ATE449183T1 - Verfahren zur herstellung von dipeptiden oder dipeptidderivaten. - Google Patents
Verfahren zur herstellung von dipeptiden oder dipeptidderivaten.Info
- Publication number
- ATE449183T1 ATE449183T1 AT05013733T AT05013733T ATE449183T1 AT E449183 T1 ATE449183 T1 AT E449183T1 AT 05013733 T AT05013733 T AT 05013733T AT 05013733 T AT05013733 T AT 05013733T AT E449183 T1 ATE449183 T1 AT E449183T1
- Authority
- AT
- Austria
- Prior art keywords
- culture
- protein
- dipeptide
- adenosine
- kinds
- Prior art date
Links
- 108010016626 Dipeptides Proteins 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- ZKHQWZAMYRWXGA-KQYNXXCUSA-N Adenosine triphosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-N 0.000 abstract 2
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 abstract 2
- 150000003862 amino acid derivatives Chemical class 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- XTWYTFMLZFPYCI-KQYNXXCUSA-N 5'-adenylphosphoric acid Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XTWYTFMLZFPYCI-KQYNXXCUSA-N 0.000 abstract 1
- UDMBCSSLTHHNCD-UHFFFAOYSA-N Coenzym Q(11) Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(O)=O)C(O)C1O UDMBCSSLTHHNCD-UHFFFAOYSA-N 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 abstract 1
- 229950006790 adenosine phosphate Drugs 0.000 abstract 1
- 229960001456 adenosine triphosphate Drugs 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 108020000161 polyphosphate kinase Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1229—Phosphotransferases with a phosphate group as acceptor (2.7.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004189007 | 2004-06-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE449183T1 true ATE449183T1 (de) | 2009-12-15 |
Family
ID=35169745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05013733T ATE449183T1 (de) | 2004-06-25 | 2005-06-24 | Verfahren zur herstellung von dipeptiden oder dipeptidderivaten. |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8257943B2 (de) |
| EP (1) | EP1616963B1 (de) |
| JP (1) | JP5424531B2 (de) |
| CN (1) | CN1973037B (de) |
| AT (1) | ATE449183T1 (de) |
| DE (1) | DE602005017707D1 (de) |
| WO (1) | WO2006001382A1 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070243581A1 (en) * | 2004-04-21 | 2007-10-18 | Hashimoto Shin-Ichi | Process for Producing Dipeptides |
| CN101151369B (zh) * | 2005-03-29 | 2017-02-15 | 协和发酵生化株式会社 | 二肽的结晶及其制备方法 |
| US8673590B2 (en) | 2007-04-06 | 2014-03-18 | Kyowa Hakko Bio Co., Ltd. | Method for producing dipeptide |
| LT2494993T (lt) | 2007-05-04 | 2018-12-27 | Marina Biotech, Inc. | Aminorūgščių lipidai ir jų panaudojimas |
| DE112009001080T5 (de) * | 2008-05-12 | 2011-03-03 | Ajinomoto Co., Inc. | Verfahren zum Herstellen von β-Alanylaminosäure oder eines Derivats davon |
| US9637746B2 (en) | 2008-12-15 | 2017-05-02 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways |
| CN105132387A (zh) * | 2008-12-22 | 2015-12-09 | 绿光生物科学公司 | 用于制造化合物的组合物和方法 |
| CN102782146B (zh) * | 2010-03-01 | 2015-07-08 | 三井化学株式会社 | 1,5-戊二异氰酸酯的制造方法 |
| JP2013526277A (ja) | 2010-05-07 | 2013-06-24 | グリーンライト バイオサイエンシーズ インコーポレーテッド | 酵素リロケーションにより代謝経路のフラックスを制御する方法 |
