PT82726B - Processo para a preparacao de novos derivados de 1,1,2,2,-tetrametil-1,2-bis(2-fluor-4-hidroxifenil-etano e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de novos derivados de 1,1,2,2,-tetrametil-1,2-bis(2-fluor-4-hidroxifenil-etano e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT82726B PT82726B PT82726A PT8272686A PT82726B PT 82726 B PT82726 B PT 82726B PT 82726 A PT82726 A PT 82726A PT 8272686 A PT8272686 A PT 8272686A PT 82726 B PT82726 B PT 82726B
- Authority
- PT
- Portugal
- Prior art keywords
- group
- preparation
- ethanone
- tetrahydro
- hydroxyphenyl
- Prior art date
Links
- ZCZIRBNZMFUCOH-UHFFFAOYSA-N 1-(2-fluoro-4-hydroxyphenyl)ethanone Chemical compound CC(=O)C1=CC=C(O)C=C1F ZCZIRBNZMFUCOH-UHFFFAOYSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010060862 Prostate cancer Diseases 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 201000001514 prostate carcinoma Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/24—Halogenated derivatives
- C07C39/367—Halogenated derivatives polycyclic non-condensed, containing only six-membered aromatic rings as cyclic parts, e.g. halogenated poly-hydroxyphenylalkanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Polyesters Or Polycarbonates (AREA)
- Hydrogenated Pyridines (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3520622 | 1985-06-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
PT82726A PT82726A (de) | 1986-07-01 |
PT82726B true PT82726B (pt) | 1988-12-15 |
Family
ID=6272805
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT82726A PT82726B (pt) | 1985-06-08 | 1986-06-06 | Processo para a preparacao de novos derivados de 1,1,2,2,-tetrametil-1,2-bis(2-fluor-4-hidroxifenil-etano e de composicoes farmaceuticas que os contem |
Country Status (19)
Country | Link |
---|---|
US (1) | US4745233A (pt) |
EP (1) | EP0206021B1 (pt) |
JP (1) | JPS6242953A (pt) |
AT (1) | ATE36312T1 (pt) |
AU (1) | AU5847386A (pt) |
CA (1) | CA1273953A (pt) |
DD (1) | DD260490A5 (pt) |
DE (1) | DE3660489D1 (pt) |
DK (1) | DK268386A (pt) |
ES (1) | ES8705357A1 (pt) |
FI (1) | FI862431A (pt) |
GR (1) | GR861480B (pt) |
HU (1) | HUT43552A (pt) |
IL (1) | IL79055A0 (pt) |
NO (1) | NO862279L (pt) |
PT (1) | PT82726B (pt) |
SU (1) | SU1676459A3 (pt) |
YU (1) | YU95986A (pt) |
ZA (1) | ZA864262B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01155753A (ja) * | 1987-12-11 | 1989-06-19 | Nippon Telegr & Teleph Corp <Ntt> | 留守番電話機 |
WO2001091744A1 (en) * | 2000-05-26 | 2001-12-06 | Harry Fisch | Methods of treating androgen deficiency in men using selective antiestrogens |
PT1411916E (pt) | 2001-07-09 | 2008-12-10 | Repros Therapeutics Inc | Métodos e materiais para o tratamento de deficiência em testosterona nos homens |
US7737185B2 (en) | 2001-07-09 | 2010-06-15 | Repros Therapeutics Inc. | Methods and compositions with trans-clomiphene |
PL383444A1 (pl) | 2005-03-22 | 2008-03-17 | Repros Therapeutics Inc. | Sposoby dawkowania trans-klomifenu |
ES2718912T3 (es) | 2007-10-16 | 2019-07-05 | Repros Therapeutics Inc | Trans-clomifeno para el tratamiento de la diabetes en hombres hipogonadales |
UA113291C2 (xx) | 2011-08-04 | 2017-01-10 | Метаболіти транскломіфену і їх застосування | |
CN104994877A (zh) | 2012-11-02 | 2015-10-21 | 利普生物药剂公司 | 用于癌症治疗的反式-克罗米芬 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2021588B (en) * | 1978-04-05 | 1983-03-30 | Biorex Laboratories Ltd | Bibenzyl derivatives the preparation thereof and pharmaceutical compositions containing them |
DE2927050A1 (de) * | 1979-07-04 | 1981-01-15 | Biorex Laboratories Ltd | Bibenzylderivate |
US4427697A (en) * | 1980-11-18 | 1984-01-24 | Biorex Laboratories Limited | 1,2-Diphenylethane derivatives |
US4467121A (en) * | 1980-12-31 | 1984-08-21 | General Electric Company | Fluorinated diphenols and method for their preparation |
-
1986
- 1986-06-04 DE DE8686107568T patent/DE3660489D1/de not_active Expired
