DK0751988T3 - Højeffektiv fremstilling og isolering af virale partikler - Google Patents

Højeffektiv fremstilling og isolering af virale partikler

Info

Publication number
DK0751988T3
DK0751988T3 DK95914170T DK95914170T DK0751988T3 DK 0751988 T3 DK0751988 T3 DK 0751988T3 DK 95914170 T DK95914170 T DK 95914170T DK 95914170 T DK95914170 T DK 95914170T DK 0751988 T3 DK0751988 T3 DK 0751988T3
Authority
DK
Denmark
Prior art keywords
exchange resin
cells
viral particles
isolation
retroviral particles
Prior art date
Application number
DK95914170T
Other languages
Danish (da)
English (en)
Inventor
Christopher P Prior
David M Weber
Richard S Gore
James J Harter
Michael E Hrinda
Jonathan J Mitschelen
Thomas W Irish
Pierre M Bay
George C Tarr
Original Assignee
Immune Response Corp Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immune Response Corp Inc filed Critical Immune Response Corp Inc
Application granted granted Critical
Publication of DK0751988T3 publication Critical patent/DK0751988T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK95914170T 1994-03-22 1995-03-22 Højeffektiv fremstilling og isolering af virale partikler DK0751988T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21583394A 1994-03-22 1994-03-22
PCT/US1995/003668 WO1995025789A1 (en) 1994-03-22 1995-03-22 Highly efficient production and isolation of viral particles

Publications (1)

Publication Number Publication Date
DK0751988T3 true DK0751988T3 (da) 2000-06-26

Family

ID=22804586

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95914170T DK0751988T3 (da) 1994-03-22 1995-03-22 Højeffektiv fremstilling og isolering af virale partikler

Country Status (12)

