ATE170875T1 - Analoge vom menschlichen insulin - Google Patents

Analoge vom menschlichen insulin

Info

Publication number
ATE170875T1
ATE170875T1 AT89313460T AT89313460T ATE170875T1 AT E170875 T1 ATE170875 T1 AT E170875T1 AT 89313460 T AT89313460 T AT 89313460T AT 89313460 T AT89313460 T AT 89313460T AT E170875 T1 ATE170875 T1 AT E170875T1
Authority
AT
Austria
Prior art keywords
human insulin
sup
insulin analogues
optionally
amino acid
Prior art date
Application number
AT89313460T
Other languages
English (en)
Inventor
Per Balschmidt
Jens Jorgen Veilgaard Brange
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26067619&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE170875(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DK721588A external-priority patent/DK721588D0/da
Priority claimed from DK477789A external-priority patent/DK477789D0/da
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE170875T1 publication Critical patent/ATE170875T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fats And Perfumes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT89313460T 1988-12-23 1989-12-21 Analoge vom menschlichen insulin ATE170875T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK721588A DK721588D0 (da) 1988-12-23 1988-12-23 Humaninsulinanaloger
DK477789A DK477789D0 (da) 1989-09-28 1989-09-28 Nye polypeptider

Publications (1)

Publication Number Publication Date
ATE170875T1 true ATE170875T1 (de) 1998-09-15

Family

ID=26067619

Family Applications (3)

Application Number Title Priority Date Filing Date
AT97121213T ATE175974T1 (de) 1988-12-23 1989-12-21 Lys(b28) insuline. analogen des menschlichen insulins
AT89313460T ATE170875T1 (de) 1988-12-23 1989-12-21 Analoge vom menschlichen insulin
AT97121214T ATE178908T1 (de) 1988-12-23 1989-12-21 Lys(b28) insuline. analoge des menschlichen insulins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT97121213T ATE175974T1 (de) 1988-12-23 1989-12-21 Lys(b28) insuline. analogen des menschlichen insulins

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT97121214T ATE178908T1 (de) 1988-12-23 1989-12-21 Lys(b28) insuline. analoge des menschlichen insulins

Country Status (17)

Country Link
US (1) US5164366A (de)
EP (3) EP0837072B1 (de)
JP (1) JPH04502465A (de)
KR (1) KR910700262A (de)
CN (1) CN1043719A (de)
AT (3) ATE175974T1 (de)
AU (1) AU641631B2 (de)
CA (1) CA2006578A1 (de)
DE (4) DE68928971T2 (de)
ES (1) ES2134669T3 (de)
FI (1) FI913037A0 (de)
HU (1) HUT56857A (de)
IL (1) IL92853A0 (de)
NO (1) NO301483B1 (de)
NZ (1) NZ231936A (de)
WO (1) WO1990007522A1 (de)
YU (1) YU243689A (de)

