ATE202102T1 - 5-arylindol-derivate und ihre verwendung als serotonin (5-ht1)-agonisten - Google Patents

5-arylindol-derivate und ihre verwendung als serotonin (5-ht1)-agonisten

Info

Publication number
ATE202102T1
ATE202102T1 AT93923389T AT93923389T ATE202102T1 AT E202102 T1 ATE202102 T1 AT E202102T1 AT 93923389 T AT93923389 T AT 93923389T AT 93923389 T AT93923389 T AT 93923389T AT E202102 T1 ATE202102 T1 AT E202102T1
Authority
AT
Austria
Prior art keywords
alkyl
aryl
hydrogen
ring
membered
Prior art date
Application number
AT93923389T
Other languages
German (de)
English (en)
Inventor
John Eugene Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE202102T1 publication Critical patent/ATE202102T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
AT93923389T 1992-11-02 1993-10-19 5-arylindol-derivate und ihre verwendung als serotonin (5-ht1)-agonisten ATE202102T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97075892A 1992-11-02 1992-11-02
PCT/US1993/009790 WO1994010171A1 (en) 1992-11-02 1993-10-19 5-arylindole derivatives and their use as serotonin (5-ht1) agonists

Publications (1)

Publication Number Publication Date
ATE202102T1 true ATE202102T1 (de) 2001-06-15

Family

ID=25517470

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93923389T ATE202102T1 (de) 1992-11-02 1993-10-19 5-arylindol-derivate und ihre verwendung als serotonin (5-ht1)-agonisten

Country Status (27)

Country Link
US (1) US5886008A (OSRAM)
EP (2) EP1094064A1 (OSRAM)
JP (1) JP2788551B2 (OSRAM)
KR (1) KR0163371B1 (OSRAM)
CN (1) CN1051313C (OSRAM)
AT (1) ATE202102T1 (OSRAM)
AU (1) AU685066B2 (OSRAM)
BR (1) BR9307348A (OSRAM)
CA (2) CA2340999C (OSRAM)
CZ (1) CZ283001B6 (OSRAM)
DE (1) DE69330351T2 (OSRAM)
DK (1) DK0666858T3 (OSRAM)
EG (1) EG20396A (OSRAM)
ES (1) ES2157224T3 (OSRAM)
FI (2) FI111257B (OSRAM)
GR (1) GR3036579T3 (OSRAM)
HU (1) HU222235B1 (OSRAM)
IL (1) IL107386A (OSRAM)
MY (1) MY109696A (OSRAM)
NO (1) NO309652B1 (OSRAM)
NZ (1) NZ257059A (OSRAM)
PL (1) PL176091B1 (OSRAM)
PT (1) PT666858E (OSRAM)
RU (1) RU2134266C1 (OSRAM)
TW (1) TW251284B (OSRAM)
WO (1) WO1994010171A1 (OSRAM)
ZA (1) ZA938137B (OSRAM)

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US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
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DE10337184A1 (de) 2003-08-13 2005-03-10 Gruenenthal Gmbh Substituierte 3-Pyrrolidin-Indol-Derivate
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RU2409576C2 (ru) 2003-11-25 2011-01-20 3М Инновейтив Пропертиз Компани Системы, содержащие имидазольное кольцо с заместителями, и способы их получения
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BRPI0709077A2 (pt) * 2006-03-22 2012-04-10 Janssen Pharmaceutica Nv derivados de alquilaminas cìclicas como inibidores da interação entre mdm2 e p53
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
HK1218623A1 (zh) 2013-03-15 2017-03-03 艾吉因生物股份有限公司 用於改善認知功能的方法和組合物
JP6804469B2 (ja) 2015-04-29 2020-12-23 ヤンセン ファーマシューティカ エヌ．ベー． ベンゾイミダゾロン及びベンゾチアゾロン化合物並びにａｍｐａ受容体調節因子としてのそれらの使用
CA2983826A1 (en) * 2015-04-29 2016-11-03 Janssen Pharmaceutica Nv Azabenzimidazoles and their use as ampa receptor modulators
CA2984305C (en) 2015-04-29 2021-12-28 Janssen Pharmaceutica Nv Indolone compounds and their use as ampa receptor modulators
CA2984307A1 (en) 2015-04-29 2016-11-03 Janssen Pharmaceutica Nv Imidazopyrazines and pyrazolopyrimidines and their use as ampa receptor modulators
CN112843005B (zh) 2015-05-22 2023-02-21 艾吉因生物股份有限公司 左乙拉西坦的延时释放药物组合物
EP3371174B1 (en) 2015-11-06 2021-03-17 H. Hoffnabb-La Roche Ag Indolin-2-one derivatives
HUE050083T2 (hu) 2015-11-06 2020-11-30 Hoffmann La Roche Indolin-2-on származékok
EP3371170B1 (en) 2015-11-06 2019-07-31 H. Hoffnabb-La Roche Ag Indolin-2-one derivatives useful in the treatment of cns diseases
JP6857653B2 (ja) 2015-11-06 2021-04-14 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｃｎｓ及び関連障害の治療において使用するためのインドリン−２−オン誘導体
CN111822047B (zh) * 2020-07-17 2022-05-27 曲阜师范大学 一种磁性介孔聚合离子液体负载催化合成吲哚类衍生物的方法
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WO2025104490A1 (en) * 2023-11-14 2025-05-22 Mindset Pharma Inc. Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto

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Also Published As

Publication number Publication date
CA2340999C (en) 2005-01-04
FI111257B (fi) 2003-06-30
NO951633D0 (no) 1995-04-28
US5886008A (en) 1999-03-23
NO309652B1 (no) 2001-03-05
EP0666858A1 (en) 1995-08-16
GR3036579T3 (en) 2001-12-31
DE69330351D1 (de) 2001-07-19
FI934825A0 (fi) 1993-11-01
WO1994010171A1 (en) 1994-05-11
FI934825L (fi) 1994-05-03
DE69330351T2 (de) 2001-09-20
FI20002505A7 (fi) 2000-11-15
EP0666858B1 (en) 2001-06-13
BR9307348A (pt) 1999-05-11
PL308669A1 (en) 1995-08-21
ES2157224T3 (es) 2001-08-16
AU5329494A (en) 1994-05-24
MY109696A (en) 1997-04-30
RU95109927A (ru) 1997-01-10
DK0666858T3 (da) 2001-08-27
PL176091B1 (pl) 1999-04-30
CA2148380C (en) 2001-08-14
CA2340999A1 (en) 1994-05-11
NO951633L (no) 1995-04-28
CZ110895A3 (en) 1995-11-15
PT666858E (pt) 2001-09-28
KR950704313A (ko) 1995-11-17
IL107386A0 (en) 1994-01-25
HUT66011A (en) 1994-08-29
AU685066B2 (en) 1998-01-15
CZ283001B6 (cs) 1997-12-17
ZA938137B (en) 1995-05-02
TW251284B (OSRAM) 1995-07-11
KR0163371B1 (ko) 1998-12-01
RU2134266C1 (ru) 1999-08-10
NZ257059A (en) 1997-07-27
CN1094727A (zh) 1994-11-09
JP2788551B2 (ja) 1998-08-20
EG20396A (en) 1999-02-28
IL107386A (en) 1999-03-12
JPH07508759A (ja) 1995-09-28
CN1051313C (zh) 2000-04-12
FI20002505L (fi) 2000-11-15
CA2148380A1 (en) 1994-05-11
HU222235B1 (hu) 2003-05-28
EP1094064A1 (en) 2001-04-25

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Legal Events

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