-24 PL PL96326555A patent/PL187093B1/pl not_active IP Right Cessation
- 1996-10-24 AT AT96934967T patent/ATE229940T1/de active
- 1996-10-24 IL IL12400296A patent/IL124002A/en not_active IP Right Cessation
- 1996-10-24 US US09/051,900 patent/US5994350A/en not_active Expired - Lifetime
- 1996-10-24 EP EP96934967A patent/EP0873309B1/de not_active Expired - Lifetime
- 1996-10-24 HU HU9900331A patent/HUP9900331A3/hu unknown
- 1996-10-24 CN CN96198579A patent/CN1106384C/zh not_active Expired - Fee Related
- 1996-10-24 TR TR1998/00719T patent/TR199800719T2/xx unknown
- 1996-10-24 DE DE69625517T patent/DE69625517T2/de not_active Expired - Lifetime
- 1996-10-24 CZ CZ19981267A patent/CZ295585B6/cs not_active IP Right Cessation
- 1996-10-24 UA UA98042064A patent/UA59345C2/uk unknown
- 1996-10-24 SK SK490-98A patent/SK284546B6/sk not_active IP Right Cessation
- 1996-10-24 RU RU98109945/04A patent/RU2167864C2/ru not_active IP Right Cessation
- 1996-10-24 DK DK96934967T patent/DK0873309T3/da active
- 1996-10-24 AU AU73080/96A patent/AU715841B2/en not_active Ceased
- 1996-10-24 BR BR9611198A patent/BR9611198A/pt not_active IP Right Cessation
- 1996-10-24 ZA ZA968945A patent/ZA968945B/xx unknown
- 1996-10-24 WO PCT/FR1996/001666 patent/WO1997015556A1/fr active IP Right Grant
- 1996-10-24 KR KR1019980702996A patent/KR100298925B1/ko not_active IP Right Cessation
- 1996-10-24 JP JP51636397A patent/JP3274471B2/ja not_active Expired - Fee Related
- 1996-10-24 EE EE9800151A patent/EE04433B1/xx not_active IP Right Cessation
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1998
- 1998-04-14 IS IS4714A patent/IS1949B/is unknown
- 1998-04-23 NO NO19981817A patent/NO310974B1/no not_active IP Right Cessation
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1999
- 1999-04-14 HK HK99101588A patent/HK1016596A1/xx not_active IP Right Cessation
- 1999-10-12 US US09/417,190 patent/US6046341A/en not_active Expired - Lifetime
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2001
- 2001-03-16 JP JP2001075467A patent/JP2001302631A/ja active Pending
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