| KR101698436B1 (ko) * | 2010-08-11 | 2017-01-20 | (주)아모레퍼시픽 | 데아닌 유도체, 이의 제조방법 및 이를 함유하는 항여드름용 피부 외용제 조성물 |
| KR101988063B1 (ko) | 2010-08-31 | 2019-09-30 | 그린라이트 바이오사이언시스, 아이엔씨. | 프로테아제 조작을 통한 대사 경로에서 유동의 제어 방법 |
| EP2753702B1 (de) | 2011-09-09 | 2021-12-15 | GreenLight Biosciences, Inc. | Zellfreie herstellung von carbapenemen |
| JP5951953B2 (ja) * | 2011-10-07 | 2016-07-13 | 協和発酵バイオ株式会社 | 新規ジペプチド合成酵素およびそれを用いたジペプチドの製造法 |
| DE102012024435A1 (de) | 2012-12-14 | 2014-07-10 | Forschungszentrum Jülich GmbH | Verfahren zur Identifizierung einer Zelle mit gegenüber ihrem Wildtyp erhöhten intrazellulären Konzentration eines bestimmten Metaboliten, wobei die Veränderung der Zelle durch Rekombi-neering erreicht wird, sowie ein Verfahren zur Herstellung einer gegenüber ihrem Wildtyp genetisch veränderten Produktionszelle mit optimierter Produktion eines bestimmten Metaboliten, ein Verfahren zur Herstellung dieses Metaboliten, sowie dafür geeignete Nukleinsäuren |
| WO2014100722A1 (en) | 2012-12-21 | 2014-06-26 | Greenlight Biosciences, Inc. | Cell-free system for converting methane into fuel, pyruvate or isobutanol |
| US9688977B2 (en) | 2013-08-05 | 2017-06-27 | Greenlight Biosciences, Inc. | Engineered phosphoglucose isomerase proteins with a protease cleavage site |
| RU2017137788A (ru) | 2015-03-30 | 2019-04-30 | Гринлайт Байосайенсис, Инк. | Бесклеточное получение рибонуклеиновой кислоты |
| KR101813759B1 (ko) * | 2015-06-24 | 2018-01-02 | 씨제이제일제당 (주) | 퓨트레신 또는 오르니틴 생산 미생물 및 이를 이용한 퓨트레신 또는 오르니틴 생산방법 |
| CN106893748B (zh) * | 2015-12-21 | 2020-11-17 | 中国科学院天津工业生物技术研究所 | 一种l-茶氨酸的合成方法 |
| CN105624238B (zh) * | 2016-01-12 | 2021-05-04 | 北京化工大学 | 一种理性设计的酶用于再生atp的方法 |
| WO2017159795A1 (ja) * | 2016-03-16 | 2017-09-21 | 国立研究開発法人産業技術総合研究所 | テントキシン合成関連遺伝子、これを用いたジヒドロテントキシン又はテントキシンの製造方法及びこれを有する形質転換体 |
| SG11201808721YA (en) | 2016-04-06 | 2018-11-29 | Greenlight Biosciences Inc | Cell-free production of ribonucleic acid |
| CN106083992B (zh) * | 2016-06-17 | 2019-08-20 | 四川松麒医药科技有限公司 | 一种肌肽衍生物的制备方法、产品及应用 |
| WO2018129275A1 (en) | 2017-01-06 | 2018-07-12 | Greenlight Biosciences, Inc. | Cell-free production of sugars |
| EP3620527A4 (de) * | 2017-05-01 | 2020-05-20 | Kaneka Corporation | Verfahren zur herstellung einer substanz unter verwendung von atp |
| CN117904236A (zh) * | 2017-09-29 | 2024-04-19 | 三菱化学株式会社 | 烟酰胺单核苷酸的制造方法 |
| JP7792196B2 (ja) | 2017-10-11 | 2025-12-25 | グリーンライト バイオサイエンシーズ インコーポレーテッド | ヌクレオシド三リン酸およびリボ核酸の生成のための方法および組成物 |
| CN108531465B (zh) * | 2018-04-04 | 2022-05-17 | 南京农业大学 | 一种环二肽合成酶及其应用 |
| JP2020022433A (ja) * | 2018-08-01 | 2020-02-13 | 東海物産株式会社 | イミダゾールジペプチドの製造方法 |
| CN109280631B (zh) * | 2018-10-24 | 2021-07-09 | 哈尔滨商业大学 | 一株磺胺二甲基嘧啶降解菌s-2及其应用 |
| CN110387379B (zh) * | 2019-07-16 | 2022-11-22 | 大连医诺生物股份有限公司 | 一种用于生产谷胱甘肽的重组大肠杆菌的混合培养工艺及其应用 |
| CN110373370B (zh) * | 2019-07-16 | 2022-11-18 | 大连医诺生物股份有限公司 | 一种耦合atp再生系统的催化体系及其在生产谷胱甘肽过程中的应用 |
| CN112680371A (zh) * | 2019-10-18 | 2021-04-20 | 广东利世康低碳科技有限公司 | 一种水解餐厨垃圾中蛋白成分的产朊假丝酵母双基因共表达菌株及其构建方法 |
| CN113025592B (zh) * | 2021-04-28 | 2022-06-24 | 上海邦林生物科技有限公司 | 一种高性能多聚磷酸激酶突变体及其应用 |
| CN113651756B (zh) * | 2021-06-30 | 2023-08-15 | 北京大学深圳研究生院 | 一种遗传编码的光交联非天然氨基酸盐及其制备方法与应用 |
