AR240918A2 - "procedimiento para obtener novedosos derivados de carboestirilo y sus sales." - Google Patents
"procedimiento para obtener novedosos derivados de carboestirilo y sus sales."Info
- Publication number
- AR240918A2 AR240918A2 AR29567584A AR29567584A AR240918A2 AR 240918 A2 AR240918 A2 AR 240918A2 AR 29567584 A AR29567584 A AR 29567584A AR 29567584 A AR29567584 A AR 29567584A AR 240918 A2 AR240918 A2 AR 240918A2
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- precedently
- general formula
- trialcoxi
- alcoxi
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
UN PROCEDIMIENTO PARA PREPARAR DERIVADOS DE CARBOESTIRILO DE FORMULA GENERAL (1-A), EN DONDE R1 ES HIDROGENO, ALQULO, ALQUENILO, ALQUNILO, FENILALAQUILO, A ES UN GRUPO ALQUILENO,LA LINEA PUNTEADA CORRESPONDE A UN ENLACE ADICIONAL ENTRE LAS POSICIONES 3 Y 4 EN EL ESQUELETO CARBOESTIRILO; R2 ES UN GRUPO BENZOILO, EVENTUALMENTE SUSTITUIDO POR: 4-CN, 4-NO2, 4-ALQUILO, 3,4-DIHALO, 3,4-METILENDIOXI, 3-HALO, 4-AMINO9, 2-O 4-ALCOXI, 3, 4-DIALCOXI, 3,4,5-TRIALCOXI; FUROILO, ALCONOILO, 4-ALQUL (CL-C4) FENIL-SO2, ALQUILO (C1-C4)-SO2, ALCOXI (C1-C4)-CO- O CIAMOILO EVENTUALMENTE SUSTITUIDO POR 3,4,5-TRIALCOXI (C1-C4) 4-ALCOXI (C1-C4) O FENOXI-ALQUILO (C1-C4), SE HACE REACCIONAR UN COMPUESTO DE FORMULA GENERAL (10), EN DONDE R1, A, EL ENLACE CARBONO-CARBONO ENTRE LAS POSICIONES 3 Y 4 EN EL ESQUELETO CARBOESTIRILO, LOS SIGNIFICADOS DE DOS PRECEDENTEMENTE, CON UNA AMINA DE FORMULA GENERAL (11) EN DONDE R2 TIENE EL SIGNIFICADO DADO PRECEDENTEMENTE, Y X3 ES DONDE R2 TIENE EL SIGNIFICADO DADO PRECEDENTEMENTE, Y X3 ES UN GRUPO HIDROXILO O UN ATOMO DE HALOGENO; Y HACER REACCIONAR LOS COMPUESTOS OBTENIDOS CON UN REACTIVO ELEGIDO PARA OBTENER LOS COMPUESTOS DE FORMULA I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56137984A JPS5838258A (ja) | 1981-09-01 | 1981-09-01 | カルボスチリル誘導体 |
JP56210368A JPS58110568A (ja) | 1981-12-25 | 1981-12-25 | カルボスチリル誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
AR240918A1 AR240918A1 (es) | 1991-03-27 |
AR240918A2 true AR240918A2 (es) | 1991-03-27 |
Family
ID=26471144
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR82290300A AR241905A1 (es) | 1981-09-01 | 1982-08-12 | Procedimiento para obtener nuevos derivados de carboestirilo y sus sales. |
AR295675A AR240918A1 (es) | 1981-09-01 | 1984-02-09 | "procedimiento para obtener novedosos derivados de carboestirilo y sus sales." |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR82290300A AR241905A1 (es) | 1981-09-01 | 1982-08-12 | Procedimiento para obtener nuevos derivados de carboestirilo y sus sales. |
Country Status (21)
Country | Link |
---|---|
US (1) | US4514401A (es) |
KR (1) | KR860000135B1 (es) |
AR (2) | AR241905A1 (es) |
AT (1) | AT383592B (es) |
AU (1) | AU532361B2 (es) |
BE (1) | BE894105A (es) |
CA (1) | CA1205807A (es) |
CH (1) | CH650783A5 (es) |
DE (1) | DE3230209C2 (es) |
DK (1) | DK166877B1 (es) |
ES (5) | ES514992A0 (es) |
FI (1) | FI78688C (es) |
FR (1) | FR2512019B1 (es) |
GB (1) | GB2108109B (es) |
IT (1) | IT1156490B (es) |
NL (1) | NL8203225A (es) |
NO (1) | NO159591C (es) |
PH (1) | PH18055A (es) |
PT (1) | PT75424B (es) |
SE (1) | SE452984B (es) |
SU (1) | SU1356962A3 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
FR2557570B1 (fr) * | 1984-01-04 | 1986-04-18 | Adir | Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
DE3423003A1 (de) * | 1984-06-22 | 1986-01-02 | Beiersdorf Ag, 2000 Hamburg | Benzo(c)(1,8)naphthyridine, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen |
DE3431303A1 (de) * | 1984-08-25 | 1986-02-27 | Goedecke Ag | 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung |
DE3784401T2 (de) * | 1986-07-31 | 1993-08-12 | Otsuka Pharma Co Ltd | Karbostyril-derivate und ihre salze, verfahren zu ihrer herstellung und diese enthaltende kardiotonische zusammensetzung. |
JPH0696555B2 (ja) * | 1986-07-31 | 1994-11-30 | 大塚製薬株式会社 | カルボスチリル誘導体 |
