AR104419A1 - Composición media para preparar toxina botulínica - Google Patents

Composición media para preparar toxina botulínica

Info

Publication number
AR104419A1
AR104419A1 ARP160101185A ARP160101185A AR104419A1 AR 104419 A1 AR104419 A1 AR 104419A1 AR P160101185 A ARP160101185 A AR P160101185A AR P160101185 A ARP160101185 A AR P160101185A AR 104419 A1 AR104419 A1 AR 104419A1
Authority
AR
Argentina
Prior art keywords
medium
botulinum toxin
composition
hydrolyzate
medium composition
Prior art date
Application number
ARP160101185A
Other languages
English (en)
Inventor
Min Kyoung
Min - Sul Hye
Young - Kim Kyoung-Yun
Original Assignee
Daewoong Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daewoong Co Ltd filed Critical Daewoong Co Ltd
Publication of AR104419A1 publication Critical patent/AR104419A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/76—Undefined extracts from plants

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente se refiere a una composición de medio para la producción de toxina botulínica y más específicamente, a una composición de medio para el cultivo de Clostridium sp. capaz de producir toxina botulínica. La composición del medio de la presente comprende al menos una peptona de origen vegetal seleccionada del grupo compuesto por un hidrolizado de guisante de jardín, un hidrolizado de semilla de algodón y un hidrolizado de gluten de trigo. Cuando se utiliza el medio de acuerdo con la presente, que contiene peptonas de origen vegetal y minerales para el cultivo de Clostridium botulinum, la tasa de crecimiento de la bacteria en el medio es alrededor de 1,5 - 2 veces mayor a la de los medios utilizados en la actualidad. Además, cuando se produce toxina botulínica mediante el cultivo de la bacteria en el medio, se puede prevenir la infección con encefalopatía espongiforme transmisible (EET) o lo similar bloqueando la introducción de componentes de origen animal.
ARP160101185A 2015-04-28 2016-04-27 Composición media para preparar toxina botulínica AR104419A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020150059654A KR101723167B1 (ko) 2015-04-28 2015-04-28 보툴리눔 독소의 제조를 위한 배지 조성물

Publications (1)

Publication Number Publication Date
AR104419A1 true AR104419A1 (es) 2017-07-19

Family

ID=57199460

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160101185A AR104419A1 (es) 2015-04-28 2016-04-27 Composición media para preparar toxina botulínica

Country Status (20)

Country Link
US (2) US9926549B2 (es)
EP (1) EP3289069B1 (es)
JP (2) JP2018500880A (es)
KR (1) KR101723167B1 (es)
CN (1) CN107109354A (es)
AR (1) AR104419A1 (es)
AU (1) AU2016253788B2 (es)
BR (1) BR112017012885A2 (es)
CA (1) CA2968041A1 (es)
DK (1) DK3289069T3 (es)
ES (1) ES2846927T3 (es)
HR (1) HRP20210092T1 (es)
HU (1) HUE052935T2 (es)
MX (1) MX2017008197A (es)
PL (1) PL3289069T3 (es)
PT (1) PT3289069T (es)
RU (1) RU2663586C1 (es)
SA (1) SA517381720B1 (es)
TW (1) TWI592484B (es)
WO (1) WO2016175565A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101723168B1 (ko) * 2015-04-28 2017-04-05 주식회사 대웅 보툴리눔 독소의 제조를 위한 배지 조성물
KR101723167B1 (ko) 2015-04-28 2017-04-05 주식회사 대웅 보툴리눔 독소의 제조를 위한 배지 조성물
KR102209159B1 (ko) * 2019-03-29 2021-01-29 (주)제테마 독소의 제조방법
TW202136518A (zh) * 2019-12-20 2021-10-01 瑞士商葛德瑪控股公司 生產肉毒桿菌毒素的方法
KR102581772B1 (ko) * 2021-03-30 2023-09-22 강원대학교 산학협력단 식물 및 곤충 단백질 가수 분해물을 이용한 배양육 제조를 위한 최적 배양 방법 및 그 응용

Family Cites Families (19)

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CA2336363A1 (en) * 1998-07-03 2000-01-13 Dsm N.V. Fermentation process to produce clavulanic acid at a low concentration of free amino acids
US6558926B1 (en) * 1999-07-16 2003-05-06 Massachusetts Institute Of Technology Method for production of tetanus toxin using media substantially free of animal products
US7148041B2 (en) 2003-09-25 2006-12-12 Allergan, Inc. Animal product free media and processes for obtaining a botulinum toxin
US7160699B2 (en) * 2003-09-25 2007-01-09 Allergan, Inc. Media for clostridium bacterium and processes for obtaining a clostridial toxin
US7354740B2 (en) * 2003-09-25 2008-04-08 Allergan, Inc. Animal product free system and process for purifying a botulinum toxin
RU2255761C1 (ru) * 2004-07-01 2005-07-10 Общество с ограниченной ответственностью "Токсины и сопутствующие продукты" Препарат для лечения мышечных дистоний из токсина культуры clostridium botulinum и способ его получения
WO2006042542A2 (en) * 2004-10-19 2006-04-27 Statens Serum Institut Production of tetanus, diphtheria, and pertussis toxins and toxoids using fermentation media containing no components of animal or soy origin
NL1029059C2 (nl) 2005-05-17 2006-11-20 Noord Nl Oliemolen Holding B V Peptidenpreparaat voor het groeien en/of kweken van micro-organismen en/of cellen.
FR2918671B1 (fr) * 2007-07-10 2010-10-15 Sanofi Pasteur Milieu de culture d'haemophilus influenzae type b.
CN101698826A (zh) * 2007-12-19 2010-04-28 杨宇 胰酪胨肉毒梭菌增菌肉汤
KR20090120222A (ko) 2008-05-19 2009-11-24 (주)메디톡스 식물 유래 성분 함유 배지 및 가요성 폐쇄 용기를 이용하여클로스트리디움 보툴리눔 독소를 생산하는 방법
US8236356B2 (en) * 2008-06-11 2012-08-07 Roche Diagnostics Operations, Inc. Growth medium for Clostridium histolyticum
BR102012013110A2 (pt) * 2012-05-31 2014-05-27 Cristalia Prod Quimicos Farm Meio de cultura para bactérias do gênero clostridium livre de componentes de origem animal e processo para produção de sobrenadante contendo uma ou mais proteases com atividade colagenolítica e gelatinolítica
BR122016023101B1 (pt) * 2012-10-21 2022-03-22 Pfizer Inc Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
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KR101729251B1 (ko) * 2015-04-28 2017-04-21 주식회사 대웅 보툴리눔 독소의 제조를 위한 배지 조성물
KR101723168B1 (ko) * 2015-04-28 2017-04-05 주식회사 대웅 보툴리눔 독소의 제조를 위한 배지 조성물
KR101723167B1 (ko) 2015-04-28 2017-04-05 주식회사 대웅 보툴리눔 독소의 제조를 위한 배지 조성물

Also Published As

Publication number Publication date
SA517381720B1 (ar) 2021-03-07
TW201638328A (zh) 2016-11-01
US10465179B2 (en) 2019-11-05
PT3289069T (pt) 2021-02-11
EP3289069B1 (en) 2020-12-09
CA2968041A1 (en) 2016-11-03
US9926549B2 (en) 2018-03-27
MX2017008197A (es) 2017-09-13
RU2663586C1 (ru) 2018-08-07
HUE052935T2 (hu) 2021-05-28
AU2016253788B2 (en) 2018-12-13
CN107109354A (zh) 2017-08-29
BR112017012885A2 (pt) 2018-01-30
PL3289069T3 (pl) 2021-07-05
TWI592484B (zh) 2017-07-21
KR101723167B1 (ko) 2017-04-05
US20180163193A1 (en) 2018-06-14
EP3289069A4 (en) 2018-10-03
HRP20210092T1 (hr) 2021-04-30
EP3289069A1 (en) 2018-03-07
JP6888049B2 (ja) 2021-06-16
WO2016175565A1 (en) 2016-11-03
KR20160127997A (ko) 2016-11-07
JP2018500880A (ja) 2018-01-18
AU2016253788A1 (en) 2017-05-25
DK3289069T3 (da) 2021-01-25
US20170247675A1 (en) 2017-08-31
JP2020022435A (ja) 2020-02-13
ES2846927T3 (es) 2021-07-30

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