AR104419A1 - Composición media para preparar toxina botulínica - Google Patents
Composición media para preparar toxina botulínicaInfo
- Publication number
- AR104419A1 AR104419A1 ARP160101185A ARP160101185A AR104419A1 AR 104419 A1 AR104419 A1 AR 104419A1 AR P160101185 A ARP160101185 A AR P160101185A AR P160101185 A ARP160101185 A AR P160101185A AR 104419 A1 AR104419 A1 AR 104419A1
- Authority
- AR
- Argentina
- Prior art keywords
- medium
- botulinum toxin
- composition
- hydrolyzate
- medium composition
- Prior art date
Links
- 108030001720 Bontoxilysin Proteins 0.000 title abstract 4
- 239000013028 medium composition Substances 0.000 title abstract 3
- 239000003053 toxin Substances 0.000 title 1
- 231100000765 toxin Toxicity 0.000 title 1
- 229940053031 botulinum toxin Drugs 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 2
- 241000196324 Embryophyta Species 0.000 abstract 2
- 239000001888 Peptone Substances 0.000 abstract 2
- 108010080698 Peptones Proteins 0.000 abstract 2
- 208000024777 Prion disease Diseases 0.000 abstract 2
- 208000010544 human prion disease Diseases 0.000 abstract 2
- 235000019319 peptone Nutrition 0.000 abstract 2
- 241000193155 Clostridium botulinum Species 0.000 abstract 1
- 241000193464 Clostridium sp. Species 0.000 abstract 1
- 108010068370 Glutens Proteins 0.000 abstract 1
- 240000004713 Pisum sativum Species 0.000 abstract 1
- 235000016816 Pisum sativum subsp sativum Nutrition 0.000 abstract 1
- 241000209140 Triticum Species 0.000 abstract 1
- 235000021307 Triticum Nutrition 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 235000012343 cottonseed oil Nutrition 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical class CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 abstract 1
- 235000021312 gluten Nutrition 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940066779 peptones Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0025—Culture media for plant cell or plant tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/76—Undefined extracts from plants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente se refiere a una composición de medio para la producción de toxina botulínica y más específicamente, a una composición de medio para el cultivo de Clostridium sp. capaz de producir toxina botulínica. La composición del medio de la presente comprende al menos una peptona de origen vegetal seleccionada del grupo compuesto por un hidrolizado de guisante de jardín, un hidrolizado de semilla de algodón y un hidrolizado de gluten de trigo. Cuando se utiliza el medio de acuerdo con la presente, que contiene peptonas de origen vegetal y minerales para el cultivo de Clostridium botulinum, la tasa de crecimiento de la bacteria en el medio es alrededor de 1,5 - 2 veces mayor a la de los medios utilizados en la actualidad. Además, cuando se produce toxina botulínica mediante el cultivo de la bacteria en el medio, se puede prevenir la infección con encefalopatía espongiforme transmisible (EET) o lo similar bloqueando la introducción de componentes de origen animal.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020150059654A KR101723167B1 (ko) | 2015-04-28 | 2015-04-28 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR104419A1 true AR104419A1 (es) | 2017-07-19 |
