AR084530A2 - Un metodo para facilitar la produccion del virus del sindrome reproductor y respiratorio porcino (prrsv) a partir de un cultivo de celulas de vertebrados - Google Patents

Un metodo para facilitar la produccion del virus del sindrome reproductor y respiratorio porcino (prrsv) a partir de un cultivo de celulas de vertebrados

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Publication number
AR084530A2
AR084530A2 ARP110104871A AR084530A2 AR 084530 A2 AR084530 A2 AR 084530A2 AR P110104871 A ARP110104871 A AR P110104871A AR 084530 A2 AR084530 A2 AR 084530A2
Authority
AR
Argentina
Prior art keywords
virus
prrsv
facilitate
production
respiratory syndrome
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English (en)
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of AR084530A2 publication Critical patent/AR084530A2/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0688—Cells from the lungs or the respiratory tract
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/12011—Asfarviridae
    • C12N2710/12051—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10051—Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un método para facilitar la producción del Virus del Síndrome Reproductor y Respiratorio Porcino (PRRSV) a partir de un cultivo de células de vertebrados que comprende los pasos de: (a) proveer una célula recombinante de vertebrados transfectada con un polinucleótido exógeno que codifica un polipéptido que tiene un dominio de transmembrana y al menos 85% de identidad de secuencia con la SEQ ID Nº 2, tal que la expresión del polipéptido en dicha célula se incrementa; (b) poner en contacto un cultivo de dicha célula con virus PRRSV bajo condiciones que permiten la infección de las células y el crecimiento del virus; y (c) recuperar el virus de dicho cultivo.
ARP110104871 2004-04-23 2011-12-21 Un metodo para facilitar la produccion del virus del sindrome reproductor y respiratorio porcino (prrsv) a partir de un cultivo de celulas de vertebrados AR084530A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56521404P 2004-04-23 2004-04-23
US63473604P 2004-12-09 2004-12-09

Publications (1)

Publication Number Publication Date
AR084530A2 true AR084530A2 (es) 2013-05-22

Family

ID=35320736

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP050101615 AR049033A1 (es) 2004-04-23 2005-04-22 Factor de permisividad celular para virus y usos del mismo
ARP110104870 AR084529A2 (es) 2004-04-23 2011-12-21 Un metodo para la produccion del virus del sindrome reproductor y respiratorio porcino (prrsv) a partir de un cultivo de celulas de vertebrados
ARP110104871 AR084530A2 (es) 2004-04-23 2011-12-21 Un metodo para facilitar la produccion del virus del sindrome reproductor y respiratorio porcino (prrsv) a partir de un cultivo de celulas de vertebrados

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ARP050101615 AR049033A1 (es) 2004-04-23 2005-04-22 Factor de permisividad celular para virus y usos del mismo
ARP110104870 AR084529A2 (es) 2004-04-23 2011-12-21 Un metodo para la produccion del virus del sindrome reproductor y respiratorio porcino (prrsv) a partir de un cultivo de celulas de vertebrados

Country Status (22)

