AR085748A1 - Piridinonas biciclicas - Google Patents
Piridinonas biciclicasInfo
- Publication number
- AR085748A1 AR085748A1 ARP120101073A ARP120101073A AR085748A1 AR 085748 A1 AR085748 A1 AR 085748A1 AR P120101073 A ARP120101073 A AR P120101073A AR P120101073 A ARP120101073 A AR P120101073A AR 085748 A1 AR085748 A1 AR 085748A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- cyano
- optionally
- fluorine
- Prior art date
Links
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 15
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 15
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 13
- 229910052739 hydrogen Inorganic materials 0.000 abstract 13
- 239000001257 hydrogen Substances 0.000 abstract 13
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 11
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 9
- 229910052731 fluorine Inorganic materials 0.000 abstract 9
- 239000011737 fluorine Substances 0.000 abstract 9
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 125000003342 alkenyl group Chemical group 0.000 abstract 6
- 125000000304 alkynyl group Chemical group 0.000 abstract 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 6
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical group 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- CPPKAGUPTKIMNP-UHFFFAOYSA-N cyanogen fluoride Chemical compound FC#N CPPKAGUPTKIMNP-UHFFFAOYSA-N 0.000 abstract 3
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001118 alkylidene group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006708 (C5-C14) heteroaryl group Chemical group 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000001308 synthesis method Methods 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/695—Silicon compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
También se divulgan las correspondientes composiciones farmacéuticas, métodos de tratamiento, métodos de síntesis, e intermediarios. Reivindicación 1: Un compuesto que tiene la estructura de la fórmula (1), en donde: X es un heteroarilo de 5 a 14 miembros que contiene 1 - 3 heteroátomos; R¹ es hidrógeno, halógeno, alquilo C₁₋₆, cicloalquilo C₃₋₆, alquenilo C₂₋₆ o alquinilo C₂₋₆ en donde dicho alquilo, cicloalquilo, alquenilo o alquinilo puede sustituirse opcionalmente e independientemente con uno a tres de los grupos flúor, ciano, -CF₃, hidroxilo, o alcoxi C₁₋₆; R²ᵃ y R²ᵇ para cada aparición son cada uno independientemente hidrógeno, flúor, ciano, -CF₃, alquilo C₁₋₆, cicloalquilo C₃₋₆, bicicloalquilo C₄₋₁₀, alquenilo C₂₋₆, alquilideno C₂₋₆, o alquinilo C₂₋₆; en donde dicho alquilo, cicloalquilo, bicicloalquilo, alquenilo, alquilideno o alquinilo puede sustituirse opcionalmente e independientemente con ciano, alquilo C₁₋₃ o uno a tres flúor; o R²ᵃ y R²ᵇ junto con el carbono al que están unidos forman un cicloalquilo de 3 a 5 miembros opcionalmente sustituido con uno a tres R⁸; R³ es -(C(R¹¹)₂)ₜ-(arilo C₆₋₁₀) o -(C(R¹¹)₂)ₜ-(heteroarilo de 5 a 14 miembros); en donde dichos restos arilo o heteroarilo pueden sustituirse opcionalmente independientemente con uno a cinco R¹⁰; R⁴ᵃ y R⁴ᵇ son cada uno independientemente hidrógeno, -CF₃, o alquilo C₁₋₆, en donde dicho alquilo está opcionalmente sustituido con uno a tres -CF₃, ciano o flúor; o R⁴ᵃ y R⁴ᵇ junto con el carbono al que están unidos forman un cicloalquilo de 3 a 5 miembros, en donde dicho cicloalquilo está opcionalmente sustituido con uno a tres de -CF₃, ciano, flúor o alquilo C₁₋₆; R⁵ᵃ y R⁵ᵇ para cada aparición son cada uno independientemente hidrógeno, -CF₃, o alquilo C₁₋₆ en donde dicho alquilo está opcionalmente sustituido con uno a tres -CF₃, ciano o flúor; o R⁵ᵃ y R⁵ᵇ junto con el carbono al que están unidos forman un cicloalquilo de 3 a 5 miembros, en donde dicho cicloalquilo