Families Citing this family (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK336188D0 (da) * 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
US6875589B1 (en) * 1988-06-23 2005-04-05 Hoechst Aktiengesellschaft Mini-proinsulin, its preparation and use
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
US5126249A (en) * 1989-05-09 1992-06-30 Eli Lilly And Company Enzymatic removal of a protein amino-terminal sequence
DK155690D0 (da) * 1990-06-28 1990-06-28 Novo Nordisk As Nye peptider
DK10191D0 (da) * 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
US5304473A (en) * 1991-06-11 1994-04-19 Eli Lilly And Company A-C-B proinsulin, method of manufacturing and using same, and intermediates in insulin production
DK72793D0 (da) * 1993-06-21 1993-06-21 Novo Nordisk As Nyt produkt
US6869930B1 (en) * 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
US5504188A (en) * 1994-06-16 1996-04-02 Eli Lilly And Company Preparation of stable zinc insulin analog crystals
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US5461031A (en) * 1994-06-16 1995-10-24 Eli Lilly And Company Monomeric insulin analog formulations
US5547929A (en) * 1994-09-12 1996-08-20 Eli Lilly And Company Insulin analog formulations
AU3562195A (en) * 1994-10-04 1996-04-26 Novo Nordisk A/S Preparations containing aspb28 human insulin and nicotinamide
US5597893A (en) * 1994-10-31 1997-01-28 Eli Lilly And Company Preparation of stable insulin analog crystals
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
CN1069649C (zh) * 1996-01-25 2001-08-15 中国科学院上海生物化学研究所 [b9谷氨酸,b10门冬氨酸]人胰岛素
US5948751A (en) * 1996-06-20 1999-09-07 Novo Nordisk A/S X14-mannitol
DE19726167B4 (de) * 1997-06-20 2008-01-24 Sanofi-Aventis Deutschland Gmbh Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung
AU1111799A (en) 1997-10-24 1999-05-17 Eli Lilly And Company Fatty acid-acylated insulin analogs
DE69826705T2 (de) * 1997-11-12 2006-02-23 Alza Corp., Palo Alto Verfahren zur dermalen verabreichung von polypeptiden
US6531448B1 (en) 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
AUPP609198A0 (en) * 1998-09-22 1998-10-15 Curtin University Of Technology Use of non-peptidyl compounds for the treatment of insulin related ailments
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US7022674B2 (en) * 1999-12-16 2006-04-04 Eli Lilly And Company Polypeptide compositions with improved stability
US6689747B2 (en) 2000-03-24 2004-02-10 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
US7060675B2 (en) 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US6852694B2 (en) * 2001-02-21 2005-02-08 Medtronic Minimed, Inc. Stabilized insulin formulations
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828305B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
US7030082B2 (en) * 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US7312192B2 (en) 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7601688B2 (en) * 2002-06-13 2009-10-13 Biocon Limited Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
CN1247616C (zh) * 2002-07-19 2006-03-29 上海中科生龙达生物技术（集团）有限公司 新的单体胰岛素，药物组合物及其制法
US7193035B2 (en) 2002-10-29 2007-03-20 Sanofi-Aventis Deutschland Gmbh Crystals of insulin analogs and processes for their preparation
EP1633876B1 (de) 2003-06-17 2008-08-20 SemBioSys Genetics Inc. Verfahren zur insulinproduktion in pflanzen
EP2107069B1 (de) 2003-08-05 2013-01-16 Novo Nordisk A/S Neuartige Insulinderivate
EP2287184A3 (de) 2003-08-05 2011-08-10 Novo Nordisk A/S Neue Insulinderivate
DK1687019T3 (en) 2003-11-20 2018-02-12 Novo Nordisk As Propylene glycol peptide formulations that are optimal for production and use in injection devices
JP5697831B2 (ja) 2003-12-03 2015-04-08 ノヴォ ノルディスク アー／エス 単鎖インシュリン
AU2005205867A1 (en) 2004-01-21 2005-08-04 Novo Nordisk Health Care Ag Transglutaminase mediated conjugation of peptides
KR101276754B1 (ko) 2004-07-19 2013-06-19 바이오콘 리미티드 인슐린―올리고머 접합체，제형 및 이들의 용도
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
EP2256130B1 (de) 2005-02-02 2013-09-25 Novo Nordisk A/S Neuartige Insulinderivate
WO2006082205A1 (en) 2005-02-02 2006-08-10 Novo Nordisk A/S Insulin derivatives
WO2006093222A1 (ja) * 2005-03-02 2006-09-08 Ajinomoto Co., Inc. インスリンの多量体形成阻害剤