Family
ID=57199460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101185A AR104419A1 (es) | 2015-04-28 | 2016-04-27 | Composición media para preparar toxina botulínica |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9926549B2 (es) |
| EP (1) | EP3289069B1 (es) |
| JP (2) | JP2018500880A (es) |
| KR (1) | KR101723167B1 (es) |
| CN (1) | CN107109354A (es) |
| AR (1) | AR104419A1 (es) |
| AU (1) | AU2016253788B2 (es) |
| BR (1) | BR112017012885A2 (es) |
| CA (1) | CA2968041A1 (es) |
| DK (1) | DK3289069T3 (es) |
| ES (1) | ES2846927T3 (es) |
| HR (1) | HRP20210092T1 (es) |
| HU (1) | HUE052935T2 (es) |
| MX (1) | MX2017008197A (es) |
| PL (1) | PL3289069T3 (es) |
| PT (1) | PT3289069T (es) |
| RU (1) | RU2663586C1 (es) |
| SA (1) | SA517381720B1 (es) |
| TW (1) | TWI592484B (es) |
| WO (1) | WO2016175565A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101723168B1 (ko) * | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| KR101723167B1 (ko) | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| KR102209159B1 (ko) * | 2019-03-29 | 2021-01-29 | (주)제테마 | 독소의 제조방법 |
| TW202136518A (zh) * | 2019-12-20 | 2021-10-01 | 瑞士商葛德瑪控股公司 | 生產肉毒桿菌毒素的方法 |
| KR102581772B1 (ko) * | 2021-03-30 | 2023-09-22 | 강원대학교 산학협력단 | 식물 및 곤충 단백질 가수 분해물을 이용한 배양육 제조를 위한 최적 배양 방법 및 그 응용 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200003828T2 (tr) * | 1998-07-03 | 2001-06-21 | Dsm N.V. | Düşük bir serbest amino asiti konsantrasyonunda klavülanik asitin üretilmesi için fermentasyon işlemi |
| US6558926B1 (en) * | 1999-07-16 | 2003-05-06 | Massachusetts Institute Of Technology | Method for production of tetanus toxin using media substantially free of animal products |
| US7148041B2 (en) | 2003-09-25 | 2006-12-12 | Allergan, Inc. | Animal product free media and processes for obtaining a botulinum toxin |
| US7160699B2 (en) * | 2003-09-25 | 2007-01-09 | Allergan, Inc. | Media for clostridium bacterium and processes for obtaining a clostridial toxin |
| RU2255761C1 (ru) * | 2004-07-01 | 2005-07-10 | Общество с ограниченной ответственностью "Токсины и сопутствующие продукты" | Препарат для лечения мышечных дистоний из токсина культуры clostridium botulinum и способ его получения |
| WO2006042542A2 (en) * | 2004-10-19 | 2006-04-27 | Statens Serum Institut | Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin |
| WO2006096163A1 (en) * | 2005-03-03 | 2006-09-14 | Allergan, Inc. | Animal product free system and process for purifying a botulinum toxin |
| NL1029059C2 (nl) | 2005-05-17 | 2006-11-20 | Noord Nl Oliemolen Holding B V | Peptidenpreparaat voor het groeien en/of kweken van micro-organismen en/of cellen. |
| FR2918671B1 (fr) * | 2007-07-10 | 2010-10-15 | Sanofi Pasteur | Milieu de culture d'haemophilus influenzae type b. |
| CN101698826A (zh) * | 2007-12-19 | 2010-04-28 | 杨宇 | 胰酪胨肉毒梭菌增菌肉汤 |
| KR20090120222A (ko) | 2008-05-19 | 2009-11-24 | (주)메디톡스 | 식물 유래 성분 함유 배지 및 가요성 폐쇄 용기를 이용하여클로스트리디움 보툴리눔 독소를 생산하는 방법 |
| US8236356B2 (en) * | 2008-06-11 | 2012-08-07 | Roche Diagnostics Operations, Inc. | Growth medium for Clostridium histolyticum |