está opcionalmente sustituido con uno a tres -CF₃, ciano, flúor o alquilo C₁₋₆; R⁶, R⁷ y R⁸ son independientemente hidrógeno, -CF₃, ciano, halógeno, alquilo C₁₋₆ o -OR⁹; siempre que R⁶ y R⁷ no pueden ser ambos -OH; R⁹ es hidrógeno, alquilo C₁₋₆, cicloalquilo C₃₋₆, alquenilo C₃₋₆ o alquinilo C₃₋₆ en donde dicho alquilo, cicloalquilo, alquenilo o alquinilo puede sustituirse opcionalmente e independientemente con ciano, o uno a tres flúor; cada R¹⁰ es independientemente hidrógeno, halógeno, ciano, -CF₃, alquilo C₁₋₆, -(C(R¹¹)₂)ₘ-(cicloalquilo C₃₋₆), -(C(R¹¹)₂)ₘ-(bicicloalquilo C₄₋₁₀), (C(R¹¹)₂)ₘ-(heterocicloalquilo de 4 a 10 miembros), -(C(R¹¹)₂)ₘ-(arilo C₆₋₁₀), (C(R¹¹)₂)ₘ-(heteroarilo de 5 a 10 miembros), (C(R¹¹)₂)ₘ-OR¹², -C(O)R¹³, -SF₅ o -Si(CH₃)₃; en donde dichos restos alquilo, cicloalquilo, bicicloalquilo, heterocicloalquilo, arilo o heteroarilo pueden sustituirse opcionalmente e independientemente con uno a tres R¹⁴; cada R¹¹ es independientemente hidrógeno, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, cicloalquilo C₃₋₄, flúor, -CF₃, -CHF₂ o -OR¹² en donde dichos retos alquilo, alquenilo, alquinilo o cicloalquilo pueden sustituirse opcionalmente independientemente con uno a tres flúor o ciano; cada R¹² es independientemente hidrógeno, alquilo C₁₋₆, -CF₃, -(C(R¹⁴)₂)ₙ-(cicloalquilo C₃₋₆), -(C(R¹⁴)₂)ₙ-(heterocicloalquilo de 4 a 10 miembros), -(C(R¹⁴)₂)ₙ-(arilo C₆₋₁₀) o -(C(R¹⁴)₂)ₙ-(heteroarilo de 5 a 10 miembros); en donde dichos restos alquilo, cicloalquilo, heterocicloalquilo, arilo o heteroarilo pueden sustituirse opcionalmente independientemente con uno a tres R¹⁶; cada R¹³ es independientemente alquilo C₁₋₆, -(C(R¹⁶)₂)ₚ-(cicloalquilo C₃), -(C(R¹⁶)₂)ₚ-(heterocicloalquilo de 4 a 10 miembros), -(C(R¹⁶)₂)ₚ-(arilo C₆₋₁₀) o -(C(R¹⁶)₂)ₚ-(heteroarilo de 5 a 10 miembros); en donde dichos restos alquilo, cicloalquilo, heterocicloalquilo, arilo o heteroarilo pueden sustituirse opcionalmente independientemente con uno a tres R¹⁶; cada R¹⁴ es independientemente hidrógeno, alquilo C₁₋₆, alquenilo C₂₋₆, alquinilo C₂₋₆, halógeno, ciano, -CF₃, -CHF₂, -OR⁹ o -OCF₃; R¹⁶ es independientemente hidrógeno, -CF₃, ciano, halógeno, alquilo C₁₋₆ o -OR⁹; en donde dicho resto alquilo puede sustituirse opcionalmente con uno a tres R¹⁷; R¹⁷ es independientemente hidrógeno, hidroxilo, -CF₃, ciano, flúor, alquenilo C₂₋₆ o alquinilo C₂₋₆; en donde dicho resto alquenilo o alquinilo puede sustituirse opcionalmente con uno a tres hidrógeno, flúor o alquilo C₁₋₆; y cada t, m, n ó p es un número entero independientemente seleccionado de 0, 1, 2, 3 y 4; z es un número entero seleccionado de 1 y 2; y es un número entero seleccionado de 1, 2, 3 y 4; y sales aceptables para uso farmacéutico del mismo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161470076P | 2011-03-31 | 2011-03-31 | |
US201261599022P | 2012-02-15 | 2012-02-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR085748A1 true AR085748A1 (es) | 2013-10-23 |
Family
ID=45937491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120101073A AR085748A1 (es) | 2011-03-31 | 2012-03-29 | Piridinonas biciclicas |
Country Status (9)
Country | Link |
---|---|
US (2) | US8697673B2 (es) |
EP (1) | EP2691393B1 (es) |
JP (1) | JP5767393B2 (es) |
AR (1) | AR085748A1 (es) |
CA (1) | CA2830027C (es) |
ES (1) | ES2602794T3 (es) |
TW (1) | TW201300384A (es) |
UY (1) | UY33978A (es) |
WO (1) | WO2012131539A1 (es) |
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CN103787839A (zh) * | 2014-01-21 | 2014-05-14 | 苏州昊帆生物科技有限公司 | 合成2, 3, 4, 5, 6-五氟苯酚的方法 |
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JP5576403B2 (ja) | 2009-02-06 | 2014-08-20 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | γ分泌酵素調節物質としての新規置換二環複素環化合物 |