JP5366546B2 (ja) 2005-08-16 2013-12-11 ノボ・ノルデイスク・エー／エス 成熟インスリンポリペプチドの作製方法
AU2006291780B2 (en) 2005-09-14 2011-12-08 F. Hoffmann-La Roche Ag Cleavage of precursors of insulins by a variant of trypsin
ATE519780T1 (de) 2005-12-28 2011-08-15 Novo Nordisk As Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
ATE482977T1 (de) 2006-02-27 2010-10-15 Novo Nordisk As Insulinderivate
US20090054305A1 (en) 2006-03-15 2009-02-26 Novo Nordisk A/S Mixtures of Amylin and Insulin
ES2553154T3 (es) 2006-05-09 2015-12-04 Novo Nordisk A/S Derivado de la insulina
US8933021B2 (en) 2006-05-09 2015-01-13 Novo Nordisk A/S Insulin derivative
US20090099064A1 (en) * 2006-06-08 2009-04-16 Diabecore Medical Inc., Derivatized insulin oligomers
PL2074141T3 (pl) 2006-09-22 2017-02-28 Novo Nordisk A/S Analogi insuliny oporne na proteazę
CN101674812B (zh) 2007-04-30 2013-12-11 诺沃-诺迪斯克有限公司 干燥蛋白组合物的方法、干燥的蛋白组合物和包含干燥的蛋白的药物组合物
EP2514406A1 (de) 2007-06-01 2012-10-24 Novo Nordisk A/S Spontan dispergierbare Vorkonzentrate mit einem Peptidwirkstoff in einem festen oder halbfesten Träger
EP2164458A1 (de) 2007-06-01 2010-03-24 Novo Nordisk A/S Stabile nichtwässrige pharmazeutische zusammensetzungen
JP5552046B2 (ja) 2007-06-13 2014-07-16 ノボ・ノルデイスク・エー／エス インスリン誘導体を含有する薬学的製剤
EP2203181B1 (de) 2007-10-16 2018-02-14 Biocon Limited Oral zu verabreichende feste pharmazeutische zusammensetzung und verfahren dafür
ES2632504T3 (es) 2007-11-20 2017-09-13 Ambrx, Inc. Polipéptidos de insulina modificados y sus usos
BRPI0907371A2 (pt) 2008-01-09 2015-11-24 Sanofi Aventis Deutschland derivados de insulina com um perfil de tempo-ação muito retardado
EP2254905B1 (de) 2008-03-14 2016-12-14 Novo Nordisk A/S Proteasestabilisierte insulinanaloga
EP2910570B1 (de) 2008-03-18 2016-10-12 Novo Nordisk A/S Proteasestabilisierte, acylierte Insulinanaloga
DE102009038210A1 (de) 2009-08-20 2011-03-03 Sanofi-Aventis Deutschland Gmbh Kombination von einem Insulin und einem GLP-1-Agonisten
HUE037449T2 (hu) 2008-10-17 2018-08-28 Sanofi Aventis Deutschland Egy inzulin és egy GLP-1 agonista kombinációja
DE102008051834A1 (de) 2008-10-17 2010-04-22 Sanofi-Aventis Deutschland Gmbh Kombination von einem Insulin und einem GLP-1-Agonisten
DE102008053048A1 (de) 2008-10-24 2010-04-29 Sanofi-Aventis Deutschland Gmbh Kombination von einem Insulin und einem GLP-1-Agonisten
KR20110085985A (ko) 2008-10-30 2011-07-27 노보 노르디스크 에이/에스 하루 한번 주사 빈도보다 적은 인슐린 주사를 사용한 진성 당뇨병의 치료
ES2614161T3 (es) 2009-07-06 2017-05-29 Sanofi-Aventis Deutschland Gmbh Preparados acuosos de insulina que comprenden metionina
WO2011003820A1 (de) 2009-07-06 2011-01-13 Sanofi-Aventis Deutschland Gmbh Hitze- und schüttelstabile insulinzubereitungen
US20120232002A1 (en) 2009-07-06 2012-09-13 Sanofi-Aventis Deutschland Gmbh Slow-acting insulin preparations
EP2459228B1 (de) 2009-07-31 2020-03-04 Sanofi-Aventis Deutschland GmbH Prodrug bestehend aus Insulin-Linker-Konjugat
KR101759499B1 (ko) 2009-07-31 2017-07-19 사노피-아벤티스 도이칠란트 게엠베하 지속형 인슐린 조성물
PE20121316A1 (es) 2009-11-13 2012-10-05 Sanofi Aventis Deutschland Composicion farmaceutica que comprende un agonista de glp-1 y metionina
RU2537239C2 (ru) 2009-11-13 2014-12-27 Санофи-Авентис Дойчланд Гмбх Фармацевтическая композиция, включающая агонист glp-1, инсулин и метионин
ES2612468T3 (es) 2010-05-10 2017-05-17 Novo Nordisk A/S Procedimiento para la preparación de complejos de insulina-zinc
PL2605789T3 (pl) 2010-08-17 2019-11-29 Ambrx Inc Zmodyfikowane polipeptydy relaksyny i ich zastosowania
PT2611458T (pt) 2010-08-30 2016-12-16 Sanofi Aventis Deutschland Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2
EP2438930A1 (de) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrug mit einem exendinbindenden Konjugat
DK2632478T3 (da) 2010-10-27 2019-10-07 Novo Nordisk As Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
AU2011322495A1 (en) 2010-10-27 2013-04-11 Novo Nordisk A/S Treating diabetes melitus using insulin injections administered with varying injection intervals
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PT2750699E (pt) 2011-08-29 2015-11-03 Sanofi Aventis Deutschland Acelerómetro pendular
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
