ATE189697T1 - Die hocheffiziente herstellung und isolierung von viruspartikeln - Google Patents
Die hocheffiziente herstellung und isolierung von viruspartikelnInfo
- Publication number
- ATE189697T1 ATE189697T1 AT95914170T AT95914170T ATE189697T1 AT E189697 T1 ATE189697 T1 AT E189697T1 AT 95914170 T AT95914170 T AT 95914170T AT 95914170 T AT95914170 T AT 95914170T AT E189697 T1 ATE189697 T1 AT E189697T1
- Authority
- AT
- Austria
- Prior art keywords
- exchange resin
- isolation
- cells
- highly efficient
- virus particles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16051—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21583394A | 1994-03-22 | 1994-03-22 | |
PCT/US1995/003668 WO1995025789A1 (en) | 1994-03-22 | 1995-03-22 | Highly efficient production and isolation of viral particles |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE189697T1 true ATE189697T1 (de) | 2000-02-15 |
Family
ID=22804586
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95914170T ATE189697T1 (de) | 1994-03-22 | 1995-03-22 | Die hocheffiziente herstellung und isolierung von viruspartikeln |
Country Status (12)
Country | Link |
---|---|
US (2) | US5661023A (de) |
EP (1) | EP0751988B1 (de) |
JP (1) | JP3313117B2 (de) |
AT (1) | ATE189697T1 (de) |
AU (1) | AU2127395A (de) |
CA (1) | CA2186034C (de) |
DE (1) | DE69515028T2 (de) |
DK (1) | DK0751988T3 (de) |
ES (1) | ES2141929T3 (de) |
GR (1) | GR3033268T3 (de) |
PT (1) | PT751988E (de) |
WO (1) | WO1995025789A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE189697T1 (de) * | 1994-03-22 | 2000-02-15 | Immune Response Corp Inc | Die hocheffiziente herstellung und isolierung von viruspartikeln |
FR2750433B1 (fr) * | 1996-07-01 | 1998-08-14 | Rhone Poulenc Rorer Sa | Procede de production d'adenovirus recombinants |
AU3447097A (en) | 1996-07-01 | 1998-01-21 | Rhone-Poulenc Rorer S.A. | Method for producing recombinant adenovirus |
US7732129B1 (en) | 1998-12-01 | 2010-06-08 | Crucell Holland B.V. | Method for the production and purification of adenoviral vectors |
DE69737107T2 (de) | 1996-11-20 | 2007-07-12 | Introgen Therapeutics Inc., Austin | Ein verbessertes verfahren zur produktion und reinigung von adenoviralen vektoren |
PT1944362E (pt) * | 1997-09-05 | 2016-01-27 | Genzyme Corp | Métodos de produção de preparações de alto título de vetores aav recombinantes desprovidos de adjuvantes |
JP2002500088A (ja) * | 1998-01-12 | 2002-01-08 | ハー マジェスティ イン ライト オブ カナダ アズ リプレゼンティッド バイ ザ ミニスター オブ アグリカルチャー アンド アグリ−フード カナダ | 非極性抽出物の単離、回収及び精製方法 |
US6689600B1 (en) | 1998-11-16 | 2004-02-10 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
DE10010342A1 (de) * | 2000-03-06 | 2001-09-20 | Merck Patent Gmbh | Verfahren zur Abreicherung von Endotoxinen |
SE0001132D0 (sv) * | 2000-03-29 | 2000-03-29 | Cavidi Tech Ab | Method of concentrating and recovering a viral enzyme activity from biological samples |
EP1284287A4 (de) * | 2000-05-10 | 2004-10-13 | Mitsubishi Pharma Corp | Verfahren zur herstellung eines virusvektors |
