ATA57675A - Verfahren zur herstellung von neuen o-substituierten 7beta-amino-3-cephem-3-o1-4-carbonsaureverbindungen - Google Patents

Verfahren zur herstellung von neuen o-substituierten 7beta-amino-3-cephem-3-o1-4-carbonsaureverbindungen

Info

Publication number
ATA57675A
ATA57675A AT57675*A AT5767573A ATA57675A AT A57675 A ATA57675 A AT A57675A AT 5767573 A AT5767573 A AT 5767573A AT A57675 A ATA57675 A AT A57675A
Authority
AT
Austria
Prior art keywords
7beta
cephem
amino
substituted
preparation
Prior art date
Application number
AT57675*A
Other languages
German (de)
English (en)
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH978872A external-priority patent/CH587268A5/de
Priority claimed from CH1872272A external-priority patent/CH605987A5/de
Priority claimed from CH265573A external-priority patent/CH605988A5/de
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of ATA57675A publication Critical patent/ATA57675A/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT57675*A 1972-06-29 1973-06-28 Verfahren zur herstellung von neuen o-substituierten 7beta-amino-3-cephem-3-o1-4-carbonsaureverbindungen ATA57675A (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH978872A CH587268A5 (en) 1972-06-29 1972-06-29 Substd carboxylic acid derivs - broad spectrum antibiotics and inters
CH1219572 1972-08-17
CH1872272A CH605987A5 (en) 1972-12-22 1972-12-22 Substd carboxylic acid derivs
CH265573A CH605988A5 (en) 1973-02-23 1973-02-23 Substd 7-beta-amino ceph-3-em-3-ol 4-carboxylic acids

Publications (1)

Publication Number Publication Date
ATA57675A true ATA57675A (de) 1975-08-15

Family

ID=27428472

Family Applications (5)

Application Number Title Priority Date Filing Date
AT57675*A ATA57675A (de) 1972-06-29 1973-06-28 Verfahren zur herstellung von neuen o-substituierten 7beta-amino-3-cephem-3-o1-4-carbonsaureverbindungen
AT569573A AT356810B (de) 1972-06-29 1973-06-28 Verfahren zur herstellung von neuen substituierten cephalosporinen
AT569473A AT356809B (de) 1972-06-29 1973-06-28 Verfahren zur herstellung von neuen enolderivaten
AT57675*7A AT329762B (de) 1972-06-29 1973-06-28 Verfahren zur herstellung von neuen o-substituierten 7beta-amino-3-cephem-3-o1-4-carbonsaureverbindungen
AT569673A AT329745B (de) 1972-06-29 1973-06-28 Verfahren zur herstellung von neuen o-substituierten 7beta-amino-cephem-3-01-4-carbonsaureverbindungen

Family Applications After (4)

Application Number Title Priority Date Filing Date
AT569573A AT356810B (de) 1972-06-29 1973-06-28 Verfahren zur herstellung von neuen substituierten cephalosporinen
AT569473A AT356809B (de) 1972-06-29 1973-06-28 Verfahren zur herstellung von neuen enolderivaten
AT57675*7A AT329762B (de) 1972-06-29 1973-06-28 Verfahren zur herstellung von neuen o-substituierten 7beta-amino-3-cephem-3-o1-4-carbonsaureverbindungen
AT569673A AT329745B (de) 1972-06-29 1973-06-28 Verfahren zur herstellung von neuen o-substituierten 7beta-amino-cephem-3-01-4-carbonsaureverbindungen

Country Status (26)

