AR081427A1 - Metodo para preparar anticuerpos con propiedades mejoradas - Google Patents
Metodo para preparar anticuerpos con propiedades mejoradasInfo
- Publication number
- AR081427A1 AR081427A1 ARP110101823A ARP110101823A AR081427A1 AR 081427 A1 AR081427 A1 AR 081427A1 AR P110101823 A ARP110101823 A AR P110101823A AR P110101823 A ARP110101823 A AR P110101823A AR 081427 A1 AR081427 A1 AR 081427A1
- Authority
- AR
- Argentina
- Prior art keywords
- improved properties
- preparing antibodies
- mutations
- region
- group
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07K14/475—Growth factors; Growth regulators
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/241—Tumor Necrosis Factors
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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Abstract
Reivindicacion 1: Un polipéptido, que contiene una region Fc que comprende las mutaciones en las posiciones aminoácidas 243 y 264 de la region Fc, en donde las mutaciones en las posiciones 243 se seleccionan a partir del grupo que consta de: F243A, F243G, F243S, F243T, F243V, F243L, F243I, F243D, F243Y, F243E, F243R, F243W y F243K y las mutaciones en la posicion 264 se seleccionan a partir del grupo que consta de: V264A, V264G, V264S, V264T, V264D, V264E, V264K, V264W, V264H, V264P, V264N, V264Q y V264L, en donde la numeracion es segun el índice EU de Kabat.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34896810P | 2010-05-27 | 2010-05-27 |
Publications (1)
Publication Number | Publication Date |
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AR081427A1 true AR081427A1 (es) | 2012-08-29 |
Family
ID=45004737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP110101823A AR081427A1 (es) | 2010-05-27 | 2011-05-27 | Metodo para preparar anticuerpos con propiedades mejoradas |
Country Status (16)
Country | Link |
---|---|
US (4) | US9187552B2 (es) |
EP (1) | EP2576616A4 (es) |
JP (2) | JP5956982B2 (es) |
KR (1) | KR101818274B1 (es) |
CN (1) | CN103080130B (es) |
AR (1) | AR081427A1 (es) |
AU (1) | AU2011258425B2 (es) |
BR (1) | BR112012030179A8 (es) |
CA (1) | CA2799595C (es) |
CO (1) | CO6640254A2 (es) |
IL (1) | IL223018A0 (es) |
MX (1) | MX339809B (es) |
NZ (1) | NZ603883A (es) |
RU (1) | RU2604811C2 (es) |
TW (1) | TW201202266A (es) |
WO (1) | WO2011149999A2 (es) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
US8680020B2 (en) | 2008-07-15 | 2014-03-25 | Academia Sinica | Glycan arrays on PTFE-like aluminum coated glass slides and related methods |
US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
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EP2576616A4 (en) | 2014-05-21 |
CO6640254A2 (es) | 2013-03-22 |
JP5956982B2 (ja) | 2016-07-27 |
CA2799595C (en) | 2022-08-16 |
BR112012030179A2 (pt) | 2016-11-01 |
US20130071390A1 (en) | 2013-03-21 |
AU2011258425B2 (en) | 2015-12-10 |
US11959118B2 (en) | 2024-04-16 |
US10858686B2 (en) | 2020-12-08 |
KR101818274B1 (ko) | 2018-01-12 |
BR112012030179A8 (pt) | 2023-03-14 |
AU2011258425A1 (en) | 2012-12-20 |
TW201202266A (en) | 2012-01-16 |
US20160083765A1 (en) | 2016-03-24 |
JP2013529908A (ja) | 2013-07-25 |
US9187552B2 (en) | 2015-11-17 |
CN103080130B (zh) | 2016-08-17 |
IL223018A0 (en) | 2013-02-03 |
KR20130109983A (ko) | 2013-10-08 |
US20210047670A1 (en) | 2021-02-18 |
CA2799595A1 (en) | 2011-12-01 |
EP2576616A2 (en) | 2013-04-10 |
NZ603883A (en) | 2015-01-30 |
WO2011149999A2 (en) | 2011-12-01 |
CN103080130A (zh) | 2013-05-01 |
MX339809B (es) | 2016-06-09 |
RU2012157270A (ru) | 2014-07-10 |
MX2012013771A (es) | 2013-01-24 |
JP2016155838A (ja) | 2016-09-01 |
WO2011149999A3 (en) | 2012-01-19 |
US20180346951A1 (en) | 2018-12-06 |
RU2604811C2 (ru) | 2016-12-10 |
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