AR247876A1 - Procedimiento para producir compuestos de n-fenil-butenamida o isoxazol - Google Patents

Procedimiento para producir compuestos de n-fenil-butenamida o isoxazol

Info

Publication number
AR247876A1
AR247876A1 AR92323708A AR32370892A AR247876A1 AR 247876 A1 AR247876 A1 AR 247876A1 AR 92323708 A AR92323708 A AR 92323708A AR 32370892 A AR32370892 A AR 32370892A AR 247876 A1 AR247876 A1 AR 247876A1
Authority
AR
Argentina
Prior art keywords
butenamide
phenyl
formula
compound
isoxazol
Prior art date
Application number
AR92323708A
Other languages
English (en)
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Application granted granted Critical
Publication of AR247876A1 publication Critical patent/AR247876A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PRODUCCION DE COMPUESTOS DE N-FENIL-BUTENAMIDA O ISOXAZOL DE FORMULA I, DONDE X ES R1(HO)C=C(CN)- O FORMULA II, R1 ES ALQUILO, R2 ES HIDROGENO O ALQUILO, R3 ES HIDROGENO O HALOGENO Y R6, R7 Y R8SON ALQUILO O R6 Y R7 JUNTO CON EL CARBONO AL CUAL ESTAN ENLAZADOS, FORMAN UN CICLOALQUILO, Y SALES DE LOS MISMOS, QUE COMPRENDE, HACER REACCIONAR UN COMPUESTO DE FORMULA VII, CON UN AMINA DE FORMULA VIII, EN DONDE Y ES HALO, PARA DAR UN COMPUESTO EN EL CUAL X ES FORMULA II Y HACER REACCIONAR O NO EL COMPUESTO ASI FORMADO CON UN ACIDO PARA LIBERAR EL COMPUESTO DONDE X ES R1(HO)C=C(CN) .
AR92323708A 1986-08-08 1992-11-20 Procedimiento para producir compuestos de n-fenil-butenamida o isoxazol AR247876A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868619432A GB8619432D0 (en) 1986-08-08 1986-08-08 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
AR247876A1 true AR247876A1 (es) 1995-04-28

Family

ID=10602473

Family Applications (2)

Application Number Title Priority Date Filing Date
AR87308368A AR244660A1 (es) 1986-08-08 1987-08-07 Procedimiento para producir compuestos de n-fenil-butenamida.
AR92323708A AR247876A1 (es) 1986-08-08 1992-11-20 Procedimiento para producir compuestos de n-fenil-butenamida o isoxazol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AR87308368A AR244660A1 (es) 1986-08-08 1987-08-07 Procedimiento para producir compuestos de n-fenil-butenamida.

Country Status (23)