Country Link
US (4) US7754464B2 (es)
EP (2) EP1742658B1 (es)
JP (2) JP5273642B2 (es)
CN (1) CN102220289B (es)
AR (3) AR049033A1 (es)
AU (2) AU2005240002B2 (es)
BR (1) BRPI0508928B1 (es)
CA (1) CA2564769C (es)
CL (1) CL2008002323A1 (es)
DK (1) DK1742658T3 (es)
EA (1) EA013071B1 (es)
ES (2) ES2530694T3 (es)
HK (1) HK1109065A1 (es)
IL (1) IL178160A0 (es)
MA (1) MA28544B1 (es)
MX (1) MXPA06012216A (es)
NO (1) NO341211B1 (es)
NZ (1) NZ550145A (es)
PL (1) PL1742658T3 (es)
TW (2) TWI438278B (es)
UY (1) UY28867A1 (es)
WO (1) WO2005107796A2 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2564769C (en) * 2004-04-23 2013-12-17 Pharmacia & Upjohn Company Llc Cellular permissivity factor for viruses, and uses thereof
AR064888A1 (es) * 2007-01-12 2009-04-29 Univ Illinois Celulas no simias para el crecimiento del virus del sindrome reproductor y respiratorio porcino (prrs)
ES2567561T3 (es) * 2007-07-27 2016-04-25 Universiteit Gent Células permisivas y sus usos
UA108902C2 (uk) * 2010-11-10 2015-06-25 Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування
KR102012109B1 (ko) * 2012-05-17 2019-08-19 조에티스 엘엘씨 이유 전 돼지 생식기 호흡기 증후군(prrs) 바이러스에 대한 효과적인 백신접종
CN103525766B (zh) * 2013-03-24 2015-06-17 西北农林科技大学 一种猪肾细胞系及其应用
GB201313235D0 (en) 2013-07-24 2013-09-04 Univ Edinburgh Antiviral Compositions Methods and Animals
CN104459160A (zh) * 2014-12-30 2015-03-25 洛阳普莱柯万泰生物技术有限公司 试剂盒及其制备方法和使用方法
GB201617559D0 (en) 2016-10-17 2016-11-30 University Court Of The University Of Edinburgh The Swine comprising modified cd163 and associated methods
CA3047294A1 (en) * 2016-12-14 2018-06-21 Zoetis Services Llc Effective vaccination against european strains of porcine reproductive and respiratory syndrome (prrs) virus prior to weaning
CN108103099B (zh) * 2017-12-18 2022-03-04 中山大学 一种抗蓝耳病Marc-145细胞系及其制备方法和应用
CN108893450B (zh) * 2018-08-13 2022-04-19 江苏省农业科学院 先天性免疫系统重构的bhk21细胞群及其细胞克隆增毒应用
CN111996213A (zh) * 2020-02-06 2020-11-27 广西大学 猪繁殖与呼吸综合征病毒双荧光标记基因重组毒株的构建方法
KR102254246B1 (ko) * 2020-03-23 2021-05-20 큐벳 주식회사 항-cd163 항체 또는 이의 항원 결합 단편을 인코딩하는 핵산 분자 및 이를 포함하는 아데노바이러스 벡터, 및 이의 아프리카 돼지열병의 예방 또는 치료용도
US11796548B2 (en) * 2020-04-22 2023-10-24 The United States Of America, As Represented By The Secretary Of Agriculture Continuous stable cell line for identification of infectious African swine fever virus in clinical samples
WO2024123640A1 (en) 2022-12-06 2024-06-13 Zoetis Services Llc Methods and compositions for vaccinating piglets against prrs-1 virus

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Also Published As

Publication number Publication date
DK1742658T3 (en) 2015-01-19
US20120015425A1 (en) 2012-01-19
CL2008002323A1 (es) 2008-12-19
CN102220289B (zh) 2014-05-21
ES2570665T3 (es) 2016-05-19
TWI438278B (zh) 2014-05-21
US8486685B2 (en) 2013-07-16
US8058050B2 (en) 2011-11-15
CN102220289A (zh) 2011-10-19
US7754464B2 (en) 2010-07-13
EP1742658A4 (en) 2007-11-28
WO2005107796A2 (en) 2005-11-17
AR049033A1 (es) 2006-06-21
AU2009202410A1 (en) 2009-07-09
TW200604343A (en) 2006-02-01
HK1109065A1 (en) 2008-05-30
IL178160A0 (en) 2006-12-31
AU2005240002A1 (en) 2005-11-17
EA200601677A1 (ru) 2007-10-26
EP1742658B1 (en) 2014-12-24
JP2007533321A (ja) 2007-11-22
EP1742658A2 (en) 2007-01-17
JP2013078324A (ja) 2013-05-02
MXPA06012216A (es) 2007-01-17
NZ550145A (en) 2009-07-31
US20100273238A1 (en) 2010-10-28
AR084529A2 (es) 2013-05-22
US9102912B2 (en) 2015-08-11
NO341211B1 (no) 2017-09-11
UY28867A1 (es) 2005-11-30
US20140141492A1 (en) 2014-05-22
BRPI0508928B1 (pt) 2015-10-06
NO20065115L (no) 2006-11-06
TWI354025B (en) 2011-12-11
ES2530694T3 (es) 2015-03-04
JP5273642B2 (ja) 2013-08-28
BRPI0508928A (pt) 2007-08-14
EA013071B1 (ru) 2010-02-26
JP5600340B2 (ja) 2014-10-01
WO2005107796A3 (en) 2007-04-12
EP2520310B1 (en) 2016-03-30
US20050271685A1 (en) 2005-12-08
MA28544B1 (fr) 2007-04-03
PL1742658T3 (pl) 2015-05-29
CA2564769A1 (en) 2005-11-17
EP2520310A1 (en) 2012-11-07
TW201134944A (en) 2011-10-16
AU2005240002B2 (en) 2009-06-18
CA2564769C (en) 2013-12-17

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