WO2002044394A2 (en) | 2000-11-29 | 2002-06-06 | University Of Southern California | Targetet retoviral vectors for cancer immunotherapy |
AU2002250914A1 (en) * | 2001-02-11 | 2002-11-05 | Aquanova German Solubilisate Technologies (Agt) Gmbh | Method for producing an active ingredient concentrate, and an active ingredient concentrate |
US20030031626A1 (en) * | 2001-07-26 | 2003-02-13 | Thomas Rheinlander | Process for the production of pharmaceutical preparations |
DE10137515A1 (de) * | 2001-07-26 | 2003-02-13 | Diagnostikforschung Inst | Verfahren zur Herstellung pharmazeutischer Zubereitungen |
US20090123428A1 (en) * | 2003-04-21 | 2009-05-14 | Hall Frederick L | Pathotropic targeted gene delivery system for cancer and other disorders |
EP1619951B1 (de) * | 2003-04-21 | 2011-06-22 | Epeius Biotechnologies Corporation | Verfahren und zusammensetzungen zur behandlung von erkrankungen |
US20070178066A1 (en) * | 2003-04-21 | 2007-08-02 | Hall Frederick L | Pathotropic targeted gene delivery system for cancer and other disorders |
AU2005305347A1 (en) | 2004-11-03 | 2006-05-18 | Introgen Therapeutics Inc. | Method of producing and purifying of adenoviral vectors |
DK3192874T3 (da) | 2008-06-18 | 2019-12-16 | Oxford Biomedica Ltd | Virusoprensning |
BR112012026095A2 (pt) | 2010-04-14 | 2015-09-15 | Emd Millipore Corp | métodos de produção de estoques de vírus de alta pureza e altos títulos e métodos de uso dos mesmos. |
DE102010046817A1 (de) * | 2010-09-28 | 2012-03-29 | Sartorius Stedim Biotech Gmbh | Verfahren zur Abtrennung von Viren aus einem Kontaminanten enthaltenden flüssigen Medium |
JP6007463B2 (ja) | 2011-04-18 | 2016-10-12 | 国立研究開発法人国立精神・神経医療研究センター | 薬剤送達粒子及びその製造方法 |
SG11201404684RA (en) | 2012-09-17 | 2014-10-30 | Grace W R & Co | Functionalized particulate support material and methods of making and using the same |
RU2015114330A (ru) | 2012-09-17 | 2016-11-10 | У.Р. Грейс Энд Ко.-Конн. | Хроматографические среды и устройства |
SG11201605712SA (en) | 2014-01-16 | 2016-08-30 | Grace W R & Co | Affinity chromatography media and chromatography devices |
EP3137209B1 (de) | 2014-05-02 | 2022-10-05 | W.R. Grace & CO. - CONN. | Funktionalisiertes trägermaterial und verfahren zur herstellung und verwendung eines funktionalisierten trägermaterials |
PL3302784T3 (pl) | 2015-06-05 | 2022-01-17 | W.R. Grace & Co.-Conn. | Adsorbentowe środki klarujące do bioprzetwarzania oraz sposoby ich wytwarzania i stosowania |
EP3714033A1 (de) * | 2017-11-22 | 2020-09-30 | Corning Incorporated | Perfusionsbioreaktorsystem und perfusionszellkulturverfahren |
US11028124B2 (en) * | 2018-05-07 | 2021-06-08 | Repligen Corporation | Methods, devices and systems for 3-stage filtration |
WO2020214676A1 (en) * | 2019-04-15 | 2020-10-22 | Children's Hospital Medical Center | Viral vector manufacturing methods |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3509070A (en) * | 1968-06-13 | 1970-04-28 | American Home Prod | Adsorbent for chromatographic purification of virus |
US3655509A (en) * | 1969-05-29 | 1972-04-11 | Monsanto Co | Process for the separation of virus from non-viral proteins |
