YU45681B - Postupak za dobijanje novih azabiciklo (3,3,1) nonana - Google Patents

Postupak za dobijanje novih azabiciklo (3,3,1) nonana

Info

Publication number
YU45681B
YU45681B YU200684A YU200684A YU45681B YU 45681 B YU45681 B YU 45681B YU 200684 A YU200684 A YU 200684A YU 200684 A YU200684 A YU 200684A YU 45681 B YU45681 B YU 45681B
Authority
YU
Yugoslavia
Prior art keywords
naphthoyl
group
chlorobenzoyl
chlorophenyl
general formula
Prior art date
Application number
YU200684A
Other languages
English (en)
Other versions
YU200684A (en
Inventor
K. Nador
G. Kraiss
M. Pellinoisz
E. Karpati
L. Szporny
Original Assignee
Richter Gedeon Vegyeszeti Gyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.
Publication of YU200684A publication Critical patent/YU200684A/xx
Publication of YU45681B publication Critical patent/YU45681B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE NOVIH AZABICIKLO (3,3,1) NONANA, opšte formule (I) u kojoj R1, R2 i R3 predstavljaju metil, etil ili n-butil grupu, R4 je hidroksi grupa koja može da se eterifikuje ili esterifikuje pri čemu se dobijaju grupe -OR5 ili -OOCR6, u kojima R5 je fenil grupa ili 2-hlorfenil, 3-hlorfenil, 4-hlorfenil, 3,4-dihlorfenil, 2,4-dibrombenil, 3-trifluorfenil, 4-metilfenil, 4-fenilfenil, benzhidril, 3-trifluormetilfenil, benzil, ili cikloheksanoil, a -OOCR6 grupa predstavlja 4-metilbenzoil, 4-hlorbenzoil, 3,4,5-trimetoksibenzoil, 4-fenilbenzoil, 2-naftoil, 9-ksantenkarbonil, 2-tenoil, 4-fluorbenzoil, 3-fluorbenzoil, 3,4-dihidrobenzoil, 2-hlorbenzoil, 3-hlorbenzoil, 3-trifluormetilbenzoil, cinamoil, 4-hlorcinamoil, 3,4,5-trimetoksicinamoil, naftoil, 6-hlor-2-naftoil, 1,2,3,4-tetrahidro-2-naftoil, fenoksiacetiloksi, 4-nitrobenzoil ili difenilacetil grupu, kao i njihovih adicionih soli kiselina koje nalaze primenu u farmaciji, naznačen time, što alkohol opšte formule (I) u kome su R1, R2 i R3 ranije definisani, R4 je hidroksi grupa, reaguje sa agensom za eterifikovanje opšte formule (III) R5 - X u kojoj R5 ranije definisano, X je hlor, brom ili fluor u prisustvu agensa za vezivanje kiseline i u dimetilformamidu na temperaturi od +20 do +60 C, ili reaguje sa karbonskom kiselinom (II) ili njenim reaktivnim derivatom sa kojim se može acilovati R6COOH u kojoj je R6 ranije definisano u prisustvu agensa za vezivanje kiseline u hloroformu, na temperaturi od 5 do 25 C. Prijava sadrži još 3 patentna zahteva.
YU200684A 1983-11-30 1984-11-27 Postupak za dobijanje novih azabiciklo (3,3,1) nonana YU45681B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU834096A HU190511B (en) 1983-11-30 1983-11-30 Process for preparing new azabicyclic compounds

Publications (2)

Publication Number Publication Date
YU200684A YU200684A (en) 1987-10-31
YU45681B true YU45681B (sh) 1992-07-20

Family

ID=10966876

Family Applications (1)

Application Number Title Priority Date Filing Date
YU200684A YU45681B (sh) 1983-11-30 1984-11-27 Postupak za dobijanje novih azabiciklo (3,3,1) nonana

Country Status (31)