Country Link
US (2) US5661023A (de)
EP (1) EP0751988B1 (de)
JP (1) JP3313117B2 (de)
AT (1) ATE189697T1 (de)
AU (1) AU2127395A (de)
CA (1) CA2186034C (de)
DE (1) DE69515028T2 (de)
DK (1) DK0751988T3 (de)
ES (1) ES2141929T3 (de)
GR (1) GR3033268T3 (de)
PT (1) PT751988E (de)
WO (1) WO1995025789A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69515028T2 (de) * 1994-03-22 2000-06-29 Immune Response Corp Inc Die hocheffiziente herstellung und isolierung von viruspartikeln
FR2750433B1 (fr) * 1996-07-01 1998-08-14 Rhone Poulenc Rorer Sa Procede de production d'adenovirus recombinants
WO1998000524A1 (fr) 1996-07-01 1998-01-08 Rhone-Poulenc Rorer S.A. Procede de production d'adenovirus recombinants
EP0968284B1 (de) * 1996-11-20 2006-12-13 Introgen Therapeutics, Inc. Ein verbessertes verfahren zur produktion und reinigung von adenoviralen vektoren
US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
CA2302992C (en) * 1997-09-05 2011-11-01 Targeted Genetics Corporation Methods for generating high titer helper-free preparations of recombinant aav vectors
EP1047438B1 (de) * 1998-01-12 2004-09-08 Her Majesty the Queen in Right of Canada as Represented by The Minister of Agriculture and Agri-Food Verfahren für die isolierung, rückgewinnung und reinigung von nicht-polaren extrakten
US6689600B1 (en) 1998-11-16 2004-02-10 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
DE10010342A1 (de) * 2000-03-06 2001-09-20 Merck Patent Gmbh Verfahren zur Abreicherung von Endotoxinen
SE0001132D0 (sv) * 2000-03-29 2000-03-29 Cavidi Tech Ab Method of concentrating and recovering a viral enzyme activity from biological samples
EP1284287A4 (de) * 2000-05-10 2004-10-13 Mitsubishi Pharma Corp Verfahren zur herstellung eines virusvektors
AU2002236517A1 (en) 2000-11-29 2002-06-11 University Of Southern California Targetet retoviral vectors for cancer immunotherapy
EP1377273B1 (de) * 2001-02-11 2009-03-18 Aquanova Ag Verfahren zur herstellung eines isoflavon-konzentrats
DE10137515A1 (de) * 2001-07-26 2003-02-13 Diagnostikforschung Inst Verfahren zur Herstellung pharmazeutischer Zubereitungen
US20030031626A1 (en) * 2001-07-26 2003-02-13 Thomas Rheinlander Process for the production of pharmaceutical preparations
EP2353389B1 (de) * 2003-04-21 2015-11-04 Epeius Biotechnologies Corporation Zusammensetzungen zur Behandlung von Erkrankungen
US20090123428A1 (en) * 2003-04-21 2009-05-14 Hall Frederick L Pathotropic targeted gene delivery system for cancer and other disorders
US20070178066A1 (en) * 2003-04-21 2007-08-02 Hall Frederick L Pathotropic targeted gene delivery system for cancer and other disorders
JP2008518632A (ja) 2004-11-03 2008-06-05 イントロゲン セラピューティックス， インコーポレイテッド アデノウイルスベクターの製造および精製のための新規方法
PL3192874T3 (pl) 2008-06-18 2020-06-29 Oxford Biomedica (Uk) Limited Oczyszczanie wirusa
BR112012026095A2 (pt) 2010-04-14 2015-09-15 Emd Millipore Corp métodos de produção de estoques de vírus de alta pureza e altos títulos e métodos de uso dos mesmos.
DE102010046817A1 (de) * 2010-09-28 2012-03-29 Sartorius Stedim Biotech Gmbh Verfahren zur Abtrennung von Viren aus einem Kontaminanten enthaltenden flüssigen Medium
EP3219313B1 (de) 2011-04-18 2020-10-28 National Center of Neurology and Psychiatry Arzneimittelabgabepartikel und verfahren zur herstellung davon
WO2014058570A1 (en) 2012-09-17 2014-04-17 Alltech Associates, Inc. Chromatography media and devices
PL2811983T3 (pl) 2012-09-17 2019-10-31 Grace W R & Co Funkcjonalizowany, złożony z cząstek materiał nośnikowy i sposoby jego wytwarzania i zastosowania
ES2887110T3 (es) 2014-01-16 2021-12-21 Grace W R & Co Medios para cromatografía de afinidad y dispositivos para cromatografía
CN107847907A (zh) 2014-05-02 2018-03-27 格雷斯公司 官能化载体材料以及制备和使用官能化载体材料的方法
EP3302784B1 (de) 2015-06-05 2021-10-06 W.R. Grace & Co.-Conn. Adsorbierende klärmittel für bioprozesstechnik und verfahren zur herstellung und verwendung davon
CN111417713B (zh) * 2017-11-22 2024-04-26 康宁股份有限公司 灌注生物反应器系统及灌注细胞培养方法
US11028124B2 (en) * 2018-05-07 2021-06-08 Repligen Corporation Methods, devices and systems for 3-stage filtration
US20220243224A1 (en) * 2019-04-15 2022-08-04 Children's Hospital Medical Center Viral vector manufacturing methods

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3509070A (en) * 1968-06-13 1970-04-28 American Home Prod Adsorbent for chromatographic purification of virus
US3655509A (en) * 1969-05-29 1972-04-11 Monsanto Co Process for the separation of virus from non-viral proteins
US3925152A (en) * 1971-06-18 1975-12-09 Exploaterings Ab Tbf Virus separation
US4647773A (en) * 1984-04-23 1987-03-03 The United States Of America As Represented By The Department Of Health And Human Services Method of continuous production of retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
JPS6147185A (ja) * 1984-08-09 1986-03-07 Chemo Sero Therapeut Res Inst 日本脳炎ウイルスの精製方法
JPS6151571A (ja) * 1984-08-21 1986-03-14 Nippon Seibutsu Kagaku Kenkyusho オ−エスキ−病診断用抗原の単離・精製法
EP0685236A1 (de) * 1987-06-10 1995-12-06 The Immune Response Corporation, Inc. Verhütung und Behandlung einer Retrovirenkrankheit
NZ225583A (en) * 1987-08-06 1991-07-26 Merck & Co Inc Process for purifying hepatitis a virions (hav)
ATE207930T1 (de) * 1990-03-09 2001-11-15 Chiron Corp Gereinigtes gp120, in dem seine natürliche konformation erhalten bleibt
FR2661834B1 (fr) * 1990-05-09 1995-01-27 Merieux Inst Procede de fabrication d'immunogenes de retrovirus et de vaccins contre les infections retrovirales, notamment hiv, et immunogenes et vaccins obtenus.
CA2098510A1 (en) * 1990-12-13 1992-06-14 Kenneth W. Culver Sustained and continuous production of high titers of recombinant viral vectors and transduced target cells for use in gene therapy
DE69515028T2 (de) * 1994-03-22 2000-06-29 Immune Response Corp Inc Die hocheffiziente herstellung und isolierung von viruspartikeln
JPH08195877A (ja) * 1995-01-18 1996-07-30 Canon Inc イメージセンサと画像処理回路

