KR830005221A - 디아자퓨린 뉴클레오사이드의 합성방법 - Google Patents
디아자퓨린 뉴클레오사이드의 합성방법 Download PDFInfo
- Publication number
- KR830005221A KR830005221A KR1019810001391A KR810001391A KR830005221A KR 830005221 A KR830005221 A KR 830005221A KR 1019810001391 A KR1019810001391 A KR 1019810001391A KR 810001391 A KR810001391 A KR 810001391A KR 830005221 A KR830005221 A KR 830005221A
- Authority
- KR
- South Korea
- Prior art keywords
- phosphorylase
- imidazo
- pyridine
- phosphate
- amino
- Prior art date
Links
- 239000002777 nucleoside Substances 0.000 title 1
- 150000003833 nucleoside derivatives Chemical class 0.000 title 1
- 238000001308 synthesis method Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims 9
- 102000004190 Enzymes Human genes 0.000 claims 4
- 108090000790 Enzymes Proteins 0.000 claims 4
- YXJDFQJKERBOBM-TXICZTDVSA-N alpha-D-ribose 1-phosphate Chemical compound OC[C@H]1O[C@H](OP(O)(O)=O)[C@H](O)[C@@H]1O YXJDFQJKERBOBM-TXICZTDVSA-N 0.000 claims 3
- DBZQFUNLCALWDY-PNHWDRBUSA-N (2r,3r,4s,5r)-2-(4-aminoimidazo[4,5-c]pyridin-1-yl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C1=NC=2C(N)=NC=CC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O DBZQFUNLCALWDY-PNHWDRBUSA-N 0.000 claims 2
- 102000009097 Phosphorylases Human genes 0.000 claims 2
- 108010073135 Phosphorylases Proteins 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 229910052816 inorganic phosphate Inorganic materials 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 150000005239 1H-imidazo[4,5-c]pyridines Chemical class 0.000 claims 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims 1
- 125000000824 D-ribofuranosyl group Chemical group [H]OC([H])([H])[C@@]1([H])OC([H])(*)[C@]([H])(O[H])[C@]1([H])O[H] 0.000 claims 1
- 101710101148 Probable 6-oxopurine nucleoside phosphorylase Proteins 0.000 claims 1
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 1
- 102000030764 Purine-nucleoside phosphorylase Human genes 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 102000001853 Pyrimidine Phosphorylases Human genes 0.000 claims 1
- 108010054917 Pyrimidine Phosphorylases Proteins 0.000 claims 1
- 101710132082 Pyrimidine/purine nucleoside phosphorylase Proteins 0.000 claims 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 1
- 102000013537 Thymidine Phosphorylase Human genes 0.000 claims 1
- 102000006405 Uridine phosphorylase Human genes 0.000 claims 1
- 108010019092 Uridine phosphorylase Proteins 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical group [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 125000003396 thiol group Chemical class [H]S* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (10)
- 4-치환-1H-이미다조-(4,5-C) 피리딘과 리보스-1-포스페이트 및 포스포릴라제타입효소로 이루어지는 리보스도너 시스템의 반응으로 구조식(Ⅰ)의 4-치환-1-β-D-리보퓨라닐-1H-이미다조-(4,5-C)-피리딘의 제조방법.
- 구조식(Ⅰ) 화합물에서 R을 아미노, 할로게노, 티올, 알킬티오 또는 치환 아미노로부터 선택하는 청구범위 제1항에 따른 방법.
- 구조식(Ⅰ) 화합물이 4-아미노-1-β-D-리보퓨라노실-1H-이미다조-(4,5-C) 피리딘인 청구범위 제1항 또는 제2항에 따른 방법.
- 리보스-1-포스페이트를 리보신도너와 무기포스페이트로부터 효소를 사용하여 만드는 청구범위 제1항 내지 제3항중의 어느 하나에 따른 방법.
- 리보실도너가 퓨린 또는 피리미딘 또는 그 혼합물인 청구범위 제1항 내지 제4항중의 어느하나에 따른 방법.
- 포스포릴라제타입효소가 퓨린뉴클레오사이드 포스포릴라제, 피리미딘 뉴클레오사이드 포스포릴라제, 티미딘 포스포릴라제 또는 유리딘 포스포릴라제인 청구범위 제1항내지 제5항중의 어느 하나에 따른 방법.
- 무기인산염이 디포타슘 수소 포스페이트인 청구범위 제1항내지 제6항중의 어느하나에 따른 방법.
- 반반이 수용액 또는 유기용 제50%까지 함유하는 매체중에서 표시되는 청구범위 제1항내지 제7항중의 어느하나에 따른 방법.
- 반응이 pH5내지 9, 온도 3내지 37℃에서 표시되는 청구범위 제1항내지 제7항중의 어느하나에 따른 방법.
