AR080043A1 - Metodos y composiciones usando polipeptidos de fusion de factor de crecimiento de fibroblastos 23 (fgf23) - Google Patents

Metodos y composiciones usando polipeptidos de fusion de factor de crecimiento de fibroblastos 23 (fgf23)

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Publication number
AR080043A1
AR080043A1 ARP110100273A ARP110100273A AR080043A1 AR 080043 A1 AR080043 A1 AR 080043A1 AR P110100273 A ARP110100273 A AR P110100273A AR P110100273 A ARP110100273 A AR P110100273A AR 080043 A1 AR080043 A1 AR 080043A1
Authority
AR
Argentina
Prior art keywords
fgf23
variant
growth factor
fibroblast growth
functionally active
Prior art date
Application number
ARP110100273A
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English (en)
Spanish (es)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR080043A1 publication Critical patent/AR080043A1/es

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
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    • C12N9/2405—Glucanases
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    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
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ARP110100273A 2010-01-29 2011-01-27 Metodos y composiciones usando polipeptidos de fusion de factor de crecimiento de fibroblastos 23 (fgf23) AR080043A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/696,693 US8420088B2 (en) 2008-01-28 2010-01-29 Methods and compositions using FGF23 fusion polypeptides

Publications (1)

Publication Number Publication Date
AR080043A1 true AR080043A1 (es) 2012-03-07

Family

ID=43828141

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ARP110100273A AR080043A1 (es) 2010-01-29 2011-01-27 Metodos y composiciones usando polipeptidos de fusion de factor de crecimiento de fibroblastos 23 (fgf23)

Country Status (16)

Country Link
US (3) US8420088B2 (OSRAM)
EP (2) EP3124612A1 (OSRAM)
JP (2) JP5964243B2 (OSRAM)
KR (1) KR20130032296A (OSRAM)
CN (3) CN102725413B (OSRAM)
AR (1) AR080043A1 (OSRAM)
AU (1) AU2011209380B2 (OSRAM)
CA (1) CA2787285A1 (OSRAM)
EA (1) EA201201047A1 (OSRAM)
ES (1) ES2605302T3 (OSRAM)
MX (1) MX336391B (OSRAM)
PL (1) PL2529016T3 (OSRAM)
PT (1) PT2529016T (OSRAM)
TW (2) TWI569805B (OSRAM)
UY (1) UY33204A (OSRAM)
WO (1) WO2011092234A1 (OSRAM)

Families Citing this family (35)

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US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
CN103649127B (zh) 2011-07-01 2021-03-19 恩格姆生物制药公司 用于代谢病症和疾病治疗的组合物、应用和方法
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
WO2014085365A2 (en) 2012-11-28 2014-06-05 Ngm Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
CN102961739A (zh) * 2012-12-12 2013-03-13 黄曙 Klotho蛋白的用途
KR102607543B1 (ko) * 2012-12-27 2023-11-30 엔지엠 바이오파마슈티컬스, 아이엔씨. 담즙산 항상성의 조절 및 담즙산 질환 및 질병의 치료 방법
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
WO2014152993A1 (en) * 2013-03-14 2014-09-25 The Board Of Regents Of The University Of Oklahoma Use of klotho nucleic acids or proteins for treatment of diabetes and diabetes-related conditions
KR101492710B1 (ko) * 2013-04-03 2015-02-13 중앙대학교 산학협력단 Fgf23 유전자를 이용한 전립선암 진단용 마커 및 이를 이용한 전립선암 예측 및 진단 방법
JP6159930B2 (ja) * 2013-10-24 2017-07-12 地方独立行政法人東京都健康長寿医療センター 筋幹細胞又は筋芽細胞、及びそれを用いた代謝変換に関与する物質のスクリーニング方法、並びにスクリーニング方法によって得られた物質を含む医薬組成物
CN105828878A (zh) 2013-10-28 2016-08-03 恩格姆生物制药公司 癌症模型及相关方法
CA2929181A1 (en) 2013-11-13 2015-05-21 Novartis Ag Mtor inhibitors for enhancing the immune response
SG10201806108TA (en) 2014-01-24 2018-08-30 Ngm Biopharmaceuticals Inc Binding proteins and methods of use thereof
JP6370577B2 (ja) * 2014-03-26 2018-08-08 国立大学法人京都工芸繊維大学 抗老化物質のスクリーニング方法
WO2015183890A2 (en) 2014-05-28 2015-12-03 Ngm Biopharmaceuticals, Inc. Methods and compositions for the treatment of metabolic disorders and diseases
EP3155005A4 (en) 2014-06-16 2018-07-11 NGM Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US10588980B2 (en) 2014-06-23 2020-03-17 Novartis Ag Fatty acids and their use in conjugation to biomolecules
CN114129709A (zh) 2014-10-23 2022-03-04 恩格姆生物制药公司 包含肽变异体的药物组合物及其使用方法
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