Country Link
US (1) US4892963A (es)
EP (1) EP0257882B1 (es)
JP (1) JPS63239259A (es)
KR (2) KR880002815A (es)
CN (1) CN1015256B (es)
AR (2) AR244660A1 (es)
AT (1) ATE65494T1 (es)
AU (1) AU604737B2 (es)
CA (1) CA1317964C (es)
DE (1) DE3771611D1 (es)
DK (1) DK169404B1 (es)
EG (1) EG18269A (es)
ES (1) ES2031510T3 (es)
GB (1) GB8619432D0 (es)
GR (1) GR3002714T3 (es)
HU (1) HU197559B (es)
IL (1) IL83432A (es)
MX (1) MX174371B (es)
NZ (1) NZ221352A (es)
PH (1) PH22821A (es)
PT (1) PT85476B (es)
RU (1) RU1771472C (es)
ZA (1) ZA875813B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3534440A1 (de) * 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US5268382A (en) * 1985-09-27 1993-12-07 Hoechst Aktiengesellschaft Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus
US4975462A (en) * 1988-07-29 1990-12-04 Bristol-Myers Company Antiarthritic α-arylcarbamoyl cyanoacetic acid derivatives
US5583150A (en) * 1989-08-18 1996-12-10 Alcon Laboratories, Inc. 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases
DD297328A5 (de) * 1989-08-18 1992-01-09 �������@���������k���Kk�� 5-methyl-isoxalol-4-carbonsaeureanilide und 2 hydroxyethyliden-cyanoessigsaeureanilide zur behandlung von augenerkrankungen
US5108999A (en) * 1990-02-02 1992-04-28 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
US5001124A (en) * 1990-02-02 1991-03-19 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
JPH04211048A (ja) * 1990-03-05 1992-08-03 Mitsubishi Kasei Corp チオカルバモイルアセトニトリル誘導体
EP0527736B1 (de) * 1990-05-18 1997-04-16 Hoechst Aktiengesellschaft Isoxazol-4-carbonsäureamide und hydroxyalkyliden-cyanessigsäureamide, diese verbindungen enthaltende arzneimittel und deren verwendung
IL102790A (en) * 1991-09-17 1996-01-31 Roussel Uclaf History of 3-cycloalkyl-prop-2-anamide
ATE128353T1 (de) * 1991-10-23 1995-10-15 Hoechst Ag N-phenyl-2-cyano-3-hydroxycrotonsäureamidderiva e und deren verwendung als arzneimittel mit immunmodulatorischer eigenschaft.
GB9200275D0 (en) * 1992-01-08 1992-02-26 Roussel Lab Ltd Chemical compounds
TW314467B (es) * 1993-03-31 1997-09-01 Hoechst Ag
WO1994024095A1 (en) * 1993-04-16 1994-10-27 Abbott Laboratories Immunosuppressive agents
GB9320299D0 (en) * 1993-10-01 1993-11-17 Roussel Lab Ltd Isoxazole derivatives
EP0787491B1 (en) * 1994-10-17 2000-07-26 Aventis Pharma Ltd. Preventive and remedy for type i allergic diseases
DE19702988A1 (de) * 1997-01-28 1998-07-30 Hoechst Ag Isoxazol- und Crotonsäureamidderivate und deren Verwendung als Arzneimittel und Diagnostika
AU779931B2 (en) * 1999-12-16 2005-02-17 Teva Pharmaceutical Industries Ltd. Novel processes for making- and a new crystalline form of- leflunomide
SK12992002A3 (sk) 2000-02-15 2003-05-02 Teva Pharmaceutical Industries Ltd. Spôsob syntézy leflunomidu
DE10311763A1 (de) * 2003-03-18 2004-10-07 Aventis Pharma Deutschland Gmbh Verfahren zur Herstellung von 2-Cyan-3-hydroxy-N-(phenyl)but-2-enamiden
US6894184B2 (en) 2003-03-18 2005-05-17 Aventis Pharma Deutschland Gmbh Process for preparing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamides
MX2016006678A (es) 2013-11-22 2016-09-13 Genzyme Corp Nuevos metodos para tratar enfermedades neurodegenerativas.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL186239B (nl) * 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
DK545976A (da) * 1975-12-11 1977-06-12 Hoechst Ag Cyaneddikesyreanilidderivater fremgangsmade til deres fremstilling og midler der indeholder disse forbindelser
DE2654797A1 (de) * 1976-12-03 1978-06-08 Hoechst Ag Verfahren zur herstellung von isoxazolderivaten
DE2655009A1 (de) * 1976-12-04 1978-06-15 Hoechst Ag Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
IL60269A (en) * 1979-06-11 1983-12-30 Ciba Geigy Alpha-carbamoyl-pyrrolpropionitriles,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
DE3771611D1 (de) 1991-08-29
EP0257882B1 (en) 1991-07-24
MX174371B (es) 1994-05-11
JPS63239259A (ja) 1988-10-05
AR244660A1 (es) 1993-11-30
RU1771472C (ru) 1992-10-23
KR880002815A (ko) 1988-05-11
PT85476B (pt) 1990-06-29
CN1015256B (zh) 1992-01-01
IL83432A (en) 1992-06-21
EP0257882A1 (en) 1988-03-02
ATE65494T1 (de) 1991-08-15
IL83432A0 (en) 1988-01-31
CN87105516A (zh) 1988-02-24
DK413987D0 (da) 1987-08-07
PH22821A (en) 1989-01-19
PT85476A (en) 1987-09-01
AU604737B2 (en) 1991-01-03
GR3002714T3 (en) 1993-01-25
DK169404B1 (da) 1994-10-24
CA1317964C (en) 1993-05-18
DK413987A (da) 1988-02-09
ZA875813B (en) 1989-04-26
MX7668A (es) 1993-08-01
NZ221352A (en) 1989-10-27
ES2031510T3 (es) 1992-12-16
KR880002823A (ko) 1988-05-11
HUT44523A (en) 1988-03-28
EG18269A (en) 1992-12-30
HU197559B (en) 1989-04-28
AU7668187A (en) 1988-02-11
GB8619432D0 (en) 1986-09-17
US4892963A (en) 1990-01-09

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