- 리보실레이션을 리보스-1-포스페이트와 포스포릴라제타입효소의 반응에 의해 효소적으로 실시함을 특징으로 하여 할로겐치환체를 아미노기로 변화시켜 4-할로게노-1H-이미다조 (4,5-C)-피리딘을 리보실화함으로 이루어지는 4-아미노-1-β-D-리보퓨라노실-1H이미다조-(4,5-C) 피리딘의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8013413 | 1980-04-23 | ||
| GB8013413 | 1980-04-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR830005221A true KR830005221A (ko) | 1983-08-03 |
| KR840001959B1 KR840001959B1 (ko) | 1984-10-26 |
Family
ID=10512974
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019810001391A KR840001959B1 (ko) | 1980-04-23 | 1981-04-22 | 4-치환-1-β-D-리보퓨라닐-1H-이미다조-(4, 5-C)-피리딘의 제조방법 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0038568B1 (ko) |
| JP (1) | JPS56164793A (ko) |
| KR (1) | KR840001959B1 (ko) |
| AT (1) | ATE4225T1 (ko) |
| AU (1) | AU548977B2 (ko) |
| CA (1) | CA1162155A (ko) |
| DE (1) | DE3160637D1 (ko) |
| DK (1) | DK179981A (ko) |
| FI (1) | FI70425C (ko) |
| HU (1) | HU185928B (ko) |
| IL (1) | IL62695A (ko) |
| IT (1) | IT1170911B (ko) |
| NZ (1) | NZ196884A (ko) |
| ZA (1) | ZA812639B (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5788195A (en) * | 1980-11-22 | 1982-06-01 | Microbial Chem Res Found | Antibiotic, oxanosine, and its preparation |
| US4918060A (en) * | 1987-09-04 | 1990-04-17 | The Johns Hopkins University | Method of treating myasthenia gravis and related diseases |
| US5137876A (en) * | 1990-10-12 | 1992-08-11 | Merck & Co., Inc. | Nucleoside antiviral and anti-inflammatory compounds and compositions and methods for using same |
| JPH06253854A (ja) * | 1993-02-26 | 1994-09-13 | Yamasa Shoyu Co Ltd | 組換えｄｎａ手法によるヌクレオシド・ホスホリラーゼの製造法 |
| IT1304500B1 (it) | 1998-12-23 | 2001-03-19 | Norpharma Spa | Ceppi batterici ricombinati per la produzione di nucleosidi naturali edi analoghi modificati. |
| US20060194782A1 (en) * | 2003-09-18 | 2006-08-31 | Altana Pharma Ag | Pharmacologically active imidazo[4,5-c] pyridines |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3976545A (en) * | 1973-03-12 | 1976-08-24 | Icn Pharmaceuticals, Inc. | 1,2,4-Triazol E-3-carboxamides as antiviral agents |
| AR205339A1 (es) * | 1973-03-12 | 1976-04-30 | Icn Pharmaceuticals | Sintesis de 1,2,4-triazolo-3-carboxamidas utiles como agentes antivirales |
| JPS5813544B2 (ja) * | 1975-04-03 | 1983-03-14 | ヴァイラテック・インコ−ポレイテッド | ３− デアザグアニン ３− デアザグアノシン オヨビ ソレラノユウドウタイノセイホウ |
| GB1573777A (en) * | 1977-11-03 | 1980-08-28 | Wellcome Found | 9-d-arabinonucleosides and an enzymatic process for their preparation |
-
1981
- 1981-04-22 AT AT81103044T patent/ATE4225T1/de not_active IP Right Cessation
- 1981-04-22 IL IL62695A patent/IL62695A/xx unknown
- 1981-04-22 DK DK179981A patent/DK179981A/da not_active Application Discontinuation
- 1981-04-22 JP JP6111481A patent/JPS56164793A/ja active Granted
- 1981-04-22 CA CA000375911A patent/CA1162155A/en not_active Expired
- 1981-04-22 NZ NZ196884A patent/NZ196884A/xx unknown
- 1981-04-22 IT IT48328/81A patent/IT1170911B/it active
- 1981-04-22 HU HU811042A patent/HU185928B/hu not_active IP Right Cessation
- 1981-04-22 AU AU69709/81A patent/AU548977B2/en not_active Ceased
- 1981-04-22 FI FI811250A patent/FI70425C/fi not_active IP Right Cessation
- 1981-04-22 ZA ZA00812639A patent/ZA812639B/xx unknown
- 1981-04-22 DE DE8181103044T patent/DE3160637D1/de not_active Expired
- 1981-04-22 EP EP81103044A patent/EP0038568B1/en not_active Expired
- 1981-04-22 KR KR1019810001391A patent/KR840001959B1/ko active
Also Published As
| Publication number | Publication date |
|---|---|
| IT1170911B (it) | 1987-06-03 |
| CA1162155A (en) | 1984-02-14 |
| IT8148328A0 (it) | 1981-04-22 |
| ZA812639B (en) | 1982-12-29 |
| ATE4225T1 (de) | 1983-08-15 |
| FI70425B (fi) | 1986-03-27 |
| AU548977B2 (en) | 1986-01-09 |
| JPH0336519B2 (ko) | 1991-05-31 |
| DE3160637D1 (en) | 1983-08-25 |
| EP0038568A1 (en) | 1981-10-28 |
| IL62695A0 (en) | 1981-06-29 |
| IL62695A (en) | 1984-03-30 |
| JPS56164793A (en) | 1981-12-17 |
| HU185928B (en) | 1985-04-28 |
| FI70425C (fi) | 1986-09-19 |
| AU6970981A (en) | 1981-10-29 |
| NZ196884A (en) | 1983-07-15 |
| EP0038568B1 (en) | 1983-07-20 |
| DK179981A (da) | 1981-10-24 |
| KR840001959B1 (ko) | 1984-10-26 |
| FI811250L (fi) | 1981-10-24 |
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