ATE20733T1 - Roentgenkontrastmittel. - Google Patents

Roentgenkontrastmittel.

Info

Publication number
ATE20733T1
ATE20733T1 AT83306766T AT83306766T ATE20733T1 AT E20733 T1 ATE20733 T1 AT E20733T1 AT 83306766 T AT83306766 T AT 83306766T AT 83306766 T AT83306766 T AT 83306766T AT E20733 T1 ATE20733 T1 AT E20733T1
Authority
AT
Austria
Prior art keywords
ch2ch
group
contrast agent
ray contrast
ch2oh
Prior art date
Application number
AT83306766T
Other languages
German (de)
English (en)
Inventor
Per-Egil Hansen
Hugo Holtermann
Knut Wille
Original Assignee
Nyegaard & Co As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard & Co As filed Critical Nyegaard & Co As
Application granted granted Critical
Publication of ATE20733T1 publication Critical patent/ATE20733T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Medicinal Preparation (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polyesters Or Polycarbonates (AREA)
AT83306766T 1982-11-08 1983-11-07 Roentgenkontrastmittel. ATE20733T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8231796 1982-11-08
EP83306766A EP0108638B1 (en) 1982-11-08 1983-11-07 X-ray contrast agents

Publications (1)

Publication Number Publication Date
ATE20733T1 true ATE20733T1 (de) 1986-08-15

Family

ID=10534110

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83306766T ATE20733T1 (de) 1982-11-08 1983-11-07 Roentgenkontrastmittel.

Country Status (10)