Also Published As

Publication number Publication date
CA2186034A1 (en) 1995-09-28
ES2141929T3 (es) 2000-04-01
PT751988E (pt) 2000-05-31
EP0751988A4 (de) 1997-11-12
US5661023A (en) 1997-08-26
WO1995025789A1 (en) 1995-09-28
AU2127395A (en) 1995-10-09
JPH10500286A (ja) 1998-01-13
EP0751988A1 (de) 1997-01-08
CA2186034C (en) 2002-11-26
US6080571A (en) 2000-06-27
GR3033268T3 (en) 2000-09-29
DE69515028T2 (de) 2000-06-29
DE69515028D1 (de) 2000-03-16
JP3313117B2 (ja) 2002-08-12
ATE189697T1 (de) 2000-02-15
EP0751988B1 (de) 2000-02-09

Similar Documents

Publication Publication Date Title
DK0751988T3 (da) Højeffektiv fremstilling og isolering af virale partikler
EP1394259A3 (de) Rekombinantes infektiöses nicht-in-Segmente-geteiltes negativ-Strange-RNS-Virus
HUP0001271A1 (hu) Eljárás rekombináns adenovírusok előállítására
AU7007491A (en) Cdna corresponding to the genome of negative-strand rna viruses, and process for the production of infectious negative-strand rna viruses
EP0923308A4 (de)
IT8020489A0 (it) Procedimento per la formazione di elettrodi sulle superficie di membrane semipermeabili e sistemi elettrodo-membrana cosi' prodotti.
FI962990A (fi) Menetelmä rekombinanttisten adenovirukseen assosioituvien virusten (AAV:iden) valmistamiseksi ja sen käyttöjä
DK0871482T3 (da) Rekombinante vesiculovirus og deres anvendelser
HK1018287A1 (en) (-)-strand rna virus vector having autonomously replicating activity
TR199901840T2 (xx) DNA'nın cross-flow-filtrasyonu ile temizlenmesi.
FR2465508B1 (fr) Membranes poreuses contenant du polyacrylonitrile modifie, pour l'ultrafiltration, procede de preparation de celles-ci et applications desdites membranes
DK0923592T3 (da) Fremgangsmåder til rensning af nukleinsyrer
PT787200E (pt) Adenovirus melhorado e metodos para a sua utilizacao
ATE333501T1 (de) Methode zur in vitro auseinander- und wiederzusammensetzung von papillomavirus virus- ähnlichen tielchen (vlps)
DK0550509T3 (da) Fremgangsmåde til fremstilling af rensede glycolipider ved membranseparationsmetoden
CA2197683A1 (en) Method for preparing an influenza virus, antigens obtained and applications thereof
YU78402A (sh) Hemostatički aktivni preparat koji sadrži vwf i postupak njegovog pripremanja
AU4440196A (en) The removal of viruses from protein solutions by ultrafiltration
AU747417C (en) Filtration method for separating viruses
DK0514421T4 (da) Fremgangsmåde til virusreduktion i opløsninger og bestemmelse af virusreduktionsraten
DE69324645T2 (de) Verfahren zur Herstellung von Hepatitis Antigenen und Impfstoffen
DE69103798D1 (de) Katalysatorsystem und -verfahren zur selektiven Herstellung von Isoprenyl-Alkylethern aus Isopren.
FI98466B (fi) FSME-viruksen läntisen alatyypin eristettyjä DNA- ja RNA-molekyylejä, näitä sisältäviä vektoreita ja soluviljelmiä sekä menetelmä näiden koodittamien peptidien valmistamiseksi
NO164023C (no) 2-azetidinyl-eddiksyre, middel inneholdende samme og anvendelse av 2-azetidinyl-eddiksyre ved sterilisering av en plantes stoevknapper.
DK154143C (da) Ren 6,6-diiodpenicillansyre og fremgangsmaade til fremstilling deraf ved diazotering af 6beta-aminopenicillansyre i naervaer af iod