EG18269A - Process for preparing n-phenyl butenamide derivatives and their use for treating arthritis - Google Patents
Process for preparing n-phenyl butenamide derivatives and their use for treating arthritisInfo
- Publication number
- EG18269A EG18269A EG448/87A EG44887A EG18269A EG 18269 A EG18269 A EG 18269A EG 448/87 A EG448/87 A EG 448/87A EG 44887 A EG44887 A EG 44887A EG 18269 A EG18269 A EG 18269A
- Authority
- EG
- Egypt
- Prior art keywords
- butenamide
- phenyl
- derivatives
- preparing
- treating arthritis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868619432A GB8619432D0 (en) | 1986-08-08 | 1986-08-08 | Pharmaceutical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EG18269A true EG18269A (en) | 1992-12-30 |
Family
ID=10602473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EG448/87A EG18269A (en) | 1986-08-08 | 1987-08-02 | Process for preparing n-phenyl butenamide derivatives and their use for treating arthritis |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4892963A (xx) |
| EP (1) | EP0257882B1 (xx) |
| JP (1) | JPS63239259A (xx) |
| KR (2) | KR880002823A (xx) |
| CN (1) | CN1015256B (xx) |
| AR (2) | AR244660A1 (xx) |
| AT (1) | ATE65494T1 (xx) |
| AU (1) | AU604737B2 (xx) |
| CA (1) | CA1317964C (xx) |
| DE (1) | DE3771611D1 (xx) |
| DK (1) | DK169404B1 (xx) |
| EG (1) | EG18269A (xx) |
| ES (1) | ES2031510T3 (xx) |
| GB (1) | GB8619432D0 (xx) |
| GR (1) | GR3002714T3 (xx) |
| HU (1) | HU197559B (xx) |
| IL (1) | IL83432A (xx) |
| MX (1) | MX174371B (xx) |
| NZ (1) | NZ221352A (xx) |
| PH (1) | PH22821A (xx) |
| PT (1) | PT85476B (xx) |
| RU (1) | RU1771472C (xx) |
| ZA (1) | ZA875813B (xx) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3534440A1 (de) * | 1985-09-27 | 1987-04-02 | Hoechst Ag | Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes |
| US5268382A (en) * | 1985-09-27 | 1993-12-07 | Hoechst Aktiengesellschaft | Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus |
| US4975462A (en) * | 1988-07-29 | 1990-12-04 | Bristol-Myers Company | Antiarthritic α-arylcarbamoyl cyanoacetic acid derivatives |
| US5583150A (en) * | 1989-08-18 | 1996-12-10 | Alcon Laboratories, Inc. | 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases |
| DD297328A5 (de) * | 1989-08-18 | 1992-01-09 | �������@���������k���Kk�� | 5-methyl-isoxalol-4-carbonsaeureanilide und 2 hydroxyethyliden-cyanoessigsaeureanilide zur behandlung von augenerkrankungen |
| US5001124A (en) * | 1990-02-02 | 1991-03-19 | Syntex (U.S.A.) Inc. | 4-isoxazolecarboxamide derivatives |
| US5108999A (en) * | 1990-02-02 | 1992-04-28 | Syntex (U.S.A.) Inc. | 4-isoxazolecarboxamide derivatives |
| JPH04211048A (ja) * | 1990-03-05 | 1992-08-03 | Mitsubishi Kasei Corp | チオカルバモイルアセトニトリル誘導体 |
| US5494911A (en) * | 1990-05-18 | 1996-02-27 | Hoechst Aktiengesellschaft | Isoxazole-4-carboxamides and hydroxyalkylidenecyanoacetamides, pharmaceuticals containing these compounds and their use |
| IL102790A (en) * | 1991-09-17 | 1996-01-31 | Roussel Uclaf | History of 3-cycloalkyl-prop-2-anamide |
| ES2079765T3 (es) * | 1991-10-23 | 1996-01-16 | Hoechst Ag | Derivados de amidas de acido n-fenil-2-ciano-3-hidroxicrotonico y su utilizacion como medicamento con propiedad inmunomoduladora. |
| GB9200275D0 (en) * | 1992-01-08 | 1992-02-26 | Roussel Lab Ltd | Chemical compounds |
| TW314467B (xx) * | 1993-03-31 | 1997-09-01 | Hoechst Ag | |
| WO1994024095A1 (en) * | 1993-04-16 | 1994-10-27 | Abbott Laboratories | Immunosuppressive agents |
| GB9320299D0 (en) * | 1993-10-01 | 1993-11-17 | Roussel Lab Ltd | Isoxazole derivatives |
| DK0787491T3 (da) * | 1994-10-17 | 2000-10-16 | Aventis Pharma Ltd | Middel til forebyggelse og behandling af allergiske sygdomme af type I |
| DE19702988A1 (de) * | 1997-01-28 | 1998-07-30 | Hoechst Ag | Isoxazol- und Crotonsäureamidderivate und deren Verwendung als Arzneimittel und Diagnostika |
| IL149792A0 (en) * | 1999-12-16 | 2002-11-10 | Teva Pharma | Novel processes for making and a new crystalline form of leflunomide |
| ES2237553T3 (es) | 2000-02-15 | 2005-08-01 | Teva Pharmaceutical Industries Ltd. | Procedimiento para la sintesis de leflunomida. |