US5098477A (en) * | 1988-12-14 | 1992-03-24 | Ciba-Geigy Corporation | Inks, particularly for ink printing |
JP2686887B2 (ja) * | 1992-08-11 | 1997-12-08 | キッセイ薬品工業株式会社 | ピペリジノ−3,4−ジヒドロカルボスチリル誘導体 |
SG151250A1 (en) * | 2003-12-10 | 2009-04-30 | Janssen Pharmaceutica Nv | Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2- quinoxalinones as poly(adp-ribose) polymerase inhibitors |
NZ597107A (en) | 2009-06-25 | 2013-12-20 | Alkermes Pharma Ireland Ltd | Heterocyclic compounds for the treatment of neurological and psychological disorders |
JP5857040B2 (ja) | 2010-05-04 | 2016-02-10 | アルカーメス ファーマ アイルランド リミテッド | 酸化ラクタム化合物の合成方法 |
RU2448698C2 (ru) * | 2010-06-21 | 2012-04-27 | Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО НижГМА Росздрава) | Способ восстановления синусового ритма при трепетании предсердий i типа |
ES2691671T3 (es) | 2010-06-24 | 2018-11-28 | Alkermes Pharma Ireland Limited | Profármacos de compuestos NH-acídicos: derivados de éster, carbonato, carbamato y fosfonato |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5118771A (ja) * | 1974-08-07 | 1976-02-14 | Akimitsu Takeya | Bantaioshigatanitaisuru keshoshiitotenchakuho |
US4081447A (en) * | 1975-04-09 | 1978-03-28 | Abbott Laboratories | 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof |
JPS597707B2 (ja) * | 1975-06-23 | 1984-02-20 | オオツカセイヤク カブシキガイシヤ | カルボスチリルユウドウタイノ セイゾウホウ |
JPS52283A (en) * | 1975-06-23 | 1977-01-05 | Otsuka Pharmaceut Co Ltd | Process for preparation of carbostyril derivatives |
GB1589871A (en) * | 1976-07-19 | 1981-05-20 | Conder Group Serv Ltd | Tank construction |
JPS5416478A (en) * | 1977-07-08 | 1979-02-07 | Otsuka Pharmaceut Co Ltd | 3,4-dihydrocarbostyril herivative |
DE2853996A1 (de) * | 1978-12-14 | 1980-07-03 | Hoechst Ag | Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung |
JPS5585520A (en) * | 1978-12-22 | 1980-06-27 | Otsuka Pharmaceut Co Ltd | Remedy for peptic ulcer |
DE2928583A1 (de) * | 1979-07-14 | 1981-01-29 | Thomae Gmbh Dr K | Verfahren zur herstellung von carbostyrilderivaten |
PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
FI77852C (fi) * | 1981-02-17 | 1989-05-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat. |
-
1982
- 1982-08-09 AU AU86980/82A patent/AU532361B2/en not_active Ceased
- 1982-08-11 US US06/407,099 patent/US4514401A/en not_active Expired - Lifetime
- 1982-08-11 CA CA000409255A patent/CA1205807A/en not_active Expired
- 1982-08-11 FI FI822803A patent/FI78688C/fi not_active IP Right Cessation
- 1982-08-12 DK DK361982A patent/DK166877B1/da active
- 1982-08-12 NO NO822749A patent/NO159591C/no unknown
- 1982-08-12 AR AR82290300A patent/AR241905A1/es active
- 1982-08-13 GB GB08223310A patent/GB2108109B/en not_active Expired
- 1982-08-13 FR FR8214117A patent/FR2512019B1/fr not_active Expired
- 1982-08-13 ES ES514992A patent/ES514992A0/es active Granted
- 1982-08-13 PT PT75424A patent/PT75424B/pt not_active IP Right Cessation
- 1982-08-13 SU SU823485500A patent/SU1356962A3/ru active
- 1982-08-13 SE SE8204677A patent/SE452984B/sv not_active IP Right Cessation
- 1982-08-13 DE DE3230209A patent/DE3230209C2/de not_active Expired
- 1982-08-13 BE BE0/208806A patent/BE894105A/fr not_active IP Right Cessation
- 1982-08-14 KR KR8203652A patent/KR860000135B1/ko active
- 1982-08-15 CH CH4880/82A patent/CH650783A5/de not_active IP Right Cessation
- 1982-08-16 IT IT68020/82A patent/IT1156490B/it active
- 1982-08-16 AT AT0310682A patent/AT383592B/de not_active IP Right Cessation
- 1982-08-16 PH PH27731A patent/PH18055A/en unknown
- 1982-08-17 NL NL8203225A patent/NL8203225A/nl not_active Application Discontinuation
-
1983
- 1983-04-14 ES ES521473A patent/ES8405001A1/es not_active Expired
- 1983-04-14 ES ES521471A patent/ES8500933A1/es not_active Expired
- 1983-04-14 ES ES521472A patent/ES8405000A1/es not_active Expired
-
1984
- 1984-02-09 AR AR295675A patent/AR240918A1/es active
- 1984-10-22 ES ES536982A patent/ES8506302A1/es not_active Expired
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