AR241492A1 - Procedimiento para la preparacion de un derivado de azabiciclo ¡3.3.1¿ nonano - Google Patents

Procedimiento para la preparacion de un derivado de azabiciclo ¡3.3.1¿ nonano

Info

Publication number
AR241492A1
AR241492A1 AR87309644A AR30964487A AR241492A1 AR 241492 A1 AR241492 A1 AR 241492A1 AR 87309644 A AR87309644 A AR 87309644A AR 30964487 A AR30964487 A AR 30964487A AR 241492 A1 AR241492 A1 AR 241492A1
Authority
AR
Argentina
Prior art keywords
phenyl
alkyl
substituted
cinnamilo
axide
Prior art date
Application number
AR87309644A
Other languages
English (en)
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Application granted granted Critical
Publication of AR241492A1 publication Critical patent/AR241492A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

OBTENCION DE UN DERIVADO DE AZABICICLO ¡3.3.1¿ NONANO DE LA FORMULA (I), DONDE R1 ES ALQUILO O BENCILO; R2 Y R3 SON ALQUILO; R4 ES HIDROXI ESTERIFICADO -OOC-R6, DONDE R6 ES ALQUILO SUSTITUIDO PORFENOXI, FENILO; CICLOHEXILO; FENILO, FENILO SUSTITUIDO POR 4-ALQUILO, 4-FENILO, 3- TRIFLUORMETILO O 4-NITRO, POR 3,4,5-TRIALCOXI O POR HALOGENO; BENZHIDRILO; 1,1-DIFENILHIDROXIMETILO; TETRAHIDRONAFTILO; TENILO O 9-XANTENILO; NAFTILO; NAFTILO 6-MONO-SUSTITUIDO POR HALOGENO; CINNAMILO O CINNAMILO 4-HALO SUSTITUIDO O GRUPOS 3,4,5-TRI-ALCOXI; ASI COMO SALES ACIDAS DE ADICION FARMACEUTICAMENTE ACEPTABLES, A PARTIR DE UN ALCOHOL DE FORMULA SIMILAR A (I) EN DONDE R7 ES OXIDRILO, QUE SE HACE REACCIONAR CON UN DERIVADO DE ACIDO CARBOXILICO R6-C0X DONDE R6 ESTA DEFINIDO ANTES Y X ES HALOGENO O ALCOXI CON UN AGENTE LIGANTE DE ACIDO O UN SOLVENTE ORGANICO Y UN CATALIZADOR.
AR87309644A 1983-11-30 1987-12-18 Procedimiento para la preparacion de un derivado de azabiciclo ¡3.3.1¿ nonano AR241492A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU834096A HU190511B (en) 1983-11-30 1983-11-30 Process for preparing new azabicyclic compounds

Publications (1)

Publication Number Publication Date
AR241492A1 true AR241492A1 (es) 1992-07-31

Family

ID=10966876

Family Applications (1)

Application Number Title Priority Date Filing Date
AR87309644A AR241492A1 (es) 1983-11-30 1987-12-18 Procedimiento para la preparacion de un derivado de azabiciclo ¡3.3.1¿ nonano

Country Status (31)

Country Link
US (1) US4769373A (es)
JP (1) JPS60185766A (es)
AR (1) AR241492A1 (es)
AT (1) AT388730B (es)
AU (1) AU570285B2 (es)
BE (1) BE901174A (es)
CA (1) CA1280751C (es)
CH (1) CH663615A5 (es)
CS (1) CS273602B2 (es)
DD (1) DD231073A1 (es)
DE (1) DE3442365A1 (es)
DK (1) DK568584A (es)
EG (1) EG16845A (es)
ES (2) ES8604579A1 (es)
FI (1) FI80445C (es)
FR (1) FR2555580B1 (es)
GB (1) GB2150558B (es)
GR (1) GR81084B (es)
HU (1) HU190511B (es)
IL (1) IL73421A (es)
IT (1) IT1178638B (es)
MX (1) MX157611A (es)
NL (1) NL8403634A (es)
NO (1) NO165292C (es)
PH (1) PH19659A (es)
PL (2) PL144546B1 (es)
PT (1) PT79568B (es)
SE (1) SE460418B (es)
SU (1) SU1395141A3 (es)
YU (1) YU45681B (es)
ZA (1) ZA848721B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0525672D0 (en) * 2005-12-16 2006-01-25 Novartis Ag Organic compounds
CN111187210B (zh) * 2020-01-08 2022-05-03 成都中医药大学 一种热解型二萜生物碱化合物及其制备方法和用途
CN113149906B (zh) * 2021-02-24 2022-05-17 成都中医药大学 一种抗心律失常药物及其制备方法
CN113149905B (zh) * 2021-02-24 2022-04-29 成都中医药大学 一种抗心律失常的化合物及其制药用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1195746A (en) * 1967-06-07 1970-06-24 Yoshitomi Pharmaceutical 3-Azabicyclo [3,3,1] Nonane Derivatives
US3740408A (en) * 1967-09-11 1973-06-19 Upjohn Co Oxygenated 3-aza bicyclo(3,3,1)nonanes
GB1393253A (en) * 1971-09-10 1975-05-07 Wyeth John & Brother Ltd 3-azabicyclo-3,3,1-nonanes

Also Published As

Publication number Publication date
GB2150558A (en) 1985-07-03
FI844480L (fi) 1985-05-31
CS273602B2 (en) 1991-03-12
EG16845A (en) 1990-12-30
SE8406046D0 (sv) 1984-11-29
PL254457A1 (en) 1987-03-23
ZA848721B (en) 1985-06-26
NO165292C (no) 1991-01-23
CS920184A2 (en) 1990-08-14
GR81084B (en) 1985-03-29
FI844480A0 (fi) 1984-11-15
SE8406046L (sv) 1985-05-31
CH663615A5 (de) 1987-12-31
DE3442365A1 (de) 1985-06-05
GB2150558B (en) 1987-10-14
HU190511B (en) 1986-09-29
PL142604B1 (en) 1987-11-30
FR2555580B1 (fr) 1988-10-28
BE901174A (fr) 1985-05-30
NL8403634A (nl) 1985-06-17
MX157611A (es) 1988-12-05
CA1280751C (en) 1991-02-26
NO165292B (no) 1990-10-15
AU3602984A (en) 1985-06-06
FI80445B (fi) 1990-02-28
PT79568B (en) 1986-09-11
IT8423805A0 (it) 1984-11-29
ES8606338A1 (es) 1986-04-01
JPS60185766A (ja) 1985-09-21
ES548112A0 (es) 1986-04-01
IL73421A (en) 1987-12-31
PT79568A (en) 1984-12-01
AU570285B2 (en) 1988-03-10
NO844750L (no) 1985-05-31
DK568584A (da) 1985-05-31
PL250635A1 (en) 1985-11-05
FR2555580A1 (fr) 1985-05-31
ES8604579A1 (es) 1986-02-01
IT1178638B (it) 1987-09-09
DK568584D0 (da) 1984-11-29
FI80445C (fi) 1990-06-11
SU1395141A3 (ru) 1988-05-07
YU45681B (sh) 1992-07-20
SE460418B (sv) 1989-10-09
US4769373A (en) 1988-09-06
DD231073A1 (de) 1985-12-18
HUT35647A (en) 1985-07-29
YU200684A (en) 1987-10-31
PH19659A (en) 1986-06-09
GB8428143D0 (en) 1984-12-12
ATA352184A (de) 1989-01-15
ES538069A0 (es) 1986-02-01
AT388730B (de) 1989-08-25
PL144546B1 (en) 1988-06-30

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