GB1146459A - Nicotinic acid derivatives and method of preparing the same - Google Patents
Nicotinic acid derivatives and method of preparing the sameInfo
- Publication number
- GB1146459A GB1146459A GB5063767A GB5063767A GB1146459A GB 1146459 A GB1146459 A GB 1146459A GB 5063767 A GB5063767 A GB 5063767A GB 5063767 A GB5063767 A GB 5063767A GB 1146459 A GB1146459 A GB 1146459A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- formula
- methyl
- acid derivatives
- nicotinic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
1,146,459. Nicotinic acid derivatives. AMERICAN CYANAMID CO. 7 Nov., 1967 [14 Nov., 1966], No. 50637/67. Addition to 1,070,620. Heading C2C. The invention comprises compounds of the Formula (I), wherein each R, the same or different, represents a trifluoromethyl, or C 1-4 alkyl radical or a halogen atom; n represents 1, 2 or 3; R 5 represents a C 1-4 alkyl radical and R 3 and R 4 represent C 1-4 alkyl or aryl radicals or R 3 and R 4 , taken together with the nitrogen atom to which they are attached, represent a pyrrolidino, piperidino, morpholino, 4-C 1-4 - alkyl - piperazino, 4 - (# - hydroxy - C 1-4 - alkyl)- piperazino or hydroxypiperidino group and their preparation by reacting a nicotinate ester of the Formula (II) with an unsymmetrical hydrazine of the Formula (III) in the presence of excess of the hydrazine as solvent or in the presence of an inert solvent. The invention also comprises N-methyl-4-(α,α,α -trinuoro-mtoluidino) nicotinamide which may be prepared by reacting methyl 4-(α,α,α-trifluoro-m-toluidino) nicotinate with methyl formamide and sodium methoxide. Therapeutic compositions in forms suitable for oral or parenteral application and having antiinflammatory, non-addicting analgesic and diuretic properties comprise compounds of the invention with a carrier.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59363866A | 1966-11-14 | 1966-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1146459A true GB1146459A (en) | 1969-03-26 |
Family
ID=24375514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5063767A Expired GB1146459A (en) | 1966-11-14 | 1967-11-07 | Nicotinic acid derivatives and method of preparing the same |
Country Status (4)
Country | Link |
---|---|
BE (1) | BE706411A (en) |
CH (1) | CH494757A (en) |
ES (1) | ES347129A2 (en) |
GB (1) | GB1146459A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2544718A1 (en) * | 1983-04-21 | 1984-10-26 | Hexachimie | NIFLUMIC ACID MORPHOLINOETHYL ESTER DINIFLUMATE, PREPARATION, THERAPEUTIC USE AS ANALGESIC AND ANTI-INFLAMMATORY |
-
1967
- 1967-11-07 GB GB5063767A patent/GB1146459A/en not_active Expired
- 1967-11-13 BE BE706411D patent/BE706411A/xx unknown
- 1967-11-13 CH CH1580467A patent/CH494757A/en not_active IP Right Cessation
- 1967-11-14 ES ES347129A patent/ES347129A2/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2544718A1 (en) * | 1983-04-21 | 1984-10-26 | Hexachimie | NIFLUMIC ACID MORPHOLINOETHYL ESTER DINIFLUMATE, PREPARATION, THERAPEUTIC USE AS ANALGESIC AND ANTI-INFLAMMATORY |
EP0129449A1 (en) * | 1983-04-21 | 1984-12-27 | HEXACHIMIE Société anonyme dite: | Diniflumate of morpholinoethyl ester of niflumic acid, its preparation, and its use in analgesic and antiinflammatory pharmaceutical compositions |
US4595686A (en) * | 1983-04-21 | 1986-06-17 | Hexachimie | Niflumic acid morpholinoethyl ester diniflumate, use as analgesic and anti-inflammatory agents and compositions |
Also Published As
Publication number | Publication date |
---|---|
ES347129A2 (en) | 1969-05-01 |
CH494757A (en) | 1970-08-15 |
BE706411A (en) | 1968-05-13 |
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