AR080001A1 - Inhibidores de virus flaviviridae - Google Patents

Inhibidores de virus flaviviridae

Info

Publication number
AR080001A1
AR080001A1 ARP110100126A ARP110100126A AR080001A1 AR 080001 A1 AR080001 A1 AR 080001A1 AR P110100126 A ARP110100126 A AR P110100126A AR P110100126 A ARP110100126 A AR P110100126A AR 080001 A1 AR080001 A1 AR 080001A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
substituted
alkyl
aryl
membered
Prior art date
Application number
ARP110100126A
Other languages
English (en)
Spanish (es)
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43538203&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR080001(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR080001A1 publication Critical patent/AR080001A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ARP110100126A 2010-01-15 2011-01-14 Inhibidores de virus flaviviridae AR080001A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29557610P 2010-01-15 2010-01-15
US35348110P 2010-06-10 2010-06-10

Publications (1)

Publication Number Publication Date
AR080001A1 true AR080001A1 (es) 2012-03-07

Family

ID=43538203

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110100126A AR080001A1 (es) 2010-01-15 2011-01-14 Inhibidores de virus flaviviridae

Country Status (27)

Country Link
US (2) US8513298B2 (enExample)
EP (2) EP3219713A1 (enExample)
JP (2) JP5868872B2 (enExample)
KR (1) KR101727776B1 (enExample)
CN (1) CN102712633B (enExample)
AP (1) AP3576A (enExample)
AR (1) AR080001A1 (enExample)
AU (1) AU2011205744B2 (enExample)
BR (1) BR112012017382A2 (enExample)
CA (1) CA2785567C (enExample)
CL (1) CL2012001960A1 (enExample)
CR (1) CR20120417A (enExample)
EA (1) EA021196B1 (enExample)
EC (1) ECSP12012104A (enExample)
ES (1) ES2626150T3 (enExample)
IL (1) IL220545B (enExample)
MX (1) MX2012008211A (enExample)
NZ (1) NZ600817A (enExample)
PE (1) PE20130281A1 (enExample)
PL (1) PL2523950T3 (enExample)
PT (1) PT2523950T (enExample)
SG (2) SG10201500298PA (enExample)
SI (1) SI2523950T1 (enExample)
TW (1) TWI491609B (enExample)
UY (1) UY33183A (enExample)
WO (1) WO2011088345A1 (enExample)
ZA (1) ZA201205248B (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010276441B2 (en) * 2009-07-21 2015-07-02 Gilead Sciences, Inc. Inhibitors of Flaviviridae viruses
JP5774008B2 (ja) 2009-09-09 2015-09-02 ギリアード サイエンシーズ， インコーポレイテッド Ｆｌａｖｉｖｉｒｉｄａｅウイルスの阻害剤
AP3576A (en) * 2010-01-15 2016-02-08 Gilead Sciences Inc Inhibitors of flaviviridae viruses
UA108221C2 (uk) * 2010-01-15 2015-04-10 Похідні тіофен-2-карбонової кислоти як інгібітори вірусів flaviviridae
JP5891241B2 (ja) * 2010-12-20 2016-03-22 ギリアード サイエンシーズ， インコーポレイテッド Ｈｃｖを処置するための組合せ
DE102011003295A1 (de) * 2011-01-28 2012-08-02 Kiekert Ag Kraftfahrzeugschloss
PT2734515E (pt) * 2011-07-13 2016-03-11 Gilead Sciences Inc Derivados de ácido tiofen-2-carboxílico úteis como inibidores de vírus flaviviridae
KR101991298B1 (ko) * 2011-09-16 2019-06-21 길리애드 파마셋 엘엘씨 Hcv 치료 방법
CN103087052A (zh) * 2011-10-31 2013-05-08 上海壹志医药科技有限公司 噻吩衍生物及其药物用途
CN104662033B (zh) 2012-06-08 2018-10-23 吉利德科学公司 黄病毒科病毒的大环抑制剂
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
KR20150040265A (ko) * 2012-06-08 2015-04-14 길리애드 사이언시즈, 인코포레이티드 플라비비리대 바이러스의 마크로시클릭 저해제
US8759544B2 (en) * 2012-08-17 2014-06-24 Gilead Sciences, Inc. Synthesis of an antiviral compound
US8927741B2 (en) 2012-08-17 2015-01-06 Gilead Sciences, Inc. Synthesis of an antiviral compound
US8841340B2 (en) 2012-08-17 2014-09-23 Gilead Sciences, Inc. Solid forms of an antiviral compound
HUE047777T2 (hu) 2013-01-31 2020-05-28 Gilead Pharmasset Llc Két vírusellenes vegyület kombinációs készítménye
US10190162B2 (en) 2014-10-23 2019-01-29 Complete Genomics, Inc. Signal confinement sequencing (SCS) and nucleotide analogues for signal confinement sequencing
HRP20211456T1 (hr) 2014-12-26 2021-12-24 Emory University Protuvirusni derivati n4-hidroksicitidina
US10328061B2 (en) 2016-05-02 2019-06-25 Florida State University Research Foundation, Inc. Treatment of Zika virus infections using alpha-glucosidase inhibitors
ES2990061T3 (es) 2016-05-10 2024-11-28 C4 Therapeutics Inc Degronímeros espirocíclicos para la degradación de proteínas diana
EP3454856B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
WO2017197051A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Amine-linked c3-glutarimide degronimers for target protein degradation
JP2019525947A (ja) 2016-06-01 2019-09-12 エムスリー・バイオテクノロジー・インコーポレイテッドＭ３ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， Ｉｎｃ． 化合物
EP3641762A4 (en) 2017-06-20 2021-03-10 C4 Therapeutics, Inc. N / O-LINKED DEGRONES AND DEGRONIMERS FOR PROTEIN DEGRADATION
SG11202004403QA (en) 2017-12-07 2020-06-29 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CN108096562B (zh) * 2017-12-25 2021-05-11 武汉百药联科科技有限公司 20s蛋白酶体抑制剂在制备治疗日本乙型脑炎病毒感染的药物中的用途
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

