MD4202C1 - Procedeu de obţinere a derivaţilor carbometoxi ai spiro[ciclopropan-oxindolilor] - Google Patents

Procedeu de obţinere a derivaţilor carbometoxi ai spiro[ciclopropan-oxindolilor]

Info

Publication number
MD4202C1
MD4202C1 MDA20120031A MD20120031A MD4202C1 MD 4202 C1 MD4202 C1 MD 4202C1 MD A20120031 A MDA20120031 A MD A20120031A MD 20120031 A MD20120031 A MD 20120031A MD 4202 C1 MD4202 C1 MD 4202C1
Authority
MD
Moldova
Prior art keywords
oxindoles
cyclopropane
spiro
carbomethoxy
derivatives
Prior art date
Application number
MDA20120031A
Other languages
English (en)
Russian (ru)
Other versions
MD4202B1 (ro
Inventor
Наталия СУКМАН
Флюр МАКАЕВ
Original Assignee
Институт Химии Академии Наук Молдовы
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Институт Химии Академии Наук Молдовы filed Critical Институт Химии Академии Наук Молдовы
Priority to MDA20120031A priority Critical patent/MD4202C1/ro
Publication of MD4202B1 publication Critical patent/MD4202B1/ro
Publication of MD4202C1 publication Critical patent/MD4202C1/ro

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  • Indole Compounds (AREA)

Abstract

Invenţia se referă la sinteza spiro[ciclopropan-oxindolilor] funcţionalizaţi cu grupa carbometoxică, care pot servi ca precursori în sinteza substanţelor cu activitate anti-HIV.Procedeul include reacţia de ciclopropanare a diazoizatinelor cu metilacrilat, care este utilizat atât în calitate de reagent, cât şi de solvent la temperatura lui de fierbere.Procedeul propus permite efectuarea reacţiei într-un timp mai scurt cu randamente înalte, fără utilizarea catalizatorilor şi a atmosferei inerte.
MDA20120031A 2012-03-21 2012-03-21 Procedeu de obţinere a derivaţilor carbometoxi ai spiro[ciclopropan-oxindolilor] MD4202C1 (ro)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20120031A MD4202C1 (ro) 2012-03-21 2012-03-21 Procedeu de obţinere a derivaţilor carbometoxi ai spiro[ciclopropan-oxindolilor]

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20120031A MD4202C1 (ro) 2012-03-21 2012-03-21 Procedeu de obţinere a derivaţilor carbometoxi ai spiro[ciclopropan-oxindolilor]

Publications (2)

Publication Number Publication Date
MD4202B1 MD4202B1 (ro) 2013-02-28
MD4202C1 true MD4202C1 (ro) 2013-09-30

Family

ID=47831223

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20120031A MD4202C1 (ro) 2012-03-21 2012-03-21 Procedeu de obţinere a derivaţilor carbometoxi ai spiro[ciclopropan-oxindolilor]

Country Status (1)

Country Link
MD (1) MD4202C1 (ro)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57102863A (en) * 1980-12-16 1982-06-26 Takeda Chem Ind Ltd Spiroindolinone and its preparation
US6046341A (en) * 1995-10-24 2000-04-04 Sanofi-Synthelabo 3-spiro-indolin-2-one derivatives
WO2004037247A1 (en) * 2002-10-21 2004-05-06 Irm Llc Oxindoles with anti-hiv activity
US20050015776A1 (en) * 2003-06-02 2005-01-20 Bimal Mehta Processing convoy workflow scenarios
WO2007008664A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. 3-spir0cycl0pr0pyl2-0xind0le kinase inhibitors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57102863A (en) * 1980-12-16 1982-06-26 Takeda Chem Ind Ltd Spiroindolinone and its preparation
US6046341A (en) * 1995-10-24 2000-04-04 Sanofi-Synthelabo 3-spiro-indolin-2-one derivatives
WO2004037247A1 (en) * 2002-10-21 2004-05-06 Irm Llc Oxindoles with anti-hiv activity
US20050015776A1 (en) * 2003-06-02 2005-01-20 Bimal Mehta Processing convoy workflow scenarios
WO2007008664A1 (en) * 2005-07-13 2007-01-18 Allergan, Inc. 3-spir0cycl0pr0pyl2-0xind0le kinase inhibitors

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Cava M.P., Litle R.L., Napier D.R. J. Amer. Chem. Soc., 1958, 80, 2257-2262 *
Chen S., Ma J., Wang J. Tetrahedron Lett., 2008, 49, 6781-6783 *
Jiang T., Kuhen K. L., Wolff K., Yin H., Bieza K., Caldwell J., Bursulaya B., Tuntland T., Zhang K., Karanewsky D., He Y. Bioorganic & Medicinal Chemistry Letters, 2006, 16, 2109-2112 *
Jiang T., Kuhen K. L., Wolff K., Yin H., Bieza K., Caldwell J., Bursulaya B., Wu T. Y. H., He Y. Bioorganic & Medicinal Chemistry Letters, 2006, 16, 2105-2108 *
Kumari G., Nutan I., Modi M., Gupta S. K., Singh R. K. Eur. J. Med. Chem., 2011, 46, 1181-1188 *
Marti C., Carreira E.M. J. Am. Chem. Soc., 2005, 127, 11505-11515 *

Also Published As

Publication number Publication date
MD4202B1 (ro) 2013-02-28

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FG4A Patent for invention issued
KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
MM4A Patent for invention definitely lapsed due to non-payment of fees