| WO2023054695A1 (ja) | 2021-09-30 | 2023-04-06 | 味の素株式会社 | 改変酵素、およびそれを用いたイミダゾールジペプチドの製造方法 |
| CN114703161B (zh) * | 2022-03-30 | 2024-07-02 | 新泰市佳禾生物科技有限公司 | 聚磷酸盐激酶1突变体及其生产菌的构建与应用 |
| CN117721165B (zh) * | 2024-02-08 | 2024-05-03 | 天津凯莱英生物科技有限公司 | Atp再生体系和多肽的合成方法 |
| WO2025262452A1 (en) * | 2024-06-18 | 2025-12-26 | Novartis Ag | Nucleic acid ligation method |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3131322B2 (ja) | 1991-12-17 | 2001-01-31 | 協和醗酵工業株式会社 | 新規α２→３シアリルトランスフェラーゼ |
| SG49117A1 (en) | 1993-03-29 | 1998-05-18 | Kyowa Hakko Kogyo Kk | Alfa -1, 3-fucosyltransferase |
| DE19932908A1 (de) | 1998-07-10 | 2000-01-20 | Ipk Inst Fuer Pflanzengenetik | Gene zur Biosynthese von Anticapsin und Bacilysin, ihre Isolierung und Verwendung |
| EP1165799A1 (de) * | 1999-03-29 | 2002-01-02 | Holland Sweetener Company V.o.F. | Mikrobiologisches verfahren zur herstellung von alpha-l-aspartyl-l-phenylalanin |
| EP1096011A1 (de) * | 1999-05-10 | 2001-05-02 | Holland Sweetener Company V.o.F. | Mikrobiologisches Verfahren zur Herstellung von Alpha-L-Aspartyl-L-Phenylalanin |
| FR2841260B1 (fr) * | 2002-06-21 | 2004-10-22 | Commissariat Energie Atomique | Polynucleotides et polypeptides codes par lesdits polynucleotides impliques dans la synthese de derives des dicetopiperazines |
| CA2511553C (en) * | 2002-12-26 | 2013-07-30 | Shin-Ichi Hashimoto | Process for producing dipeptides |
| WO2004076477A1 (en) * | 2003-02-26 | 2004-09-10 | Holland Sweetener Company | MICROBIOLOGICAL PRODUCTION METHOD FOR α-L-ASPARTYL-L-PHENYLALANINE |
| US20050106703A1 (en) * | 2003-11-05 | 2005-05-19 | Kyowa Hakko Kogyo Co., Ltd. | Microorganisms producing dipeptides and process for producing dipeptides using the microorganisms |
| US20050148048A1 (en) * | 2003-11-27 | 2005-07-07 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing dipeptides |
| US7514243B2 (en) * | 2004-06-25 | 2009-04-07 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing dipeptides |
-
2005
- 2005-06-24 US US11/165,226 patent/US8257943B2/en not_active Expired - Lifetime
- 2005-06-24 CN CN2005800207400A patent/CN1973037B/zh not_active Expired - Lifetime
- 2005-06-24 DE DE602005017707T patent/DE602005017707D1/de not_active Expired - Lifetime
- 2005-06-24 WO PCT/JP2005/011639 patent/WO2006001382A1/ja not_active Ceased
- 2005-06-24 JP JP2006528633A patent/JP5424531B2/ja not_active Expired - Lifetime
- 2005-06-24 AT AT05013733T patent/ATE449183T1/de not_active IP Right Cessation
- 2005-06-24 EP EP05013733A patent/EP1616963B1/de not_active Expired - Lifetime
-
2012
- 2012-03-27 US US13/430,937 patent/US8709752B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006001382A1 (ja) | 2006-01-05 |
| US8709752B2 (en) | 2014-04-29 |
| DE602005017707D1 (de) | 2009-12-31 |
| EP1616963A3 (de) | 2006-05-31 |
| EP1616963B1 (de) | 2009-11-18 |
| JPWO2006001382A1 (ja) | 2008-04-17 |
| EP1616963A2 (de) | 2006-01-18 |
| CN1973037B (zh) | 2011-10-19 |
| US20120258490A1 (en) | 2012-10-11 |
| US8257943B2 (en) | 2012-09-04 |
| JP5424531B2 (ja) | 2014-02-26 |
| CN1973037A (zh) | 2007-05-30 |
| US20050287627A1 (en) | 2005-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |