TWI569805B - 使用ｆｇｆ２３融合多肽之方法及組合物 - Google Patents

使用ｆｇｆ２３融合多肽之方法及組合物 Download PDF

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TWI569805B
TWI569805B TW103100421A TW103100421A TWI569805B TW I569805 B TWI569805 B TW I569805B TW 103100421 A TW103100421 A TW 103100421A TW 103100421 A TW103100421 A TW 103100421A TW I569805 B TWI569805 B TW I569805B
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fgf23
seq
polypeptide
klotho
amino acid
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TW103100421A
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Chinese (zh)
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TW201414488A (zh
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大衛 葛萊斯
秀 義 胡
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諾華公司
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Diabetes (AREA)
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TW103100421A 2010-01-29 2011-01-28 使用ｆｇｆ２３融合多肽之方法及組合物 TWI569805B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/696,693 US8420088B2 (en) 2008-01-28 2010-01-29 Methods and compositions using FGF23 fusion polypeptides

Publications (2)

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TW201414488A TW201414488A (zh) 2014-04-16
TWI569805B true TWI569805B (zh) 2017-02-11

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TW100103508A TWI430805B (zh) 2010-01-29 2011-01-28 使用ｆｇｆ２３融合多肽之方法及組合物

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US (3) US8420088B2 (OSRAM)
EP (2) EP3124612A1 (OSRAM)
JP (2) JP5964243B2 (OSRAM)
KR (1) KR20130032296A (OSRAM)
CN (3) CN103204941B (OSRAM)
AR (1) AR080043A1 (OSRAM)
AU (1) AU2011209380B2 (OSRAM)
CA (1) CA2787285A1 (OSRAM)
EA (1) EA201201047A1 (OSRAM)
ES (1) ES2605302T3 (OSRAM)
MX (1) MX336391B (OSRAM)
PL (1) PL2529016T3 (OSRAM)
PT (1) PT2529016T (OSRAM)
TW (2) TWI569805B (OSRAM)
UY (1) UY33204A (OSRAM)
WO (1) WO2011092234A1 (OSRAM)

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TW200936156A (en) 2008-01-28 2009-09-01 Novartis Ag Methods and compositions using Klotho-FGF fusion polypeptides
US8420088B2 (en) 2008-01-28 2013-04-16 Novartis Ag Methods and compositions using FGF23 fusion polypeptides
ES2748038T3 (es) 2011-07-01 2020-03-12 Ngm Biopharmaceuticals Inc Composiciones, usos y métodos para el tratamiento de trastornos y enfermedades metabólicos
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
EP2925775B1 (en) 2012-11-28 2020-09-16 NGM Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
CN102961739A (zh) * 2012-12-12 2013-03-13 黄曙 Klotho蛋白的用途
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
EP2938740B1 (en) 2012-12-27 2022-04-20 NGM Biopharmaceuticals, Inc. Chimeric fgf19 peptides for use in treating bile acid disorders
WO2014152993A1 (en) * 2013-03-14 2014-09-25 The Board Of Regents Of The University Of Oklahoma Use of klotho nucleic acids or proteins for treatment of diabetes and diabetes-related conditions
KR101492710B1 (ko) * 2013-04-03 2015-02-13 중앙대학교 산학협력단 Fgf23 유전자를 이용한 전립선암 진단용 마커 및 이를 이용한 전립선암 예측 및 진단 방법
ES2714127T3 (es) 2013-10-24 2019-05-27 Tokyo Metropolitan Geriatric Hospital And Inst Of Gerontology Células madre musculares o mioblastos, procedimiento de cribado de sustancias que participan en la conversión metabólica usando las mismas, y composición farmacéutica que comprende la sustancia obtenida de dicho procedimiento del cribado
KR102178945B1 (ko) 2013-10-28 2020-11-13 엔지엠 바이오파마슈티컬스, 아이엔씨. 암 모델 및 관련 방법
US20150140036A1 (en) 2013-11-13 2015-05-21 Novartis Institutes For Biomedical Research, Inc. Low, immune enhancing, dose mtor inhibitors and uses thereof
PE20170256A1 (es) 2014-01-24 2017-04-22 Ngm Biopharmaceuticals Inc Proteinas de union y sus metodos de uso
JP6370577B2 (ja) * 2014-03-26 2018-08-08 国立大学法人京都工芸繊維大学 抗老化物質のスクリーニング方法
US10398758B2 (en) 2014-05-28 2019-09-03 Ngm Biopharmaceuticals, Inc. Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions
WO2015195509A2 (en) 2014-06-16 2015-12-23 Ngm Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
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