TWI461425B (zh) | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
CN102439005B (zh) | 2009-05-07 | 2015-07-22 | 杨森制药公司 | 作为γ-分泌酶调节剂的取代的吲唑和氮杂-吲唑衍生物 |
BR112012000915A2 (pt) | 2009-07-15 | 2019-09-24 | Janssen Pharmaceuticals Inc | derivados de triazol e imidazol substituídos como moduladores de gama secretase. |
US9145399B2 (en) | 2010-01-15 | 2015-09-29 | Janssen Pharmaceuticals, Inc. | Substituted bicyclic triazole derivatives as gamma secretase modulators |
AU2012230348A1 (en) | 2011-03-24 | 2013-08-29 | Cellzome Limited | Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators |
KR101913135B1 (ko) | 2011-07-15 | 2018-10-30 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절 인자로서의 신규의 치환 인돌 유도체 |
CN106063787A (zh) | 2012-02-03 | 2016-11-02 | 泰华制药工业有限公司 | 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途 |
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UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
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JP2014101316A (ja) * | 2012-11-20 | 2014-06-05 | Toyobo Co Ltd | ベンゾ[1,2−d;4,5−d’]ビスチアゾール化合物の製造方法 |
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JP6283691B2 (ja) * | 2013-01-17 | 2018-02-21 | ヤンセン ファーマシューティカ エヌ.ベー. | γセクレターゼ調節剤としての新規な置換ピリド−ピペラジノン誘導体 |
EP3052495B1 (en) * | 2013-10-04 | 2019-06-26 | Pfizer Inc | Novel bicyclic pyridinones as gamma-secretase modulators |
JP6541667B2 (ja) * | 2014-01-16 | 2019-07-10 | エフ エム シー コーポレーションFmc Corporation | 除草剤としてのピリミジニルオキシベンゼン誘導体 |
US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
CA2944308A1 (en) * | 2014-04-01 | 2015-10-08 | Pfizer Inc. | Chromene and 1,1 a,2,7b-tetrahydrocyclopropa[c]chromene pyridopyrazinediones as gamma-secretase modulators |
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KR20170005434A (ko) | 2014-04-29 | 2017-01-13 | 테바 파마슈티컬 인더스트리즈 리미티드 | 높은 장애 상태를 갖는 재발-완화형 다발성 경화증(rrms) 환자 치료용 라퀴니모드 |
EA033423B1 (ru) | 2015-02-03 | 2019-10-31 | Pfizer | Циклопропанбензофуранилпиридопиразиндионы |
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WO2018031680A1 (en) * | 2016-08-10 | 2018-02-15 | Fronthera U.S. Pharmaceuticals Llc | Novel compounds, uses and methods for their preparation |
CN110256369A (zh) * | 2019-07-01 | 2019-09-20 | 中国人民大学 | 一种制备多氟烷基取代的异恶唑化合物的方法 |
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- 2012-03-21 ES ES12713360.1T patent/ES2602794T3/es active Active
- 2012-03-21 EP EP12713360.1A patent/EP2691393B1/en not_active Not-in-force
- 2012-03-21 WO PCT/IB2012/051348 patent/WO2012131539A1/en active Application Filing
- 2012-03-21 CA CA2830027A patent/CA2830027C/en not_active Expired - Fee Related
- 2012-03-21 JP JP2014501751A patent/JP5767393B2/ja not_active Expired - Fee Related
- 2012-03-28 TW TW101110869A patent/TW201300384A/zh unknown
- 2012-03-28 UY UY0001033978A patent/UY33978A/es not_active Application Discontinuation
- 2012-03-29 AR ARP120101073A patent/AR085748A1/es not_active Application Discontinuation
- 2012-03-29 US US13/433,452 patent/US8697673B2/en active Active
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103787839A (zh) * | 2014-01-21 | 2014-05-14 | 苏州昊帆生物科技有限公司 | 合成2, 3, 4, 5, 6-五氟苯酚的方法 |
CN103787839B (zh) * | 2014-01-21 | 2015-12-02 | 苏州昊帆生物科技有限公司 | 合成2,3,4,5,6-五氟苯酚的方法 |
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UY33978A (es) | 2012-10-31 |
CA2830027C (en) | 2016-04-26 |
ES2602794T3 (es) | 2017-02-22 |
CA2830027A1 (en) | 2012-10-04 |
EP2691393B1 (en) | 2016-09-14 |
TW201300384A (zh) | 2013-01-01 |
WO2012131539A1 (en) | 2012-10-04 |
US9067934B2 (en) | 2015-06-30 |
US20120252758A1 (en) | 2012-10-04 |
JP2014510747A (ja) | 2014-05-01 |
US20140045790A1 (en) | 2014-02-13 |
US8697673B2 (en) | 2014-04-15 |
EP2691393A1 (en) | 2014-02-05 |
JP5767393B2 (ja) | 2015-08-19 |
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