AR240918A2 - "procedimiento para obtener novedosos derivados de carboestirilo y sus sales." - Google Patents

"procedimiento para obtener novedosos derivados de carboestirilo y sus sales."

Info

Publication number
AR240918A2
AR240918A2 AR29567584A AR29567584A AR240918A2 AR 240918 A2 AR240918 A2 AR 240918A2 AR 29567584 A AR29567584 A AR 29567584A AR 29567584 A AR29567584 A AR 29567584A AR 240918 A2 AR240918 A2 AR 240918A2
Authority
AR
Argentina
Prior art keywords
alkyl
carboestirile
precedently
procedure
general formula
Prior art date
Application number
AR29567584A
Other languages
English (en)
Other versions
AR240918A1 (es
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56137984A external-priority patent/JPS5838258A/ja
Priority claimed from JP56210368A external-priority patent/JPS58110568A/ja
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Application granted granted Critical
Publication of AR240918A1 publication Critical patent/AR240918A1/es
Publication of AR240918A2 publication Critical patent/AR240918A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR DERIVADOS DE CARBOESTIRILO DE FORMULA GENERAL (1-A), EN DONDE R1 ES HIDROGENO, ALQULO, ALQUENILO, ALQUNILO, FENILALAQUILO, A ES UN GRUPO ALQUILENO,LA LINEA PUNTEADA CORRESPONDE A UN ENLACE ADICIONAL ENTRE LAS POSICIONES 3 Y 4 EN EL ESQUELETO CARBOESTIRILO; R2 ES UN GRUPO BENZOILO, EVENTUALMENTE SUSTITUIDO POR: 4-CN, 4-NO2, 4-ALQUILO, 3,4-DIHALO, 3,4-METILENDIOXI, 3-HALO, 4-AMINO9, 2-O 4-ALCOXI, 3, 4-DIALCOXI, 3,4,5-TRIALCOXI; FUROILO, ALCONOILO, 4-ALQUL (CL-C4) FENIL-SO2, ALQUILO (C1-C4)-SO2, ALCOXI (C1-C4)-CO- O CIAMOILO EVENTUALMENTE SUSTITUIDO POR 3,4,5-TRIALCOXI (C1-C4) 4-ALCOXI (C1-C4) O FENOXI-ALQUILO (C1-C4), SE HACE REACCIONAR UN COMPUESTO DE FORMULA GENERAL (10), EN DONDE R1, A, EL ENLACE CARBONO-CARBONO ENTRE LAS POSICIONES 3 Y 4 EN EL ESQUELETO CARBOESTIRILO, LOS SIGNIFICADOS DE DOS PRECEDENTEMENTE, CON UNA AMINA DE FORMULA GENERAL (11) EN DONDE R2 TIENE EL SIGNIFICADO DADO PRECEDENTEMENTE, Y X3 ES DONDE R2 TIENE EL SIGNIFICADO DADO PRECEDENTEMENTE, Y X3 ES UN GRUPO HIDROXILO O UN ATOMO DE HALOGENO; Y HACER REACCIONAR LOS COMPUESTOS OBTENIDOS CON UN REACTIVO ELEGIDO PARA OBTENER LOS COMPUESTOS DE FORMULA I.
AR295675A 1981-09-01 1984-02-09 "procedimiento para obtener novedosos derivados de carboestirilo y sus sales." AR240918A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56137984A JPS5838258A (ja) 1981-09-01 1981-09-01 カルボスチリル誘導体
JP56210368A JPS58110568A (ja) 1981-12-25 1981-12-25 カルボスチリル誘導体

Publications (2)

Publication Number Publication Date
AR240918A1 AR240918A1 (es) 1991-03-27
AR240918A2 true AR240918A2 (es) 1991-03-27

Family

ID=26471144

Family Applications (2)

Application Number Title Priority Date Filing Date
AR82290300A AR241905A1 (es) 1981-09-01 1982-08-12 Procedimiento para obtener nuevos derivados de carboestirilo y sus sales.
AR295675A AR240918A1 (es) 1981-09-01 1984-02-09 "procedimiento para obtener novedosos derivados de carboestirilo y sus sales."

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AR82290300A AR241905A1 (es) 1981-09-01 1982-08-12 Procedimiento para obtener nuevos derivados de carboestirilo y sus sales.

Country Status (21)