Country Link
US (1) US4769373A (sh)
JP (1) JPS60185766A (sh)
AR (1) AR241492A1 (sh)
AT (1) AT388730B (sh)
AU (1) AU570285B2 (sh)
BE (1) BE901174A (sh)
CA (1) CA1280751C (sh)
CH (1) CH663615A5 (sh)
CS (1) CS273602B2 (sh)
DD (1) DD231073A1 (sh)
DE (1) DE3442365A1 (sh)
DK (1) DK568584A (sh)
EG (1) EG16845A (sh)
ES (2) ES8604579A1 (sh)
FI (1) FI80445C (sh)
FR (1) FR2555580B1 (sh)
GB (1) GB2150558B (sh)
GR (1) GR81084B (sh)
HU (1) HU190511B (sh)
IL (1) IL73421A (sh)
IT (1) IT1178638B (sh)
MX (1) MX157611A (sh)
NL (1) NL8403634A (sh)
NO (1) NO165292C (sh)
PH (1) PH19659A (sh)
PL (2) PL144546B1 (sh)
PT (1) PT79568B (sh)
SE (1) SE460418B (sh)
SU (1) SU1395141A3 (sh)
YU (1) YU45681B (sh)
ZA (1) ZA848721B (sh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0525672D0 (en) * 2005-12-16 2006-01-25 Novartis Ag Organic compounds
CN111187210B (zh) * 2020-01-08 2022-05-03 成都中医药大学 一种热解型二萜生物碱化合物及其制备方法和用途
CN113149905B (zh) * 2021-02-24 2022-04-29 成都中医药大学 一种抗心律失常的化合物及其制药用途
CN113149906B (zh) * 2021-02-24 2022-05-17 成都中医药大学 一种抗心律失常药物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1195746A (en) * 1967-06-07 1970-06-24 Yoshitomi Pharmaceutical 3-Azabicyclo [3,3,1] Nonane Derivatives
US3740408A (en) * 1967-09-11 1973-06-19 Upjohn Co Oxygenated 3-aza bicyclo(3,3,1)nonanes
GB1393253A (en) * 1971-09-10 1975-05-07 Wyeth John & Brother Ltd 3-azabicyclo-3,3,1-nonanes

Also Published As

Publication number Publication date
IL73421A (en) 1987-12-31
FR2555580A1 (fr) 1985-05-31
EG16845A (en) 1990-12-30
DK568584D0 (da) 1984-11-29
ZA848721B (en) 1985-06-26
FR2555580B1 (fr) 1988-10-28
GB8428143D0 (en) 1984-12-12
ES8606338A1 (es) 1986-04-01
PL250635A1 (en) 1985-11-05
NO165292C (no) 1991-01-23
DD231073A1 (de) 1985-12-18
IT8423805A0 (it) 1984-11-29
SU1395141A3 (ru) 1988-05-07
PL142604B1 (en) 1987-11-30
SE8406046D0 (sv) 1984-11-29
GB2150558A (en) 1985-07-03
PT79568A (en) 1984-12-01
AU3602984A (en) 1985-06-06
FI80445C (fi) 1990-06-11
NL8403634A (nl) 1985-06-17
FI844480A0 (fi) 1984-11-15
FI80445B (fi) 1990-02-28
AU570285B2 (en) 1988-03-10
AT388730B (de) 1989-08-25
YU200684A (en) 1987-10-31
CS920184A2 (en) 1990-08-14
CH663615A5 (de) 1987-12-31
ES538069A0 (es) 1986-02-01
FI844480L (fi) 1985-05-31
NO165292B (no) 1990-10-15
MX157611A (es) 1988-12-05
IT1178638B (it) 1987-09-09
ES8604579A1 (es) 1986-02-01
SE8406046L (sv) 1985-05-31
US4769373A (en) 1988-09-06
ES548112A0 (es) 1986-04-01
PH19659A (en) 1986-06-09
HUT35647A (en) 1985-07-29
AR241492A1 (es) 1992-07-31
CS273602B2 (en) 1991-03-12
NO844750L (no) 1985-05-31
SE460418B (sv) 1989-10-09
DE3442365A1 (de) 1985-06-05
HU190511B (en) 1986-09-29
CA1280751C (en) 1991-02-26
JPS60185766A (ja) 1985-09-21
PL144546B1 (en) 1988-06-30
PT79568B (en) 1986-09-11
PL254457A1 (en) 1987-03-23
GR81084B (en) 1985-03-29
GB2150558B (en) 1987-10-14
BE901174A (fr) 1985-05-30
ATA352184A (de) 1989-01-15
DK568584A (da) 1985-05-31

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