ES8502111A1 - Un procedimiento de preparacion de diniflumato del ester morfolinoetilico del acido niflumico - Google Patents

Un procedimiento de preparacion de diniflumato del ester morfolinoetilico del acido niflumico

Info

Publication number
ES8502111A1
ES8502111A1 ES531679A ES531679A ES8502111A1 ES 8502111 A1 ES8502111 A1 ES 8502111A1 ES 531679 A ES531679 A ES 531679A ES 531679 A ES531679 A ES 531679A ES 8502111 A1 ES8502111 A1 ES 8502111A1
Authority
ES
Spain
Prior art keywords
analgesic
diniflumate
preparation
pharmaceutical compositions
niflumic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531679A
Other languages
English (en)
Other versions
ES531679A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hexachimie SA
Original Assignee
Hexachimie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hexachimie SA filed Critical Hexachimie SA
Publication of ES8502111A1 publication Critical patent/ES8502111A1/es
Publication of ES531679A0 publication Critical patent/ES531679A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DINIFLUMATO DEL ESTER MORFOLINOETILICO DEL ACIDO NIFLUMICO.CONSISTE EN LA REACCION DE 2-(3-TRIFLUORMETIL-FENILAMINO)NICOTINATO DE BBB-MORFOLINOETILO CON EL DOBLE DE LA CANTIDAD ESTEQUIOMETRICA DE ACIDO 2-(3-TRIFLUORMETIL-FENILAMINO)NICOTINICO, EN UN DISOLVENTE ADECUADO, TAL COMO ETER ETILICO, A LA TEMPERATURA AMBIENTE.ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS POR SUS ACTIVIDADES ANTIINFLAMATORIAS, ANALGESICA Y ULCERIGENA.
ES531679A 1983-04-21 1984-04-17 Un procedimiento de preparacion de diniflumato del ester morfolinoetilico del acido niflumico Granted ES531679A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8306579A FR2544718B1 (fr) 1983-04-21 1983-04-21 Diniflumate d'ester morpholinoethylique d'acide niflumique, preparation, utilisation en therapeutique comme analgesique et anti-inflammatoire

Publications (2)

Publication Number Publication Date
ES8502111A1 true ES8502111A1 (es) 1984-12-16
ES531679A0 ES531679A0 (es) 1984-12-16

Family

ID=9288097

Family Applications (1)

Application Number Title Priority Date Filing Date
ES531679A Granted ES531679A0 (es) 1983-04-21 1984-04-17 Un procedimiento de preparacion de diniflumato del ester morfolinoetilico del acido niflumico

Country Status (26)

Country Link
US (1) US4595686A (es)
EP (1) EP0129449B1 (es)
JP (1) JPS59199676A (es)
KR (1) KR880001477B1 (es)
AR (1) AR240314A1 (es)
AT (1) ATE33639T1 (es)
AU (1) AU561210B2 (es)
CA (1) CA1218064A (es)
DE (1) DE3470534D1 (es)
DK (1) DK157858C (es)
EG (1) EG17886A (es)
ES (1) ES531679A0 (es)
FR (1) FR2544718B1 (es)
GB (1) GB2140008B (es)
GR (1) GR81476B (es)
HU (1) HU194877B (es)
IE (1) IE57219B1 (es)
IL (1) IL71525A (es)
MA (1) MA20097A1 (es)
MY (1) MY100483A (es)
NZ (1) NZ207913A (es)
PH (1) PH18986A (es)
PT (1) PT78432B (es)
SG (1) SG107587G (es)
YU (1) YU65784A (es)
ZA (1) ZA842672B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192724A (en) * 1992-03-17 1993-03-09 Phillips Petroleum Company Reactivation of spent cracking catalysts
GB0006897D0 (en) * 2000-03-23 2000-05-10 Smithkline Beecham Plc Medicaments
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
EA024559B1 (ru) 2009-05-06 2016-09-30 Лаборэтори Скин Кэа, Инк. Композиции для нанесения на кератинизированную поверхность кожи млекопитающего и способ доставки
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US27822A (en) * 1860-04-10 Isaac mott
GB1146459A (en) * 1966-11-14 1969-03-26 American Cyanamid Co Nicotinic acid derivatives and method of preparing the same
GB1187259A (en) * 1967-10-23 1970-04-08 Hexachimie New Aminoalkyl Esters of 2-Anilino-Nicotinic Acids and process for their manufacture
USRE27822E (en) 1971-07-06 1973-11-27 Substituted phenoxy-z-hydroxy- j-isopropylamino-propanes
DE2601548C2 (de) * 1976-01-16 1984-01-26 Hoechst Ag, 6230 Frankfurt 2-[4-(2'-Chlor-4'-bromphenoxy)-phenoxy]-propionsäure und Derivate sowie diese enthaltende herbizide Mittel
AR208619A1 (es) * 1976-09-02 1977-02-15 Bago Sa Labor Un procedimiento para la obtencion de 2(3'-trifluormetilanilino)nicotinato de 5-hidroxi-6-metil-3,4-piridina dimetano
US4386090A (en) * 1980-12-22 1983-05-31 Delalande S.A. Nitrogen containing 2,3-dihydro naphthalenes, compositions and use
IT1150194B (it) * 1982-02-23 1986-12-10 Chiesi Farma Spa Formulazioni farmaceutiche ad attivita'antiinfiammatoria, analgesica,antipiretica e gastroprotettiva

Also Published As

Publication number Publication date
IL71525A0 (en) 1984-07-31
PH18986A (en) 1985-11-29
SG107587G (en) 1988-05-20
GB2140008B (en) 1986-11-12
EP0129449A1 (fr) 1984-12-27
IE840843L (en) 1984-10-21
ZA842672B (en) 1984-11-28
AU561210B2 (en) 1987-04-30
IL71525A (en) 1987-11-30
DK200884A (da) 1984-10-22
IE57219B1 (en) 1992-06-03
US4595686A (en) 1986-06-17
AU2674884A (en) 1984-10-25
NZ207913A (en) 1986-11-12
FR2544718B1 (fr) 1985-12-20
KR840008359A (ko) 1984-12-14
MA20097A1 (fr) 1984-12-31
GR81476B (es) 1984-12-11
CA1218064A (en) 1987-02-17
AR240314A1 (es) 1990-03-30
JPS59199676A (ja) 1984-11-12
DK200884D0 (da) 1984-04-18
DK157858B (da) 1990-02-26
EG17886A (en) 1991-03-30
ATE33639T1 (de) 1988-05-15
GB8409104D0 (en) 1984-05-16
YU65784A (en) 1986-10-31
ES531679A0 (es) 1984-12-16
EP0129449B1 (fr) 1988-04-20
FR2544718A1 (fr) 1984-10-26
DE3470534D1 (en) 1988-05-26
MY100483A (en) 1990-10-15
KR880001477B1 (ko) 1988-08-13
HUT34188A (en) 1985-02-28
DK157858C (da) 1990-07-30
HU194877B (en) 1988-03-28
PT78432A (fr) 1984-05-01
GB2140008A (en) 1984-11-21
PT78432B (fr) 1986-05-27

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