BR112014013483A2 (pt) 2011-12-15 2019-09-24 Jiangsu Hengrui Medicine Co análogo de insulina humana e derivado acilado do mesmo
AU2013255880B2 (en) 2012-05-01 2017-07-20 Novo Nordisk A/S Pharmaceutical composition
US20130315891A1 (en) 2012-05-25 2013-11-28 Matthew Charles Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
PL2854841T3 (pl) 2012-06-04 2017-08-31 Diamedica Inc. Izoformy glikozylacji ludzkiej kalikreiny tkankowej 1
CN104902922B (zh) 2012-11-13 2017-12-12 阿道恰公司 包含经取代阴离子化合物的速效胰岛素制剂
WO2014093696A2 (en) 2012-12-12 2014-06-19 Massachusetts Institute Of Technology Insulin derivatives for diabetes treatment
US9707275B2 (en) 2012-12-19 2017-07-18 Wockhardt Limited Stable aqueous composition comprising human insulin or an analogue or derivative thereof
AU2013368990B2 (en) 2012-12-26 2017-05-18 Wockhardt Limited Pharmaceutical composition
KR20140088837A (ko) * 2013-01-03 2014-07-11 한미약품 주식회사 Ｎ-말단 전하가 변형된 인슐린 분비 펩티드 유도체
TWI780236B (zh) 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
EP2991672A1 (de) 2013-04-30 2016-03-09 Novo Nordisk A/S Neuartiges verabreichungsschema
AU2014326181A1 (en) 2013-09-30 2016-03-17 Wockhardt Limited Pharmaceutical composition
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
RU2016132386A (ru) 2014-01-09 2018-02-14 Санофи Стабилизированные фармацевтические составы без глицерина на основе инсулиновых аналогов и/или инсулиновых производных
AU2015205620A1 (en) 2014-01-09 2016-07-14 Sanofi Stabilized pharmaceutical formulations of insulin aspart
WO2015104314A1 (en) 2014-01-09 2015-07-16 Sanofi Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
AR099569A1 (es) * 2014-02-28 2016-08-03 Novo Nordisk As Derivados de insulina y los usos médicos de estos
CN104017809A (zh) * 2014-06-05 2014-09-03 山东省农业科学院生物技术研究中心 改造的人Insulin蛋白表达基因及表达方法
WO2016001862A1 (en) 2014-07-04 2016-01-07 Wockhardt Limited Extended release formulations of insulins
CA2970200A1 (en) 2014-12-12 2016-06-16 Sanofi-Aventis Deutschland Gmbh Insulin glargine/lixisenatide fixed ratio formulation
AR102869A1 (es) 2014-12-16 2017-03-29 Lilly Co Eli Composiciones de insulina de rápida acción
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
JO3749B1 (ar) 2015-08-27 2021-01-31 Lilly Co Eli تركيبات إنسولين سريعة المفعول
UY36870A (es) * 2015-08-28 2017-03-31 Hanmi Pharm Ind Co Ltd Análogos de insulina novedosos
CN105440125B (zh) * 2015-11-25 2019-09-24 华润昂德生物药业有限公司 地特胰岛素或其类似物的制备方法
GB201607918D0 (en) 2016-05-06 2016-06-22 Arecor Ltd Novel formulations
WO2018056764A1 (ko) 2016-09-23 2018-03-29 한미약품 주식회사 인슐린 수용체와의 결합력이 감소된, 인슐린 아날로그 및 이의 용도
JP7145849B2 (ja) 2016-09-29 2022-10-03 アレコル リミテッド 新規の製剤
SI3554534T1 (sl) 2016-12-16 2021-09-30 Novo Nordisk A/S Farmacevtski sestavki, ki vsebujejo inzulin
JP2020510023A (ja) 2017-03-09 2020-04-02 ダイアメディカ， インコーポレイテッド 組織カリクレイン１の剤形
TWI798209B (zh) 2017-03-23 2023-04-11 南韓商韓美藥品股份有限公司 對胰島素受體有降低親和性之胰島素類似物之接合物及其用途
GB201707189D0 (en) 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
GB201707187D0 (en) 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
GB201707188D0 (en) 2017-05-05 2017-06-21 Arecor Ltd Novel formulations
JOP20190277B1 (ar) 2017-06-01 2023-09-17 Lilly Co Eli تركيبات إنسولين سريعة المفعول
IL277720B2 (en) 2018-04-04 2024-03-01 Arecor Ltd A medical infusion pump system for administration of an insulin compound
WO2019193349A1 (en) 2018-04-04 2019-10-10 Arecor Limited Medical infusion pump system for the delivery of an insulin compound
EP3773474A1 (de) 2018-04-04 2021-02-17 Arecor Limited Medizinisches infusionspumpensystem zur abgabe einer insulinverbindung
CA3100869A1 (en) 2018-05-24 2019-11-28 Jiangsu Hengrui Medicine Co., Ltd. Method for preparing precursor of recombinant human insulin or analogue thereof
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
KR20220119730A (ko) 2019-12-30 2022-08-30 간 앤 리 파마슈티칼스 컴퍼니, 리미티드 인슐린 유도체
JP2023510218A (ja) 2019-12-30 2023-03-13 ガン アンド リー ファーマスゥーティカルズ カンパニー リミテッド 長時間作用型ｇｌｐ－１化合物
GB202004814D0 (en) 2020-04-01 2020-05-13 Arecor Ltd Novel formulations
CN114075275A (zh) * 2020-08-17 2022-02-22 成都奥达生物科技有限公司 一种长效胰岛素类似物
CN115493919B (zh) * 2022-11-21 2023-04-07 保定佳瑞源生物芯片有限公司 一种c肽和胰岛素检测试剂盒的校准品稀释液