| BR102012013110A2 (pt) | 2012-05-31 | 2014-05-27 | Cristalia Prod Quimicos Farm | Meio de cultura para bactérias do gênero clostridium livre de componentes de origem animal e processo para produção de sobrenadante contendo uma ou mais proteases com atividade colagenolítica e gelatinolítica |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| CN103215310B (zh) * | 2013-03-27 | 2015-01-21 | 中棉紫光生物科技（上海）有限公司 | 用于发酵的棉籽蛋白及其制备方法和应用 |
| KR101339349B1 (ko) | 2013-08-02 | 2013-12-09 | 주식회사 대웅 | 보툴리눔 독소의 제조방법 |
| KR101729251B1 (ko) * | 2015-04-28 | 2017-04-21 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| KR101723168B1 (ko) * | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
| KR101723167B1 (ko) | 2015-04-28 | 2017-04-05 | 주식회사 대웅 | 보툴리눔 독소의 제조를 위한 배지 조성물 |
-
2015
- 2015-04-28 KR KR1020150059654A patent/KR101723167B1/ko active IP Right Grant
-
2016
- 2016-04-27 TW TW105113079A patent/TWI592484B/zh active
- 2016-04-27 AR ARP160101185A patent/AR104419A1/es unknown
- 2016-04-28 CA CA2968041A patent/CA2968041A1/en not_active Abandoned
- 2016-04-28 WO PCT/KR2016/004430 patent/WO2016175565A1/en active Application Filing
- 2016-04-28 BR BR112017012885A patent/BR112017012885A2/pt active Search and Examination
- 2016-04-28 US US15/521,817 patent/US9926549B2/en active Active
- 2016-04-28 CN CN201680004195.4A patent/CN107109354A/zh active Pending
- 2016-04-28 EP EP16786751.4A patent/EP3289069B1/en active Active
- 2016-04-28 PT PT167867514T patent/PT3289069T/pt unknown
- 2016-04-28 ES ES16786751T patent/ES2846927T3/es active Active
- 2016-04-28 RU RU2017120811A patent/RU2663586C1/ru active
- 2016-04-28 DK DK16786751.4T patent/DK3289069T3/da active
- 2016-04-28 HU HUE16786751A patent/HUE052935T2/hu unknown
- 2016-04-28 MX MX2017008197A patent/MX2017008197A/es unknown
- 2016-04-28 JP JP2017524476A patent/JP2018500880A/ja active Pending
- 2016-04-28 AU AU2016253788A patent/AU2016253788B2/en active Active
- 2016-04-28 PL PL16786751T patent/PL3289069T3/pl unknown
-
2017
- 2017-06-14 SA SA517381720A patent/SA517381720B1/ar unknown
-
2018
- 2018-02-09 US US15/893,297 patent/US10465179B2/en active Active
-
2019
- 2019-06-05 JP JP2019105170A patent/JP6888049B2/ja active Active
-
2021
- 2021-01-19 HR HRP20210092TT patent/HRP20210092T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20160127997A (ko) | 2016-11-07 |
| TW201638328A (zh) | 2016-11-01 |
| JP2020022435A (ja) | 2020-02-13 |
| EP3289069A4 (en) | 2018-10-03 |
| DK3289069T3 (da) | 2021-01-25 |
| TWI592484B (zh) | 2017-07-21 |
| MX2017008197A (es) | 2017-09-13 |
| RU2663586C1 (ru) | 2018-08-07 |
| PL3289069T3 (pl) | 2021-07-05 |
| JP6888049B2 (ja) | 2021-06-16 |
| HUE052935T2 (hu) | 2021-05-28 |
| CA2968041A1 (en) | 2016-11-03 |
| EP3289069A1 (en) | 2018-03-07 |
| ES2846927T3 (es) | 2021-07-30 |
| US10465179B2 (en) | 2019-11-05 |
| AU2016253788A1 (en) | 2017-05-25 |
| HRP20210092T1 (hr) | 2021-04-30 |
| BR112017012885A2 (pt) | 2018-01-30 |
| US20170247675A1 (en) | 2017-08-31 |
| AU2016253788B2 (en) | 2018-12-13 |
| WO2016175565A1 (en) | 2016-11-03 |
| US9926549B2 (en) | 2018-03-27 |
| JP2018500880A (ja) | 2018-01-18 |
| PT3289069T (pt) | 2021-02-11 |
| SA517381720B1 (ar) | 2021-03-07 |
| CN107109354A (zh) | 2017-08-29 |
| KR101723167B1 (ko) | 2017-04-05 |
| EP3289069B1 (en) | 2020-12-09 |
| US20180163193A1 (en) | 2018-06-14 |
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