ES2079765T3 - Derivados de amidas de acido n-fenil-2-ciano-3-hidroxicrotonico y su utilizacion como medicamento con propiedad inmunomoduladora. - Google Patents

Derivados de amidas de acido n-fenil-2-ciano-3-hidroxicrotonico y su utilizacion como medicamento con propiedad inmunomoduladora.

Info

Publication number
ES2079765T3
ES2079765T3 ES92117906T ES92117906T ES2079765T3 ES 2079765 T3 ES2079765 T3 ES 2079765T3 ES 92117906 T ES92117906 T ES 92117906T ES 92117906 T ES92117906 T ES 92117906T ES 2079765 T3 ES2079765 T3 ES 2079765T3
Authority
ES
Spain
Prior art keywords
phenyl
derivatives
hydroxicrotonic
ciane
medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92117906T
Other languages
English (en)
Inventor
Rudolf Dr Schleyerbach
Robert Ryder Dr Bartlett
Elizabeth Anne Kuo
Edward James Little
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2079765T3 publication Critical patent/ES2079765T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/27—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/23—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same unsaturated acyclic carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

SE DESCRIBE EL EMPLEO DE DERIVADOS DE LA AMIDA DEL ACIDO CROTONICO N-FENILO-2-CIANO-3-HIDROXI DE LA FORMULA I EN LA QUE R1 ES UN ATOMO DE HIDROGENO O ALQUILO (C1-C4), R2 ES CN, CX3, WCX3, W(CH2)NCX3, NO2, (CH2)NCX3, HALOGENO, EN DONDE X ES HALOGENO, W ES UN ATOMO DE OXIGENO O DE AZUFRE Y N ES UN NUMERO ENTERO DESDE 1 HASTA 3, R3 ES ALQUILO (C1-C4), CICLOALQUILO (C3-C6), CN O -CO-R4, EN LA QUE R4 ES ALQUILO (C1C4) O CICLOALQUILO (C3-C6) Y/O SUS SALES COMPATIBLES FISIOLOGICAMENTE, PARA EL TRATAMIENTO DE ENFERMEDADES REUMATICAS, ENFERMEDADES AUTOINMUNES, ASI COMO REACCIONES DE RECHAZO DE RECEPTORES DE ORGANOS CONTRA EL ORGANO TRANSPLANTADO.
ES92117906T 1991-10-23 1992-10-20 Derivados de amidas de acido n-fenil-2-ciano-3-hidroxicrotonico y su utilizacion como medicamento con propiedad inmunomoduladora. Expired - Lifetime ES2079765T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4134934 1991-10-23

Publications (1)

Publication Number Publication Date
ES2079765T3 true ES2079765T3 (es) 1996-01-16

Family

ID=6443223

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92117906T Expired - Lifetime ES2079765T3 (es) 1991-10-23 1992-10-20 Derivados de amidas de acido n-fenil-2-ciano-3-hidroxicrotonico y su utilizacion como medicamento con propiedad inmunomoduladora.

Country Status (23)

Country Link
US (2) US5747664A (es)
EP (1) EP0538783B1 (es)
JP (1) JP3119738B2 (es)
KR (1) KR930007443A (es)
CN (1) CN1071833A (es)
AT (1) ATE128353T1 (es)
AU (1) AU658679B2 (es)
BR (1) BR9204124A (es)
CA (1) CA2081173A1 (es)
CZ (1) CZ281693B6 (es)
DE (1) DE59203828D1 (es)
DK (1) DK0538783T3 (es)
ES (1) ES2079765T3 (es)
FI (1) FI924779L (es)
GR (1) GR3017751T3 (es)
HU (1) HUT63610A (es)
IL (1) IL103487A (es)
MX (1) MX9206082A (es)
NO (1) NO178922C (es)
NZ (1) NZ244814A (es)
RU (1) RU2090553C1 (es)
SK (1) SK319892A3 (es)
ZA (1) ZA928159B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4127737A1 (de) 1991-08-22 1993-02-25 Hoechst Ag Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen
US6133301A (en) * 1991-08-22 2000-10-17 Aventis Pharma Deutschland Gmbh Pharmaceuticals for the treatment of rejection reactions in organ transplantations
WO1994024095A1 (en) * 1993-04-16 1994-10-27 Abbott Laboratories Immunosuppressive agents
US5519042A (en) * 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
US5624946A (en) * 1994-07-05 1997-04-29 Williams; James Use of leflunomide to control and reverse chronic allograft rejection
DE19539638A1 (de) * 1995-10-25 1997-04-30 Hoechst Ag Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen
DE19547648A1 (de) * 1995-12-20 1997-06-26 Hoechst Ag Zubereitung, enthaltend High Density Lipoproteine und Crotonsäureamidderivate
US6011051A (en) * 1996-07-31 2000-01-04 Hoechst Aktiengesellschaft Use of isoxazole and crotonamide derivatives for the modulation of apoptosis
DE19702988A1 (de) 1997-01-28 1998-07-30 Hoechst Ag Isoxazol- und Crotonsäureamidderivate und deren Verwendung als Arzneimittel und Diagnostika
US6303652B1 (en) 1998-08-21 2001-10-16 Hughes Institute BTK inhibitors and methods for their identification and use
US6355678B1 (en) 1998-06-29 2002-03-12 Parker Hughes Institute Inhibitors of the EGF-receptor tyrosine kinase and methods for their use
DE19857009A1 (de) * 1998-12-10 2000-06-15 Aventis Pharma Gmbh Zubereitung mit verbesserter therapeutischer Breite, enthaltend Nukleotidsyntheseinhibitoren
DE102005017592A1 (de) * 2005-04-16 2006-10-19 Lindner, Jürgen, Dr. med. Darreichungsformen und Kombinationspräparate von Pyrimidinbiosyntheseinhibitoren zur Erzielung zusätzlicher Wirkungen auf das Immunsystem
AU2014352920A1 (en) 2013-11-22 2016-06-23 Genzyme Corporation Novel methods for treating neurodegenerative diseases