Country Link
US (2) US4405778A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (3) JPS5934716B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (6) AR206201A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (5) ATA57675A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE801597A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BG (1) BG24954A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1110230A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DD (3) DD106184A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2331133C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK153324B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (3) FI59601C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2190418B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1435111A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK73778A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (3) HU169032B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE37767B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL42506A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (3) LU67888A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY7900008A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (3) NL7309139A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (3) NO145242C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH18567A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL91608B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RO (4) RO63761A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (5) SE417430B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (8) YU39910B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU36970B (en) * 1973-02-23 1984-08-31 Lilly Co Eli Process for obtaining 7-(amino)-acylamido-3-halocephalosporins
AU498131B2 (en) * 1974-02-26 1979-02-15 Ciba-Geigy Ag Production of cephems by cyclization
US4301278A (en) * 1974-02-26 1981-11-17 Ciba-Geigy Corporation Process for the manufacture of enol derivatives
US3928334A (en) * 1974-06-06 1975-12-23 Bristol Myers Co Process for the production of cefamandole
US4045435A (en) * 1974-10-09 1977-08-30 Eli Lilly And Company Preparation of cephalosporin ethers
AT342197B (de) * 1975-02-20 1978-03-28 Ciba Geigy Ag Neues verfahren zur herstellung von 3-cephemverbindungen
US4147864A (en) * 1975-02-20 1979-04-03 Ciba-Geigy Corporation Process for the manufacture of 7β-amino-3-cephem-3-ol-4 carboxylic acid compounds
CH622802A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1975-08-20 1981-04-30 Ciba Geigy Ag
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
US4604386A (en) * 1984-07-09 1986-08-05 Eli Lilly And Company 3-(alkynylalkyloxy) cephalosporins
DE3677253D1 (de) 1985-04-30 1991-03-07 Lilly Co Eli 7-substituierte bicyclische pyrazolidinone.
JP2676763B2 (ja) * 1987-02-27 1997-11-17 萬有製薬株式会社 セファロスポリン誘導体
EP0280240B1 (en) * 1987-02-27 1994-09-14 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, process for their preparation and antibacterial agents
JPS63255800A (ja) * 1987-04-14 1988-10-24 礒井　誠二郎 警報装置
AU618029B2 (en) * 1987-11-02 1991-12-12 Imperial Chemical Industries Plc Polypeptide compounds
GB8813356D0 (en) * 1988-06-06 1988-07-13 Ici Plc Polypeptide compounds
DK0521827T3 (da) 1991-07-03 1996-11-11 Ciba Geigy Ag Farmakologisk virksomme hydrazinderivater og fremgangsmåde til deres fremstilling
GB9115203D0 (en) * 1991-07-15 1991-08-28 Biochemie Gmbh Improvements in or relating to beta lactam production
CN1209099C (zh) * 1999-04-01 2005-07-06 Dsm公司 结晶化附聚物
US6627556B1 (en) * 2002-04-24 2003-09-30 Lsi Logic Corporation Method of chemically altering a silicon surface and associated electrical devices
CN102268023B (zh) * 2011-08-15 2013-04-17 南京丰融化学技术有限公司 头孢类衍生物cxd的晶型
CN115160097B (zh) * 2022-07-22 2024-05-28 温州大学 一种硫代乙酸还原n-o键合成酰胺的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1308822A (en) * 1970-04-14 1973-03-07 Beecham Group Ltd 4-isopropylidene-3-oxocephams
GB1348984A (en) * 1970-06-16 1974-03-27 Merck & Co Inc Antibiotics and processes for their production
IL37879A (en) * 1970-10-27 1974-12-31 Ciba Geigy Ag 3-unsubstituted cephalosporin derivatives,process for their manufacture and compositions containing them
US3704297A (en) * 1971-03-05 1972-11-28 American Home Prod 7 - (1,4 - cyclohexadienylacylamido)cephalosporanic acids and related compounds
US3741962A (en) * 1971-05-21 1973-06-26 Squibb & Sons Inc Alpha-thioureidocephalosporanic acid compounds
US3846417A (en) * 1972-06-23 1974-11-05 Squibb & Sons Inc 1,4-cyclohexadienyl imidazolidinyl cephalosporanic acids and derivatives thereof
US3917588A (en) * 1972-11-28 1975-11-04 Lilly Co Eli {60 -Aminoacyl cephalosporin ethers
US3917587A (en) * 1972-11-28 1975-11-04 Lilly Co Eli Cephalosporin ethers
US3907786A (en) * 1973-09-04 1975-09-23 Bristol Myers Co 7-{8 {60 -(2-aminomethyl-1,4-cyclohexadienyl)acetamido{9 -3-heterocyclic-thiomethyl-3-cephem-4-carboxylic acids and salts