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1426061A (en) * 1972-12-28 1976-02-25 Ici Ltd Polypeptides
JPS55138393A (en) * 1979-04-13 1980-10-29 Shionogi & Co Ltd Semisynthesis of insulin
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DK347086D0 (da) * 1986-07-21 1986-07-21 Novo Industri As Novel peptides
PH25772A (en) * 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
DE10075034I1 (de) * 1987-02-25 2001-05-23 Novo Nordisk As Insulinderivate
DK257988D0 (da) * 1988-05-11 1988-05-11 Novo Industri As Nye peptider
PT93057B (pt) * 1989-02-09 1995-12-29 Lilly Co Eli Processo para a preparacao de analogos da insulina

Also Published As

Publication number Publication date
EP0375437A2 (de) 1990-06-27
EP0837072A3 (de) 1998-08-19
NO912438D0 (no) 1991-06-21
NO301483B1 (no) 1997-11-03
IL92853A0 (en) 1990-09-17
WO1990007522A1 (en) 1990-07-12
EP0861851A1 (de) 1998-09-02
CN1043719A (zh) 1990-07-11
DE861851T1 (de) 1999-04-22
DE68928971D1 (de) 1999-05-27
EP0837072B1 (de) 1999-01-20
US5164366A (en) 1992-11-17
ATE175974T1 (de) 1999-02-15
FI913037A0 (fi) 1991-06-20
CA2006578A1 (en) 1990-06-23
NZ231936A (en) 1992-04-28
HUT56857A (en) 1991-10-28
DE68928917D1 (de) 1999-03-04
DE68928810D1 (de) 1998-10-15
EP0375437B1 (de) 1998-09-09
NO912438L (no) 1991-08-21
AU4834490A (en) 1990-08-01
YU243689A (en) 1991-10-31
DE68928917T2 (de) 1999-08-05
EP0375437A3 (de) 1991-09-11
DE68928810T2 (de) 1999-03-18
KR910700262A (ko) 1991-03-14
ES2134669T3 (es) 1999-10-01
AU641631B2 (en) 1993-09-30
EP0837072A2 (de) 1998-04-22
DE68928971T2 (de) 1999-12-02
JPH04502465A (ja) 1992-05-07
ATE178908T1 (de) 1999-04-15
EP0861851B1 (de) 1999-04-14

Similar Documents

Publication Publication Date Title
ATE170875T1 (de) Analoge vom menschlichen insulin
MY102873A (en) Novel peptides
ES8800276A1 (es) Un procedimiento para preparar nuevos derivados de insulina
ES2010299A6 (es) Un procedimiento para la preparacion de analogos de insulina humana que presentan actividad biologica.
ES8801674A1 (es) Un procedimiento para la preparacion de una proteina que presenta actividad procoagulante.
CA2050300A1 (en) Tnf-inhibiting proteins and the preparation thereof
AU1633200A (en) Human parathyroid hormone modifications, preparation and use
KR930009591A (ko) 트리-아르기닌 인슐린
GR3026553T3 (en) Porcine CNP gene and precursor protein
DE3261304D1 (en) Retro-inverso analogues of c-terminal penta and hexapeptides of substance p.
EP0161007A3 (de) Retro-inverso C-Terminal-Hexapeptid-Analoga von der Verbindung P
NZ334714A (en) Liver proteins as agents against autoimmune diseases
GB1532169A (en) Fragments of secretin
EP0244169A3 (de) Peptide mit ANF-Wirksamkeit
DK119391A (da) Humaninsulinanaloger
BJÖRKROTH et al. Synthesis of Substance P Analogs and Agonistic and Antagonistic Activities
GB1333723A (en) Hypocalcaemic peptides and process for their manufacture