AR092071A1 - Proceso para la preparacion de derivados de ester heterociclicos - Google Patents
Proceso para la preparacion de derivados de ester heterociclicosInfo
- Publication number
- AR092071A1 AR092071A1 ARP130102809A ARP130102809A AR092071A1 AR 092071 A1 AR092071 A1 AR 092071A1 AR P130102809 A ARP130102809 A AR P130102809A AR P130102809 A ARP130102809 A AR P130102809A AR 092071 A1 AR092071 A1 AR 092071A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- formula
- group
- compound
- carbon monoxide
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- 238000002360 preparation method Methods 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 7
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 230000008878 coupling Effects 0.000 abstract 2
- 238000010168 coupling process Methods 0.000 abstract 2
- 238000005859 coupling reaction Methods 0.000 abstract 2
- 239000007789 gas Substances 0.000 abstract 2
- 150000007530 organic bases Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- -1 -OCH2CH3 Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 108010058398 Macrophage Colony-Stimulating Factor Receptor Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/0825—Preparations of compounds not comprising Si-Si or Si-cyano linkages
- C07F7/083—Syntheses without formation of a Si-C bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos son útiles como productos intermedios en la síntesis de derivados útiles como inhibidores de proteína tirosina, más particularmente, inhibidores de c-fms quinasa. Reivindicación 1: Un proceso para la preparación de un compuesto de fórmula (1) en donde A¹ se selecciona del grupo que cosiste en alquilo C₁₋₃; en donde el resto de fórmula (2) se selecciona del grupo que consiste en grupo de fórmulas (3); en donde cada R⁴ se selecciona independientemente del grupo que consiste en H, F, Cl, Br, I, -OH, -OCH₃, -OCH₂CH₃, alquilo -SC₁₋₄, alquilo -SOC₁₋₄, alquilo -SO₂C₁₋₄, alquilo C₁₋₃, -CO₂Rᵈ, -CONRᵉRᶠ, -CCRᵍ y -CN; y en donde Rᵈ se selecciona del grupo que consiste en hidrógeno y alquilo C₁₋₃; Rᵉ se selecciona del grupo que consiste en H y alquilo C₁₋₃; Rᶠ se selecciona del grupo que consiste en H y alquilo C₁₋₃; y Rᵍ se selecciona del grupo que consiste en H, -CH₂OH y -CH₂CH₂OH; o una sal farmacéuticamente aceptable de estos; el proceso comprende: hacer reaccionar un compuesto de la fórmula (4) con gas monóxido de carbono o una fuente de monóxido de carbono; en presencia de una base orgánica terciaria; en presencia de sistema de acoplamiento; en un alcohol de la fórmula A¹OH; a una temperatura en el intervalo de aproximadamente 60ºC a aproximadamente 120ºC; para dar el compuesto correspondiente de la fórmula (1). Reivindicación 40: Un proceso para la preparación de un compuesto de fórmula (5), A¹ se selecciona del grupo que consiste en alquilo C₁₋₃; o una sal farmacéuticamente aceptable de estos; el proceso comprende: hacer reaccionar el compuesto de la fórmula (6) con gas monóxido de carbono CO₍ᵍ₎ o una fuente de monóxido de carbono; en presencia de una base orgánica terciaria; en presencia de sistema de acoplamiento; en un alcohol de la fórmula A¹OH; a una temperatura en el intervalo de aproximadamente 60ºC a aproximadamente 120ºC; para dar el compuesto correspondiente de la fórmula (5).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261680412P | 2012-08-07 | 2012-08-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR092071A1 true AR092071A1 (es) | 2015-03-18 |
Family
ID=48985861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP130102809A AR092071A1 (es) | 2012-08-07 | 2013-08-07 | Proceso para la preparacion de derivados de ester heterociclicos |
Country Status (13)
Country | Link |
---|---|
US (2) | US9303046B2 (es) |
EP (1) | EP2882757B1 (es) |
JP (1) | JP6359537B2 (es) |
CN (1) | CN104870454B (es) |
AR (1) | AR092071A1 (es) |
AU (1) | AU2013299922B2 (es) |
ES (1) | ES2608628T3 (es) |
HK (2) | HK1209753A1 (es) |
IN (1) | IN2015DN00659A (es) |
JO (1) | JO3185B1 (es) |
TW (1) | TWI608009B (es) |
UY (1) | UY34973A (es) |
WO (1) | WO2014025675A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2882757B1 (en) * | 2012-08-07 | 2016-10-05 | Janssen Pharmaceutica, N.V. | Process for the preparation of heterocyclic ester derivatives |
WO2018130443A1 (de) | 2017-01-10 | 2018-07-19 | Bayer Aktiengesellschaft | Heterocyclen-derivate als schädlingsbekämpfungsmittel |
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2013
- 2013-08-05 EP EP13748442.4A patent/EP2882757B1/en active Active
- 2013-08-05 WO PCT/US2013/053595 patent/WO2014025675A1/en active Application Filing
- 2013-08-05 ES ES13748442.4T patent/ES2608628T3/es active Active
- 2013-08-05 US US13/959,120 patent/US9303046B2/en active Active
- 2013-08-05 AU AU2013299922A patent/AU2013299922B2/en active Active
- 2013-08-05 JP JP2015526601A patent/JP6359537B2/ja active Active
- 2013-08-05 CN CN201380041843.XA patent/CN104870454B/zh active Active
- 2013-08-05 IN IN659DEN2015 patent/IN2015DN00659A/en unknown
- 2013-08-06 JO JOP/2013/0238A patent/JO3185B1/ar active
- 2013-08-06 TW TW102128025A patent/TWI608009B/zh active
- 2013-08-07 UY UY0001034973A patent/UY34973A/es not_active Application Discontinuation
- 2013-08-07 AR ARP130102809A patent/AR092071A1/es not_active Application Discontinuation
-
2015
- 2015-10-23 HK HK15110432.8A patent/HK1209753A1/xx unknown
- 2015-11-19 HK HK15111395.1A patent/HK1210617A1/xx not_active IP Right Cessation
-
2016
- 2016-02-23 US US15/051,052 patent/US20160168170A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN104870454B (zh) | 2020-03-03 |
UY34973A (es) | 2014-02-28 |
JP2015525796A (ja) | 2015-09-07 |
AU2013299922B2 (en) | 2018-06-21 |
US20160168170A1 (en) | 2016-06-16 |
TWI608009B (zh) | 2017-12-11 |
WO2014025675A1 (en) | 2014-02-13 |
JP6359537B2 (ja) | 2018-07-18 |
EP2882757A1 (en) | 2015-06-17 |
JO3185B1 (ar) | 2018-03-08 |
US20140046072A1 (en) | 2014-02-13 |
AU2013299922A1 (en) | 2015-02-12 |
EP2882757B1 (en) | 2016-10-05 |
HK1209753A1 (en) | 2016-04-08 |
TW201427986A (zh) | 2014-07-16 |
HK1210617A1 (en) | 2016-04-29 |
IN2015DN00659A (es) | 2015-06-26 |
ES2608628T3 (es) | 2017-04-12 |
US9303046B2 (en) | 2016-04-05 |
CN104870454A (zh) | 2015-08-26 |
AU2013299922A8 (en) | 2015-03-12 |
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