ES8401058A1 - Un procedimiento para la preparacion de un derivado carbostirilo. - Google Patents
Un procedimiento para la preparacion de un derivado carbostirilo.Info
- Publication number
- ES8401058A1 ES8401058A1 ES514992A ES514992A ES8401058A1 ES 8401058 A1 ES8401058 A1 ES 8401058A1 ES 514992 A ES514992 A ES 514992A ES 514992 A ES514992 A ES 514992A ES 8401058 A1 ES8401058 A1 ES 8401058A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- substituted
- activity
- carbostyril
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CARBOSTIRILO, DE FORMULA (I), EN LA QUE A ES ALQUILENO INFERIOR; R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES; Y LA LINEA DISCONTINUA REPRESENTA DOS ATOMOS DE HIDROGENO O UN ENLACE.CONSISTE EN LA REACCION DE UN DERIVADO DE CARBOSTIRILO, DE FORMULA (II), CON UN ACIDO CARBOXILICO O UN DERIVADO ACTIVO DEL MISMO, DE FORMULA HOR2, EN LAS QUE TODOS LOS SIMBOLOS TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE -20JC Y 180JC.ESTOSCOMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES CARDIOTONICOS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56137984A JPS5838258A (ja) | 1981-09-01 | 1981-09-01 | カルボスチリル誘導体 |
JP56210368A JPS58110568A (ja) | 1981-12-25 | 1981-12-25 | カルボスチリル誘導体 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES514992A0 ES514992A0 (es) | 1983-11-16 |
ES8401058A1 true ES8401058A1 (es) | 1983-11-16 |
Family
ID=26471144
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES514992A Expired ES8401058A1 (es) | 1981-09-01 | 1982-08-13 | Un procedimiento para la preparacion de un derivado carbostirilo. |
ES521471A Granted ES521471A0 (es) | 1981-09-01 | 1983-04-14 | Un procedimiento para la preparacion de un derivado de carbostirilo. |
ES521472A Expired ES8405000A1 (es) | 1981-09-01 | 1983-04-14 | Un procedimiento para la preparacion de un derivado de carbostirilo. |
ES521473A Expired ES8405001A1 (es) | 1981-09-01 | 1983-04-14 | Un procedimiento para la preparacion de un derivado de carbostirilo. |
ES536982A Expired ES8506302A1 (es) | 1981-09-01 | 1984-10-22 | Un procedimiento para la preparacion de un derivado de carbostirilo |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES521471A Granted ES521471A0 (es) | 1981-09-01 | 1983-04-14 | Un procedimiento para la preparacion de un derivado de carbostirilo. |
ES521472A Expired ES8405000A1 (es) | 1981-09-01 | 1983-04-14 | Un procedimiento para la preparacion de un derivado de carbostirilo. |
ES521473A Expired ES8405001A1 (es) | 1981-09-01 | 1983-04-14 | Un procedimiento para la preparacion de un derivado de carbostirilo. |
ES536982A Expired ES8506302A1 (es) | 1981-09-01 | 1984-10-22 | Un procedimiento para la preparacion de un derivado de carbostirilo |
Country Status (21)
Country | Link |
---|---|
US (1) | US4514401A (es) |
KR (1) | KR860000135B1 (es) |
AR (2) | AR241905A1 (es) |
AT (1) | AT383592B (es) |
AU (1) | AU532361B2 (es) |
BE (1) | BE894105A (es) |
CA (1) | CA1205807A (es) |
CH (1) | CH650783A5 (es) |
DE (1) | DE3230209C2 (es) |
DK (1) | DK166877B1 (es) |
ES (5) | ES8401058A1 (es) |
FI (1) | FI78688C (es) |
FR (1) | FR2512019B1 (es) |
GB (1) | GB2108109B (es) |
IT (1) | IT1156490B (es) |
NL (1) | NL8203225A (es) |
NO (1) | NO159591C (es) |
PH (1) | PH18055A (es) |
PT (1) | PT75424B (es) |
SE (1) | SE452984B (es) |
SU (1) | SU1356962A3 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
FR2557570B1 (fr) * | 1984-01-04 | 1986-04-18 | Adir | Nouveaux derives de la quinoleine, leur procede de preparation et les compositions pharmaceutiques les renfermant |
DE3423003A1 (de) * | 1984-06-22 | 1986-01-02 | Beiersdorf Ag, 2000 Hamburg | Benzo(c)(1,8)naphthyridine, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen |
DE3431303A1 (de) * | 1984-08-25 | 1986-02-27 | Goedecke Ag | 1,6-naphthyridin-derivate, verfahren zu deren herstellung und deren verwendung |
US4886809A (en) * | 1986-07-31 | 1989-12-12 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives and salts thereof |
JPH0696555B2 (ja) * | 1986-07-31 | 1994-11-30 | 大塚製薬株式会社 | カルボスチリル誘導体 |
US5098477A (en) * | 1988-12-14 | 1992-03-24 | Ciba-Geigy Corporation | Inks, particularly for ink printing |
JP2686887B2 (ja) * | 1992-08-11 | 1997-12-08 | キッセイ薬品工業株式会社 | ピペリジノ−3,4−ジヒドロカルボスチリル誘導体 |
NZ547278A (en) * | 2003-12-10 | 2010-01-29 | Janssen Pharmaceutica Nv | Substituted 6-cyclohexylalkyl substituted 2-quinolinones and 2-quinoxalinones as PARP inhibitors for chemosensitization or radiosensitization |
HRP20171415T4 (hr) | 2009-06-25 | 2023-03-03 | Alkermes Pharma Ireland Limited | Heterociklični spojevi za liječenje neuroloških i psiholoških poremećaja |
ES2834973T3 (es) | 2010-05-04 | 2021-06-21 | Alkermes Pharma Ireland Ltd | Procedimiento de síntesis de compuestos de lactama oxidada |
RU2448698C2 (ru) * | 2010-06-21 | 2012-04-27 | Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО НижГМА Росздрава) | Способ восстановления синусового ритма при трепетании предсердий i типа |
EP2585066B1 (en) | 2010-06-24 | 2018-09-26 | Alkermes Pharma Ireland Limited | Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5118771A (ja) * | 1974-08-07 | 1976-02-14 | Akimitsu Takeya | Bantaioshigatanitaisuru keshoshiitotenchakuho |
US4081447A (en) * | 1975-04-09 | 1978-03-28 | Abbott Laboratories | 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof |
JPS597707B2 (ja) * | 1975-06-23 | 1984-02-20 | オオツカセイヤク カブシキガイシヤ | カルボスチリルユウドウタイノ セイゾウホウ |
JPS52283A (en) * | 1975-06-23 | 1977-01-05 | Otsuka Pharmaceut Co Ltd | Process for preparation of carbostyril derivatives |
GB1589871A (en) * | 1976-07-19 | 1981-05-20 | Conder Group Serv Ltd | Tank construction |
JPS5416478A (en) * | 1977-07-08 | 1979-02-07 | Otsuka Pharmaceut Co Ltd | 3,4-dihydrocarbostyril herivative |
DE2853996A1 (de) * | 1978-12-14 | 1980-07-03 | Hoechst Ag | Neue substituierte phenylpiperazinderivate und verfahren zu deren herstellung |
JPS5585520A (en) * | 1978-12-22 | 1980-06-27 | Otsuka Pharmaceut Co Ltd | Remedy for peptic ulcer |
DE2928583A1 (de) * | 1979-07-14 | 1981-01-29 | Thomae Gmbh Dr K | Verfahren zur herstellung von carbostyrilderivaten |
PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
FI77852C (fi) * | 1981-02-17 | 1989-05-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av nya, saosom hjaertmediciner anvaendbara substituerade amid- och (maettad heterocykel)karbonylkarbostyrilderivat. |
-
1982
- 1982-08-09 AU AU86980/82A patent/AU532361B2/en not_active Ceased
- 1982-08-11 CA CA000409255A patent/CA1205807A/en not_active Expired
- 1982-08-11 FI FI822803A patent/FI78688C/fi not_active IP Right Cessation
- 1982-08-11 US US06/407,099 patent/US4514401A/en not_active Expired - Lifetime
- 1982-08-12 DK DK361982A patent/DK166877B1/da active
- 1982-08-12 AR AR82290300A patent/AR241905A1/es active
- 1982-08-12 NO NO822749A patent/NO159591C/no unknown
- 1982-08-13 DE DE3230209A patent/DE3230209C2/de not_active Expired
- 1982-08-13 PT PT75424A patent/PT75424B/pt not_active IP Right Cessation
- 1982-08-13 GB GB08223310A patent/GB2108109B/en not_active Expired
- 1982-08-13 FR FR8214117A patent/FR2512019B1/fr not_active Expired
- 1982-08-13 ES ES514992A patent/ES8401058A1/es not_active Expired
- 1982-08-13 SU SU823485500A patent/SU1356962A3/ru active
- 1982-08-13 BE BE0/208806A patent/BE894105A/fr not_active IP Right Cessation
- 1982-08-13 SE SE8204677A patent/SE452984B/sv not_active IP Right Cessation
- 1982-08-14 KR KR8203652A patent/KR860000135B1/ko active
- 1982-08-15 CH CH4880/82A patent/CH650783A5/de not_active IP Right Cessation
- 1982-08-16 AT AT0310682A patent/AT383592B/de not_active IP Right Cessation
- 1982-08-16 IT IT68020/82A patent/IT1156490B/it active
- 1982-08-16 PH PH27731A patent/PH18055A/en unknown
- 1982-08-17 NL NL8203225A patent/NL8203225A/nl not_active Application Discontinuation
-
1983
- 1983-04-14 ES ES521471A patent/ES521471A0/es active Granted
- 1983-04-14 ES ES521472A patent/ES8405000A1/es not_active Expired
- 1983-04-14 ES ES521473A patent/ES8405001A1/es not_active Expired
-
1984
- 1984-02-09 AR AR295675A patent/AR240918A1/es active
- 1984-10-22 ES ES536982A patent/ES8506302A1/es not_active Expired
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20040601 |