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JP2012510525A (ja) 2008-12-03 2012-05-10 プレシディオ ファーマシューティカルズ インコーポレイテッド Ｈｃｖｎｓ５ａの阻害剤
AU2010276441B2 (en) 2009-07-21 2015-07-02 Gilead Sciences, Inc. Inhibitors of Flaviviridae viruses
JP5774008B2 (ja) 2009-09-09 2015-09-02 ギリアード サイエンシーズ， インコーポレイテッド Ｆｌａｖｉｖｉｒｉｄａｅウイルスの阻害剤
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UA108221C2 (uk) * 2010-01-15 2015-04-10 Похідні тіофен-2-карбонової кислоти як інгібітори вірусів flaviviridae
AP3576A (en) * 2010-01-15 2016-02-08 Gilead Sciences Inc Inhibitors of flaviviridae viruses
JP2013529684A (ja) 2010-06-28 2013-07-22 バーテックス ファーマシューティカルズ インコーポレイテッド フラビウイルス感染の処置または予防のための化合物および方法
PT2734515E (pt) 2011-07-13 2016-03-11 Gilead Sciences Inc Derivados de ácido tiofen-2-carboxílico úteis como inibidores de vírus flaviviridae

Also Published As

Publication number Publication date
US8513298B2 (en) 2013-08-20
JP5868872B2 (ja) 2016-02-24
US20130315861A1 (en) 2013-11-28
AU2011205744B2 (en) 2015-06-25
US9321753B2 (en) 2016-04-26
ES2626150T3 (es) 2017-07-24
EA021196B1 (ru) 2015-04-30
WO2011088345A1 (en) 2011-07-21
TWI491609B (zh) 2015-07-11
CA2785567A1 (en) 2011-07-21
IL220545B (en) 2018-02-28
SI2523950T1 (sl) 2017-06-30
UY33183A (es) 2011-08-31
AU2011205744A1 (en) 2012-07-26
ECSP12012104A (es) 2012-09-28
IL220545A0 (en) 2012-08-30
EP2523950B1 (en) 2017-03-15
KR101727776B1 (ko) 2017-04-17
US20110178129A1 (en) 2011-07-21
EP3219713A1 (en) 2017-09-20
NZ600817A (en) 2014-08-29
SG10201500298PA (en) 2015-03-30
JP2016041732A (ja) 2016-03-31
AP2012006414A0 (en) 2012-08-31
CR20120417A (es) 2012-11-30
EP2523950A1 (en) 2012-11-21
KR20120101733A (ko) 2012-09-14
SG182475A1 (en) 2012-08-30
BR112012017382A2 (pt) 2017-12-05
CL2012001960A1 (es) 2012-10-26
CA2785567C (en) 2018-03-27
PE20130281A1 (es) 2013-03-08
CN102712633B (zh) 2015-07-29
CN102712633A (zh) 2012-10-03
MX2012008211A (es) 2012-08-08
EA201290576A1 (ru) 2013-01-30
PL2523950T3 (pl) 2017-09-29
AP3576A (en) 2016-02-08
JP2013517291A (ja) 2013-05-16
ZA201205248B (en) 2013-03-27
PT2523950T (pt) 2017-06-01
TW201134822A (en) 2011-10-16

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