Also Published As

Publication number Publication date
JPS4949987A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-05-15
YU39911B (en) 1985-06-30
LU67888A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-04-11
SE417099B (sv) 1981-02-23
PL91608B1 (en) 1977-03-31
HK73778A (en) 1978-12-22
FI59601B (fi) 1981-05-29
US4073902A (en) 1978-02-14
GB1435111A (en) 1976-05-12
NL7309139A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-01-02
NO145242C (no) 1982-02-10
NL7309136A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-01-02
HU167726B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-12-25
RO63761A (fr) 1978-12-15
NO145241B (no) 1981-11-02
YU223881A (en) 1983-06-30
AT356810B (de) 1980-05-27
AU5738673A (en) 1975-01-09
NO145241C (no) 1982-02-10
YU179273A (en) 1982-06-30
DK153324B (da) 1988-07-04
NL7309137A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-01-02
YU179573A (en) 1982-06-30
JPS5933598B2 (ja) 1984-08-16
LU67891A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-04-11
CA1110230A (en) 1981-10-06
BG24954A3 (en) 1978-06-15
HU168017B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-02-28
FI59602C (fi) 1981-09-10
SE7612053L (sv) 1976-10-29
NO145240C (no) 1982-02-10
YU284280A (en) 1983-01-21
RO64226A (fr) 1979-05-15
AR212317A1 (es) 1978-06-30
FI60870B (fi) 1981-12-31
ATA569573A (de) 1975-06-15
YU280780A (en) 1983-02-28
YU39910B (en) 1985-06-30
JPS5934716B2 (ja) 1984-08-24
IE37767B1 (en) 1977-10-12
DD107470A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-08-05
AR211871A1 (es) 1978-03-31
AT329745B (de) 1976-05-25
SE417429B (sv) 1981-03-16
FI59602B (fi) 1981-05-29
SE7308234L (sv) 1973-12-31
IL42506A (en) 1976-09-30
DD106184A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-06-05
BE801597A (fr) 1973-12-28
ATA569473A (de) 1975-04-15
DE2331133A1 (de) 1974-01-17
JPS4949988A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-05-15
NO145240B (no) 1981-11-02
FR2190418A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-02-01
PH18567A (en) 1985-08-12
YU223681A (en) 1983-06-30
JPS5933599B2 (ja) 1984-08-16
DE2331133C2 (de) 1984-04-12
RO64419A (fr) 1979-07-15
YU179373A (en) 1982-06-30
AR212028A1 (es) 1978-04-28
SE7308235L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1973-12-31
DD106187A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-06-05
AT329762B (de) 1976-05-25
RO73345A (ro) 1982-09-09
HU169032B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-09-28
SE7308237L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-01-08
MY7900008A (en) 1979-12-31
SE7308233L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1973-12-31
IE37767L (en) 1973-12-29
YU39909B (en) 1985-06-30
NO145242B (no) 1981-11-02
ATA569673A (de) 1975-08-15
US4405778A (en) 1983-09-20
FI60870C (fi) 1982-04-13
YU223781A (en) 1983-06-30
IL42506A0 (en) 1973-08-29
JPS4949986A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1974-05-15
AR212576A1 (es) 1978-08-15
SE417430B (sv) 1981-03-16
AR206201A1 (es) 1976-07-07
AR211870A1 (es) 1978-03-31
FR2190418B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1977-07-15
AT356809B (de) 1980-05-27
FI59601C (fi) 1981-09-10
SE435289B (sv) 1984-09-17
LU67887A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-04-11

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