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL186239B (nl) * 1975-06-05 Hoechst Ag Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze.
DE2555685A1 (de) 1975-12-11 1977-06-23 Hoechst Ag Neue cyanessigsaeureanilid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
DE2555789A1 (de) * 1975-12-11 1977-07-07 Hoechst Ag Neue cyanessigsaeureanilid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
DE2557003A1 (de) 1975-12-18 1977-06-23 Hoechst Ag Neue cyanessigsaeureanilid-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
JPH0776202B2 (ja) * 1985-07-01 1995-08-16 三井東圧化学株式会社 アシルアミノブテニルニトリル誘導体、その製造法およびそれらを含有する除草剤および農園芸用殺菌剤
DE3534440A1 (de) * 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
GB8619432D0 (en) * 1986-08-08 1986-09-17 Lilly Industries Ltd Pharmaceutical compounds
EP0397052B1 (en) * 1989-05-09 1993-08-18 SDS Biotech K.K. Crotonic acid amide derivatives and insectides containing the same
DD297328A5 (de) * 1989-08-18 1992-01-09 �������@���������k���Kk�� 5-methyl-isoxalol-4-carbonsaeureanilide und 2 hydroxyethyliden-cyanoessigsaeureanilide zur behandlung von augenerkrankungen
US5034410A (en) * 1989-10-11 1991-07-23 Syntex (U.S.A.) Inc. Anthelmintically active benzenepropanamide derivatives
IL99811A (en) * 1990-10-30 1996-03-31 Roussel Uclaf 3-cycloalkyl-propanamides their tautomer forms and their salts preparation process and compositions containing them

Also Published As

Publication number Publication date
IL103487A0 (en) 1993-03-15
NO178922C (no) 1996-07-03
IL103487A (en) 1998-01-04
JP3119738B2 (ja) 2000-12-25
FI924779A7 (fi) 1993-04-24
ATE128353T1 (de) 1995-10-15
MX9206082A (es) 1993-07-01
JPH05201948A (ja) 1993-08-10
FI924779L (fi) 1993-04-24
US5747664A (en) 1998-05-05
KR930007443A (ko) 1993-05-20
US5773470A (en) 1998-06-30
FI924779A0 (fi) 1992-10-21
CZ281693B6 (cs) 1996-12-11
BR9204124A (pt) 1993-06-01
DK0538783T3 (da) 1996-02-05
NZ244814A (en) 1994-06-27
NO924093D0 (no) 1992-10-22
AU658679B2 (en) 1995-04-27
GR3017751T3 (en) 1996-01-31
CZ319892A3 (en) 1993-05-12
HUT63610A (en) 1993-09-28
NO924093L (no) 1993-04-26
EP0538783B1 (de) 1995-09-27
ZA928159B (en) 1993-08-04
HU9203327D0 (en) 1992-12-28
CN1071833A (zh) 1993-05-12
SK319892A3 (en) 1995-03-08
RU2090553C1 (ru) 1997-09-20
AU2721592A (en) 1993-04-29
CA2081173A1 (en) 1993-04-24
DE59203828D1 (de) 1995-11-02
EP0538783A1 (de) 1993-04-28
NO178922B (no) 1996-03-25

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