Country Link
US (1) US5349085A (enExample)
EP (1) EP0108638B1 (enExample)
JP (1) JPS59104352A (enExample)
AT (1) ATE20733T1 (enExample)
DE (1) DE3364536D1 (enExample)
DK (1) DK160868C (enExample)
HK (1) HK46791A (enExample)
LU (1) LU88639I2 (enExample)
NL (1) NL950010I1 (enExample)
NO (2) NO161368C (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3731542A1 (de) * 1987-09-17 1989-03-30 Schering Ag Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
DE3739098A1 (de) * 1987-11-16 1989-05-24 Schering Ag Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
GB8919929D0 (en) * 1989-09-04 1989-10-18 Nycomed As Compositions
IT1252180B (it) * 1991-12-10 1995-06-05 Bracco Ind Chimica Spa 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
WO1994022810A1 (es) * 1993-04-01 1994-10-13 Centro Investigacion Justesa Imagen, S.A. Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen
US5840967A (en) * 1996-08-29 1998-11-24 Nycomed Imaging As Process for the preparation of contrast agents
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
GB9720969D0 (en) * 1997-10-02 1997-12-03 Nycomed Imaging As Process
GB9903109D0 (en) * 1999-02-11 1999-04-07 Nycomed Imaging As Process
US6660248B2 (en) 2000-11-10 2003-12-09 William Marsh Rice University Fullerene (C60)-based X-ray contrast agent for diagnostic imaging
EP1490090A4 (en) 2002-02-22 2006-09-20 New River Pharmaceuticals Inc SYSTEMS FOR DELIVERING ACTIVE AGENTS AND METHODS FOR PROTECTING AND DELIVERING ACTIVE AGENTS
KR100574087B1 (ko) 2004-09-09 2006-04-27 주식회사태준제약 아이오디사놀의 제조방법
JP2008527119A (ja) 2005-01-13 2008-07-24 シンベンション アーゲー 炭素ナノ粒子を含有する複合材料
ES2413761T3 (es) 2005-12-19 2013-07-17 Ge Healthcare As Procedimiento de purificación de iodixanol
DE602007012208D1 (de) 2006-02-15 2011-03-10 Ge Healthcare As Kontrastmittel
FR2899581B1 (fr) * 2006-04-07 2008-06-27 Guerbet Sa Procede d'atomisation du ioxilan
US7662859B2 (en) 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
DK2178568T3 (da) 2007-07-12 2014-07-21 Ge Healthcare As Kontrastmidler
EP2200655B1 (en) 2007-10-12 2012-07-18 GE Healthcare AS Contrast agents
US20100221191A1 (en) 2007-10-12 2010-09-02 Duncan George Wynn Contrast agents
US20100209356A1 (en) 2007-10-12 2010-08-19 Duncan George Wynn Contrast agents
US8202511B2 (en) 2007-10-12 2012-06-19 Ge Healthcare As Contrast agents
EP2245003A2 (en) * 2008-02-27 2010-11-03 GE Healthcare AS Contrast agents
WO2009106551A2 (en) * 2008-02-27 2009-09-03 Ge Healthcare As Contrast agents
WO2010060941A2 (en) * 2008-11-27 2010-06-03 Ge Healthcare As Contrast agents
EP2385845A1 (en) * 2009-01-09 2011-11-16 Ge Healthcare As Contrast media compositions
US8962886B2 (en) * 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in methanol
US20110021832A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Synthesis of iodixanol in water
US8962887B2 (en) * 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
US7999135B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using ultrasound
US7754920B1 (en) * 2009-07-21 2010-07-13 Ge Healthcare As Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
US7999134B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using milling
US8969619B2 (en) * 2009-07-21 2015-03-03 Ge Healthcare As Synthesis of iodixanol in propyleneglycol
US7696381B1 (en) * 2009-07-21 2010-04-13 Ge Healthcare As Alternative dimerisation reagents for synthesis of iodixanol
PT2493511E (pt) * 2009-10-29 2013-11-18 Ge Healthcare As Composição de diagnóstico que compreende catiões do plasma com perfil de segurança superior
EP2504298B1 (en) * 2009-11-26 2016-09-21 iMAX Diagnostic Imaging Holding Limited Preparation and purification of iodixanol
CA2801828A1 (en) 2010-07-12 2012-01-19 Ge Healthcare As X-ray imaging at low contrast agent concentrations and/or low dose radiation
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
CN102816125B (zh) * 2011-06-08 2014-03-26 浙江司太立制药股份有限公司 一种造影剂
CN107982550A (zh) 2012-01-11 2018-05-04 通用电气医疗集团股份有限公司 具有低碘浓度的x-射线成像造影介质和x-射线成像方法
CN104661996A (zh) 2012-09-27 2015-05-27 通用电气医疗集团股份有限公司 Ioforminol的中间体化合物的制备
ES2692071T3 (es) 2012-11-12 2018-11-30 Ge Healthcare As Preparación de intermedios de agentes de contraste para rayos X
CN107249570B (zh) 2014-11-21 2022-08-09 丹麦技术大学 用于局部药物释放的凝胶制剂
PT108524B (pt) 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
BR112018073493A2 (pt) 2016-05-20 2019-03-26 Technical University Of Denmark composição de marcador palpável, método e kit de partes para identificar e/ou localizar um tumor não palpável, um tumor palpável com maior precisão e/ou um tecido alvo, e, uso de uma composição de marcador palpável
CN111440084B (zh) * 2019-01-16 2023-01-06 苏州纳微科技股份有限公司 一种碘克沙醇的纯化方法
WO2020249801A1 (en) 2019-06-12 2020-12-17 Technical University Of Denmark Dissacharide formulations for controlled drug release
CN113121377A (zh) * 2019-12-31 2021-07-16 江苏汉邦科技有限公司 碘克沙醇的纯化方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE344166B (enExample) * 1966-12-13 1972-04-04 Pharmacia Ab
SE315975B (enExample) * 1967-12-28 1969-10-13 Pharmacia Ab
SE315974B (enExample) * 1967-12-28 1969-10-13 Pharmacia Ab
US3763227A (en) * 1967-12-28 1973-10-02 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
US3804892A (en) * 1967-12-28 1974-04-16 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
BR7020080D0 (pt) * 1969-06-27 1973-03-13 Nyegaard & Co As Processo para a preparacao de agentes de contraste para raio x
NL7102816A (enExample) * 1970-03-12 1971-09-14
DD104193A5 (enExample) * 1972-12-22 1974-03-05
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
FR2511871A1 (fr) * 1981-08-28 1983-03-04 Guerbet Sa Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus

Also Published As

Publication number Publication date
EP0108638A1 (en) 1984-05-16
NO834056L (no) 1984-05-09
DE3364536D1 (en) 1986-08-21
JPS59104352A (ja) 1984-06-16
NO1994015I1 (no) 1994-09-05
US5349085A (en) 1994-09-20
NO161368B (no) 1989-05-02
NL950010I2 (nl) 1997-02-03
JPS6355509B2 (enExample) 1988-11-02
DK160868B (da) 1991-04-29
LU88639I2 (fr) 1996-02-01
EP0108638B1 (en) 1986-07-16
DK160868C (da) 1991-10-14
NO161368C (no) 1989-08-09
HK46791A (en) 1991-06-21
DK508283D0 (da) 1983-11-07
DK508283A (da) 1984-05-09
NL950010I1 (nl) 1997-02-03

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