ES2196001T3 - Derivado de pirroloazepina. - Google Patents

Derivado de pirroloazepina.

Info

Publication number
ES2196001T3
ES2196001T3 ES92916818T ES92916818T ES2196001T3 ES 2196001 T3 ES2196001 T3 ES 2196001T3 ES 92916818 T ES92916818 T ES 92916818T ES 92916818 T ES92916818 T ES 92916818T ES 2196001 T3 ES2196001 T3 ES 2196001T3
Authority
ES
Spain
Prior art keywords
alkyl
represent
bond
pirroloazepina
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92916818T
Other languages
English (en)
Inventor
Akira Mizuno
Hidetsura Cho
Mikiko Miya
Toshio Tatsuoka
Takafumi Ishihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asubio Pharma Co Ltd
Original Assignee
Daiichi Suntory Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Suntory Pharma Co Ltd filed Critical Daiichi Suntory Pharma Co Ltd
Application granted granted Critical
Publication of ES2196001T3 publication Critical patent/ES2196001T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

UN DERIVADO DE LA PIRROLAZEPINA REPRESENTADO POR UNA FORMULA GENERAL (1), Y UNA SAL DEL MISMO, UN PROCEDIMIENTO PARA SU PRODUCCION Y UN REMEDIO PARA LAS ENFERMEDADES DE LOS ORGANOS CIRCULATORIOS CONTENIENDOLO COMO INGREDIENTE ACTIVO. EN LA FORMULA (1) Z1 REPRESENTA H CUANDO EXISTE UN ENLACE REPRESENTADO POR UNA LINEA DE PUNTOS, MIENTRAS QUE CUANDO NO EXISTE DICHO ENLACE, Z1 REPRESENTA H Y Z2 REPRESENTA OH, O ALTERNATIVAMENTE Z1 Y Z2 SE COMBINAN JUNTOS PARA REPRESENTAR O O NOR1 (DONDE R1 REPRESENTA H, ALQUILO, ETC.); R REPRESENTA H, ALQUILO, ETC.; A REPRESENTA AL ALQUILENO, ALQUENILENO O ALQUINILENO, CADA UNO DE LOS CUALES PUEDE SER SUBSTITUIDO POR UN GRUPO OH; E Y REPRESENTA (ALFA) O (BETA) DONDE R2 Y R3 REPRESENTA CADA UNO H, ALQUILO, ETC.; R4 Y R5 REPRESENTAN, CADA UNO, H O ALQUILO; B REPRESENTA CARBONILO, SULFONILO, ETC.; M REPRESENTA 1 O 2; N REPRESENTA 0 O 1; Y D REPRESENTA ALCOXI, Y HETEROCICLOS AROMATICOS, ETC.
ES92916818T 1991-08-07 1992-08-06 Derivado de pirroloazepina. Expired - Lifetime ES2196001T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22119191 1991-08-07

Publications (1)

Publication Number Publication Date
ES2196001T3 true ES2196001T3 (es) 2003-12-16

Family

ID=16762903

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92916818T Expired - Lifetime ES2196001T3 (es) 1991-08-07 1992-08-06 Derivado de pirroloazepina.

Country Status (10)

Country Link
US (1) US5397780A (es)
EP (1) EP0551527B8 (es)
JP (1) JP3242652B2 (es)
KR (1) KR100243514B1 (es)
AT (1) ATE236162T1 (es)
AU (1) AU655841B2 (es)
CA (1) CA2093631C (es)
DE (1) DE69232980T2 (es)
ES (1) ES2196001T3 (es)
WO (1) WO1993003031A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3563076B2 (ja) * 1995-12-01 2004-09-08 第一サントリーファーマ株式会社 ピロロアゼピン誘導体
JPH10251258A (ja) 1997-03-14 1998-09-22 Suntory Ltd ピロロアゼピン系化合物
JPH11193289A (ja) 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体
JPH11193290A (ja) 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド系化合物
EP4092013A1 (en) 2017-06-20 2022-11-23 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3563979A (en) * 1966-10-21 1971-02-16 Upjohn Co 1,2,3,4,5,6 - hexahydroazepino(4,3 - b)indoles and 1,2,3,4,5,6-hexahydroazepino(3,2-b)indoles
US3573324A (en) * 1969-02-28 1971-03-30 Upjohn Co 2,3,4,5,10,10a-hexahydroazepino(2,3-b)indoles
US3573323A (en) * 1969-02-28 1971-03-30 Upjohn Co 1,2,3,4,5,10-hexahydroazepino(2,3-b)indoles
JPS62161786A (ja) * 1986-01-08 1987-07-17 Mitsubishi Chem Ind Ltd ピロ−ル化合物
US4729996A (en) * 1986-05-29 1988-03-08 Harbor Branch Oceanographic Institution, Inc. Antitumor compositions and their methods of use
DE3903368A1 (de) * 1989-02-04 1990-08-09 Basf Ag Verfahren zur herstellung von kondensierten cyclischen amidinen
JP3198117B2 (ja) * 1990-02-07 2001-08-13 サントリー株式会社 ピロロアゼピン誘導体

Also Published As

Publication number Publication date
CA2093631C (en) 2003-09-23
WO1993003031A1 (en) 1993-02-18
KR100243514B1 (ko) 2000-03-02
EP0551527B8 (en) 2003-08-13
AU2403192A (en) 1993-03-02
DE69232980D1 (de) 2003-05-08
ATE236162T1 (de) 2003-04-15
US5397780A (en) 1995-03-14
EP0551527B1 (en) 2003-04-02
CA2093631A1 (en) 1993-02-08
AU655841B2 (en) 1995-01-12
KR930702354A (ko) 1993-09-08
EP0551527A1 (en) 1993-07-21
EP0551527A4 (es) 1994-08-31
JP3242652B2 (ja) 2001-12-25
DE69232980T2 (de) 2004-02-05

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