- 1986-06-04 EP EP86107568A patent/EP0206021B1/de not_active Expired
- 1986-06-04 AT AT86107568T patent/ATE36312T1/de not_active IP Right Cessation
- 1986-06-05 YU YU00959/86A patent/YU95986A/xx unknown
- 1986-06-06 FI FI862431A patent/FI862431A/fi not_active IP Right Cessation
- 1986-06-06 CA CA000511010A patent/CA1273953A/en not_active Expired - Lifetime
- 1986-06-06 NO NO862279A patent/NO862279L/no unknown
- 1986-06-06 DD DD86291079A patent/DD260490A5/de unknown
- 1986-06-06 HU HU862404A patent/HUT43552A/hu unknown
- 1986-06-06 DK DK268386A patent/DK268386A/da not_active Application Discontinuation
- 1986-06-06 PT PT82726A patent/PT82726B/pt not_active IP Right Cessation
- 1986-06-06 GR GR861480A patent/GR861480B/el unknown
- 1986-06-06 IL IL79055A patent/IL79055A0/xx unknown
- 1986-06-06 JP JP61130455A patent/JPS6242953A/ja active Pending
- 1986-06-06 AU AU58473/86A patent/AU5847386A/en not_active Abandoned
- 1986-06-06 ES ES555785A patent/ES8705357A1/es not_active Expired
- 1986-06-06 ZA ZA864262A patent/ZA864262B/xx unknown
- 1986-06-09 US US06/871,892 patent/US4745233A/en not_active Expired - Fee Related
-
1987
- 1987-02-06 SU SU874028942A patent/SU1676459A3/ru active
Also Published As
Publication number | Publication date |
---|---|
ATE36312T1 (de) | 1988-08-15 |
CA1273953A (en) | 1990-09-11 |
YU95986A (en) | 1988-02-29 |
DD260490A5 (de) | 1988-09-28 |
ES555785A0 (es) | 1987-05-01 |
DE3660489D1 (en) | 1988-09-15 |
US4745233A (en) | 1988-05-17 |
DK268386A (da) | 1986-12-09 |
GR861480B (en) | 1986-10-07 |
FI862431A0 (fi) | 1986-06-06 |
SU1676459A3 (ru) | 1991-09-07 |
HUT43552A (en) | 1987-11-30 |
IL79055A0 (en) | 1986-09-30 |
JPS6242953A (ja) | 1987-02-24 |
AU5847386A (en) | 1986-12-11 |
NO862279D0 (no) | 1986-06-06 |
EP0206021A1 (de) | 1986-12-30 |
ZA864262B (en) | 1987-02-25 |
PT82726A (de) | 1986-07-01 |
DK268386D0 (da) | 1986-06-06 |
EP0206021B1 (de) | 1988-08-10 |
ES8705357A1 (es) | 1987-05-01 |
NO862279L (no) | 1986-12-09 |
FI862431A (fi) | 1986-12-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES525653A0 (es) | Procedimiento para preparar nuevos diazabiciclo-(3.3.1)-nonanos | |
ZA80403B (en) | Antineoplastic compositions | |
NO820429L (no) | Tetrahydronaftalin- og indanforbindelser | |
GR78806B (pt) | ||
PT82726B (pt) | Processo para a preparacao de novos derivados de 1,1,2,2,-tetrametil-1,2-bis(2-fluor-4-hidroxifenil-etano e de composicoes farmaceuticas que os contem | |
ES519690A0 (es) | Procedimiento para la obtencion de azolil-fenoxi-tetrahidrofuran-2-iliden-metanos. | |
ES492537A0 (es) | Procedimiento para la obtencion de pseudo-trisacaridos | |
DK26581A (da) | Hidtil ukendte substituerede 1,8-dihydroxy-9-(10h) anthracenoner samt fremgangsmaade til deres fremstilling | |
ES8301889A1 (es) | Procedimiento de preparacion de una composicion tintorea pa-ra fibras queratinicas | |
DE58907417D1 (de) | Verfahren zur Herstellung von Addukten von 1,2-Butylenoxid an Alkohole. | |
ES492846A0 (es) | Procedimiento para el cultivo superficial de celulas que contienen nucleos. | |
GR76023B (pt) | ||
PT84077B (pt) | Processo para a preparacao de novos derivados da tironina | |
SE7903971L (sv) | Antitumordeoxiantracykliner | |
ES477534A2 (es) | Mejoras introducidas en el objeto de la patente principal n.454.779, por procedimiento para la obtencion de hidroxidihe-terociclos eterados. | |
ES8307803A1 (es) | Procedimiento de preparar trimetoxibenzoatos de apovincaminol substituidos con efecto inhibidor de las fosfodiestebasas. | |
SE7906464L (sv) | Doxorubicinderivat | |
IL57838A (en) | Process for the preparation of o-methyl-n-cyclohexyl-2,5-dimethyl-furan-3-hydroxamic acid,n-cyclohexyl-n-methoxyacetoacetamide employed as intermediate therein and its preparation | |
ES474955A1 (es) | Un procedimiento para la preparacion de un compuesto polici-clico |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19911126 |