ATE150487T1 - Verfahren zur herstellung von cytidin-diphosphat- cholin - Google Patents

Verfahren zur herstellung von cytidin-diphosphat- cholin

Info

Publication number
ATE150487T1
ATE150487T1 AT93101323T AT93101323T ATE150487T1 AT E150487 T1 ATE150487 T1 AT E150487T1 AT 93101323 T AT93101323 T AT 93101323T AT 93101323 T AT93101323 T AT 93101323T AT E150487 T1 ATE150487 T1 AT E150487T1
Authority
AT
Austria
Prior art keywords
choline
cytidine
producing
diphosphat
cytidine diphosphate
Prior art date
Application number
AT93101323T
Other languages
English (en)
Inventor
Akihiko Maruyama
Tatsuro Fujio
Sadao Teshiba
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Application granted granted Critical
Publication of ATE150487T1 publication Critical patent/ATE150487T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
AT93101323T 1992-01-30 1993-01-28 Verfahren zur herstellung von cytidin-diphosphat- cholin ATE150487T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1485892 1992-01-30

Publications (1)

Publication Number Publication Date
ATE150487T1 true ATE150487T1 (de) 1997-04-15

Family

ID=11872731

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93101323T ATE150487T1 (de) 1992-01-30 1993-01-28 Verfahren zur herstellung von cytidin-diphosphat- cholin

Country Status (8)

Country Link
US (2) US6387667B1 (de)
EP (1) EP0553821B1 (de)
KR (1) KR0177841B1 (de)
CN (1) CN1060215C (de)
AT (1) ATE150487T1 (de)
DE (1) DE69308908D1 (de)
ES (1) ES2100376T3 (de)
HK (1) HK1000604A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1110568C (zh) * 1995-10-20 2003-06-04 傅责中 富含ctp水溶液的生产工艺
CN100335647C (zh) * 1996-09-13 2007-09-05 协和发酵工业株式会社 糖核苷酸的制造方法
US6821756B2 (en) 1996-09-17 2004-11-23 Kyowa Hakko Kogyo Co., Ltd. Processes for reproducing sugar nucleotides and complex carbohydrates
ATE437956T1 (de) * 2002-05-08 2009-08-15 Kyowa Hakko Bio Co Ltd Verfahren zur herstellung von cytidin 5'- diphosphatcholin
JP2006512066A (ja) * 2002-12-23 2006-04-13 サイノファーム・バイオテック・リミテッド リボヌクレオチドの酵素的還元によるデオキシリボヌクレオチド製造
TW200741005A (en) 2005-08-10 2007-11-01 Kyowa Hakko Kogyo Kk A purification method of cytidine diphosphate
US9637746B2 (en) 2008-12-15 2017-05-02 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways
CN102333878B (zh) * 2008-12-22 2015-08-26 绿光生物科学公司 用于制造化合物的组合物和方法
CN101792786B (zh) * 2010-03-04 2012-07-11 南京工业大学 一种定向催化合成胞苷磷酰化合物的方法
EP2566953B1 (de) 2010-05-07 2019-01-02 Greenlight Biosciences, Inc. Verfahren zur flusssteuerung bei stoffwechselwegen druch enzymumpositionierung
CA2809284C (en) 2010-08-31 2021-02-23 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways through protease manipulation
CN102212096A (zh) * 2011-04-08 2011-10-12 南通香地生物有限公司 利用复合溶剂及缚酸剂制作5′-胞苷酸的方法
EP2753702B1 (de) 2011-09-09 2021-12-15 GreenLight Biosciences, Inc. Zellfreie herstellung von carbapenemen
US9688977B2 (en) 2013-08-05 2017-06-27 Greenlight Biosciences, Inc. Engineered phosphoglucose isomerase proteins with a protease cleavage site
CN103483408B (zh) * 2013-09-18 2015-07-15 南京工业大学 一种用微通道反应装置连续生产5′-核苷酸的方法
AU2016243623B2 (en) 2015-03-30 2022-04-14 Greenlight Biosciences, Inc. Cell-free production of ribonucleic acid
CN104774799B (zh) * 2015-04-17 2018-01-30 南京工业大学 一株表达胆碱激酶及磷酰胆碱胞苷转移酶的基因工程菌及其构建方法与应用
CN105463042A (zh) * 2015-10-23 2016-04-06 苏州天马精细化学品股份有限公司 一种生物酶催化制备胞二磷胆碱的方法
EP3440215A1 (de) 2016-04-06 2019-02-13 Greenlight Biosciences, Inc. Zellfreie herstellung von ribonukleinsäure
CN110300800A (zh) 2017-01-06 2019-10-01 绿光生物科技股份有限公司 糖的无细胞生产
CN109207415B (zh) * 2017-07-07 2022-09-16 苏州华赛生物工程技术有限公司 一种生产胞二磷胆碱的重组微生物及生产胞二磷胆碱的方法
AR113764A1 (es) 2017-10-11 2020-06-10 Greenlight Biosciences Inc Métodos y composiciones para la producción de nucleósido trifosfato y ácido ribonucleico
CN108424859B (zh) * 2017-11-23 2021-09-10 华东理工大学 生产胞磷胆碱的基因工程菌的构建与应用
CN115725536A (zh) * 2021-08-27 2023-03-03 北京天开易达生物科技有限公司 一种双功能酶、双功能酶突变体及其应用
CN116790466B (zh) * 2023-07-19 2023-11-03 山东理工大学 一种工程改造枯草芽孢杆菌发酵生产胞磷胆碱的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4840757B1 (de) 1969-02-21 1973-12-03
JPS4840758B1 (de) 1969-03-24 1973-12-03
JPS4841555B1 (de) * 1969-08-04 1973-12-07
USRE28886E (en) * 1969-08-04 1976-06-29 Kyowa Hakko Kogyo Co., Ltd. Method for preparing cytidine diphosphate choline
JPS5140159B1 (de) 1969-11-26 1976-11-01
JPS521175Y2 (de) 1971-06-02 1977-01-12
JPS53109996A (en) 1977-03-07 1978-09-26 Hikari Kimura Production of cytidine diphosphoric acid choline
JPS599158B2 (ja) 1977-07-01 1984-02-29 協和醗酵工業株式会社 シチジン二リン酸コリンの製造法
JPS601199A (ja) 1983-06-16 1985-01-07 Kohjin Co Ltd シチジン−５′−ジリン酸コリンの製造方法
US4774180A (en) * 1986-02-26 1988-09-27 Massachusetts Institute Of Technology Construction and application of polyproteins
IT1188178B (it) * 1985-07-05 1988-01-07 Bioresearch Spa Sali della citidin-difospocolina particolarmente idonei per uso orale
JP2724825B2 (ja) 1987-06-15 1998-03-09 旭化成工業株式会社 シチジンジリン酸コリンの製造方法
JPH0710235B2 (ja) 1987-10-19 1995-02-08 協和醗酵工業株式会社 発酵法によるオロット酸の製造法

Also Published As

Publication number Publication date
HK1000604A1 (en) 1998-04-09
CN1074938A (zh) 1993-08-04
EP0553821B1 (de) 1997-03-19
KR0177841B1 (ko) 1999-04-01
US6387667B1 (en) 2002-05-14
DE69308908D1 (de) 1997-04-24
CN1060215C (zh) 2001-01-03
ES2100376T3 (es) 1997-06-16
KR930016543A (ko) 1993-08-26
US20020151036A1 (en) 2002-10-17
US7226767B2 (en) 2007-06-05
EP0553821A1 (de) 1993-08-04

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