| US6894184B2 (en) | 2003-03-18 | 2005-05-17 | Aventis Pharma Deutschland Gmbh | Process for preparing 2-cyano-3-hydroxy-N-(phenyl)but-2-enamides |
| DE10311763A1 (de) * | 2003-03-18 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Verfahren zur Herstellung von 2-Cyan-3-hydroxy-N-(phenyl)but-2-enamiden |
| JP2016537360A (ja) | 2013-11-22 | 2016-12-01 | ジェンザイム・コーポレーション | 神経変性疾患を治療するための新規な方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL186239B (nl) * | 1975-06-05 | Hoechst Ag | Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze. | |
| DK545976A (da) * | 1975-12-11 | 1977-06-12 | Hoechst Ag | Cyaneddikesyreanilidderivater fremgangsmade til deres fremstilling og midler der indeholder disse forbindelser |
| DE2654797A1 (de) * | 1976-12-03 | 1978-06-08 | Hoechst Ag | Verfahren zur herstellung von isoxazolderivaten |
| DE2655009A1 (de) * | 1976-12-04 | 1978-06-15 | Hoechst Ag | Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel |
| FI71129C (fi) * | 1979-06-11 | 1986-11-24 | Ciba Geigy Ag | Foerfarande foer framstaellning av farmaceutiskt aktiva alfakarbamoylpyrrolpropionitriler |
-
1986
- 1986-08-08 GB GB868619432A patent/GB8619432D0/en active Pending
-
1987
- 1987-08-02 EG EG448/87A patent/EG18269A/xx active
- 1987-08-03 PH PH35615A patent/PH22821A/en unknown
- 1987-08-04 PT PT85476A patent/PT85476B/pt not_active IP Right Cessation
- 1987-08-04 IL IL83432A patent/IL83432A/xx not_active IP Right Cessation
- 1987-08-05 NZ NZ221352A patent/NZ221352A/xx unknown
- 1987-08-05 CA CA000543739A patent/CA1317964C/en not_active Expired - Fee Related
- 1987-08-06 ZA ZA875813A patent/ZA875813B/xx unknown
- 1987-08-06 ES ES198787306988T patent/ES2031510T3/es not_active Expired - Lifetime
- 1987-08-06 DE DE8787306988T patent/DE3771611D1/de not_active Expired - Fee Related
- 1987-08-06 MX MX007668A patent/MX174371B/es unknown
- 1987-08-06 AT AT87306988T patent/ATE65494T1/de active
- 1987-08-06 RU SU874203189A patent/RU1771472C/ru active
- 1987-08-06 EP EP87306988A patent/EP0257882B1/en not_active Expired - Lifetime
- 1987-08-07 KR KR1019870008651A patent/KR880002823A/ko not_active Application Discontinuation
- 1987-08-07 AR AR87308368A patent/AR244660A1/es active
- 1987-08-07 DK DK413987A patent/DK169404B1/da not_active IP Right Cessation
- 1987-08-07 US US07/083,538 patent/US4892963A/en not_active Expired - Fee Related
- 1987-08-07 HU HU873604A patent/HU197559B/hu not_active IP Right Cessation
- 1987-08-07 CN CN87105516A patent/CN1015256B/zh not_active Expired
- 1987-08-07 JP JP62198006A patent/JPS63239259A/ja active Pending
- 1987-08-07 AU AU76681/87A patent/AU604737B2/en not_active Ceased
- 1987-08-07 KR KR1019870008650A patent/KR880002815A/ko not_active Application Discontinuation
-
1991
- 1991-09-12 GR GR91401318T patent/GR3002714T3/el unknown
-
1992
- 1992-11-20 AR AR92323708A patent/AR247876A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| DK169404B1 (da) | 1994-10-24 |
| US4892963A (en) | 1990-01-09 |
| PT85476B (pt) | 1990-06-29 |
| ZA875813B (en) | 1989-04-26 |
| IL83432A (en) | 1992-06-21 |
| GR3002714T3 (en) | 1993-01-25 |
| HUT44523A (en) | 1988-03-28 |
| RU1771472C (ru) | 1992-10-23 |
| PT85476A (en) | 1987-09-01 |
| AR244660A1 (es) | 1993-11-30 |
| CA1317964C (en) | 1993-05-18 |
| DK413987A (da) | 1988-02-09 |
| GB8619432D0 (en) | 1986-09-17 |
| AR247876A1 (es) | 1995-04-28 |
| EP0257882A1 (en) | 1988-03-02 |
| CN1015256B (zh) | 1992-01-01 |
| KR880002815A (ko) | 1988-05-11 |
| PH22821A (en) | 1989-01-19 |
| MX174371B (es) | 1994-05-11 |
| EP0257882B1 (en) | 1991-07-24 |
| IL83432A0 (en) | 1988-01-31 |
| HU197559B (en) | 1989-04-28 |
| KR880002823A (ko) | 1988-05-11 |
| NZ221352A (en) | 1989-10-27 |
| DK413987D0 (da) | 1987-08-07 |
| ES2031510T3 (es) | 1992-12-16 |
| CN87105516A (zh) | 1988-02-24 |
| MX7668A (es) | 1993-08-01 |
| JPS63239259A (ja) | 1988-10-05 |
| DE3771611D1 (de) | 1991-08-29 |
| ATE65494T1 (de) | 1991-08-15 |
| AU604737B2 (en) | 1991-01-03 |
| AU7668187A (en) | 1988-02-11 |
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