AR111362A1 - Anticuerpos anti-ilt4 y fragmentos de unión a antígeno - Google Patents
Anticuerpos anti-ilt4 y fragmentos de unión a antígenoInfo
- Publication number
- AR111362A1 AR111362A1 ARP180100863A ARP180100863A AR111362A1 AR 111362 A1 AR111362 A1 AR 111362A1 AR P180100863 A ARP180100863 A AR P180100863A AR P180100863 A ARP180100863 A AR P180100863A AR 111362 A1 AR111362 A1 AR 111362A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- fragments
- antigen
- antibody
- ilt4
- Prior art date
Links
- 239000012634 fragment Substances 0.000 title abstract 4
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 abstract 2
- 229910052805 deuterium Inorganic materials 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 101000984189 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 2 Proteins 0.000 abstract 1
- 108060003951 Immunoglobulin Proteins 0.000 abstract 1
- 102100025583 Leukocyte immunoglobulin-like receptor subfamily B member 2 Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 102000018358 immunoglobulin Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
También se proporcionan procedimientos de uso de los mismos, por ejemplo, para tratar o prevenir el cáncer en un sujeto; y procedimientos de preparación de dichos anticuerpos y fragmentos. Reivindicación 1: Un anticuerpo o fragmento de unión a antígeno del mismo que se une a uno o más de los residuos de aminoácidos en un epítopo humano de un transcrito de tipo inmunoglobulina 4 (ILT4) seleccionado del grupo que consiste en LYREKKSASW (SEQ ID Nº 59), TRIRPEL (SEQ ID Nº 60), NGQF (SEQ ID Nº 61) y HTGRYGCQ (SEQ ID Nº 62), y protege al epítopo del intercambio de deuterio en presencia de una fuente de deuterio. Reivindicación 23: Una composición farmacéutica que comprende el anticuerpo o fragmento de cualquiera de las reivindicaciones 1 - 22. Reivindicación 27: Un vector que comprende el polinucleótido de la reivindicación 26.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762483019P | 2017-04-07 | 2017-04-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR111362A1 true AR111362A1 (es) | 2019-07-03 |
Family
ID=62063229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP180100863A AR111362A1 (es) | 2017-04-07 | 2018-04-05 | Anticuerpos anti-ilt4 y fragmentos de unión a antígeno |
Country Status (27)
Country | Link |
---|---|
US (3) | US11053315B2 (es) |
EP (1) | EP3606958A1 (es) |
JP (2) | JP7045392B2 (es) |
KR (1) | KR102357823B1 (es) |
CN (1) | CN110719917A (es) |
AR (1) | AR111362A1 (es) |
AU (2) | AU2018248294B2 (es) |
BR (1) | BR112019021000A2 (es) |
CA (1) | CA3057378A1 (es) |
CL (1) | CL2019002855A1 (es) |
CO (1) | CO2019011155A2 (es) |
CR (1) | CR20190459A (es) |
DO (1) | DOP2019000253A (es) |
EA (1) | EA201992402A1 (es) |
EC (1) | ECSP19072235A (es) |
GE (1) | GEP20227440B (es) |
IL (1) | IL269593A (es) |
JO (1) | JOP20190236B1 (es) |
MX (1) | MX2019011927A (es) |
NI (1) | NI201900103A (es) |
PE (1) | PE20191813A1 (es) |
PH (1) | PH12019502275A1 (es) |
SG (1) | SG11201909081YA (es) |
TN (1) | TN2019000272A1 (es) |
TW (1) | TWI796329B (es) |
UA (1) | UA126865C2 (es) |
WO (1) | WO2018187518A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2616355T3 (es) | 2007-06-18 | 2017-06-12 | Merck Sharp & Dohme B.V. | Anticuerpos para el receptor humano de muerte programada PD-1 |
EA202091540A1 (ru) * | 2017-12-22 | 2021-03-22 | Джаунс Терапьютикс, Инк. | Антитела к lilrb2 |