Country Link
US (1) US4514401A (es)
KR (1) KR860000135B1 (es)
AR (2) AR241905A1 (es)
AT (1) AT383592B (es)
AU (1) AU532361B2 (es)
BE (1) BE894105A (es)
CA (1) CA1205807A (es)
CH (1) CH650783A5 (es)
DE (1) DE3230209C2 (es)
DK (1) DK166877B1 (es)
ES (5) ES514992A0 (es)
FI (1) FI78688C (es)
FR (1) FR2512019B1 (es)
GB (1) GB2108109B (es)
IT (1) IT1156490B (es)
NL (1) NL8203225A (es)
NO (1) NO159591C (es)
PH (1) PH18055A (es)
PT (1) PT75424B (es)
SE (1) SE452984B (es)
SU (1) SU1356962A3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FR2557570B1 (fr) * 1984-01-04 1986-04-18 Adir Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant
DE3423003A1 (de) * 1984-06-22 1986-01-02 Beiersdorf Ag, 2000 Hamburg Benzo(c)(1,8)naphthyridine, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
DE3431303A1 (de) * 1984-08-25 1986-02-27 Goedecke Ag 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung
EP0255134B1 (en) * 1986-07-31 1993-03-03 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives and salts thereof, process for preparing them, and cardiotonic composition containing same
JPH0696555B2 (ja) * 1986-07-31 1994-11-30 大塚製薬株式会社 カルボスチリル誘導体
US5098477A (en) * 1988-12-14 1992-03-24 Ciba-Geigy Corporation Inks, particularly for ink printing
JP2686887B2 (ja) * 1992-08-11 1997-12-08 キッセイ薬品工業株式会社 ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
BRPI0417571A (pt) * 2003-12-10 2007-03-20 Janssen Pharmaceutica Nv 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-ciclohexil-alquila substituìda como inibidores da poli(adp-ribose) polimerase
AU2010266018B2 (en) 2009-06-25 2014-01-09 Alkermes Pharma Ireland Limited Heterocyclic compounds for the treatment of neurological and psychological disorders
WO2011140183A1 (en) 2010-05-04 2011-11-10 Alkermes, Inc. Process for synthesizing oxidized lactam compounds
RU2448698C2 (ru) * 2010-06-21 2012-04-27 Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО НижГМА Росздрава) Способ восстановления синусового ритма при трепетании предсердий i типа
CA2802733C (en) 2010-06-24 2017-11-21 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5118771A (ja) * 1974-08-07 1976-02-14 Akimitsu Takeya Bantaioshigatanitaisuru keshoshiitotenchakuho
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
JPS52283A (en) * 1975-06-23 1977-01-05 Otsuka Pharmaceut Co Ltd Process for preparation of carbostyril derivatives
JPS597707B2 (ja) * 1975-06-23 1984-02-20 オオツカセイヤク カブシキガイシヤ カルボスチリルユウドウタイノ セイゾウホウ
GB1589871A (en) * 1976-07-19 1981-05-20 Conder Group Serv Ltd Tank construction
JPS5416478A (en) * 1977-07-08 1979-02-07 Otsuka Pharmaceut Co Ltd 3,4-dihydrocarbostyril herivative
DE2853996A1 (de) * 1978-12-14 1980-07-03 Hoechst Ag Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung
JPS5585520A (en) * 1978-12-22 1980-06-27 Otsuka Pharmaceut Co Ltd Remedy for peptic ulcer
DE2928583A1 (de) * 1979-07-14 1981-01-29 Thomae Gmbh Dr K Verfahren zur herstellung von carbostyrilderivaten
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (fi) * 1981-02-17 1989-05-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat.

Also Published As

Publication number Publication date
BE894105A (fr) 1983-02-14
ES8401058A1 (es) 1983-11-16
FI78688C (fi) 1989-09-11
PT75424A (en) 1982-09-01
IT1156490B (it) 1987-02-04
GB2108109B (en) 1985-05-09
NO159591C (no) 1989-01-18
NO822749L (no) 1983-03-02
ES521471A0 (es) 1984-11-01
DE3230209A1 (de) 1983-03-10
IT8268020A0 (it) 1982-08-16
DE3230209C2 (de) 1985-08-22
ES521473A0 (es) 1984-05-16
SE8204677L (sv) 1983-03-02
PT75424B (en) 1985-01-04
DK361982A (da) 1983-03-02
ES8405000A1 (es) 1984-05-16
AT383592B (de) 1987-07-27
CA1205807A (en) 1986-06-10
IT8268020A1 (it) 1984-02-16
KR860000135B1 (ko) 1986-02-26
ATA310682A (de) 1986-12-15
AR240918A1 (es) 1991-03-27
DK166877B1 (da) 1993-07-26
SE452984B (sv) 1988-01-04
AR241905A1 (es) 1993-01-29
ES536982A0 (es) 1985-07-01
KR840001157A (ko) 1984-03-28
FI822803A0 (fi) 1982-08-11
FI822803L (fi) 1983-03-02
SE8204677D0 (sv) 1982-08-13
ES8405001A1 (es) 1984-05-16
FR2512019B1 (fr) 1986-01-03
FI78688B (fi) 1989-05-31
ES8506302A1 (es) 1985-07-01
NO159591B (no) 1988-10-10
PH18055A (en) 1985-03-18
US4514401A (en) 1985-04-30
ES8500933A1 (es) 1984-11-01
NL8203225A (nl) 1983-04-05
GB2108109A (en) 1983-05-11
FR2512019A1 (fr) 1983-03-04
ES521472A0 (es) 1984-05-16
ES514992A0 (es) 1983-11-16
AU8698082A (en) 1983-04-14
AU532361B2 (en) 1983-09-29
CH650783A5 (de) 1985-08-15
SU1356962A3 (ru) 1987-11-30

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