AR057954A1 - Compuestos derivados de acido tartarico, composiciones farmaceuticas que los contienen y usos como agentes antimicrobianos. - Google Patents

Compuestos derivados de acido tartarico, composiciones farmaceuticas que los contienen y usos como agentes antimicrobianos.

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Publication number
AR057954A1
AR057954A1 ARP060105292A ARP060105292A AR057954A1 AR 057954 A1 AR057954 A1 AR 057954A1 AR P060105292 A ARP060105292 A AR P060105292A AR P060105292 A ARP060105292 A AR P060105292A AR 057954 A1 AR057954 A1 AR 057954A1
Authority
AR
Argentina
Prior art keywords
group
alkyl
cycloalkyl
heterocyclyl
heteroaryl
Prior art date
Application number
ARP060105292A
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English (en)
Original Assignee
Schering Corp
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Publication date
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Publication of AR057954A1 publication Critical patent/AR057954A1/es

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
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Abstract

Compuestos de la formula (1) o su sal o solvato farmacéuticamente aceptable, donde: A se selecciona del grupo formado por las formula (2) y -CO2R1; d es 0 a 4; J se selecciona del grupo formado por O, S, y NR5; E se selecciona del grupo formado por O, S, y NR5; T es O o S; R1 y R2 son iguales o diferentes, cada uno se selecciona independientemente del grupo formado por H, alquilo, cicloalquilo, heterociclilo, arilo, arilalquilo, heteroaralquilo, y heteroarilo; o alternativamente R1 y R2, tomados en forma conjunta con el N al cual R1 y R2 se muestran unidos, representan un anillo heterocíclico de 4-8 miembros que tiene 1-3 heteroátomos incluyendo dicho N, estando dicho anillo heterocíclico opcionalmente fusionado con arilo, heteroarilo, cicloalquilo, o heterociclilo, donde cada un de dicho alquilo, cicloalquilo, heterociclilo, arilo, arilalquilo, heteroaralquilo, heteroarilo y anillo heterocíclico de 4-8 miembros puede estar no sustituido u opcionalmente sustituido en forma independiente con una o más porciones las cuales pueden ser iguales o diferentes, estando cada porcion seleccionada independientemente del grupo de porciones R70 más abajo; R10 se selecciona del grupo formado por H, alquilo, y fluoralquilo; R20 se selecciona del grupo formado por H, alquilo, y fluoralquilo; R30 es H o alquilo, o alternativamente R30 y R40 tomados en conjunto con el N al cual R40 se muestra unido en formula (1), se unen para formar un anillo heterocíclico de 4-7 miembros, done dicho anillo heterocíclico está sin sustituir u opcionalmente sustituido en forma independiente con una o más porciones las cuales pueden ser iguales o diferentes, estando cada porcion seleccionada independientemente del grupo de porciones R70 más abajo R40 es H o alquilo; R50 es H o alquilo; W es -(CR132)n-, donde n es 0 a 5 o un enlace covalente, o alternativamente dos grupos R13 pueden fusionarse para formar un cicloalquilo de 3-8 miembros, donde dicho cicloalquilo de 3-8 miembros puede estar sin sustituir u opcionalmente sustituido en forma independiente con una o más porciones las cuales pueden ser iguales o diferentes, cada porcion se selecciona independientemente del grupo de porciones R6 que se muestra más abajo; X está ausente o presente, y si X presente se selecciona del grupo formado por un enlace covalente, alquilo, alquenilo, alquinilo, cicloalquilo, heterociclilo, arilo, y heteroarilo, donde dicho alquilo, alquenilo, alquinilo, cicloalquilo, heterociclilo, arilo, y heteroarilo pueden estar sin sustituir u opcionalmente sustituidos independientemente con una o más porciones las cuales pueden ser iguales o diferentes, estando cada porcion seleccionada independientemente del grupo de porciones R70 que aparece más abajo; Y está ausente o presente, y si Y está presente, se selecciona del grupo formado por un enlace covalente, -[C(R6)2]n- donde n es 1 a 2, -O-, -S-, -NR1-, -SOv- donde v es 1 a 2, -SOn(CR62)p- donde n es 1 o 2 y p es 1 a 4, O(CR62)q- o -(CR62)qO- donde q es 1 a 4, -N(R7)S(O)n- o -S(O)nN(R7)- donde n es 1 o 2, y -N(R7)C(O)- o -C(O)N(R7)-; Z se selecciona el grupo formado por alquilo, alquenilo, alquinilo, cicloalquilo, heterociclilo, arilo, y heteroarilo, dicho cicloalquilo, heterociclilo, arilo, y heteroarilo están opcionalmente fusionados con arilo, heterociclilo, heteroarilo o cicloalquilo; donde cada uno de dicho alquilo, alquenilo, alquinilo, cicloalquilo, heterociclilo, arilo, y heteroarilo puede estar sin sustituir u opcionalmente sustituido en forma independiente con una o más porciones las cuales pueden ser iguales o diferentes, estando cada porcion seleccionada independientemente del grupo de porciones R70 que aparece más abajo; R5 se selecciona del grupo formado por H, alquilo, y alquilarilo, cada R6 es igual o diferente y se selecciona independientemente del grupo formado por H, halogeno, -SR15, -S(O)qR15 donde q es 1 a 2, alquilo cicloalquilo, heterociclilo, alcoxilo, hidroxi, nitro, ciano, amino, alquenilo, alquinilo, arilalquilo, aminocarbonilo, alquilcarbonilo, y alcoxicarbonilo; cada R7 es igual o diferente y se selecciona independientemente del grupo formado por H, alquilo, arilo, cicloalquilo, heteroarilo, heterociclilo, alquenilo, alquinilo, arilalquilo, alquilcarbonilo, y alcoxicarbonilo, donde cada uno del arilo, heteroarilo y heterociclilo puede estar sin sustituir u opcionalmente sustituido en forma independiente con una o más porciones las cuales pueden ser iguales o diferentes, estando cada porcion seleccionada independientemente del grupo de porciones R70 que aparece más abajo; R13 es igual o diferente y se selecciona independientemente del grupo formado por H, halogeno, -OH, -OR14, alquilo, cicloalquilo, heterociclilo, alquenilo, alquinilo, alquilarilo, alquilamino, y alquilcarbonilo; R14 es alquilo; cada R70 es un sustituyente para H donde se indica y es igual o diferente y se selecciona independientemente del grupo formado por alquilo, alquenilo, alquinilo, cicloalquilo, cicloalquenilo, heterociclilo, arilo, arilalquilo, heteroarilo, heteroarilalquilo, halo, -CN, -CF3, -OCF3, -OR15, -C(O)R15, C(O)OR15, -C(O)N(R15)(R16), -SR15, -S(O)qN(R15)(R16) donde q es 1 a 2, C(=NOR15)R16, -N(R15)(R16), -alquil-N(R15)(R16), -N(R15)C(O)R16, -CH2-N(R15)C(O)R16, -N(R15)S(O)R16, -N(R15)S(O)2R16, -CH2-N(R15)S(O)2R16, -N(R17)S(O)2N(R16)(R15), -N(R17)S(O)(R16)(R15), -N(R17)C(O)N(R16)(R15), -CH2-N(R17)C(O)(R16)(R15), - N(R15)C(O)OR16, -CH2-N(R15)C(O)OR16, y -S(O)qR15 donde q es de 1 a 2; y donde cada uno de alquilo, cicloalquilo, heterociclilo, arilo, arilalquilo, heteroarilo, heteroarilalquilo, alquenilo y alquinilo son independientemente no sustituidos o sustituidos con 1 a 5 grupos seleccionados en forma independiente del grupo formado por alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, halo, -CF3, -CN, -OR15, -N(R15)(R16), -C(O)OR15, -C(O)N(R15)(R16), y -N(R15)S(O)R16; y cada R15, R16 y R17 se seleccionan independientemente del grupo formado por H, alquilo, cicloalquilo, heterociclilo, arilo, y heteroarilo, o alternativamente R15 y R16 tomados en conjunto con el N al cual se muestran unidos, se unen para formar un anillo heterocíclicos de 4-8 miembros, donde dicho cicloalquilo de 4-8 miembros puede estar sin sustituir u opcionalmente sustituido en forma independiente con una o más porciones las cuales pueden ser iguales o diferentes, cada porcion es seleccionada en forma independiente del grupo formado por porciones R75 que aparecen más abajo; cada R75 se selecciona independientemente del grupo formado por alquilo, cicloalquilo, heterociclilo, arilo, arilalquilo, heteroarilo, heteroarilalquilo, alquenilo y alquinilo, y donde cada uno de alquilo, cicloalquilo, heterociclilo, arilo, arilalquilo, heteroarilo, heteroarilalquilo, alquenilo y alquinilo es independientemente no sustituido o sustituido con 1 a 5 grupos seleccionados en forma independiente del grupo formado por alquilo, cicloalquilo, heterociclilo, arilo, heteroarilo, halo, -CF3, -CN, -OR19, -N(R19)2, -C(O)OR19, -C(O)N(R19)2, y -N(R19)S(O)R19; y cada R19 se selecciona independientemente el grupo formado por H, alquilo, cicloalquilo, heterociclilo, arilo, y heteroarilo.
ARP060105292A 2005-12-01 2006-11-30 Compuestos derivados de acido tartarico, composiciones farmaceuticas que los contienen y usos como agentes antimicrobianos. AR057954A1 (es)

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EP1957058A1 (en) 2008-08-20
IL191772A0 (en) 2008-12-29
JP2009518294A (ja) 2009-05-07
CN101426486A (zh) 2009-05-06
TW200806610A (en) 2008-02-01
US7638513B2 (en) 2009-12-29
CA2632922A1 (en) 2007-06-07
ZA200804742B (en) 2009-11-25
KR20080071200A (ko) 2008-08-01
US20060178366A1 (en) 2006-08-10
WO2007064749A1 (en) 2007-06-07

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