KR20210030405A (ko) * | 2018-07-09 | 2021-03-17 | 파이브 프라임 테라퓨틱스, 인크. | Ilt4에 결합하는 항체 |
EP3827020A1 (en) * | 2018-07-24 | 2021-06-02 | Amgen Inc. | Combination of lilrb1/2 pathway inhibitors and pd-1 pathway inhibitors |
KR20210108940A (ko) * | 2018-09-17 | 2021-09-03 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | 항-lilrb2 항체 및 이의 이용 방법 |
CA3150428A1 (en) | 2019-08-12 | 2021-02-18 | Biond Biologics Ltd. | Antibodies against ilt2 and use thereof |
CN112442527B (zh) * | 2019-08-27 | 2022-11-11 | 深圳市英马诺生物科技有限公司 | 孤独症诊断试剂盒、基因芯片、基因靶点筛选方法及应用 |
BR112022012081A2 (pt) * | 2019-12-20 | 2022-08-30 | Merck Sharp & Dohme Llc | Método para tratar câncer, kit, e, uso de uma combinação terapêutica |
MX2022008216A (es) * | 2020-01-02 | 2022-08-04 | Merck Sharp & Dohme Llc | Tratamiento de cancer en combinacion usando un antagonista de pd-1, un antagonista de ilt4 y lenvatinib o sales del mismo. |
US20230068663A1 (en) * | 2020-02-05 | 2023-03-02 | The Board Of Regents Of The University Of Texas System | Novel lilrb2 antibodies and uses thereof |
PE20221894A1 (es) | 2020-05-01 | 2022-12-13 | Ngm Biopharmaceuticals Inc | Agentes de union a ilt y metodos para su uso |
JP2023541656A (ja) * | 2020-09-17 | 2023-10-03 | メルク・シャープ・アンド・ドーム・エルエルシー | 癌を治療するための抗ilt4抗体またはそれと抗pd-1抗体との組合せの投与レジメン |
KR20240006541A (ko) * | 2021-04-09 | 2024-01-15 | 셀덱스 쎄라퓨틱스, 인크. | Ilt4에 대한 항체, 이중특이적 항-ilt4/pd-l1 항체 및 이의 용도 |
AU2022322029A1 (en) | 2021-08-05 | 2024-02-15 | Immunos Therapeutics Ag | Combination medicaments comprising hla fusion proteins |
WO2023012347A1 (en) | 2021-08-05 | 2023-02-09 | Immunos Therapeutics Ag | Pharmaceutical compositions comprising hla fusion proteins |
WO2023077521A1 (en) * | 2021-11-08 | 2023-05-11 | Celldex Therapeutics, Inc | Anti-ilt4 and anti-pd-1 bispecific constructs |
WO2023114346A2 (en) * | 2021-12-16 | 2023-06-22 | Merck Sharp & Dohme Llc | Biomarkers for predicting eligibility for an anti-ilt4 and anti-pd-1 combination therapy |
WO2023170434A1 (en) | 2022-03-11 | 2023-09-14 | Macomics Limited | Compositions and methods for modulation of macrophage activity |
WO2023192798A2 (en) * | 2022-03-28 | 2023-10-05 | Coherus Biosciences, Inc. | Anti-ilt4 compositions and methods |
WO2023211868A1 (en) * | 2022-04-29 | 2023-11-02 | Merck Sharp & Dohme Llc | Stable formulations of anti-ilt4 antibodies or antigen-binding fragments thererof in combination with anti-pd-1 antibodies and methods of use thereof |
TW202409088A (zh) * | 2022-07-08 | 2024-03-01 | 中國商科望(蘇州)生物醫藥科技有限公司 | 抗lilrb2抗體及其用途 |
WO2024022462A1 (zh) * | 2022-07-29 | 2024-02-01 | 盛禾(中国)生物制药有限公司 | 一种抗ilt4的单域抗体及其应用 |
WO2024041315A1 (en) * | 2022-08-22 | 2024-02-29 | Antengene (Hangzhou) Biologics Co., Ltd. | Novel anti-lilrb2 antibodies and uses thereof |
WO2024051804A1 (zh) * | 2022-09-08 | 2024-03-14 | 江苏恒瑞医药股份有限公司 | 抗ilt4抗体及其医药用途 |
WO2024120526A1 (zh) * | 2022-12-09 | 2024-06-13 | 诺纳生物(苏州)有限公司 | 抗ilt4抗体及其制备方法和应用 |
CN117925759A (zh) * | 2024-01-23 | 2024-04-26 | 通化康元生物科技有限公司 | 林蛙多肽制剂及其在食品和化妆品中的应用 |
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CN109790213B (zh) | 2016-07-29 | 2022-10-18 | 德克萨斯大学体系董事会 | 用于鉴定lilrb阻断抗体的方法 |
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KR20210030405A (ko) | 2018-07-09 | 2021-03-17 | 파이브 프라임 테라퓨틱스, 인크. | Ilt4에 결합하는 항체 |
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