ATE210651T1 - Benzamidanaloga zur verwendung als parp- (adp- ribosyltransferase, adprt) dns-reparaturenzym inhibitoren - Google Patents
Benzamidanaloga zur verwendung als parp- (adp- ribosyltransferase, adprt) dns-reparaturenzym inhibitorenInfo
- Publication number
- ATE210651T1 ATE210651T1 AT98202102T AT98202102T ATE210651T1 AT E210651 T1 ATE210651 T1 AT E210651T1 AT 98202102 T AT98202102 T AT 98202102T AT 98202102 T AT98202102 T AT 98202102T AT E210651 T1 ATE210651 T1 AT E210651T1
- Authority
- AT
- Austria
- Prior art keywords
- adp
- parp
- dna repair
- repair enzyme
- adprt
- Prior art date
Links
- 102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 title abstract 3
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 title abstract 3
- 102000011724 DNA Repair Enzymes Human genes 0.000 title abstract 2
- 108010076525 DNA Repair Enzymes Proteins 0.000 title abstract 2
- 102000009062 ADP Ribose Transferases Human genes 0.000 title 2
- 108010049290 ADP Ribose Transferases Proteins 0.000 title 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical class NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 title 1
- 239000002532 enzyme inhibitor Substances 0.000 title 1
- AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical class C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 230000003389 potentiating effect Effects 0.000 abstract 2
- 125000003107 substituted aryl group Chemical group 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 101710179684 Poly [ADP-ribose] polymerase Proteins 0.000 abstract 1
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 abstract 1
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9404485A GB9404485D0 (en) | 1994-03-09 | 1994-03-09 | Benzamide analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE210651T1 true ATE210651T1 (de) | 2001-12-15 |
Family
ID=10751492
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98202103T ATE231494T1 (de) | 1994-03-09 | 1995-03-09 | Chinazoline als chemotherapeutika |
| AT98202102T ATE210651T1 (de) | 1994-03-09 | 1995-03-09 | Benzamidanaloga zur verwendung als parp- (adp- ribosyltransferase, adprt) dns-reparaturenzym inhibitoren |
| AT95910653T ATE184271T1 (de) | 1994-03-09 | 1995-03-09 | Analoge von benzamid, zur verwendung als parp(adp-ribosyltransferase, adprt) dns- reparaturenzyminhibitoren |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98202103T ATE231494T1 (de) | 1994-03-09 | 1995-03-09 | Chinazoline als chemotherapeutika |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95910653T ATE184271T1 (de) | 1994-03-09 | 1995-03-09 | Analoge von benzamid, zur verwendung als parp(adp-ribosyltransferase, adprt) dns- reparaturenzyminhibitoren |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US5756510A (de) |
| EP (3) | EP0749415B1 (de) |
| JP (1) | JPH09510704A (de) |
| CN (1) | CN1081624C (de) |
| AT (3) | ATE231494T1 (de) |
| CA (1) | CA2184747C (de) |
| DE (3) | DE69529482T2 (de) |
| DK (2) | DK0749415T3 (de) |
| ES (2) | ES2135707T3 (de) |
| GB (1) | GB9404485D0 (de) |
| GR (1) | GR3031886T3 (de) |
| PT (1) | PT879820E (de) |
| WO (1) | WO1995024379A1 (de) |
Families Citing this family (137)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6372770B1 (en) | 1994-10-12 | 2002-04-16 | Euro-Celtique, S.A. | Benzoxazoles |
| US5589483A (en) * | 1994-12-21 | 1996-12-31 | Geron Corporation | Isoquinoline poly (ADP-ribose) polymerase inhibitors to treat skin diseases associated with cellular senescence |
| WO1998027975A1 (en) * | 1996-12-20 | 1998-07-02 | Geron Corporation | Poly(adp-ribose) polymerase inhibitors to treat diseases associated with cellular senescence |
| GB9702701D0 (en) * | 1997-02-01 | 1997-04-02 | Univ Newcastle Ventures Ltd | Quinazolinone compounds |
| DE19726824C1 (de) * | 1997-06-24 | 1999-03-04 | Deutsches Krebsforsch | Verfahren zur Identifizierung kanzerogener Agenzien |
| US6426415B1 (en) | 1997-09-03 | 2002-07-30 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods and compositions for inhibiting parp activity |
| US20020028813A1 (en) * | 1997-09-03 | 2002-03-07 | Paul F. Jackson | Thioalkyl compounds, methods, and compositions for inhibiting parp activity |
| WO1999011644A1 (en) * | 1997-09-03 | 1999-03-11 | Guilford Pharmaceuticals Inc. | Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity |
| US6346536B1 (en) | 1997-09-03 | 2002-02-12 | Guilford Pharmaceuticals Inc. | Poly(ADP-ribose) polymerase inhibitors and method for treating neural or cardiovascular tissue damage using the same |
| WO1999011622A1 (en) * | 1997-09-03 | 1999-03-11 | Guilford Pharmaceuticals Inc. | Amino-substituted compounds, methods, and compositions for inhibiting parp activity |
| US6235748B1 (en) | 1997-09-03 | 2001-05-22 | Guilford Pharmaceuticals Inc. | Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity |
| US6197785B1 (en) | 1997-09-03 | 2001-03-06 | Guilford Pharmaceuticals Inc. | Alkoxy-substituted compounds, methods, and compositions for inhibiting PARP activity |
| US6291425B1 (en) | 1999-09-01 | 2001-09-18 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating cellular damage, such as neural or cardiovascular tissue damage |
| US6635642B1 (en) * | 1997-09-03 | 2003-10-21 | Guilford Pharmaceuticals Inc. | PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same |
| US20020022636A1 (en) * | 1997-09-03 | 2002-02-21 | Jia-He Li | Oxo-substituted compounds, process of making, and compositions and methods for inhibiting parp activity |
| US6514983B1 (en) | 1997-09-03 | 2003-02-04 | Guilford Pharmaceuticals Inc. | Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage |
| US6121278A (en) * | 1997-09-03 | 2000-09-19 | Guilford Pharmaceuticals, Inc. | Di-n-heterocyclic compounds, methods, and compositions for inhibiting parp activity |
| FR2776291B1 (fr) * | 1998-03-18 | 2000-06-16 | Pf Medicament | Nouveaux derives bis-benzamides, leur procede de fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme medicament |
| US6380193B1 (en) | 1998-05-15 | 2002-04-30 | Guilford Pharmaceuticals Inc. | Fused tricyclic compounds, methods and compositions for inhibiting PARP activity |
| AU9298798A (en) * | 1998-05-15 | 1999-12-06 | Guilford Pharmaceuticals Inc. | Fused tricyclic compounds which inhibit parp activity |
| US6395749B1 (en) | 1998-05-15 | 2002-05-28 | Guilford Pharmaceuticals Inc. | Carboxamide compounds, methods, and compositions for inhibiting PARP activity |
| CA2332279A1 (en) * | 1998-05-15 | 1999-11-25 | Jia-He Li | Carboxamide compounds, compositions, and methods for inhibiting parp activity |
| PT1143954E (pt) | 1998-12-01 | 2004-12-31 | Univ Kentucky Res Found | Utilizacao de derivados de acido nocotinico para o tratamento de danos no adn em celulas da pele |
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| US6201020B1 (en) | 1998-12-31 | 2001-03-13 | Guilford Pharmaceuticals, Inc. | Ortho-diphenol compounds, methods and pharmaceutical compositions for inhibiting parp |
| US6495541B1 (en) | 1999-01-11 | 2002-12-17 | Agouron Pharmaceuticals, Inc. | Tricyclic inhibitors of poly(ADP-ribose) polymerases |
| ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
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- 1994-03-09 GB GB9404485A patent/GB9404485D0/en active Pending
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- 1995-03-09 DE DE69529482T patent/DE69529482T2/de not_active Expired - Fee Related
- 1995-03-09 AT AT98202103T patent/ATE231494T1/de not_active IP Right Cessation
- 1995-03-09 DK DK95910653T patent/DK0749415T3/da active
- 1995-03-09 EP EP95910653A patent/EP0749415B1/de not_active Expired - Lifetime
- 1995-03-09 ES ES95910653T patent/ES2135707T3/es not_active Expired - Lifetime
- 1995-03-09 ES ES98202102T patent/ES2169472T3/es not_active Expired - Lifetime
- 1995-03-09 EP EP98202103A patent/EP0897915B1/de not_active Expired - Lifetime
- 1995-03-09 EP EP98202102A patent/EP0879820B1/de not_active Expired - Lifetime
- 1995-03-09 DK DK98202102T patent/DK0879820T3/da active
- 1995-03-09 CN CN95192011A patent/CN1081624C/zh not_active Expired - Fee Related
- 1995-03-09 WO PCT/GB1995/000513 patent/WO1995024379A1/en not_active Ceased
- 1995-03-09 DE DE69512036T patent/DE69512036T2/de not_active Expired - Fee Related
- 1995-03-09 JP JP7523316A patent/JPH09510704A/ja active Pending
- 1995-03-09 AT AT98202102T patent/ATE210651T1/de not_active IP Right Cessation
- 1995-03-09 DE DE69524641T patent/DE69524641T2/de not_active Expired - Fee Related
- 1995-03-09 PT PT98202102T patent/PT879820E/pt unknown
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| CA2184747A1 (en) | 1995-09-14 |
| EP0879820B1 (de) | 2001-12-12 |
| DK0879820T3 (da) | 2002-04-02 |
| ES2135707T3 (es) | 1999-11-01 |
| EP0897915A1 (de) | 1999-02-24 |
| DE69512036D1 (de) | 1999-10-14 |
| US5756510A (en) | 1998-05-26 |
| DE69512036T2 (de) | 1999-12-30 |
| US6316455B1 (en) | 2001-11-13 |
| US6015827A (en) | 2000-01-18 |
| DE69524641D1 (de) | 2002-01-24 |
| DE69529482D1 (de) | 2003-02-27 |
| PT879820E (pt) | 2002-06-28 |
| ATE184271T1 (de) | 1999-09-15 |
| GR3031886T3 (en) | 2000-02-29 |
| EP0749415B1 (de) | 1999-09-08 |
| CA2184747C (en) | 2003-10-14 |
| GB9404485D0 (en) | 1994-04-20 |
| AU693167B2 (en) | 1998-06-25 |
| CN1143358A (zh) | 1997-02-19 |
| ES2169472T3 (es) | 2002-07-01 |
| AU1856595A (en) | 1995-09-25 |
| DE69529482T2 (de) | 2003-06-12 |
| DK0749415T3 (da) | 2000-03-20 |
| EP0879820A1 (de) | 1998-11-25 |
| ATE231494T1 (de) | 2003-02-15 |
| WO1995024379A1 (en) | 1995-09-14 |
| EP0749415A1 (de) | 1996-12-27 |
| EP0897915B1 (de) | 2003-01-22 |
| CN1081624C (zh) | 2002-03-27 |
| DE69524641T2 (de) | 2002-08-14 |
| JPH09510704A (ja) | 1997-10-28 |
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