US3925152A (en) * | 1971-06-18 | 1975-12-09 | Exploaterings Ab Tbf | Virus separation |
US4647773A (en) * | 1984-04-23 | 1987-03-03 | The United States Of America As Represented By The Department Of Health And Human Services | Method of continuous production of retroviruses (HTLV-III) from patients with AIDS and pre-AIDS |
JPS6147185A (ja) * | 1984-08-09 | 1986-03-07 | Chemo Sero Therapeut Res Inst | 日本脳炎ウイルスの精製方法 |
JPS6151571A (ja) * | 1984-08-21 | 1986-03-14 | Nippon Seibutsu Kagaku Kenkyusho | オ−エスキ−病診断用抗原の単離・精製法 |
WO1988009670A1 (en) * | 1987-06-10 | 1988-12-15 | The Immune Response Corporation, Inc. | Prevention and treatment of retroviral disease |
NZ225583A (en) * | 1987-08-06 | 1991-07-26 | Merck & Co Inc | Process for purifying hepatitis a virions (hav) |
IE910779A1 (en) * | 1990-03-09 | 1991-09-11 | Chiron Corp | PURIFIED gp120 COMPOSITION RETAINING NATURAL CONFORMATION |
FR2661834B1 (fr) * | 1990-05-09 | 1995-01-27 | Merieux Inst | Procede de fabrication d'immunogenes de retrovirus et de vaccins contre les infections retrovirales, notamment hiv, et immunogenes et vaccins obtenus. |
JPH06500927A (ja) * | 1990-12-13 | 1994-01-27 | アメリカ合衆国 | 高力価の組換えウイルスベクターおよび遺伝子療法に用いられる形質導入標的細胞の持続的及び連続的生産 |
ATE189697T1 (de) * | 1994-03-22 | 2000-02-15 | Immune Response Corp Inc | Die hocheffiziente herstellung und isolierung von viruspartikeln |
JPH08195877A (ja) * | 1995-01-18 | 1996-07-30 | Canon Inc | イメージセンサと画像処理回路 |
-
1995
- 1995-03-22 AT AT95914170T patent/ATE189697T1/de not_active IP Right Cessation
- 1995-03-22 WO PCT/US1995/003668 patent/WO1995025789A1/en active IP Right Grant
- 1995-03-22 EP EP95914170A patent/EP0751988B1/de not_active Expired - Lifetime
- 1995-03-22 DE DE69515028T patent/DE69515028T2/de not_active Expired - Fee Related
- 1995-03-22 ES ES95914170T patent/ES2141929T3/es not_active Expired - Lifetime
- 1995-03-22 JP JP52482495A patent/JP3313117B2/ja not_active Expired - Fee Related
- 1995-03-22 DK DK95914170T patent/DK0751988T3/da active
- 1995-03-22 CA CA002186034A patent/CA2186034C/en not_active Expired - Fee Related
- 1995-03-22 PT PT95914170T patent/PT751988E/pt unknown
- 1995-03-22 AU AU21273/95A patent/AU2127395A/en not_active Abandoned
-
1996
- 1996-03-11 US US08/613,920 patent/US5661023A/en not_active Expired - Fee Related
-
1997
- 1997-04-15 US US08/842,702 patent/US6080571A/en not_active Expired - Fee Related
-
2000
- 2000-04-19 GR GR20000400951T patent/GR3033268T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE69515028D1 (de) | 2000-03-16 |
DK0751988T3 (da) | 2000-06-26 |
EP0751988A1 (de) | 1997-01-08 |
WO1995025789A1 (en) | 1995-09-28 |
AU2127395A (en) | 1995-10-09 |
GR3033268T3 (en) | 2000-09-29 |
DE69515028T2 (de) | 2000-06-29 |
EP0751988B1 (de) | 2000-02-09 |
PT751988E (pt) | 2000-05-31 |
EP0751988A4 (de) | 1997-11-12 |
ES2141929T3 (es) | 2000-04-01 |
JP3313117B2 (ja) | 2002-08-12 |
US5661023A (en) | 1997-08-26 |
CA2186034C (en) | 2002-11-26 |
US6080571A (en) | 2000-06-27 |
CA2186034A1 (en) | 1995-09-28 |
JPH10500286A (ja) | 1998-01-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |